LLPS-Art-1171
VHA-a3

▼ OVERVIEW

Status: Reviewed
Protein Name: V-type proton ATPase subunit a3
Gene Name: VHA-a3, At4g39080, F19H22.180
Ensembl Gene: AT4G39080
Ensembl Protein: AT4G39080.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Involved in vacuolar nutrient storage (e.g. accumulation and storage of nitrate) and in tolerance to some toxic ions (e.g. zinc ions sequestration in vacuoles).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAESGGGGGC  CPPMDLMRSE  TMQLVQLIVP  MESAHLTVSY  LGDLGLVQFK  DLNSEKSPFQ  60
61    RTYAAQIKRC  GEMARKIRFF  RDQMSKAGVP  AKEMQGKEND  IDLDDVEVKL  GELEAELVEI  120
121   NANNDKLQRS  YNELMEYKLV  LQKAGEFFSS  AHRSAADQQR  ETESQQAGED  LLESPLLQEE  180
181   KSIDSTKQVK  LGFLTGLVPR  EKSMVFERIL  FRATRGNIFI  RQTVIEEPVI  DPNSGEKAEK  240
241   NVFVVFYSGE  RAKSKILKIC  EAFGANRYPF  SEDLGRQAQM  ITEVSGRLSE  LKTTIDAGLG  300
301   QRNILLQTIG  DKFELWNLKV  RKEKAIYHTL  NMLSLDVTKK  CLVAEGWSPV  FASREIQDAL  360
361   QRAAVDSNSQ  VGSIFQVLRT  KESPPTYFRT  NKFTSAIQEI  VDAYGVAKYQ  EANPGVFTIV  420
421   TFPFLFAVMF  GDWGHGICIL  LATMYLILKE  KKLASQKLGD  IMEMAFGGRY  VILMMSLFSI  480
481   YTGLIYNEFF  SIPFPLFAPS  AYDCRDVSCS  EATTIGLIKV  RDTYPFGLDP  VWHGSRSELP  540
541   FLNSLKMKMS  ILLGVSQMNL  GIIMSYFNAR  FFKSSVNIWF  QFIPQMIFLN  SLFGYLSVLI  600
601   IIKWCTGSQA  DLYHVMIYMF  LSPMDELGEN  QLFPHQKTLQ  LVLLFLALVS  VPCMLLPKPF  660
661   ILKKQHEARH  QGQAYAPLDE  TDESLHVETN  GGGSHGHEEF  EFSEIFVHQL  IHTIEFVLGA  720
721   VSNTASYLRL  WALSLAHSEL  SSVFYEKVLL  LAWGYNNPLI  LIVGVLVFIF  ATVGVLLVME  780
781   TLSAFLHALR  LHWVEFQNKF  YEGDGYKFAP  FTFIFTANED  E  821
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGAAA  GTGGCGGTGG  CGGTGGCTGT  TGTCCGCCGA  TGGATCTGAT  GCGTTCAGAG  60
61    ACGATGCAAC  TTGTTCAGCT  CATTGTTCCC  ATGGAATCTG  CTCATCTCAC  CGTCTCTTAC  120
121   CTTGGAGATC  TTGGCCTCGT  CCAATTCAAA  GACCTTAATT  CAGAGAAGAG  CCCATTTCAA  180
181   CGTACTTACG  CAGCACAGAT  TAAAAGATGT  GGAGAAATGG  CACGGAAAAT  ACGTTTCTTC  240
241   AGGGATCAAA  TGTCAAAAGC  AGGAGTTCCA  GCCAAGGAAA  TGCAAGGGAA  AGAAAATGAC  300
301   ATTGACTTGG  ATGATGTTGA  GGTAAAGCTT  GGAGAGCTAG  AAGCTGAACT  TGTTGAAATC  360
361   AATGCTAATA  ATGACAAGTT  GCAGCGCTCC  TATAATGAGC  TTATGGAGTA  CAAGTTGGTT  420
421   CTTCAGAAGG  CTGGTGAGTT  CTTTTCTTCT  GCTCATAGAA  GTGCCGCAGA  TCAACAGAGA  480
481   GAGACAGAAT  CACAACAAGC  GGGTGAAGAT  CTGCTGGAGT  CTCCTTTGTT  ACAGGAAGAG  540
541   AAGTCCATTG  ATTCGACAAA  GCAAGTAAAG  CTTGGATTTC  TTACCGGATT  AGTGCCTCGT  600
601   GAAAAGTCTA  TGGTCTTTGA  GAGGATTCTG  TTCCGTGCGA  CCAGGGGCAA  CATTTTTATC  660
661   CGACAGACTG  TCATTGAGGA  GCCAGTCATT  GATCCCAACT  CTGGGGAGAA  GGCTGAGAAA  720
721   AATGTTTTTG  TTGTCTTCTA  TTCCGGGGAA  AGAGCGAAAA  GCAAAATTCT  GAAAATATGT  780
781   GAAGCTTTTG  GGGCCAATCG  TTATCCTTTC  AGTGAGGACC  TTGGAAGACA  AGCTCAGATG  840
841   ATAACCGAGG  TTTCTGGTCG  ATTATCCGAG  CTTAAAACCA  CGATAGATGC  TGGGTTAGGT  900
901   CAGCGTAACA  TTCTTTTGCA  GACCATTGGA  GATAAGTTTG  AACTATGGAA  CCTCAAGGTA  960
961   CGCAAAGAGA  AAGCTATCTA  TCATACATTG  AACATGCTTA  GTCTTGATGT  GACGAAGAAG  1020
1021  TGCCTCGTGG  CCGAGGGCTG  GAGTCCTGTC  TTTGCATCAA  GAGAAATTCA  AGATGCATTA  1080
1081  CAGCGTGCCG  CCGTTGACTC  CAATTCTCAA  GTTGGATCAA  TTTTCCAGGT  CCTAAGAACC  1140
1141  AAAGAGTCGC  CACCAACTTA  TTTTCGCACA  AACAAATTTA  CTTCTGCAAT  CCAGGAAATT  1200
1201  GTTGATGCGT  ATGGTGTGGC  CAAGTATCAG  GAAGCCAATC  CAGGTGTATT  CACCATTGTT  1260
1261  ACCTTCCCCT  TCCTTTTCGC  TGTTATGTTT  GGTGATTGGG  GGCATGGAAT  ATGCATTCTG  1320
1321  CTTGCAACTA  TGTACTTGAT  ATTGAAAGAA  AAGAAACTTG  CCAGCCAGAA  ACTTGGGGAT  1380
1381  ATTATGGAAA  TGGCTTTTGG  TGGGCGTTAT  GTCATTTTGA  TGATGTCACT  CTTCTCAATA  1440
1441  TACACTGGAT  TAATCTACAA  CGAGTTCTTC  TCTATACCAT  TCCCATTGTT  TGCTCCTTCA  1500
1501  GCGTATGATT  GCCGGGATGT  CTCTTGCAGC  GAAGCTACAA  CAATTGGTTT  GATAAAGGTC  1560
1561  AGAGACACTT  ATCCATTTGG  TCTAGATCCT  GTGTGGCATG  GATCCCGCAG  TGAGCTGCCA  1620
1621  TTCCTGAACT  CGCTGAAGAT  GAAAATGTCA  ATCCTTCTCG  GAGTTTCTCA  AATGAACCTC  1680
1681  GGAATCATAA  TGAGCTACTT  TAATGCTAGA  TTCTTCAAAT  CAAGTGTAAA  TATATGGTTC  1740
1741  CAGTTCATTC  CCCAAATGAT  ATTCTTGAAC  AGCTTGTTTG  GCTATCTCTC  AGTCCTCATC  1800
1801  ATCATAAAGT  GGTGCACTGG  TTCTCAAGCA  GATTTGTATC  ATGTAATGAT  ATATATGTTC  1860
1861  CTGAGCCCAA  TGGACGAGTT  AGGAGAGAAT  CAACTGTTCC  CTCACCAGAA  AACATTACAG  1920
1921  CTTGTGCTTC  TCTTTCTGGC  TCTTGTTTCT  GTTCCGTGTA  TGTTGCTTCC  AAAGCCGTTC  1980
1981  ATCTTGAAGA  AACAACATGA  AGCTAGGCAT  CAAGGCCAGG  CGTACGCACC  TCTTGACGAG  2040
2041  ACAGATGAGA  GTCTTCATGT  AGAGACAAAC  GGAGGAGGAT  CCCATGGGCA  TGAGGAGTTT  2100
2101  GAATTCAGCG  AGATATTTGT  GCATCAGCTG  ATTCACACCA  TAGAGTTTGT  GCTTGGAGCT  2160
2161  GTTTCCAACA  CCGCTTCTTA  CCTGCGTCTA  TGGGCTCTCA  GTCTTGCCCA  CTCGGAGCTG  2220
2221  TCATCAGTCT  TCTATGAGAA  GGTCCTCCTT  CTCGCTTGGG  GTTACAACAA  TCCGTTGATC  2280
2281  CTGATCGTTG  GGGTCTTGGT  GTTCATATTC  GCAACCGTGG  GAGTTTTGCT  GGTGATGGAG  2340
2341  ACACTAAGCG  CGTTCCTTCA  CGCGCTGCGT  CTTCACTGGG  TTGAGTTTCA  GAACAAATTC  2400
2401  TACGAAGGAG  ATGGTTACAA  GTTCGCTCCT  TTCACTTTCA  TTTTCACGGC  AAACGAAGAC  2460
2461  GAGTGA  2466

▼ KEYWORD

ID
Family
Acetylation
Coiled coil
Complete proteome
Hydrogen ion transport
Ion transport
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport
Vacuole

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast
Cellular Component
Chloroplast envelope
Cellular Component
Golgi apparatus
Cellular Component
Integral component of membrane
Cellular Component
Membrane
Cellular Component
Plant-type vacuole
Cellular Component
Plant-type vacuole membrane
Cellular Component
Plasma membrane
Cellular Component
Vacuolar membrane
Cellular Component
Vacuolar proton-transporting V-type ATPase complex
Cellular Component
Vacuolar proton-transporting V-type ATPase, V0 domain
Cellular Component
Vacuole
Molecular Function
ATPase binding
Molecular Function
Hydrogen-translocating pyrophosphatase activity
Molecular Function
Nutrient reservoir activity
Molecular Function
Proton-transporting ATPase activity, rotational mechanism
Biological Process
ATP hydrolysis coupled proton transport
Biological Process
ATP synthesis coupled proton transport
Biological Process
Sequestering of zinc ion
Biological Process
Vacuolar acidification
Biological Process
Vacuolar proton-transporting V-type ATPase complex assembly
Biological Process
Vacuolar sequestering

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
Compute pI/MwAAindex
Function
CGDBPIRSF
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-1547Arabidopsis lyrata97.20.01565
LLPS-Brn-3023Brassica napus93.910.01545
LLPS-Brr-2024Brassica rapa93.910.01545
LLPS-Bro-1400Brassica oleracea92.940.01520
LLPS-Coc-0969Corchorus capsularis81.822e-0655.8
LLPS-Gor-0838Gossypium raimondii81.30.01330
LLPS-Mae-0566Manihot esculenta80.490.01333
LLPS-Pot-0646Populus trichocarpa80.170.01336
LLPS-Thc-1611Theobroma cacao79.530.01324
LLPS-Prp-2141Prunus persica79.260.01290
LLPS-Glm-1233Glycine max78.870.01306
LLPS-Viv-1468Vitis vinifera78.840.01287
LLPS-Cus-2132Cucumis sativus78.40.01271
LLPS-Phv-1862Phaseolus vulgaris77.980.01295
LLPS-Hea-0655Helianthus annuus77.820.01301
LLPS-Met-0810Medicago truncatula77.740.01297
LLPS-Nia-2261Nicotiana attenuata77.490.01266
LLPS-Sol-0360Solanum lycopersicum77.40.01274
LLPS-Orbr-1205Oryza brachyantha77.380.01275
LLPS-Sob-0171Sorghum bicolor77.290.01273
LLPS-Amt-0677Amborella trichopoda77.080.01249
LLPS-Mua-1230Musa acuminata76.890.01276
LLPS-Orm-0226Oryza meridionalis76.760.01260
LLPS-Tra-0805Triticum aestivum76.670.01288
LLPS-Zem-0269Zea mays76.420.01247
LLPS-Orgl-1318Oryza glumaepatula76.270.01254
LLPS-Orni-1272Oryza nivara76.270.01254
LLPS-Orr-1310Oryza rufipogon76.270.01254
LLPS-Ors-0358Oryza sativa76.270.01254
LLPS-Sei-1271Setaria italica76.140.01247
LLPS-Org-1719Oryza glaberrima76.140.01254
LLPS-Orp-1779Oryza punctata76.10.01250
LLPS-Orb-2369Oryza barthii76.020.01250
LLPS-Hov-1636Hordeum vulgare75.790.01283
LLPS-Vir-1286Vigna radiata75.740.01291
LLPS-Dac-0403Daucus carota75.710.01227
LLPS-Ori-1759Oryza indica75.70.01261
LLPS-Brd-2231Brachypodium distachyon75.610.01282
LLPS-Lep-0165Leersia perrieri75.240.01262
LLPS-Sot-2197Solanum tuberosum74.510.01231
LLPS-Tru-0944Triticum urartu74.00.01252
LLPS-Php-1669Physcomitrella patens66.180.01055
LLPS-Sem-1090Selaginella moellendorffii64.730.01035
LLPS-Via-1873Vigna angularis62.070.01032
LLPS-Chr-1488Chlamydomonas reinhardtii51.830.0 838
LLPS-Osl-0079Ostreococcus lucimarinus51.30.0 800
LLPS-Abg-0105Absidia glauca43.480.0 644
LLPS-Mum-4322Mus musculus43.250.0 621
LLPS-Ran-0982Rattus norvegicus43.110.0 621
LLPS-Chc-0752Chondrus crispus42.990.0 669
LLPS-Loa-2927Loxodonta africana42.870.0 624
LLPS-Orc-1737Oryctolagus cuniculus42.860.0 619
LLPS-Myl-1104Myotis lucifugus42.790.0 624
LLPS-Aim-0504Ailuropoda melanoleuca42.670.0 614
LLPS-Cap-4622Cavia porcellus42.630.0 620
LLPS-Gaga-0779Gallus gallus42.590.0 599
LLPS-Caf-0242Canis familiaris42.570.0 615
LLPS-Tag-1187Taeniopygia guttata42.570.0 621
LLPS-Mea-0301Mesocricetus auratus42.530.0 621
LLPS-Sus-2179Sus scrofa42.470.0 611
LLPS-Mod-1751Monodelphis domestica42.470.0 624
LLPS-Pap-0887Pan paniscus42.430.0 617
LLPS-Pat-4504Pan troglodytes42.430.0 617
LLPS-Hos-3719Homo sapiens42.430.0 618
LLPS-Otg-3535Otolemur garnettii42.430.0 615
LLPS-Cas-3868Carlito syrichta42.420.0 615
LLPS-Gog-4794Gorilla gorilla42.40.0 615
LLPS-Ova-3666Ovis aries42.380.0 610
LLPS-Mup-3201Mustela putorius furo42.380.0 616
LLPS-Fia-0308Ficedula albicollis42.370.0 612
LLPS-Paa-4560Papio anubis42.310.0 612
LLPS-Mam-3285Macaca mulatta42.310.0 612
LLPS-Sah-3132Sarcophilus harrisii42.30.0 618
LLPS-Man-3627Macaca nemestrina42.30.0 612
LLPS-Rhb-3018Rhinopithecus bieti42.30.0 610
LLPS-Icp-0386Ictalurus punctatus42.290.0 629
LLPS-Eqc-4644Equus caballus42.230.0 607
LLPS-Tut-1721Tursiops truncatus42.20.0 581
LLPS-Bot-2393Bos taurus42.170.0 612
LLPS-Meg-2974Meleagris gallopavo42.170.0 611
LLPS-Tum-0799Tuber melanosporum42.140.0 609
LLPS-Aon-3032Aotus nancymaae42.040.0 608
LLPS-Pes-3565Pelodiscus sinensis42.030.0 610
LLPS-Xet-1025Xenopus tropicalis41.940.0 613
LLPS-Urm-3270Ursus maritimus41.940.0 604
LLPS-Chs-2268Chlorocebus sabaeus41.920.0 605
LLPS-Maf-2691Macaca fascicularis41.910.0 613
LLPS-Cea-4607Cercocebus atys41.910.0 614
LLPS-Xim-1963Xiphophorus maculatus41.820.0 632
LLPS-Orn-1041Oreochromis niloticus41.740.0 627
LLPS-Pof-2642Poecilia formosa41.70.0 627
LLPS-Drm-1972Drosophila melanogaster41.670.0 585
LLPS-Tar-0767Takifugu rubripes41.570.0 619
LLPS-Dar-4006Danio rerio41.530.0 617
LLPS-Ten-0828Tetraodon nigroviridis41.430.0 620
LLPS-Gas-0792Galdieria sulphuraria41.420.0 605
LLPS-Orl-3338Oryzias latipes41.330.0 619
LLPS-Cym-0166Cyanidioschyzon merolae41.30.0 610
LLPS-Fud-0796Fukomys damarensis41.280.0 605
LLPS-Scf-2296Scleropages formosus41.210.0 623
LLPS-Caj-3940Callithrix jacchus41.170.0 570
LLPS-Dio-1138Dipodomys ordii41.150.0 576
LLPS-Fec-0186Felis catus41.060.0 598
LLPS-Asfu-0274Aspergillus fumigatus41.030.0 576
LLPS-Anp-2828Anas platyrhynchos41.030.0 572
LLPS-Ict-3276Ictidomys tridecemlineatus41.010.0 602
LLPS-Nol-2627Nomascus leucogenys41.00.0 584
LLPS-Anc-1592Anolis carolinensis40.960.0 610
LLPS-Lac-0676Latimeria chalumnae40.90.0 577
LLPS-Poa-0009Pongo abelii40.830.0 602
LLPS-Nef-0190Neosartorya fischeri40.80.0 572
LLPS-Gaa-1398Gasterosteus aculeatus40.680.0 619
LLPS-Crn-1564Cryptococcus neoformans40.650.0 565
LLPS-Asm-1613Astyanax mexicanus40.630.0 627
LLPS-Lem-1400Leptosphaeria maculans40.530.0 565
LLPS-Aso-0589Aspergillus oryzae40.530.0 578
LLPS-Asf-0583Aspergillus flavus40.530.0 578
LLPS-Cii-2063Ciona intestinalis40.50.0 595
LLPS-Scm-0329Scophthalmus maximus40.470.0 616
LLPS-Mal-3041Mandrillus leucophaeus40.421e-175 532
LLPS-Phn-0625Phaeosphaeria nodorum40.190.0 571
LLPS-Scs-0424Sclerotinia sclerotiorum40.160.0 566
LLPS-Asc-1476Aspergillus clavatus40.120.0 571
LLPS-Ast-0272Aspergillus terreus40.020.0 572
LLPS-Nec-0307Neurospora crassa39.930.0 559
LLPS-Asni-1033Aspergillus niger39.930.0 573
LLPS-Leo-3654Lepisosteus oculatus39.910.0 564
LLPS-Asn-0100Aspergillus nidulans39.840.0 569
LLPS-Zyt-0067Zymoseptoria tritici39.790.0 561
LLPS-Ved-0737Verticillium dahliae39.720.0 565
LLPS-Put-0818Puccinia triticina39.650.0 563
LLPS-Fus-0769Fusarium solani39.63e-179 545
LLPS-Coo-1006Colletotrichum orbiculare39.582e-179 545
LLPS-Fuo-0238Fusarium oxysporum39.557e-178 541
LLPS-Mel-0442Melampsora laricipopulina39.510.0 568
LLPS-Pyt-0796Pyrenophora teres39.460.0 563
LLPS-Cogr-0988Colletotrichum graminicola39.40.0 554
LLPS-Pytr-1137Pyrenophora triticirepentis39.390.0 563
LLPS-Cog-0172Colletotrichum gloeosporioides39.360.0 552
LLPS-Miv-0009Microbotryum violaceum39.320.0 564
LLPS-Trr-0375Trichoderma reesei39.291e-177 541
LLPS-Pug-0624Puccinia graminis39.280.0 559
LLPS-Cis-0233Ciona savignyi39.230.0 553
LLPS-Dos-0353Dothistroma septosporum39.230.0 550
LLPS-Map-0239Magnaporthe poae39.227e-147 454
LLPS-Cae-0052Caenorhabditis elegans39.00.0 584
LLPS-Blg-0188Blumeria graminis38.940.0 559
LLPS-Beb-0402Beauveria bassiana38.841e-178 543
LLPS-Mao-0149Magnaporthe oryzae38.720.0 551
LLPS-Ora-2733Ornithorhynchus anatinus38.412e-167 511
LLPS-Scp-1567Schizosaccharomyces pombe38.352e-174 531
LLPS-Usm-0086Ustilago maydis38.326e-178 541
LLPS-Spr-0474Sporisorium reilianum38.279e-178 541
LLPS-Scc-0355Schizosaccharomyces cryophilus38.212e-173 529
LLPS-Gag-0076Gaeumannomyces graminis38.170.0 556
LLPS-Trv-0065Trichoderma virens38.131e-179 546
LLPS-Fuv-0425Fusarium verticillioides37.684e-160 493
LLPS-Scj-1429Schizosaccharomyces japonicus37.179e-172 525
LLPS-Asg-0299Ashbya gossypii37.162e-165 508
LLPS-Yal-1219Yarrowia lipolytica36.941e-163 503
LLPS-Sac-1151Saccharomyces cerevisiae36.99e-166 509
LLPS-Kop-1002Komagataella pastoris36.627e-166 510