• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tar-0767
atp6v0a1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: V-type proton ATPase subunit a
Gene Name: atp6v0a1
Ensembl Gene: ENSTRUG00000015258.2
Ensembl Protein: ENSTRUP00000038977.1
Organism: Takifugu rubripes
Taxa ID: 31033
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQLFRSEEM  TLAQLFLQSE  AAYCCVSELG  EIGMVQFRDL  NPDVNVFQRK  FVNEVRRCEE  60
61    MDRKLRFVEK  EIKKANIPII  DTGENPEVPF  PRDMIDLEAS  FEKLENELKE  INTNQEALKK  120
121   NFLELTELKH  ILRRTQQFFD  EMEDPSILEE  SSTLMDPNDP  HRGAPLRLGF  VAGVIGRERI  180
181   PTFERMLWRV  CRGNVFLRQA  DIEDSLEDPA  TGDQVHKSVF  IIFFQGDQLK  NRVKKICEGF  240
241   RATLYPCPET  PQERKEMLAG  VNARIEDLQM  VLNQTEDHRQ  RVLQAAAKTV  RVWFIKVRKM  300
301   KAIYHTLNLC  NIDVTQKCLI  AEVWCPVSDL  DSIQFALRRG  TEKSGSTVPS  ILNRMQTKQT  360
361   PPTYNKTNKF  TSGFQNIVDA  YGIGTYREMN  PAPYTIITFP  FLFAVMFGDM  GHGALMTCAA  420
421   LYLVLRESRL  MAQKNDNEMF  NMVFAGRYII  LLMGVFSVYT  GIIYNDCFSK  SLNVFGSGWS  480
481   VRPMFDPQVG  GNWTFATLEG  NRLLQLDPAI  DGVFKGPYPI  GIDPIWNIAV  NKLTFLNSFK  540
541   MKMSIILGVI  HMLFGVSLSL  FNHLYFKKPL  NIYLGFIPEV  IFMSSLFGYL  VILIFYKWVS  600
601   FTARTSKDAP  SLLIAFINMF  LFNYNDPSNK  PLYSGQMGLQ  IFLVLIALAC  VPCMLVVKTL  660
661   VLRRQHLWRK  HLGTQNFGGI  RVGNGPTEDQ  AEIIQHDQLS  QHSEEETEPC  LLSSAVKAHE  720
721   EEEFNFADVA  VHQAIHTIEY  CLGCISNTAS  YLRLWALSLA  HAQLSEVLWS  MVMHIGLSSR  780
781   SFGGFFLLTI  VFFFFGVLTV  AILLIMEGLS  AFLHALRLHW  VEFQNKFYSG  QGFKFLPFTF  840
841   ESILDGRFEE  850
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCAGT  TGTTCAGAAG  TGAGGAGATG  ACCTTGGCTC  AGCTTTTCCT  TCAGTCTGAA  60
61    GCAGCTTACT  GTTGTGTCAG  CGAACTGGGA  GAAATCGGAA  TGGTGCAGTT  CCGTGATCTC  120
121   AACCCGGATG  TAAACGTCTT  CCAACGAAAG  TTTGTCAATG  AAGTGCGAAG  GTGTGAGGAG  180
181   ATGGATCGCA  AACTGAGATT  TGTGGAAAAA  GAAATAAAGA  AGGCAAACAT  CCCAATTATT  240
241   GACACAGGAG  AGAACCCCGA  GGTCCCTTTT  CCACGAGACA  TGATTGACCT  GGAGGCCTCA  300
301   TTTGAGAAGC  TTGAAAATGA  GCTGAAGGAA  ATAAACACCA  ATCAAGAGGC  CCTGAAGAAG  360
361   AACTTCCTGG  AACTGACTGA  ACTCAAGCAC  ATTCTGCGTC  GTACTCAGCA  GTTTTTCGAT  420
421   GAGATGGAGG  ATCCCAGCAT  ACTGGAGGAG  TCGTCCACGC  TCATGGACCC  AAATGACCCG  480
481   CACCGAGGGG  CCCCTCTGAG  ACTGGGGTTT  GTGGCCGGAG  TCATCGGAAG  GGAGCGGATT  540
541   CCAACATTTG  AGAGGATGTT  GTGGAGGGTT  TGCAGAGGAA  ATGTGTTCCT  GAGACAGGCA  600
601   GATATTGAAG  ACTCTCTGGA  GGACCCAGCG  ACAGGGGACC  AGGTCCACAA  GTCAGTCTTC  660
661   ATCATCTTCT  TCCAGGGAGA  CCAGCTGAAG  AATAGAGTGA  AGAAGATCTG  TGAGGGCTTC  720
721   AGAGCTACAT  TGTACCCATG  TCCAGAAACC  CCTCAGGAGA  GGAAAGAGAT  GCTAGCAGGG  780
781   GTGAACGCGC  GCATTGAGGA  CCTGCAAATG  GTGCTAAACC  AGACTGAGGA  CCACAGGCAG  840
841   AGGGTCCTGC  AGGCTGCAGC  CAAGACCGTC  AGGGTGTGGT  TCATCAAAGT  GAGAAAAATG  900
901   AAGGCCATCT  ACCACACTCT  CAACCTCTGC  AACATCGACG  TGACGCAGAA  GTGTCTGATC  960
961   GCCGAGGTGT  GGTGTCCCGT  CTCCGACCTG  GACTCCATCC  AGTTTGCTCT  GCGGAGGGGG  1020
1021  ACGGAGAAGA  GCGGCTCCAC  TGTGCCTTCC  ATCCTCAATA  GGATGCAGAC  CAAGCAGACC  1080
1081  CCTCCCACCT  ATAACAAGAC  CAACAAATTC  ACCTCGGGCT  TTCAGAACAT  AGTTGATGCC  1140
1141  TATGGAATCG  GCACCTACCG  TGAGATGAAT  CCAGCGCCAT  ACACCATCAT  CACCTTCCCC  1200
1201  TTTCTGTTTG  CGGTCATGTT  TGGTGACATG  GGCCACGGGG  CCCTCATGAC  CTGCGCCGCC  1260
1261  CTCTATCTTG  TACTGAGAGA  GAGCAGACTG  ATGGCCCAGA  AGAATGACAA  TGAGATGTTC  1320
1321  AACATGGTCT  TTGCGGGCCG  TTACATCATC  CTGCTGATGG  GAGTATTCTC  GGTCTACACT  1380
1381  GGGATCATTT  ACAACGACTG  CTTCTCCAAG  TCATTAAATG  TGTTTGGCTC  TGGCTGGAGC  1440
1441  GTGAGGCCCA  TGTTCGACCC  TCAAGTGGGA  GGCAACTGGA  CGTTTGCAAC  CCTGGAAGGC  1500
1501  AACCGGCTTC  TGCAGTTGGA  CCCAGCCATT  GATGGGGTAT  TTAAGGGCCC  TTACCCCATC  1560
1561  GGCATAGACC  CGATATGGAA  CATTGCAGTC  AATAAGCTGA  CTTTCTTGAA  CTCGTTCAAG  1620
1621  ATGAAGATGT  CCATTATCCT  GGGAGTCATC  CACATGCTGT  TTGGTGTTTC  TCTGAGTCTC  1680
1681  TTCAATCACC  TGTACTTCAA  AAAGCCACTG  AATATCTACC  TTGGATTCAT  CCCAGAGGTT  1740
1741  ATTTTTATGT  CCAGCCTGTT  TGGCTACCTC  GTCATTCTTA  TCTTTTATAA  GTGGGTCTCC  1800
1801  TTCACTGCGC  GCACCTCCAA  GGATGCTCCC  AGCCTCCTCA  TCGCATTTAT  AAACATGTTC  1860
1861  CTCTTCAACT  ATAACGACCC  CAGTAACAAA  CCTCTGTACA  GTGGACAAAT  GGGCCTCCAA  1920
1921  ATATTCCTGG  TGTTAATCGC  TCTTGCATGT  GTCCCCTGTA  TGTTGGTTGT  GAAAACGTTA  1980
1981  GTGTTGCGGA  GGCAGCATTT  GTGGCGGAAA  CACTTGGGCA  CGCAGAACTT  TGGAGGGATC  2040
2041  CGGGTGGGCA  ATGGGCCCAC  TGAGGACCAG  GCTGAAATCA  TCCAGCACGA  CCAGCTCTCA  2100
2101  CAGCACTCTG  AAGAGGAAAC  TGAGCCTTGC  CTTTTGTCGT  CTGCCGTCAA  GGCCCATGAG  2160
2161  GAGGAAGAGT  TTAACTTTGC  CGATGTGGCG  GTGCATCAGG  CGATACACAC  CATCGAGTAC  2220
2221  TGCCTGGGCT  GCATCTCCAA  CACTGCTTCC  TATCTGAGGC  TTTGGGCCCT  GAGTCTTGCC  2280
2281  CATGCTCAGT  TGTCGGAGGT  GCTGTGGTCC  ATGGTGATGC  ACATCGGCCT  TTCCTCGAGA  2340
2341  AGCTTTGGAG  GCTTCTTTCT  CCTCACCATA  GTCTTTTTCT  TCTTTGGAGT  TCTAACAGTT  2400
2401  GCCATTCTAC  TCATTATGGA  AGGCCTGTCA  GCGTTCTTAC  ACGCGCTGCG  ATTGCACTGG  2460
2461  GTGGAGTTCC  AGAACAAGTT  TTATTCAGGC  CAGGGCTTCA  AGTTCCTGCC  ATTCACTTTT  2520
2521  GAAAGCATCC  TGGACGGCAG  ATTTGAGGAG  TGA  2553

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Hydrogen ion transport
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function
Proton transmembrane transporter activity
Biological Process
ATP hydrolysis coupled proton transport
Biological Process
Autophagosome maturation
Biological Process
Neural crest cell migration
Biological Process
Phagolysosome assembly

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ten-0828Tetraodon nigroviridis93.580.01606
LLPS-Scm-0329Scophthalmus maximus91.180.01599
LLPS-Orl-3338Oryzias latipes90.720.01584
LLPS-Gaa-1398Gasterosteus aculeatus89.890.01560
LLPS-Orn-1041Oreochromis niloticus89.880.01560
LLPS-Xim-1963Xiphophorus maculatus89.410.01565
LLPS-Pof-2642Poecilia formosa89.290.01550
LLPS-Scf-2462Scleropages formosus88.350.01531
LLPS-Asm-1613Astyanax mexicanus87.530.01536
LLPS-Dar-2395Danio rerio86.820.01521
LLPS-Icp-0386Ictalurus punctatus85.650.01496
LLPS-Eqc-4644Equus caballus82.120.01418
LLPS-Caj-3940Callithrix jacchus82.050.01359
LLPS-Ova-3666Ovis aries82.00.01422
LLPS-Sus-2179Sus scrofa82.00.01429
LLPS-Aon-3032Aotus nancymaae82.00.01414
LLPS-Fia-0308Ficedula albicollis81.880.01406
LLPS-Chs-2268Chlorocebus sabaeus81.880.01409
LLPS-Pes-3565Pelodiscus sinensis81.680.01419
LLPS-Anp-2828Anas platyrhynchos81.660.01348
LLPS-Meg-2974Meleagris gallopavo81.540.01390
LLPS-Ran-3906Rattus norvegicus81.530.01421
LLPS-Mum-4120Mus musculus81.410.01420
LLPS-Otg-3535Otolemur garnettii81.330.01412
LLPS-Cas-3868Carlito syrichta81.290.01394
LLPS-Tag-1187Taeniopygia guttata81.210.01398
LLPS-Loa-2927Loxodonta africana81.210.01410
LLPS-Cap-4084Cavia porcellus81.180.01407
LLPS-Leo-3654Lepisosteus oculatus81.050.01401
LLPS-Hos-3719Homo sapiens80.980.01399
LLPS-Mam-3285Macaca mulatta80.860.01397
LLPS-Pap-0887Pan paniscus80.860.01397
LLPS-Pat-4504Pan troglodytes80.860.01397
LLPS-Paa-4560Papio anubis80.860.01397
LLPS-Caf-0242Canis familiaris80.750.01400
LLPS-Aim-0504Ailuropoda melanoleuca80.750.01400
LLPS-Myl-1104Myotis lucifugus80.630.01400
LLPS-Mup-3201Mustela putorius furo80.510.01398
LLPS-Urm-3270Ursus maritimus80.30.01392
LLPS-Tut-1721Tursiops truncatus79.950.01316
LLPS-Mea-3626Mesocricetus auratus79.950.01327
LLPS-Fec-0186Felis catus79.770.01405
LLPS-Poa-0009Pongo abelii79.660.01400
LLPS-Anc-1592Anolis carolinensis79.660.01416
LLPS-Bot-3594Bos taurus79.540.01407
LLPS-Xet-1025Xenopus tropicalis79.530.01373
LLPS-Nol-2627Nomascus leucogenys79.460.01361
LLPS-Ict-3276Ictidomys tridecemlineatus79.430.01397
LLPS-Gaga-3764Gallus gallus79.20.01384
LLPS-Orc-4383Oryctolagus cuniculus79.20.01386
LLPS-Fud-0796Fukomys damarensis79.00.01397
LLPS-Mod-1751Monodelphis domestica77.410.01373
LLPS-Lac-0676Latimeria chalumnae75.060.01305
LLPS-Sah-3132Sarcophilus harrisii61.330.01055
LLPS-Maf-2691Macaca fascicularis60.750.01035
LLPS-Cea-4607Cercocebus atys60.750.01035
LLPS-Man-3627Macaca nemestrina60.630.01035
LLPS-Rhb-3018Rhinopithecus bieti60.510.01036
LLPS-Cii-2063Ciona intestinalis60.440.01052
LLPS-Gog-4794Gorilla gorilla60.420.01038
LLPS-Mal-3041Mandrillus leucophaeus59.510.0 933
LLPS-Drm-1972Drosophila melanogaster58.80.0 986
LLPS-Ora-2733Ornithorhynchus anatinus57.580.0 906
LLPS-Cae-0052Caenorhabditis elegans56.890.0 965
LLPS-Dio-1138Dipodomys ordii56.840.0 939
LLPS-Cis-0233Ciona savignyi55.190.0 926
LLPS-Abg-0105Absidia glauca45.430.0 686
LLPS-Map-0239Magnaporthe poae43.840.0 549
LLPS-Php-1642Physcomitrella patens43.40.0 636
LLPS-Put-0818Puccinia triticina42.940.0 654
LLPS-Miv-0009Microbotryum violaceum42.780.0 681
LLPS-Crn-1564Cryptococcus neoformans42.760.0 653
LLPS-Pug-0624Puccinia graminis42.670.0 656
LLPS-Orbr-1205Oryza brachyantha42.610.0 644
LLPS-Tum-0799Tuber melanosporum42.450.0 636
LLPS-Asn-0100Aspergillus nidulans42.410.0 647
LLPS-Cus-2132Cucumis sativus42.360.0 635
LLPS-Zem-0269Zea mays42.310.0 625
LLPS-Coc-0651Corchorus capsularis42.260.0 624
LLPS-Mua-1230Musa acuminata42.260.0 624
LLPS-Ast-0272Aspergillus terreus42.120.0 636
LLPS-Mel-0442Melampsora laricipopulina42.120.0 662
LLPS-Asc-1476Aspergillus clavatus42.090.0 634
LLPS-Prp-2141Prunus persica42.060.0 642
LLPS-Viv-1468Vitis vinifera42.060.0 629
LLPS-Ori-1759Oryza indica42.040.0 634
LLPS-Mae-0566Manihot esculenta42.030.0 624
LLPS-Asni-1033Aspergillus niger41.950.0 629
LLPS-Pot-0646Populus trichocarpa41.910.0 625
LLPS-Sob-0171Sorghum bicolor41.910.0 627
LLPS-Sac-1151Saccharomyces cerevisiae41.870.0 617
LLPS-Asfu-0274Aspergillus fumigatus41.860.0 621
LLPS-Amt-0677Amborella trichopoda41.860.0 619
LLPS-Usm-0086Ustilago maydis41.760.0 638
LLPS-Sem-1090Selaginella moellendorffii41.720.0 620
LLPS-Orp-1779Oryza punctata41.670.0 620
LLPS-Nia-2261Nicotiana attenuata41.660.0 629
LLPS-Aso-0589Aspergillus oryzae41.650.0 647
LLPS-Asf-0583Aspergillus flavus41.650.0 647
LLPS-Nef-0190Neosartorya fischeri41.630.0 614
LLPS-Gag-0076Gaeumannomyces graminis41.620.0 645
LLPS-Sol-2198Solanum lycopersicum41.590.0 634
LLPS-Art-1171Arabidopsis thaliana41.570.0 625
LLPS-Arl-1547Arabidopsis lyrata41.570.0 635
LLPS-Bro-1400Brassica oleracea41.550.0 640
LLPS-Brn-1174Brassica napus41.550.0 643
LLPS-Gor-0838Gossypium raimondii41.540.0 622
LLPS-Chr-1488Chlamydomonas reinhardtii41.470.0 640
LLPS-Orr-1310Oryza rufipogon41.440.0 624
LLPS-Org-1719Oryza glaberrima41.440.0 624
LLPS-Ors-0358Oryza sativa41.440.0 624
LLPS-Orgl-1318Oryza glumaepatula41.440.0 623
LLPS-Brd-1742Brachypodium distachyon41.440.0 623
LLPS-Orni-1272Oryza nivara41.440.0 624
LLPS-Spr-0474Sporisorium reilianum41.40.0 639
LLPS-Sot-2197Solanum tuberosum41.40.0 632
LLPS-Brr-2024Brassica rapa41.380.0 642
LLPS-Hea-0655Helianthus annuus41.380.0 634
LLPS-Tra-0805Triticum aestivum41.360.0 626
LLPS-Phv-1862Phaseolus vulgaris41.340.0 627
LLPS-Orm-0226Oryza meridionalis41.320.0 622
LLPS-Orb-2369Oryza barthii41.320.0 621
LLPS-Yal-1219Yarrowia lipolytica41.30.0 602
LLPS-Cogr-0988Colletotrichum graminicola41.290.0 618
LLPS-Thc-1611Theobroma cacao41.250.0 616
LLPS-Trv-0065Trichoderma virens41.180.0 625
LLPS-Glm-1906Glycine max41.160.0 634
LLPS-Dac-0403Daucus carota41.10.0 613
LLPS-Beb-0402Beauveria bassiana41.090.0 620
LLPS-Mao-0149Magnaporthe oryzae41.090.0 610
LLPS-Cog-0172Colletotrichum gloeosporioides41.050.0 614
LLPS-Hov-1636Hordeum vulgare40.950.0 615
LLPS-Fuo-0238Fusarium oxysporum40.90.0 612
LLPS-Ved-0737Verticillium dahliae40.880.0 626
LLPS-Nec-0307Neurospora crassa40.840.0 609
LLPS-Blg-0188Blumeria graminis40.80.0 625
LLPS-Trr-0375Trichoderma reesei40.740.0 612
LLPS-Scs-0424Sclerotinia sclerotiorum40.720.0 612
LLPS-Pytr-1137Pyrenophora triticirepentis40.670.0 599
LLPS-Fus-0769Fusarium solani40.650.0 605
LLPS-Phn-0625Phaeosphaeria nodorum40.640.0 582
LLPS-Sei-1271Setaria italica40.580.0 615
LLPS-Lem-1400Leptosphaeria maculans40.510.0 612
LLPS-Met-0810Medicago truncatula40.510.0 626
LLPS-Coo-1006Colletotrichum orbiculare40.490.0 613
LLPS-Pyt-0796Pyrenophora teres40.440.0 599
LLPS-Lep-0165Leersia perrieri40.370.0 617
LLPS-Osl-0079Ostreococcus lucimarinus40.320.0 601
LLPS-Scp-1567Schizosaccharomyces pombe40.270.0 605
LLPS-Via-1873Vigna angularis40.190.0 593
LLPS-Scj-1429Schizosaccharomyces japonicus40.050.0 613
LLPS-Vir-1286Vigna radiata40.020.0 615
LLPS-Tru-0944Triticum urartu39.950.0 609
LLPS-Zyt-0067Zymoseptoria tritici39.70.0 614
LLPS-Dos-0353Dothistroma septosporum39.440.0 594
LLPS-Gas-0792Galdieria sulphuraria39.430.0 578
LLPS-Chc-0752Chondrus crispus39.140.0 594
LLPS-Asg-0299Ashbya gossypii39.130.0 577
LLPS-Kop-1002Komagataella pastoris39.00.0 605
LLPS-Scc-0355Schizosaccharomyces cryophilus38.970.0 593
LLPS-Cym-0166Cyanidioschyzon merolae38.290.0 578
LLPS-Fuv-0425Fusarium verticillioides38.016e-177 538