• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Cap-4622
ATP6V0A4

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: V-type proton ATPase subunit a
Gene Name: ATP6V0A4
Ensembl Gene: ENSCPOG00000011332.4
Ensembl Protein: ENSCPOP00000025919.1
Organism: Cavia porcellus
Taxa ID: 10141
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION


Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MASVFRSEEM  CLSQLFLQVE  AAYCCVAELG  ELGLVQFKDL  NASVNSFQRR  FVNEVRRCES  60
61    LERILRFLED  EMQNEITVHL  PEKYPQIPLP  REMIGLETTL  EKLEGELQEA  NQNHQALKKS  120
121   FLELTELKYL  LKKTQDFFET  EANLAEDFFT  EDTSGLLELR  AVPAFMAGKL  GFMVGVINRE  180
181   RMASFERLLW  RVCRGNIYLK  FSEMDTPLED  PVTREEIKKN  IFIIFYQGEQ  LRQKVKKICD  240
241   GFRATVYPCP  EPAAERREML  AGVNVRLEDL  ITVITQTESH  RQRLLQEAAA  NWHCWATKVQ  300
301   KMKAIYHILN  MCNIDVTQQC  VIAEIWFPVA  DTARIKRALE  QGMELSGSSM  APIMTEVQSR  360
361   TAPPTFNRTN  KFTAGFQNIV  DAYGVGSYRE  MNPAPYTIIT  FPFLFAVMFG  DCGHGAVMLL  420
421   GALWMVLNEQ  RLLSQKSSNE  IWNTFFHGRY  LILLMGIFSI  YTGLIYNDCF  SKSFNIFGSS  480
481   WSVQPMFRNG  TWNAEIVETT  PHLQLDPALP  GVYSGNPYPF  GIDPIWNLAS  NKLTFLNSYK  540
541   MKMSVILGIV  QMVFGVVLSL  FNHIYFRKTY  NIILQFIPEM  IFILCLFGYL  VFMIIFKWCQ  600
601   YDAHMSQSAP  SILIHFINMF  LFDYDSSSNV  PLYEHQQEVQ  TFFVVMALVS  VPWMLLIKPF  660
661   FLRAKHRKSQ  LQAFLVQENT  TEDVEGGISS  PSGSADTHEA  QDDHEEEFNF  GDVFVHQAIH  720
721   TIEYCLGCVS  NTASYLRLWA  LSLAHSELSE  VLWTMVMNIG  LRLQGWGGFI  GVFVIFAVFA  780
781   VLTVAILLIM  EGLSAFLHAL  RLHWVEFQNK  FYVGAGYKFS  PFSFKNILEG  TAEE  834
Nucleotide CDS Sequence (FASTA)
1     ATGGCGTCTG  TGTTCCGCAG  TGAGGAGATG  TGTTTGTCCC  AACTCTTCCT  CCAGGTGGAG  60
61    GCTGCCTATT  GCTGTGTAGC  TGAGCTCGGA  GAGCTTGGCC  TGGTTCAGTT  CAAAGATTTA  120
121   AACGCCAGTG  TGAACAGCTT  CCAGAGGAGA  TTCGTGAATG  AGGTTCGGAG  GTGCGAGTCG  180
181   CTGGAAAGGA  TCCTCCGTTT  TCTGGAAGAT  GAGATGCAGA  ATGAGATTAC  TGTCCACCTG  240
241   CCTGAGAAGT  ACCCACAGAT  CCCGCTGCCC  CGGGAAATGA  TTGGCCTGGA  GACTACTCTA  300
301   GAGAAACTGG  AAGGAGAGTT  ACAAGAAGCC  AACCAGAACC  ACCAGGCTTT  AAAGAAAAGC  360
361   TTCCTAGAGC  TGACCGAACT  CAAATATCTC  CTGAAGAAAA  CCCAGGATTT  CTTTGAGACA  420
421   GAAGCCAATT  TGGCTGAAGA  TTTCTTTACT  GAAGACACTT  CTGGTCTCCT  AGAGTTAAGA  480
481   GCTGTTCCTG  CATTCATGGC  TGGAAAGCTG  GGATTCATGG  TCGGCGTGAT  AAACCGGGAG  540
541   CGGATGGCTT  CTTTTGAACG  GCTGCTGTGG  AGAGTTTGCC  GGGGAAACAT  CTACCTAAAG  600
601   TTCAGTGAAA  TGGACACCCC  ACTGGAGGAT  CCTGTCACGA  GAGAAGAAAT  TAAAAAGAAT  660
661   ATATTCATCA  TATTTTACCA  AGGAGAGCAG  CTCAGGCAGA  AAGTCAAGAA  GATCTGTGAT  720
721   GGGTTTCGAG  CCACTGTCTA  CCCCTGCCCA  GAGCCTGCCG  CGGAGCGCAG  AGAGATGCTG  780
781   GCTGGTGTCA  ACGTGAGGCT  GGAAGATCTA  ATCACAGTCA  TAACCCAGAC  AGAGTCTCAC  840
841   CGCCAGCGCC  TATTGCAGGA  AGCAGCTGCC  AACTGGCACT  GCTGGGCCAC  TAAAGTGCAG  900
901   AAGATGAAAG  CTATTTACCA  CATCCTGAAC  ATGTGCAACA  TTGATGTCAC  CCAGCAGTGT  960
961   GTCATTGCTG  AGATCTGGTT  CCCAGTGGCG  GACACTGCAC  GTATCAAGAG  GGCCTTGGAG  1020
1021  CAAGGCATGG  AACTAAGTGG  CTCCTCCATG  GCCCCCATCA  TGACTGAAGT  GCAGTCGAGA  1080
1081  ACAGCCCCTC  CCACCTTTAA  CAGGACCAAT  AAATTCACAG  CTGGCTTCCA  GAACATTGTT  1140
1141  GATGCATATG  GCGTTGGCAG  CTACCGGGAG  ATGAACCCAG  CTCCCTACAC  CATCATCACC  1200
1201  TTCCCCTTCC  TGTTCGCTGT  GATGTTTGGG  GACTGCGGTC  ACGGAGCGGT  GATGCTGCTG  1260
1261  GGAGCCCTCT  GGATGGTACT  CAATGAGCAA  CGATTGCTCT  CCCAGAAAAG  CAGCAATGAG  1320
1321  ATCTGGAATA  CCTTCTTCCA  CGGGCGCTAC  CTGATCCTGC  TCATGGGCAT  CTTCTCCATC  1380
1381  TACACGGGCT  TGATCTACAA  TGACTGCTTC  TCCAAGTCTT  TCAACATTTT  TGGTTCTTCT  1440
1441  TGGAGTGTCC  AGCCTATGTT  CAGGAACGGG  ACATGGAATG  CTGAAATAGT  GGAAACAACT  1500
1501  CCCCATCTGC  AGCTGGACCC  AGCCCTGCCT  GGAGTGTATT  CCGGGAACCC  ATATCCATTT  1560
1561  GGGATCGACC  CGATTTGGAA  CCTGGCTTCA  AACAAACTCA  CCTTTTTGAA  TTCCTATAAA  1620
1621  ATGAAGATGT  CGGTTATTCT  GGGAATCGTC  CAGATGGTTT  TTGGAGTTGT  TCTCAGCCTG  1680
1681  TTCAATCACA  TATACTTCAG  AAAAACTTAC  AATATCATTC  TGCAATTCAT  CCCCGAGATG  1740
1741  ATTTTCATCC  TGTGCCTGTT  TGGGTACCTG  GTTTTCATGA  TCATTTTCAA  ATGGTGTCAG  1800
1801  TATGACGCCC  ACATGTCCCA  GAGCGCACCA  AGCATCCTCA  TCCACTTCAT  CAACATGTTC  1860
1861  CTGTTTGACT  ATGACAGCTC  TTCCAACGTG  CCCCTGTATG  AACACCAGCA  AGAAGTCCAA  1920
1921  ACATTCTTTG  TGGTAATGGC  CTTAGTTTCT  GTGCCGTGGA  TGCTTCTGAT  TAAGCCATTT  1980
1981  TTTCTTAGAG  CCAAGCATCG  GAAATCCCAG  CTACAGGCAT  TCTTGGTTCA  AGAAAATACC  2040
2041  ACAGAGGATG  TTGAAGGTGG  CATCTCCAGC  CCCTCTGGTT  CTGCAGACAC  CCACGAGGCT  2100
2101  CAGGACGACC  ATGAAGAGGA  GTTCAACTTC  GGAGACGTCT  TTGTTCACCA  GGCCATCCAC  2160
2161  ACCATTGAGT  ACTGTCTGGG  CTGCGTCTCC  AACACCGCCT  CCTACCTGCG  GCTCTGGGCA  2220
2221  CTCAGCCTGG  CACACTCCGA  ACTGTCTGAA  GTCCTCTGGA  CCATGGTCAT  GAACATCGGC  2280
2281  CTCCGTCTGC  AAGGCTGGGG  AGGATTTATC  GGGGTCTTTG  TCATTTTTGC  TGTGTTTGCC  2340
2341  GTCCTGACAG  TGGCCATTCT  CCTCATCATG  GAGGGCCTGT  CTGCCTTTCT  CCATGCCCTG  2400
2401  CGGCTGCACT  GGGTGGAGTT  CCAGAACAAG  TTCTACGTCG  GAGCTGGGTA  CAAGTTCTCT  2460
2461  CCATTCTCCT  TCAAGAACAT  CCTGGAAGGG  ACGGCGGAGG  AGTAG  2505

▼ KEYWORD


ID
Family
Coiled coil
Complete proteome
Hydrogen ion transport
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Apical plasma membrane
Cellular Component
Brush border membrane
Cellular Component
Endosome
Cellular Component
Integral component of membrane
Cellular Component
Vacuolar proton-transporting V-type ATPase complex
Cellular Component
Vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function
ATPase binding
Molecular Function
Proton transmembrane transporter activity
Biological Process
ATP hydrolysis coupled proton transport
Biological Process
Excretion
Biological Process
Ossification
Biological Process
Regulation of pH
Biological Process
Sensory perception of sound

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-3041Mandrillus leucophaeus87.870.01329
LLPS-Maf-2691Macaca fascicularis87.830.01440
LLPS-Cea-4607Cercocebus atys87.830.01440
LLPS-Man-3627Macaca nemestrina87.590.01432
LLPS-Gog-4794Gorilla gorilla87.140.01438
LLPS-Rhb-3018Rhinopithecus bieti86.990.01421
LLPS-Orc-1737Oryctolagus cuniculus86.330.01438
LLPS-Mea-0301Mesocricetus auratus86.120.01422
LLPS-Mum-4322Mus musculus86.090.01424
LLPS-Ran-0982Rattus norvegicus86.090.01422
LLPS-Ova-2478Ovis aries84.410.01401
LLPS-Bot-2393Bos taurus84.050.01401
LLPS-Dio-1138Dipodomys ordii82.850.01324
LLPS-Sah-3132Sarcophilus harrisii79.880.01339
LLPS-Pes-2204Pelodiscus sinensis78.380.01309
LLPS-Gaga-0779Gallus gallus77.460.01276
LLPS-Ora-2733Ornithorhynchus anatinus74.290.01092
LLPS-Chs-2268Chlorocebus sabaeus61.80.0 991
LLPS-Aon-3032Aotus nancymaae61.80.0 991
LLPS-Sus-2179Sus scrofa61.680.0 994
LLPS-Eqc-4644Equus caballus61.680.0 998
LLPS-Myl-1104Myotis lucifugus61.470.0 991
LLPS-Caj-3940Callithrix jacchus61.450.0 945
LLPS-Paa-4560Papio anubis61.290.0 990
LLPS-Mam-3285Macaca mulatta61.290.0 990
LLPS-Cas-3868Carlito syrichta61.270.0 986
LLPS-Otg-3535Otolemur garnettii61.250.0 991
LLPS-Fia-0308Ficedula albicollis61.10.0 990
LLPS-Hos-3719Homo sapiens61.060.0 988
LLPS-Pat-4504Pan troglodytes61.060.0 988
LLPS-Pap-0887Pan paniscus61.060.0 988
LLPS-Loa-2927Loxodonta africana61.060.0 994
LLPS-Mod-1751Monodelphis domestica61.050.0 994
LLPS-Tag-1187Taeniopygia guttata60.940.0 990
LLPS-Meg-2974Meleagris gallopavo60.870.0 982
LLPS-Mup-3201Mustela putorius furo60.820.0 988
LLPS-Scf-2462Scleropages formosus60.780.0 978
LLPS-Urm-3270Ursus maritimus60.710.0 985
LLPS-Caf-0242Canis familiaris60.710.0 984
LLPS-Aim-0504Ailuropoda melanoleuca60.590.0 983
LLPS-Fec-0186Felis catus60.480.0 993
LLPS-Anp-2828Anas platyrhynchos60.460.0 943
LLPS-Tut-1721Tursiops truncatus60.30.0 922
LLPS-Xim-1963Xiphophorus maculatus60.290.0 984
LLPS-Orl-3338Oryzias latipes60.260.0 978
LLPS-Ict-3276Ictidomys tridecemlineatus60.250.0 989
LLPS-Poa-0009Pongo abelii60.140.0 987
LLPS-Scm-0329Scophthalmus maximus60.070.0 972
LLPS-Anc-1592Anolis carolinensis59.980.0 984
LLPS-Xet-1025Xenopus tropicalis59.810.0 978
LLPS-Fud-0796Fukomys damarensis59.720.0 986
LLPS-Asm-1613Astyanax mexicanus59.550.0 968
LLPS-Nol-2627Nomascus leucogenys59.530.0 951
LLPS-Tar-0767Takifugu rubripes59.370.0 971
LLPS-Icp-0386Ictalurus punctatus59.220.0 959
LLPS-Dar-2395Danio rerio59.190.0 959
LLPS-Pof-2642Poecilia formosa59.060.0 970
LLPS-Gaa-1398Gasterosteus aculeatus59.020.0 976
LLPS-Ten-0828Tetraodon nigroviridis58.930.0 972
LLPS-Orn-1041Oreochromis niloticus58.620.0 964
LLPS-Leo-3654Lepisosteus oculatus58.590.0 933
LLPS-Lac-0676Latimeria chalumnae57.210.0 902
LLPS-Cii-2063Ciona intestinalis53.380.0 849
LLPS-Drm-1972Drosophila melanogaster53.290.0 810
LLPS-Cae-0052Caenorhabditis elegans50.90.0 804
LLPS-Cis-0233Ciona savignyi50.290.0 795
LLPS-Chc-0752Chondrus crispus47.52e-1481.6
LLPS-Scj-1429Schizosaccharomyces japonicus47.222e-1171.6
LLPS-Cym-0166Cyanidioschyzon merolae47.061e-1172.8
LLPS-Php-1642Physcomitrella patens43.740.0 585
LLPS-Mae-0566Manihot esculenta43.490.0 597
LLPS-Cus-2132Cucumis sativus43.420.0 603
LLPS-Prp-2141Prunus persica43.370.0 608
LLPS-Viv-1468Vitis vinifera43.250.0 595
LLPS-Nia-2505Nicotiana attenuata43.210.0 585
LLPS-Sot-2197Solanum tuberosum43.160.0 598
LLPS-Coc-0651Corchorus capsularis43.060.0 589
LLPS-Hea-0655Helianthus annuus42.890.0 603
LLPS-Arl-1547Arabidopsis lyrata42.890.0 597
LLPS-Brd-1742Brachypodium distachyon42.860.0 598
LLPS-Sem-1090Selaginella moellendorffii42.820.0 568
LLPS-Glm-1233Glycine max42.770.0 607
LLPS-Sol-2198Solanum lycopersicum42.770.0 599
LLPS-Art-1171Arabidopsis thaliana42.750.0 590
LLPS-Phv-1862Phaseolus vulgaris42.60.0 592
LLPS-Sei-1271Setaria italica42.420.0 583
LLPS-Brn-3023Brassica napus42.390.0 608
LLPS-Brr-2024Brassica rapa42.390.0 608
LLPS-Tra-0805Triticum aestivum42.380.0 603
LLPS-Hov-1636Hordeum vulgare42.380.0 597
LLPS-Abg-0105Absidia glauca42.290.0 617
LLPS-Amt-0677Amborella trichopoda42.220.0 570
LLPS-Orbr-1205Oryza brachyantha42.210.0 597
LLPS-Orni-1272Oryza nivara42.160.0 598
LLPS-Orb-2369Oryza barthii42.160.0 596
LLPS-Orgl-1318Oryza glumaepatula42.160.0 597
LLPS-Ors-0358Oryza sativa42.160.0 598
LLPS-Org-1719Oryza glaberrima42.160.0 598
LLPS-Orr-1310Oryza rufipogon42.160.0 598
LLPS-Ori-1759Oryza indica42.140.0 596
LLPS-Map-0239Magnaporthe poae42.137e-166 504
LLPS-Gor-0838Gossypium raimondii42.110.0 592
LLPS-Thc-1611Theobroma cacao42.090.0 583
LLPS-Dac-1286Daucus carota42.050.0 589
LLPS-Orp-1779Oryza punctata42.040.0 593
LLPS-Orm-0226Oryza meridionalis42.040.0 595
LLPS-Sob-0171Sorghum bicolor41.810.0 593
LLPS-Mua-1230Musa acuminata41.720.0 594
LLPS-Pot-0646Populus trichocarpa41.720.0 582
LLPS-Met-0810Medicago truncatula41.70.0 585
LLPS-Lep-0165Leersia perrieri41.670.0 590
LLPS-Bro-1400Brassica oleracea41.60.0 591
LLPS-Zem-0269Zea mays41.480.0 597
LLPS-Kop-1002Komagataella pastoris41.291e-161 499
LLPS-Vir-1286Vigna radiata41.130.0 585
LLPS-Miv-0009Microbotryum violaceum40.980.0 603
LLPS-Mel-0442Melampsora laricipopulina40.890.0 607
LLPS-Pug-0624Puccinia graminis40.70.0 592
LLPS-Put-0818Puccinia triticina40.680.0 586
LLPS-Tru-0944Triticum urartu40.640.0 571
LLPS-Via-1873Vigna angularis40.560.0 563
LLPS-Coo-1006Colletotrichum orbiculare40.540.0 549
LLPS-Tum-0799Tuber melanosporum40.540.0 583
LLPS-Gas-0792Galdieria sulphuraria40.471e-179 546
LLPS-Crn-1564Cryptococcus neoformans40.330.0 588
LLPS-Lem-1400Leptosphaeria maculans40.090.0 564
LLPS-Beb-0402Beauveria bassiana39.932e-177 540
LLPS-Asn-0100Aspergillus nidulans39.910.0 563
LLPS-Chr-1488Chlamydomonas reinhardtii39.910.0 560
LLPS-Scs-0424Sclerotinia sclerotiorum39.842e-176 538
LLPS-Gag-0076Gaeumannomyces graminis39.70.0 556
LLPS-Asf-0583Aspergillus flavus39.680.0 562
LLPS-Aso-0589Aspergillus oryzae39.680.0 562
LLPS-Trr-0375Trichoderma reesei39.656e-179 545
LLPS-Cog-0172Colletotrichum gloeosporioides39.636e-180 546
LLPS-Ved-0737Verticillium dahliae39.585e-178 542
LLPS-Mao-0149Magnaporthe oryzae39.369e-175 534
LLPS-Asc-1476Aspergillus clavatus39.291e-178 543
LLPS-Ast-0272Aspergillus terreus39.261e-179 546
LLPS-Trv-0065Trichoderma virens39.260.0 550
LLPS-Asfu-0274Aspergillus fumigatus39.243e-179 545
LLPS-Nef-0190Neosartorya fischeri39.227e-178 541
LLPS-Blg-0188Blumeria graminis39.123e-175 535
LLPS-Usm-0086Ustilago maydis39.090.0 559
LLPS-Phn-0625Phaeosphaeria nodorum39.088e-169 527
LLPS-Asni-1033Aspergillus niger39.070.0 550
LLPS-Nec-0307Neurospora crassa38.987e-177 539
LLPS-Fuo-0238Fusarium oxysporum38.956e-173 529
LLPS-Cogr-0988Colletotrichum graminicola38.811e-176 538
LLPS-Dos-0353Dothistroma septosporum38.647e-168 516
LLPS-Spr-0474Sporisorium reilianum38.580.0 557
LLPS-Zyt-0067Zymoseptoria tritici38.535e-175 534
LLPS-Pyt-0796Pyrenophora teres38.431e-174 533
LLPS-Fus-0769Fusarium solani38.254e-174 532
LLPS-Sac-1151Saccharomyces cerevisiae38.220.0 559
LLPS-Osl-0079Ostreococcus lucimarinus38.186e-176 536
LLPS-Asg-0299Ashbya gossypii38.122e-163 503
LLPS-Scp-1567Schizosaccharomyces pombe38.066e-180 546
LLPS-Pytr-1137Pyrenophora triticirepentis37.81e-176 538
LLPS-Yal-1219Yarrowia lipolytica37.031e-166 511
LLPS-Fuv-0425Fusarium verticillioides36.749e-152 472
LLPS-Scc-0355Schizosaccharomyces cryophilus36.054e-170 521