• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cas-0302
TUBA4A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin alpha chain
Gene Name: TUBA4A
Ensembl Gene: ENSTSYG00000011750.2
Ensembl Protein: ENSTSYP00000010778.2
Organism: Carlito syrichta
Taxa ID: 1868482
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole body, Microtubule, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MELQLSLDKF  PRECISVHVG  QAGVQMGNAC  WELYCLEHGI  QPDGQMPSDK  TIGGGDDSFT  60
61    TFFCETGAGK  HVPRAVFVDL  EPTVIDEIRN  GPYRQLFHPE  QLITGKEDAA  NNYARGHYTI  120
121   GKEIIDPVLD  RIRKLSDQCT  GLQGFLVFHS  FGGGTGSGFT  SLLMERLSVD  YGKKSKLEFS  180
181   IYPAPQVSTA  VVEPYNSILT  THTTLEHSDC  AFMVDNEAIY  DICRRNLDIE  RPTYTNLNRL  240
241   ISQIVSSITA  SLRFDGALNV  DLTEFQTNLV  PYPRIHFPLA  TYAPVISAEK  AYHEQLSVAE  300
301   ITNACFEPAN  QMVKCDPRHG  KYMACCLLYR  GDVVPKDVNA  AIAAIKTKRS  IQFVDWCPTG  360
361   FKVGINYQPP  TVVPGGDLAK  VQRAVCMLSN  TTAIAEAWAR  LDHKFDLMYA  KRAFVHWYVG  420
421   EGMEEGEFSE  AREDMAALEK  DYEEVGIDSY  EDEDEGEE  458
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCTAC  AGCTCTCACT  TGACAAATTC  CCCCGTGAAT  GCATCTCAGT  CCATGTGGGC  60
61    CAGGCAGGTG  TCCAGATGGG  CAATGCCTGC  TGGGAGCTCT  ACTGTCTGGA  ACACGGGATT  120
121   CAGCCTGATG  GGCAGATGCC  CAGTGACAAG  ACCATTGGTG  GAGGGGATGA  CTCCTTCACC  180
181   ACCTTCTTCT  GTGAAACCGG  TGCTGGAAAA  CATGTTCCCC  GGGCAGTTTT  TGTGGATCTG  240
241   GAGCCCACTG  TAATTGATGA  GATCCGAAAT  GGCCCATACC  GACAGCTCTT  CCACCCAGAG  300
301   CAGCTCATCA  CTGGGAAAGA  GGATGCGGCC  AACAACTATG  CCCGTGGTCA  CTACACCATT  360
361   GGCAAGGAGA  TCATTGACCC  AGTACTGGAC  CGGATCCGCA  AGCTGTCTGA  CCAGTGCACA  420
421   GGACTTCAGG  GCTTCCTGGT  GTTCCACAGC  TTTGGTGGGG  GCACTGGCTC  TGGTTTCACC  480
481   TCACTCCTCA  TGGAGCGGCT  CTCTGTTGAC  TATGGCAAGA  AATCCAAGCT  GGAATTCTCC  540
541   ATCTACCCAG  CCCCCCAGGT  GTCCACAGCT  GTGGTGGAGC  CCTACAACTC  CATCCTGACC  600
601   ACTCACACCA  CCCTGGAGCA  CTCAGACTGT  GCCTTCATGG  TGGACAACGA  AGCCATCTAT  660
661   GACATCTGTC  GCCGCAACCT  GGACATCGAG  CGCCCAACCT  ACACCAACCT  CAATCGCCTC  720
721   ATCAGTCAAA  TCGTCTCCTC  CATCACAGCT  TCTCTACGCT  TCGATGGGGC  CCTCAATGTG  780
781   GACCTGACAG  AGTTCCAGAC  CAACCTGGTG  CCATACCCTC  GTATCCACTT  CCCCCTGGCC  840
841   ACCTATGCGC  CAGTCATCTC  TGCAGAGAAG  GCATACCATG  AGCAGCTGTC  AGTGGCAGAG  900
901   ATTACGAATG  CCTGCTTTGA  GCCTGCCAAC  CAGATGGTGA  AGTGTGACCC  CCGGCATGGC  960
961   AAGTATATGG  CCTGCTGCCT  GCTGTACCGT  GGAGATGTGG  TGCCCAAGGA  TGTCAACGCC  1020
1021  GCCATCGCCG  CCATCAAGAC  CAAGCGCAGC  ATTCAGTTTG  TGGACTGGTG  CCCCACGGGC  1080
1081  TTCAAGGTTG  GTATCAACTA  CCAGCCGCCC  ACTGTGGTGC  CTGGGGGTGA  CCTGGCCAAG  1140
1141  GTGCAGCGTG  CCGTGTGCAT  GCTGAGCAAC  ACGACCGCCA  TCGCCGAGGC  CTGGGCCCGC  1200
1201  CTGGACCACA  AGTTTGACCT  GATGTATGCC  AAGAGGGCGT  TTGTGCACTG  GTATGTGGGC  1260
1261  GAGGGCATGG  AGGAGGGTGA  GTTCTCTGAG  GCCCGGGAGG  ATATGGCTGC  CCTGGAGAAG  1320
1321  GATTATGAGG  AAGTAGGCAT  CGACTCCTAT  GAGGATGAAG  ATGAAGGAGA  AGAGTAG  1377

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orc-0207Oryctolagus cuniculus100.00.0 909
LLPS-Fec-0667Felis catus100.00.0 909
LLPS-Hos-2428Homo sapiens100.00.0 909
LLPS-Pat-0626Pan troglodytes100.00.0 909
LLPS-Urm-0192Ursus maritimus100.00.0 909
LLPS-Pap-1378Pan paniscus100.00.0 909
LLPS-Loa-0952Loxodonta africana100.00.0 908
LLPS-Man-3189Macaca nemestrina100.00.0 909
LLPS-Nol-3750Nomascus leucogenys100.00.0 909
LLPS-Ict-0591Ictidomys tridecemlineatus100.00.0 909
LLPS-Cap-3258Cavia porcellus100.00.0 909
LLPS-Poa-4183Pongo abelii100.00.0 909
LLPS-Caf-2494Canis familiaris100.00.0 909
LLPS-Mam-1513Macaca mulatta100.00.0 909
LLPS-Gog-3374Gorilla gorilla100.00.0 909
LLPS-Caj-3586Callithrix jacchus100.00.0 909
LLPS-Fud-3854Fukomys damarensis100.00.0 909
LLPS-Chs-1953Chlorocebus sabaeus100.00.0 909
LLPS-Maf-1494Macaca fascicularis100.00.0 909
LLPS-Mea-3088Mesocricetus auratus100.00.0 909
LLPS-Sus-0792Sus scrofa100.00.0 909
LLPS-Cea-4054Cercocebus atys100.00.0 909
LLPS-Aon-0890Aotus nancymaae100.00.0 909
LLPS-Ran-1795Rattus norvegicus100.00.0 909
LLPS-Mup-2364Mustela putorius furo100.00.0 908
LLPS-Ova-0667Ovis aries100.00.0 909
LLPS-Paa-3009Papio anubis100.00.0 909
LLPS-Mal-1464Mandrillus leucophaeus100.00.0 909
LLPS-Bot-1516Bos taurus100.00.0 909
LLPS-Dio-2329Dipodomys ordii100.00.0 909
LLPS-Otg-3104Otolemur garnettii99.780.0 907
LLPS-Mod-1204Monodelphis domestica99.780.0 908
LLPS-Eqc-3111Equus caballus99.780.0 907
LLPS-Myl-1151Myotis lucifugus99.780.0 908
LLPS-Sah-1137Sarcophilus harrisii99.330.0 906
LLPS-Xet-0393Xenopus tropicalis98.170.0 877
LLPS-Gaga-1750Gallus gallus97.720.0 877
LLPS-Meg-1613Meleagris gallopavo97.490.0 872
LLPS-Ora-0959Ornithorhynchus anatinus97.490.0 871
LLPS-Mum-4242Mus musculus97.490.0 871
LLPS-Tut-0018Tursiops truncatus97.490.0 871
LLPS-Fia-1806Ficedula albicollis97.260.0 867
LLPS-Lac-1000Latimeria chalumnae97.260.0 870
LLPS-Dar-3733Danio rerio97.260.0 870
LLPS-Pof-3465Poecilia formosa97.260.0 869
LLPS-Icp-1141Ictalurus punctatus97.260.0 870
LLPS-Asm-0148Astyanax mexicanus97.260.0 870
LLPS-Orl-0238Oryzias latipes97.260.0 870
LLPS-Aim-3885Ailuropoda melanoleuca97.260.0 866
LLPS-Scf-2328Scleropages formosus97.260.0 870
LLPS-Anc-2036Anolis carolinensis97.030.0 868
LLPS-Xim-1672Xiphophorus maculatus96.80.0 868
LLPS-Pes-2127Pelodiscus sinensis96.640.0 880
LLPS-Leo-3078Lepisosteus oculatus96.640.0 880
LLPS-Scm-0904Scophthalmus maximus96.580.0 867
LLPS-Gaa-2776Gasterosteus aculeatus96.580.0 865
LLPS-Ten-2970Tetraodon nigroviridis96.380.0 869
LLPS-Ere-0754Erinaceus europaeus96.350.0 862
LLPS-Orn-1753Oreochromis niloticus96.120.0 858
LLPS-Tar-3942Takifugu rubripes96.120.0 860
LLPS-Cii-2287Ciona intestinalis95.430.0 862
LLPS-Drm-0758Drosophila melanogaster95.210.0 861
LLPS-Cis-1540Ciona savignyi94.290.0 858
LLPS-Anp-1080Anas platyrhynchos93.970.0 865
LLPS-Tag-0253Taeniopygia guttata93.740.0 865
LLPS-Cae-0112Caenorhabditis elegans91.290.0 838