LLPS-Cea-1868
TUBB4B
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tubulin beta chain |
| Gene Name: | TUBB4B |
| Ensembl Gene: | ENSCATG00000036347.1 |
| Ensembl Protein: | ENSCATP00000025915.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCATT00000050149.1 | ENSCATP00000025915.1 |
| Ensembl | ENSCATT00000050101.1 | ENSCATP00000025868.1 |
| Ensembl | ENSCATT00000050167.1 | ENSCATP00000025933.1 |
| Ensembl | ENSCATT00000050165.1 | ENSCATP00000025931.1 |
| Ensembl | ENSCATT00000050143.1 | ENSCATP00000025909.1 |
| UniProt | A0A2K5ML20, A0A2K5ML20_CERAT |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV 60 61 PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV 120 121 RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV 180 181 EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL 240 241 RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM 300 301 AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG 360 361 LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE FTAMFRRKAF 420 421 LHWYTGEGMD EMEFTEAESN MNDLVSEYQQ YQDATAEEEG EFEEEAEEEV A 471 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGGAAA TCGTGCACCT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTC 60 61 TGGGAGGTGA TCAGCGATGA GCACGGCATC GACCCCACGG GCACCTACCA CGGGGACAGC 120 121 GACCTGCAGC TGGAGCGCAT CAACGTGTAC TACAACGAGG CCACCGGCGG CAAGTACGTG 180 181 CCCCGCGCCG TGCTCGTGGA TCTGGAGCCC GGCACCATGG ACTCCGTGCG CTCGGGGCCC 240 241 TTCGGGCAGA TCTTCCGGCC GGACAACTTC GTCTTCGGTC AGAGTGGTGC TGGGAACAAC 300 301 TGGGCCAAGG GGCACTACAC AGAAGGCGCG GAGCTGGTGG ACTCGGTGCT GGATGTTGTG 360 361 AGGAAGGAGG CTGAGAGCTG TGACTGCCTG CAGGGATTCC AGCTGACCCA CTCCCTGGGT 420 421 GGGGGGACGG GGTCTGGGAT GGGTACCCTC CTCATCAGCA AGATCCGGGA GGAGTACCCA 480 481 GACAGGATCA TGAACACGTT CAGTGTGGTG CCTTCGCCCA AGGTGTCAGA CACAGTGGTG 540 541 GAGCCCTACA ACGCCACCCT CTCCGTCCAC CAGCTGGTAG AAAACACAGA CGAGACCTAC 600 601 TGCATTGATA ACGAAGCTCT CTACGACATT TGCTTCAGAA CCCTAAAGTT GACCACGCCC 660 661 ACCTATGGTG ACCTGAACCA CCTGGTGTCT GCTACCATGA GTGGGGTCAC CACCTGCCTG 720 721 CGCTTCCCAG GCCAGCTCAA TGCTGACCTG CGGAAGCTGG CTGTGAACAT GGTCCCATTC 780 781 CCCCGCCTGC ACTTCTTCAT GCCCGGCTTT GCCCCACTGA CCAGCCGGGG CAGCCAGCAG 840 841 TACCGGGCCC TGACCGTGCC CGAGCTCACC CAGCAGATGT TTGATGCCAA GAACATGATG 900 901 GCTGCTTGTG ACCCCCGCCA TGGCCGCTAC CTGACGGTTG CTGCCGTGTT CAGGGGCCGC 960 961 ATGTCCATGA AGGAGGTGGA CGAGCAAATG CTTAATGTCC AAAACAAAAA CAGCAGCTAT 1020 1021 TTTGTTGAGT GGATCCCCAA CAATGTGAAA ACAGCTGTCT GTGACATCCC GCCCCGGGGG 1080 1081 CTAAAAATGT CCGCCACCTT CATCGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 1140 1141 ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 1200 1201 GAGGGCATGG ACGAGATGGA GTTCACCGAG TTCACGGCCA TGTTCCGGCG CAAGGCCTTC 1260 1261 CTGCACTGGT ACACGGGCGA GGGCATGGAC GAGATGGAGT TCACCGAGGC TGAGAGCAAC 1320 1321 ATGAACGACC TGGTGTCTGA GTACCAGCAG TACCAGGACG CCACGGCCGA GGAGGAGGGC 1380 1381 GAGTTCGAGG AGGAGGCTGA GGAGGAGGTG GCCTAG 1416 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule | |
Molecular Function | Double-stranded RNA binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | Structural constituent of cytoskeleton | |
Biological Process | Microtubule-based process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sus-0286 | Sus scrofa | 97.77 | 0.0 | 793 |
| LLPS-Mea-3878 | Mesocricetus auratus | 94.26 | 0.0 | 840 |
| LLPS-Mum-1755 | Mus musculus | 94.26 | 0.0 | 840 |
| LLPS-Chs-0448 | Chlorocebus sabaeus | 94.26 | 0.0 | 840 |
| LLPS-Sah-3322 | Sarcophilus harrisii | 94.26 | 0.0 | 840 |
| LLPS-Fud-3138 | Fukomys damarensis | 94.26 | 0.0 | 841 |
| LLPS-Caj-2185 | Callithrix jacchus | 94.26 | 0.0 | 840 |
| LLPS-Bot-4278 | Bos taurus | 94.26 | 0.0 | 840 |
| LLPS-Hos-2792 | Homo sapiens | 94.26 | 0.0 | 840 |
| LLPS-Lac-4047 | Latimeria chalumnae | 94.26 | 0.0 | 840 |
| LLPS-Mod-3852 | Monodelphis domestica | 94.26 | 0.0 | 840 |
| LLPS-Fec-0114 | Felis catus | 94.26 | 0.0 | 840 |
| LLPS-Man-4381 | Macaca nemestrina | 94.26 | 0.0 | 840 |
| LLPS-Caf-3592 | Canis familiaris | 94.26 | 0.0 | 840 |
| LLPS-Cap-3489 | Cavia porcellus | 94.26 | 0.0 | 840 |
| LLPS-Mam-0567 | Macaca mulatta | 94.26 | 0.0 | 840 |
| LLPS-Xet-1448 | Xenopus tropicalis | 94.26 | 0.0 | 842 |
| LLPS-Gaga-0553 | Gallus gallus | 94.26 | 0.0 | 841 |
| LLPS-Ict-2948 | Ictidomys tridecemlineatus | 94.26 | 0.0 | 840 |
| LLPS-Anc-3698 | Anolis carolinensis | 94.26 | 0.0 | 840 |
| LLPS-Maf-3352 | Macaca fascicularis | 94.04 | 0.0 | 839 |
| LLPS-Cii-2095 | Ciona intestinalis | 94.04 | 0.0 | 840 |
| LLPS-Cis-0796 | Ciona savignyi | 94.04 | 0.0 | 840 |
| LLPS-Scf-3711 | Scleropages formosus | 93.82 | 0.0 | 839 |
| LLPS-Dar-4256 | Danio rerio | 93.82 | 0.0 | 840 |
| LLPS-Leo-2361 | Lepisosteus oculatus | 93.6 | 0.0 | 838 |
| LLPS-Asm-3759 | Astyanax mexicanus | 93.6 | 0.0 | 838 |
| LLPS-Scm-0259 | Scophthalmus maximus | 93.6 | 0.0 | 838 |
| LLPS-Rhb-2745 | Rhinopithecus bieti | 93.6 | 0.0 | 836 |
| LLPS-Orn-2508 | Oreochromis niloticus | 93.58 | 0.0 | 837 |
| LLPS-Icp-0893 | Ictalurus punctatus | 93.38 | 0.0 | 838 |
| LLPS-Aon-3799 | Aotus nancymaae | 92.94 | 0.0 | 832 |
| LLPS-Ran-2428 | Rattus norvegicus | 92.94 | 0.0 | 832 |
| LLPS-Myl-2541 | Myotis lucifugus | 92.94 | 0.0 | 832 |
| LLPS-Mup-3527 | Mustela putorius furo | 92.94 | 0.0 | 832 |
| LLPS-Pap-1145 | Pan paniscus | 92.94 | 0.0 | 832 |
| LLPS-Pat-0017 | Pan troglodytes | 92.94 | 0.0 | 832 |
| LLPS-Otg-1654 | Otolemur garnettii | 92.94 | 0.0 | 832 |
| LLPS-Orc-3339 | Oryctolagus cuniculus | 92.94 | 0.0 | 832 |
| LLPS-Eqc-3902 | Equus caballus | 92.94 | 0.0 | 825 |
| LLPS-Gaa-1346 | Gasterosteus aculeatus | 92.92 | 0.0 | 832 |
| LLPS-Gog-0740 | Gorilla gorilla | 92.72 | 0.0 | 832 |
| LLPS-Xim-1769 | Xiphophorus maculatus | 92.72 | 0.0 | 835 |
| LLPS-Dio-3081 | Dipodomys ordii | 92.72 | 0.0 | 832 |
| LLPS-Mal-0435 | Mandrillus leucophaeus | 92.72 | 0.0 | 832 |
| LLPS-Paa-0932 | Papio anubis | 92.72 | 0.0 | 829 |
| LLPS-Ova-2492 | Ovis aries | 92.72 | 0.0 | 832 |
| LLPS-Urm-3705 | Ursus maritimus | 92.72 | 0.0 | 832 |
| LLPS-Pof-0256 | Poecilia formosa | 92.72 | 0.0 | 835 |
| LLPS-Poa-2450 | Pongo abelii | 92.72 | 0.0 | 832 |
| LLPS-Cas-0144 | Carlito syrichta | 92.72 | 0.0 | 832 |
| LLPS-Nol-3585 | Nomascus leucogenys | 92.72 | 0.0 | 832 |
| LLPS-Orl-3812 | Oryzias latipes | 92.49 | 0.0 | 831 |
| LLPS-Tut-2274 | Tursiops truncatus | 92.49 | 0.0 | 833 |
| LLPS-Aim-3912 | Ailuropoda melanoleuca | 92.49 | 0.0 | 833 |
| LLPS-Fia-0318 | Ficedula albicollis | 92.49 | 0.0 | 833 |
| LLPS-Ten-2857 | Tetraodon nigroviridis | 92.49 | 0.0 | 831 |
| LLPS-Tar-2601 | Takifugu rubripes | 92.27 | 0.0 | 832 |
| LLPS-Pes-0306 | Pelodiscus sinensis | 92.27 | 0.0 | 831 |
| LLPS-Ora-3257 | Ornithorhynchus anatinus | 92.05 | 0.0 | 828 |
| LLPS-Ere-0293 | Erinaceus europaeus | 92.05 | 0.0 | 825 |
| LLPS-Tag-2634 | Taeniopygia guttata | 92.05 | 0.0 | 830 |
| LLPS-Drm-0325 | Drosophila melanogaster | 91.94 | 0.0 | 786 |
| LLPS-Anp-3174 | Anas platyrhynchos | 91.31 | 0.0 | 768 |
| LLPS-Cae-1271 | Caenorhabditis elegans | 90.29 | 0.0 | 814 |
| LLPS-Loa-2963 | Loxodonta africana | 90.07 | 0.0 | 806 |
| LLPS-Php-1447 | Physcomitrella patens | 85.43 | 0.0 | 783 |
| LLPS-Chr-0860 | Chlamydomonas reinhardtii | 85.43 | 0.0 | 781 |
| LLPS-Sem-1389 | Selaginella moellendorffii | 84.11 | 0.0 | 774 |
| LLPS-Orbr-1685 | Oryza brachyantha | 83.89 | 0.0 | 764 |
| LLPS-Sob-2219 | Sorghum bicolor | 83.44 | 0.0 | 761 |