LLPS-Cas-1514
INSR
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tyrosine-protein kinase receptor |
| Gene Name: | INSR |
| Ensembl Gene: | ENSTSYG00000001830.2 |
| Ensembl Protein: | ENSTSYP00000023206.1 |
| Organism: | Carlito syrichta |
| Taxa ID: | 1868482 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Others | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSTSYT00000048027.1 | ENSTSYP00000023206.1 |
| Ensembl | ENSTSYT00000025787.1 | ENSTSYP00000034971.1 |
| Ensembl | ENSTSYT00000001836.2 | ENSTSYP00000001708.2 |
| UniProt | A0A1U7US90, A0A1U7US90_TARSY | |
| RefSeq | , XM_008070535.1, XM_021718802.1 | , XP_008068726.1, XP_021574477.1, XP_008068726.1, XP_021574477.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 GGRGGWRVCP GMDIRNNLTR LHELENCSVI EGHLQILLMF KTKPEDFRDL SFPKLIMITD 60 61 YLLLFRVYGL ESLKDLFPNL TVIRGSRLFF NYALVIFEMV HLKELGLYSL MNITRGSVRI 120 121 EKNNELCYLA TIDWSRILDS VEDNYIVLNK DDNEECGDIC PGTAKGKTNC PATVINGQFV 180 181 ERCWTHSHCQ KVCPTICKSH GCTAEGLCCH SECLGNCSEP DDPTKCVACR NFYLDGRCVE 240 241 TCPPPYYHFQ DWRCVNFSFC QDLHNKCKNS RRQNCPLYVI HNNKCIPECP SGYTMNSSNL 300 301 MCTPCLGPCP KVCPIPEGEK TIDSVTSAQE LRGCTVINGS LIINVRGGNN LAAELEANLG 360 361 LIEEISGYLK IRRSYALVSL SFFRKLRLIR GETLEIGNYS FYALDNQNLR QLWDWSKHNL 420 421 TITQGKLFFH YNPKLCLSEI HKMEEVSGTK GRQERNDIAL KTNGDQASCE NELLKFSSIR 480 481 TTSDKILLKW EPYWPPDFRD LLGFMLFYKE APYQNVTEFD GQDACGSNSW TVVDIDPPQR 540 541 SNDPKSQNHP GWLMRGLKPW TQYAIFVKTL VTFSDERRTY GAKSDIIYVQ TDATNPSVPL 600 601 DPISVSNSSS QIILKWKPPS DPNGNITHYL VFWERQEEDS ELYELDYCLK GLKLPSRTWS 660 661 PPFESEDSQK HNQSEYEESA GECCSCPKTD SQILKELEES SFRKTFEDYL HNVVFVPRET 720 721 SPGTGAEDTR PSRKRRSLGA IGNVTAAAPT VAAFLNTTST SVPTSPEEHR PFEKVVNKES 780 781 LVISGLRHFT GYRIELQACN QDTPEERCSV AAYVSARTMP EAKADDIVGP VTHEVFENNI 840 841 VHLMWQEPKE PNGLIVLYEV SYRRYGDEEL HLCVSRKHYA LERGCRLRGL SPGNYSVRVR 900 901 ATSLAGNGSW TEATYFYVTD YLDVPSNIAK IIIGPLIFVF LFSVVIGSIY LFLRKRQPDG 960 961 PLGPLYASSN PEYLSASDVF PCSVYVPDEW EVPREKITLL RELGQGSFGM VYEGNAKDIV 1020 1021 KGEPETRVAV KTVNESASLR ERIEFLNEAS VMKGFTCHHV VRLLGVVSKG QPTLVVMELM 1080 1081 AHGDLKSYLR SLRPEAENNP GRPPPTLQEM IQMAAEIADG MAYLNAKKFV HRDLAARNCM 1140 1141 VAHDFTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMAPE SLKDGVFTTS SDMWSFGVVL 1200 1201 WEITSLAEQP YQGLSNEQVL KFVMDGGYLD QPDNCPERVT DLMRMCWQFN PKMRPTFLDI 1260 1261 VNLLKDDLHP SFPEVSFFHS DENKAPEAEE LEMEFEDMES VPLDRSSHCQ REEAGGREGG 1320 1321 SSLGLKRNYE EHIPYTHMNG GKKNGRILTL PRSNPS 1356 |
| Nucleotide CDS Sequence (FASTA) |
1 AGACGAGTGT GTCCCGGTAT GGATATCCGG AACAACCTCA CCAGGTTGCA TGAGCTGGAG 60 61 AACTGCTCGG TCATCGAGGG CCACTTGCAG ATACTCCTGA TGTTCAAAAC GAAGCCGGAA 120 121 GACTTCCGAG ACCTCAGTTT CCCCAAGCTC ATCATGATCA CCGATTACCT GCTGCTCTTC 180 181 CGGGTCTACG GACTGGAGAG CCTGAAGGAC TTGTTCCCCA ACCTCACGGT CATCCGGGGC 240 241 TCGCGGCTCT TCTTCAACTA TGCGCTGGTC ATCTTCGAGA TGGTTCACCT GAAGGAGCTC 300 301 GGCCTCTACA GCCTGATGAA TATCACCCGG GGTTCCGTCC GCATCGAGAA AAACAATGAG 360 361 CTCTGCTACT TGGCCACCAT CGACTGGTCC CGGATCCTGG ACTCTGTGGA GGATAACTAC 420 421 ATCGTGCTGA ACAAGGATGA CAATGAGGAG TGCGGGGACA TCTGTCCGGG CACCGCGAAG 480 481 GGCAAGACCA ACTGCCCCGC CACCGTCATC AACGGGCAGT TTGTTGAGCG CTGTTGGACG 540 541 CACAGTCATT GCCAGAAAGT CTGCCCGACC ATCTGTAAGT CACATGGCTG TACCGCCGAG 600 601 GGCCTTTGCT GCCACAGCGA GTGCTTGGGG AACTGCTCCG AGCCTGATGA CCCCACCAAG 660 661 TGCGTGGCCT GCCGCAACTT CTACCTGGAC GGCAGGTGTG TGGAGACCTG CCCACCCCCA 720 721 TACTACCACT TCCAGGACTG GCGCTGCGTG AACTTCAGCT TCTGCCAGGA TCTGCACAAC 780 781 AAATGCAAGA ACTCACGGCG GCAGAACTGT CCCCTTTATG TCATTCACAA CAACAAGTGT 840 841 ATCCCTGAGT GCCCTTCTGG GTACACGATG AACTCCAGCA ACCTGATGTG CACCCCCTGC 900 901 CTGGGCCCCT GTCCCAAGGT CTGCCCCATC CCGGAAGGTG AGAAGACCAT CGACTCAGTG 960 961 ACGTCGGCCC AGGAGCTCCG AGGATGCACC GTCATCAACG GCAGCCTGAT CATCAACGTC 1020 1021 CGAGGAGGCA ACAACCTGGC AGCTGAGCTA GAAGCCAACC TCGGCCTCAT TGAAGAAATT 1080 1081 TCGGGGTATC TAAAAATTCG CCGATCCTAC GCACTGGTGT CACTTTCTTT CTTCCGGAAG 1140 1141 TTACGTCTGA TTCGAGGAGA GACCTTAGAA ATCGGGAACT ACTCCTTCTA TGCCCTGGAC 1200 1201 AACCAAAACC TGAGGCAGCT CTGGGACTGG AGCAAGCACA ACCTCACCAT CACGCAGGGC 1260 1261 AAGCTCTTCT TCCACTACAA CCCTAAGCTC TGTTTGTCGG AAATCCACAA GATGGAAGAA 1320 1321 GTTTCCGGAA CCAAGGGGCG ACAGGAGAGA AACGACATCG CCCTGAAGAC CAATGGGGAC 1380 1381 CAGGCATCCT GTGAAAATGA ATTACTTAAA TTTTCTTCCA TCCGGACAAC GTCTGACAAG 1440 1441 ATCTTGCTGA AATGGGAGCC GTACTGGCCC CCAGACTTCC GAGACCTCTT GGGGTTCATG 1500 1501 CTGTTCTACA AAGAGGCCCC TTATCAGAAC GTTACGGAAT TCGACGGGCA AGACGCATGT 1560 1561 GGCTCCAACA GCTGGACTGT GGTGGACATT GATCCACCCC AGAGGTCCAA CGACCCCAAG 1620 1621 TCACAGAACC ACCCTGGGTG GCTGATGAGG GGTCTCAAAC CCTGGACCCA GTATGCCATC 1680 1681 TTTGTCAAGA CCTTGGTCAC CTTTTCTGAT GAACGCCGGA CCTACGGGGC CAAGAGTGAC 1740 1741 ATCATTTATG TCCAGACAGA TGCCACCAAT CCCTCCGTCC CCCTGGACCC AATCTCGGTG 1800 1801 TCTAATTCCT CCTCTCAGAT TATTTTGAAA TGGAAGCCCC CCTCCGACCC CAATGGCAAC 1860 1861 ATCACCCACT ACTTAGTCTT CTGGGAGAGG CAGGAGGAAG ACAGTGAGCT GTACGAGTTG 1920 1921 GATTATTGCC TCAAAGGGCT GAAGCTGCCC TCCCGCACCT GGTCTCCACC ATTTGAGTCT 1980 1981 GAGGATTCCC AGAAACACAA TCAGAGTGAA TATGAGGAGT CCGCTGGTGA ATGTTGCTCC 2040 2041 TGCCCAAAGA CCGACTCCCA GATTCTGAAG GAGCTGGAGG AGTCCTCATT CAGGAAGACG 2100 2101 TTTGAGGATT ATCTGCACAA TGTGGTGTTT GTCCCCAGAG AAACCTCTCC AGGCACAGGT 2160 2161 GCCGAGGACA CTAGGCCATC TCGGAAACGC AGGTCCCTTG GCGCCATTGG GAACGTAACT 2220 2221 GCAGCTGCCC CCACGGTCGC AGCCTTCCTC AACACCACCT CAACCAGCGT GCCCACCAGC 2280 2281 CCCGAGGAGC ACCGGCCTTT CGAAAAAGTG GTGAACAAAG AGTCGCTGGT CATCTCCGGC 2340 2341 CTGCGCCACT TCACAGGCTA TCGCATCGAG CTGCAGGCCT GCAACCAGGA CACTCCTGAG 2400 2401 GAGCGGTGTA GTGTGGCAGC CTATGTCAGC GCCAGGACCA TGCCCGAAGC CAAGGCAGAT 2460 2461 GATATTGTCG GCCCCGTGAC CCACGAGGTC TTCGAGAACA ACATTGTTCA CTTGATGTGG 2520 2521 CAGGAGCCGA AGGAACCCAA CGGCCTGATC GTGCTGTACG AAGTGAGTTA CCGGCGATAT 2580 2581 GGCGATGAGG AACTGCACCT CTGCGTCTCT CGCAAGCATT ACGCTCTGGA GCGGGGCTGC 2640 2641 CGGCTGCGTG GGCTGTCGCC GGGGAACTAC AGCGTGCGGG TCCGGGCCAC CTCCCTGGCG 2700 2701 GGCAATGGCT CCTGGACAGA AGCCACTTAT TTCTATGTGA CAGACTATTT AGACGTCCCA 2760 2761 TCAAATATTG CAAAAATTAT CATCGGCCCC CTCATCTTTG TCTTCCTCTT CAGTGTTGTG 2820 2821 ATTGGAAGTA TTTATCTATT CTTGAGAAAA CGGCAGCCGG ATGGGCCTCT GGGACCGCTG 2880 2881 TATGCATCTT CAAACCCTGA GTACCTCAGT GCCAGTGATG TGTTTCCGTG CTCTGTGTAC 2940 2941 GTGCCGGACG AGTGGGAGGT GCCCCGAGAG AAGATCACCC TCCTCCGAGA GCTGGGCCAG 3000 3001 GGCTCCTTTG GCATGGTGTA CGAGGGCAAC GCCAAGGACA TCGTCAAGGG TGAGCCGGAG 3060 3061 ACCCGGGTGG CGGTGAAGAC AGTCAACGAG TCGGCCAGTC TCCGAGAGCG GATCGAGTTC 3120 3121 CTCAATGAGG CATCGGTCAT GAAGGGCTTC ACCTGCCATC ATGTGGTGCG CCTCCTGGGG 3180 3181 GTGGTGTCCA AGGGCCAGCC GACACTGGTG GTGATGGAGC TGATGGCCCA CGGGGACCTG 3240 3241 AAAAGCTACC TCCGTTCCCT GCGGCCAGAG GCTGAGAACA ATCCCGGCCG CCCTCCCCCA 3300 3301 ACCCTGCAAG AGATGATCCA GATGGCAGCA GAGATTGCAG ATGGGATGGC ATACCTGAAT 3360 3361 GCCAAGAAGT TTGTGCATCG AGACCTGGCG GCCAGGAACT GCATGGTGGC CCATGATTTT 3420 3421 ACTGTCAAGA TTGGAGACTT TGGAATGACC AGAGACATCT ATGAAACGGA TTACTACCGG 3480 3481 AAAGGGGGCA AGGGACTGCT CCCCGTAAGG TGGATGGCAC CAGAATCCCT GAAGGATGGG 3540 3541 GTCTTTACCA CTTCTTCCGA TATGTGGTCC TTTGGCGTGG TCCTTTGGGA AATCACCAGC 3600 3601 CTGGCCGAAC AGCCTTACCA GGGCCTGTCT AATGAGCAGG TGTTGAAATT TGTCATGGAT 3660 3661 GGAGGGTATC TGGATCAACC TGACAACTGT CCAGAGAGAG TCACCGACCT GATGCGCATG 3720 3721 TGCTGGCAGT TCAACCCCAA GATGCGGCCG ACCTTCCTAG ACATCGTCAA CCTGCTCAAG 3780 3781 GACGACCTGC ACCCCAGCTT CCCGGAAGTT TCCTTCTTCC ATAGCGATGA GAACAAGGCT 3840 3841 CCCGAGGCCG AGGAGCTGGA GATGGAGTTC GAGGACATGG AGAGTGTCCC TCTGGACCGG 3900 3901 TCCTCACACT GTCAGAGGGA GGAGGCGGGG GGCCGGGAGG GGGGGTCCTC GCTGGGCCTC 3960 3961 AAGCGGAACT ACGAGGAGCA CATCCCTTAC ACCCACATGA ACGGGGGCAA GAAGAACGGG 4020 4021 CGGATCCTGA CCCTGCCTCG GTCCAACCCC TCCTAA 4056 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-1444 | Pan troglodytes | 96.81 | 0.0 | 2593 |
| LLPS-Hos-3705 | Homo sapiens | 96.66 | 0.0 | 2589 |
| LLPS-Maf-3909 | Macaca fascicularis | 96.66 | 0.0 | 2582 |
| LLPS-Paa-2894 | Papio anubis | 96.66 | 0.0 | 2593 |
| LLPS-Eqc-1472 | Equus caballus | 96.22 | 0.0 | 2578 |
| LLPS-Sus-4092 | Sus scrofa | 95.85 | 0.0 | 2574 |
| LLPS-Bot-3756 | Bos taurus | 95.85 | 0.0 | 2568 |
| LLPS-Ova-3581 | Ovis aries | 95.77 | 0.0 | 2571 |
| LLPS-Otg-4376 | Otolemur garnettii | 95.56 | 0.0 | 2561 |
| LLPS-Aim-1537 | Ailuropoda melanoleuca | 95.48 | 0.0 | 2536 |
| LLPS-Orc-3000 | Oryctolagus cuniculus | 95.39 | 0.0 | 2536 |
| LLPS-Ict-1579 | Ictidomys tridecemlineatus | 94.61 | 0.0 | 2549 |
| LLPS-Ran-2399 | Rattus norvegicus | 94.37 | 0.0 | 2542 |
| LLPS-Rhb-3446 | Rhinopithecus bieti | 94.15 | 0.0 | 2478 |
| LLPS-Mam-4624 | Macaca mulatta | 93.99 | 0.0 | 2126 |
| LLPS-Caj-4693 | Callithrix jacchus | 93.18 | 0.0 | 2510 |
| LLPS-Cap-3159 | Cavia porcellus | 93.03 | 0.0 | 2506 |
| LLPS-Gog-1491 | Gorilla gorilla | 92.88 | 0.0 | 2483 |
| LLPS-Fud-1308 | Fukomys damarensis | 92.71 | 0.0 | 2499 |
| LLPS-Cea-1544 | Cercocebus atys | 92.15 | 0.0 | 2413 |
| LLPS-Pap-3996 | Pan paniscus | 91.87 | 0.0 | 2419 |
| LLPS-Chs-3766 | Chlorocebus sabaeus | 91.86 | 0.0 | 2444 |
| LLPS-Poa-2299 | Pongo abelii | 91.4 | 0.0 | 2427 |
| LLPS-Myl-0603 | Myotis lucifugus | 90.59 | 0.0 | 2436 |
| LLPS-Man-2108 | Macaca nemestrina | 86.31 | 0.0 | 2305 |
| LLPS-Aon-1424 | Aotus nancymaae | 86.31 | 0.0 | 2286 |
| LLPS-Lac-3729 | Latimeria chalumnae | 75.15 | 0.0 | 1264 |
| LLPS-Leo-3233 | Lepisosteus oculatus | 72.8 | 0.0 | 1954 |
| LLPS-Pof-0133 | Poecilia formosa | 70.15 | 0.0 | 1845 |
| LLPS-Asm-2540 | Astyanax mexicanus | 69.42 | 0.0 | 1867 |
| LLPS-Ten-3402 | Tetraodon nigroviridis | 68.54 | 0.0 | 1359 |
| LLPS-Scm-3919 | Scophthalmus maximus | 68.52 | 0.0 | 1838 |
| LLPS-Orl-2585 | Oryzias latipes | 68.11 | 0.0 | 1806 |
| LLPS-Scf-3697 | Scleropages formosus | 67.88 | 0.0 | 1781 |
| LLPS-Xim-2692 | Xiphophorus maculatus | 66.52 | 0.0 | 1757 |
| LLPS-Dar-1804 | Danio rerio | 66.32 | 0.0 | 1751 |
| LLPS-Xet-1869 | Xenopus tropicalis | 66.13 | 0.0 | 1759 |
| LLPS-Orn-3814 | Oreochromis niloticus | 66.1 | 0.0 | 1773 |
| LLPS-Gaa-1374 | Gasterosteus aculeatus | 65.86 | 0.0 | 1738 |
| LLPS-Anp-0995 | Anas platyrhynchos | 58.69 | 0.0 | 1524 |
| LLPS-Tag-3528 | Taeniopygia guttata | 58.68 | 0.0 | 1524 |
| LLPS-Pes-1023 | Pelodiscus sinensis | 58.57 | 0.0 | 1521 |
| LLPS-Gaga-2523 | Gallus gallus | 58.46 | 0.0 | 1523 |
| LLPS-Mod-1992 | Monodelphis domestica | 58.08 | 0.0 | 1504 |
| LLPS-Anc-0520 | Anolis carolinensis | 58.0 | 0.0 | 1500 |
| LLPS-Sah-0185 | Sarcophilus harrisii | 57.91 | 0.0 | 1163 |
| LLPS-Fia-3235 | Ficedula albicollis | 57.66 | 0.0 | 1280 |
| LLPS-Fec-3832 | Felis catus | 57.41 | 0.0 | 1481 |
| LLPS-Meg-2956 | Meleagris gallopavo | 57.37 | 0.0 | 679 |
| LLPS-Mup-0374 | Mustela putorius furo | 57.37 | 0.0 | 1484 |
| LLPS-Mum-4413 | Mus musculus | 57.31 | 0.0 | 1481 |
| LLPS-Caf-3254 | Canis familiaris | 57.23 | 0.0 | 1481 |
| LLPS-Tut-2068 | Tursiops truncatus | 57.1 | 0.0 | 1472 |
| LLPS-Loa-1697 | Loxodonta africana | 56.24 | 0.0 | 1245 |
| LLPS-Dio-0065 | Dipodomys ordii | 55.64 | 0.0 | 984 |
| LLPS-Cii-2292 | Ciona intestinalis | 54.71 | 3e-136 | 433 |
| LLPS-Tar-3646 | Takifugu rubripes | 54.69 | 0.0 | 1359 |
| LLPS-Mal-2931 | Mandrillus leucophaeus | 54.04 | 0.0 | 1350 |
| LLPS-Urm-1083 | Ursus maritimus | 53.83 | 0.0 | 1383 |
| LLPS-Nol-3980 | Nomascus leucogenys | 53.6 | 0.0 | 1170 |
| LLPS-Mea-4125 | Mesocricetus auratus | 53.32 | 0.0 | 1334 |
| LLPS-Icp-2904 | Ictalurus punctatus | 52.49 | 0.0 | 1301 |
| LLPS-Ora-2782 | Ornithorhynchus anatinus | 51.44 | 0.0 | 1087 |
| LLPS-Drm-1667 | Drosophila melanogaster | 42.81 | 4e-64 | 244 |
| LLPS-Cis-2073 | Ciona savignyi | 38.7 | 0.0 | 824 |
| LLPS-Cae-0235 | Caenorhabditis elegans | 38.34 | 2e-88 | 322 |