LLPS-Coo-1560
GET3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | ATPase GET3; Arsenical pump-driving ATPase; Arsenite-stimulated ATPase; Golgi to ER traffic protein 3; Guided entry of tail-anchored proteins 3 |
| Gene Name: | GET3, Cob_09709 |
| Ensembl Gene: | Cob_09709 |
| Ensembl Protein: | ENH82063 |
| Organism: | Colletotrichum orbiculare |
| Taxa ID: | 1213857 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENH82063 | ENH82063 |
| UniProt | N4V249, N4V249_COLOR | |
| GeneBank | KB725947 | ENH82063.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAIIDADDA MEPTLQSLLD QRSLRWIFVG GKGGVGKTTT SCSLAIQLAK HRRSVLLIST 60 61 DPAHNLSDAF NQKFGKEARL IDGFENLSAM EIDPNGSMQD LLAGQGEDLD AMSGGMGGMM 120 121 QDLAFAIPGI DEAMSFAEVL KQVKSMSYET IIFDTAPTGH TLRFLSFPSV LEKALAKVSQ 180 181 LSSQYGPLLN GFLGQGGQLP NGQNLSDMME KLETLRETIS EVNAQFKDEN LTTFVCVCIP 240 241 EFLSLYETER MIQELANYGI DTHSIVVNQL LFPKKGSNCD QCNARRKMQK KYLEQIEELY 300 301 DEFNVVRMPL LVEEVRGKEK LERFSEMLTT PYVPPEMDA 339 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGCCA TCATCGACGC CGACGACGCG ATGGAGCCCA CGCTCCAGTC CCTCCTCGAC 60 61 CAGCGCTCGC TGCGCTGGAT CTTCGTCGGA GGAAAGGGAG GTGTCGGAAA GACGACGACG 120 121 TCTTGCTCCC TCGCAATCCA GCTCGCCAAG CACCGCCGCT CCGTCCTGCT CATCTCGACC 180 181 GACCCCGCGC ATAACCTCTC CGACGCCTTC AACCAGAAGT TCGGCAAGGA GGCCCGCCTC 240 241 ATCGACGGCT TCGAGAACCT CTCGGCCATG GAGATTGACC CCAACGGCAG CATGCAGGAC 300 301 CTCCTCGCCG GCCAGGGTGA GGACCTCGAC GCCATGAGCG GCGGCATGGG CGGAATGATG 360 361 CAGGACCTTG CCTTTGCTAT CCCCGGTATC GACGAAGCCA TGTCCTTCGC CGAGGTCCTC 420 421 AAGCAAGTAA AGTCCATGTC CTACGAGACC ATCATCTTCG ACACGGCCCC AACCGGCCAC 480 481 ACCCTCCGCT TCCTCTCCTT CCCCTCCGTC CTCGAAAAGG CCCTCGCAAA GGTCTCCCAG 540 541 CTCAGCTCCC AGTACGGACC CCTCCTCAAC GGCTTCCTCG GCCAGGGCGG CCAGCTCCCC 600 601 AACGGCCAGA ACCTCAGCGA CATGATGGAG AAGCTCGAGA CGCTCCGCGA GACCATCTCC 660 661 GAGGTCAACG CCCAGTTCAA GGATGAGAAC CTCACCACCT TCGTCTGCGT CTGCATCCCA 720 721 GAGTTCCTCA GCCTGTACGA GACGGAGCGC ATGATCCAGG AGCTCGCAAA CTACGGCATT 780 781 GACACCCACA GCATCGTCGT CAACCAGCTC CTCTTCCCCA AAAAGGGCAG CAACTGCGAC 840 841 CAGTGCAACG CCCGCCGCAA GATGCAGAAG AAATACCTCG AGCAGATTGA GGAGCTCTAC 900 901 GACGAGTTCA ACGTCGTGCG CATGCCCCTG CTCGTCGAGG AGGTCCGCGG AAAGGAGAAG 960 961 CTTGAAAGGT TTAGCGAGAT GTTGACCACG CCCTACGTTC CTCCCGAGAT GGACGCCTAG 1020 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Molecular Function | ATP binding | |
Molecular Function | ATPase activity | |
Molecular Function | Metal ion binding | |
Biological Process | Protein insertion into ER membrane |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cog-1445 | Colletotrichum gloeosporioides | 97.26 | 0.0 | 583 |
| LLPS-Cogr-0829 | Colletotrichum graminicola | 93.62 | 0.0 | 568 |
| LLPS-Ved-1188 | Verticillium dahliae | 91.49 | 0.0 | 548 |
| LLPS-Nec-0933 | Neurospora crassa | 89.3 | 0.0 | 513 |
| LLPS-Trr-0356 | Trichoderma reesei | 89.09 | 2e-180 | 511 |
| LLPS-Trv-1259 | Trichoderma virens | 88.79 | 0.0 | 528 |
| LLPS-Beb-0241 | Beauveria bassiana | 88.15 | 1e-176 | 501 |
| LLPS-Gag-1594 | Gaeumannomyces graminis | 87.43 | 0.0 | 518 |
| LLPS-Scs-0905 | Sclerotinia sclerotiorum | 87.38 | 0.0 | 523 |
| LLPS-Mao-0871 | Magnaporthe oryzae | 87.35 | 2e-179 | 508 |
| LLPS-Fuo-1050 | Fusarium oxysporum | 87.27 | 0.0 | 518 |
| LLPS-Fuv-0546 | Fusarium verticillioides | 86.97 | 0.0 | 517 |
| LLPS-Fus-1086 | Fusarium solani | 86.93 | 0.0 | 523 |
| LLPS-Map-1333 | Magnaporthe poae | 86.45 | 7e-176 | 499 |
| LLPS-Phn-0018 | Phaeosphaeria nodorum | 83.86 | 6e-169 | 481 |
| LLPS-Blg-1586 | Blumeria graminis | 83.49 | 7e-171 | 486 |
| LLPS-Lem-0728 | Leptosphaeria maculans | 82.07 | 7e-175 | 499 |
| LLPS-Pytr-0927 | Pyrenophora triticirepentis | 81.46 | 2e-175 | 498 |
| LLPS-Pyt-0964 | Pyrenophora teres | 81.46 | 2e-175 | 498 |
| LLPS-Nef-0553 | Neosartorya fischeri | 80.79 | 6e-175 | 496 |
| LLPS-Asni-1552 | Aspergillus niger | 80.79 | 2e-175 | 498 |
| LLPS-Ast-1342 | Aspergillus terreus | 80.73 | 1e-172 | 491 |
| LLPS-Asfu-1511 | Aspergillus fumigatus | 80.49 | 7e-174 | 494 |
| LLPS-Asc-0362 | Aspergillus clavatus | 80.18 | 2e-174 | 495 |
| LLPS-Asn-1200 | Aspergillus nidulans | 80.12 | 5e-173 | 491 |
| LLPS-Asf-0682 | Aspergillus flavus | 80.0 | 9e-163 | 468 |
| LLPS-Aso-0103 | Aspergillus oryzae | 79.57 | 6e-172 | 489 |
| LLPS-Tum-0519 | Tuber melanosporum | 75.3 | 1e-160 | 460 |
| LLPS-Dos-1287 | Dothistroma septosporum | 69.91 | 1e-144 | 419 |
| LLPS-Zyt-0613 | Zymoseptoria tritici | 69.7 | 2e-146 | 424 |
| LLPS-Put-0585 | Puccinia triticina | 68.0 | 7e-136 | 397 |
| LLPS-Usm-1104 | Ustilago maydis | 67.48 | 5e-141 | 410 |
| LLPS-Pug-0991 | Puccinia graminis | 67.48 | 5e-135 | 395 |
| LLPS-Spr-1255 | Sporisorium reilianum | 67.18 | 5e-140 | 407 |
| LLPS-Mel-0048 | Melampsora laricipopulina | 67.08 | 1e-136 | 399 |
| LLPS-Miv-0064 | Microbotryum violaceum | 66.36 | 2e-135 | 396 |
| LLPS-Scj-1028 | Schizosaccharomyces japonicus | 66.25 | 2e-132 | 388 |
| LLPS-Abg-1398 | Absidia glauca | 66.15 | 7e-143 | 414 |
| LLPS-Crn-0734 | Cryptococcus neoformans | 65.75 | 5e-143 | 415 |
| LLPS-Yal-1554 | Yarrowia lipolytica | 65.62 | 4e-134 | 392 |
| LLPS-Scp-1378 | Schizosaccharomyces pombe | 63.98 | 9e-129 | 379 |
| LLPS-Scc-1628 | Schizosaccharomyces cryophilus | 62.73 | 1e-126 | 373 |
| LLPS-Myl-3705 | Myotis lucifugus | 56.9 | 2e-53 | 181 |
| LLPS-Cis-1536 | Ciona savignyi | 55.96 | 3e-110 | 333 |
| LLPS-Kop-1233 | Komagataella pastoris | 55.76 | 4e-106 | 322 |
| LLPS-Bro-1581 | Brassica oleracea | 55.73 | 2e-105 | 320 |
| LLPS-Arl-2700 | Arabidopsis lyrata | 55.73 | 9e-107 | 323 |
| LLPS-Brn-2437 | Brassica napus | 55.73 | 2e-105 | 320 |
| LLPS-Sem-1308 | Selaginella moellendorffii | 55.62 | 2e-103 | 315 |
| LLPS-Prp-1361 | Prunus persica | 55.42 | 6e-105 | 320 |
| LLPS-Php-2002 | Physcomitrella patens | 55.42 | 6e-108 | 327 |
| LLPS-Nia-0472 | Nicotiana attenuata | 55.11 | 3e-104 | 317 |
| LLPS-Art-0584 | Arabidopsis thaliana | 55.11 | 5e-106 | 322 |
| LLPS-Glm-1760 | Glycine max | 54.66 | 2e-102 | 312 |
| LLPS-Brr-1004 | Brassica rapa | 54.49 | 5e-105 | 319 |
| LLPS-Met-0637 | Medicago truncatula | 54.21 | 7e-103 | 313 |
| LLPS-Gor-2554 | Gossypium raimondii | 54.18 | 1e-103 | 315 |
| LLPS-Hea-0701 | Helianthus annuus | 54.18 | 4e-103 | 314 |
| LLPS-Orbr-1778 | Oryza brachyantha | 53.89 | 6e-101 | 308 |
| LLPS-Sob-0732 | Sorghum bicolor | 53.89 | 2e-101 | 310 |
| LLPS-Cus-1618 | Cucumis sativus | 53.87 | 9e-102 | 311 |
| LLPS-Thc-1923 | Theobroma cacao | 53.87 | 9e-102 | 311 |
| LLPS-Lac-0814 | Latimeria chalumnae | 53.85 | 7e-107 | 323 |
| LLPS-Org-0807 | Oryza glaberrima | 53.58 | 2e-100 | 307 |
| LLPS-Zem-1520 | Zea mays | 53.58 | 6e-101 | 309 |
| LLPS-Orm-0503 | Oryza meridionalis | 53.58 | 2e-100 | 308 |
| LLPS-Orr-2345 | Oryza rufipogon | 53.58 | 2e-100 | 307 |
| LLPS-Ors-1105 | Oryza sativa | 53.58 | 2e-100 | 307 |
| LLPS-Orp-1004 | Oryza punctata | 53.58 | 2e-100 | 308 |
| LLPS-Sei-1427 | Setaria italica | 53.58 | 2e-101 | 310 |
| LLPS-Orni-0900 | Oryza nivara | 53.58 | 2e-100 | 307 |
| LLPS-Orb-1473 | Oryza barthii | 53.58 | 2e-100 | 307 |
| LLPS-Ori-2105 | Oryza indica | 53.58 | 2e-100 | 307 |
| LLPS-Tut-2481 | Tursiops truncatus | 53.49 | 3e-96 | 295 |
| LLPS-Orgl-2022 | Oryza glumaepatula | 53.27 | 1e-99 | 305 |
| LLPS-Sot-0920 | Solanum tuberosum | 53.27 | 2e-100 | 307 |
| LLPS-Lep-1440 | Leersia perrieri | 53.25 | 8e-101 | 308 |
| LLPS-Cas-2750 | Carlito syrichta | 53.23 | 6e-106 | 321 |
| LLPS-Ict-3904 | Ictidomys tridecemlineatus | 53.23 | 6e-106 | 321 |
| LLPS-Anc-3834 | Anolis carolinensis | 53.23 | 5e-106 | 321 |
| LLPS-Poa-1666 | Pongo abelii | 53.23 | 6e-106 | 321 |
| LLPS-Eqc-3853 | Equus caballus | 53.23 | 1e-105 | 320 |
| LLPS-Cap-4015 | Cavia porcellus | 53.23 | 2e-105 | 320 |
| LLPS-Mam-0930 | Macaca mulatta | 53.23 | 7e-106 | 321 |
| LLPS-Otg-4345 | Otolemur garnettii | 53.23 | 8e-106 | 321 |
| LLPS-Rhb-4762 | Rhinopithecus bieti | 53.23 | 6e-106 | 321 |
| LLPS-Pof-3321 | Poecilia formosa | 53.23 | 7e-106 | 321 |
| LLPS-Pap-2114 | Pan paniscus | 53.23 | 6e-106 | 321 |
| LLPS-Urm-3504 | Ursus maritimus | 53.23 | 6e-106 | 321 |
| LLPS-Hos-4280 | Homo sapiens | 53.23 | 6e-106 | 321 |
| LLPS-Fec-0392 | Felis catus | 53.23 | 6e-106 | 321 |
| LLPS-Mod-4085 | Monodelphis domestica | 53.23 | 4e-106 | 322 |
| LLPS-Man-0873 | Macaca nemestrina | 53.23 | 6e-106 | 321 |
| LLPS-Loa-2699 | Loxodonta africana | 53.23 | 8e-106 | 321 |
| LLPS-Ran-1852 | Rattus norvegicus | 53.23 | 6e-106 | 321 |
| LLPS-Paa-0671 | Papio anubis | 53.23 | 6e-106 | 321 |
| LLPS-Mal-2189 | Mandrillus leucophaeus | 53.23 | 6e-106 | 321 |
| LLPS-Aim-2872 | Ailuropoda melanoleuca | 53.23 | 6e-106 | 321 |
| LLPS-Mup-0229 | Mustela putorius furo | 53.23 | 6e-106 | 321 |
| LLPS-Ova-2011 | Ovis aries | 53.23 | 6e-106 | 321 |
| LLPS-Dio-4069 | Dipodomys ordii | 53.23 | 5e-106 | 321 |
| LLPS-Bot-1334 | Bos taurus | 53.23 | 6e-106 | 321 |
| LLPS-Fud-3396 | Fukomys damarensis | 53.23 | 9e-106 | 320 |
| LLPS-Asm-2538 | Astyanax mexicanus | 53.23 | 7e-106 | 321 |
| LLPS-Caj-1802 | Callithrix jacchus | 53.23 | 6e-106 | 321 |
| LLPS-Maf-1555 | Macaca fascicularis | 53.23 | 6e-106 | 321 |
| LLPS-Mum-3112 | Mus musculus | 53.23 | 6e-106 | 321 |
| LLPS-Chs-0873 | Chlorocebus sabaeus | 53.23 | 7e-106 | 321 |
| LLPS-Aon-3694 | Aotus nancymaae | 53.23 | 6e-106 | 321 |
| LLPS-Sah-2036 | Sarcophilus harrisii | 53.23 | 4e-106 | 322 |
| LLPS-Cea-2200 | Cercocebus atys | 53.23 | 6e-106 | 321 |
| LLPS-Sus-4227 | Sus scrofa | 53.23 | 6e-106 | 321 |
| LLPS-Phv-2501 | Phaseolus vulgaris | 53.11 | 4e-101 | 309 |
| LLPS-Amt-1299 | Amborella trichopoda | 53.09 | 1e-99 | 305 |
| LLPS-Cii-1640 | Ciona intestinalis | 53.09 | 1e-106 | 322 |
| LLPS-Asg-1486 | Ashbya gossypii | 53.06 | 3e-102 | 311 |
| LLPS-Viv-0748 | Vitis vinifera | 52.96 | 2e-98 | 303 |
| LLPS-Pot-2307 | Populus trichocarpa | 52.94 | 2e-99 | 305 |
| LLPS-Orn-3402 | Oreochromis niloticus | 52.92 | 5e-105 | 318 |
| LLPS-Scm-3613 | Scophthalmus maximus | 52.92 | 3e-105 | 319 |
| LLPS-Tar-1146 | Takifugu rubripes | 52.92 | 6e-105 | 318 |
| LLPS-Gog-1932 | Gorilla gorilla | 52.92 | 1e-104 | 318 |
| LLPS-Orl-1120 | Oryzias latipes | 52.92 | 4e-105 | 318 |
| LLPS-Leo-3897 | Lepisosteus oculatus | 52.92 | 2e-105 | 320 |
| LLPS-Dar-1539 | Danio rerio | 52.76 | 3e-105 | 319 |
| LLPS-Scf-2649 | Scleropages formosus | 52.76 | 2e-105 | 320 |
| LLPS-Brd-1007 | Brachypodium distachyon | 52.65 | 6e-99 | 303 |
| LLPS-Coc-1857 | Corchorus capsularis | 52.63 | 2e-99 | 305 |
| LLPS-Mae-1169 | Manihot esculenta | 52.63 | 4e-94 | 291 |
| LLPS-Xim-0032 | Xiphophorus maculatus | 52.62 | 1e-104 | 318 |
| LLPS-Icp-2882 | Ictalurus punctatus | 52.62 | 7e-105 | 318 |
| LLPS-Hov-2065 | Hordeum vulgare | 52.17 | 3e-96 | 299 |
| LLPS-Chr-1484 | Chlamydomonas reinhardtii | 52.08 | 9e-100 | 306 |
| LLPS-Drm-0597 | Drosophila melanogaster | 51.98 | 1e-102 | 312 |
| LLPS-Pat-4113 | Pan troglodytes | 51.69 | 1e-105 | 320 |
| LLPS-Tra-1944 | Triticum aestivum | 51.55 | 2e-96 | 297 |
| LLPS-Gaa-0555 | Gasterosteus aculeatus | 51.53 | 2e-97 | 298 |
| LLPS-Sac-1375 | Saccharomyces cerevisiae | 51.45 | 4e-99 | 304 |
| LLPS-Ora-0424 | Ornithorhynchus anatinus | 51.19 | 1e-97 | 298 |
| LLPS-Cae-1581 | Caenorhabditis elegans | 51.03 | 1e-102 | 312 |
| LLPS-Dac-0723 | Daucus carota | 49.77 | 5e-51 | 176 |
| LLPS-Mua-0307 | Musa acuminata | 49.7 | 3e-95 | 295 |
| LLPS-Tru-1195 | Triticum urartu | 49.49 | 8e-86 | 270 |
| LLPS-Xet-1105 | Xenopus tropicalis | 48.62 | 6e-91 | 282 |
| LLPS-Caf-4175 | Canis familiaris | 48.31 | 1e-92 | 287 |
| LLPS-Nol-1743 | Nomascus leucogenys | 48.16 | 3e-71 | 229 |
| LLPS-Gaga-3173 | Gallus gallus | 47.26 | 3e-79 | 252 |
| LLPS-Chc-0676 | Chondrus crispus | 47.11 | 2e-82 | 270 |
| LLPS-Gas-0745 | Galdieria sulphuraria | 44.71 | 7e-72 | 243 |
| LLPS-Ten-2250 | Tetraodon nigroviridis | 43.64 | 9e-71 | 230 |
| LLPS-Cym-0841 | Cyanidioschyzon merolae | 40.0 | 2e-64 | 223 |
| LLPS-Vir-1467 | Vigna radiata | 39.24 | 1e-64 | 216 |
| LLPS-Orc-4050 | Oryctolagus cuniculus | 31.8 | 5e-30 | 122 |