DrLLPS - Data resource of LLPS

LLPS-Caf-1335
CSNK2B

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Casein kinase II subunit beta
Gene Name:	CSNK2B
Ensembl Gene:	ENSCAFG00000000604.3
Ensembl Protein:	ENSCAFP00000033466.2
Organism:	Canis familiaris
Taxa ID:	9615
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, PML nuclear body, Balbiani body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Danio rerio	LLPS-Dar-0003	Q91398	Regulator	Balbiani body	99.47	5e-126	365
Mus musculus	LLPS-Mum-2470	P67871	Regulator	Nucleolus, PML nuclear body	97.67	5e-71	226
Bos taurus	LLPS-Bot-0043	P67868	Client	Nucleolus	99.47	7e-126	365
Rattus norvegicus	LLPS-Ran-1994	P67874	Client	Nucleolus	99.47	7e-126	365

▼ FUNCTION

Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSCAFT00000037840.2	ENSCAFP00000033466.2
UniProt		E2RP71, E2RP71_CANLF
GeneBank	AAEX03008214, AAEX03008213, AAEX03008215

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 60 61 ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 120 121 PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA 180 181 NQFVPRLSGT PRIRAWEQRP SPSPGVPIPS TPSPPPATLI SLVFSFTSPV WEKRQKGEEA 240 241 EKETCTEGHR GMVKSAWVFF CHLRAPLPLY PTPSRPSFPA DPIPPRTLLG RLLWM 295
Nucleotide CDS Sequence (FASTA)
1 ATGAGCAGCT CAGAGGAGGT GTCTTGGATA TCCTGGTTCT GTGGGCTCCG TGGCAATGAA 60 61 TTCTTTTGTG AAGTGGATGA AGACTACATC CAGGATAAAT TCAATCTCAC TGGACTCAAT 120 121 GAGCAGGTGC CTCACTATCG ACAAGCTCTA GACATGATCT TGGACCTGGA GCCTGATGAA 180 181 GAGCTGGAAG ACAACCCCAA CCAGAGCGAC CTGATTGAGC AGGCAGCCGA GATGCTTTAT 240 241 GGATTGATCC ACGCCCGCTA TATCCTCACC AACCGTGGCA TCGCCCAGAT GTTGGAAAAG 300 301 TACCAGCAGG GAGACTTTGG CTACTGTCCC CGTGTGTACT GTGAGAACCA GCCAATGCTT 360 361 CCCATCGGCC TTTCGGACAT CCCAGGTGAG GCCATGGTGA AGCTCTACTG CCCCAAGTGC 420 421 ATGGACGTGT ACACACCCAA GTCATCGAGG CACCATCACA CGGATGGCGC CTACTTCGGC 480 481 ACCGGTTTCC CTCACATGCT CTTCATGGTG CACCCCGAGT ACCGGCCCAA GCGGCCCGCG 540 541 AACCAGTTTG TGCCCAGGCT CTCCGGGACC CCCCGGATCA GGGCATGGGA GCAGCGGCCC 600 601 AGCCCCTCCC CTGGCGTCCC CATCCCATCC ACACCGTCTC CCCCTCCGGC CACGCTGATT 660 661 TCTTTAGTTT TCTCTTTTAC TTCACCTGTC TGGGAGAAAA GACAGAAAGG GGAGGAGGCA 720 721 GAGAAAGAGA CATGCACAGA AGGGCATCGG GGGATGGTTA AGAGCGCCTG GGTCTTCTTC 780 781 TGCCACCTCC GGGCGCCCCT CCCACTTTAC CCCACCCCCT CCAGACCTTC CTTTCCTGCC 840 841 GACCCCATTC CACCCCGCAC CCTTCTGGGT CGGCTTCTTT GGATGTAG 888

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0031519	Cellular Component	PcG protein complex
GO:0005886	Cellular Component	Plasma membrane
GO:0005956	Cellular Component	Protein kinase CK2 complex
GO:0003682	Molecular Function	Chromatin binding
GO:0042802	Molecular Function	Identical protein binding
GO:0019904	Molecular Function	Protein domain specific binding
GO:0019887	Molecular Function	Protein kinase regulator activity
GO:0004674	Molecular Function	Protein serine/threonine kinase activity
GO:0043021	Molecular Function	Ribonucleoprotein complex binding
GO:0005102	Molecular Function	Signaling receptor binding
GO:0008134	Molecular Function	Transcription factor binding
GO:0033211	Biological Process	Adiponectin-activated signaling pathway
GO:0061154	Biological Process	Endothelial tube morphogenesis
GO:0097421	Biological Process	Liver regeneration
GO:0043537	Biological Process	Negative regulation of blood vessel endothelial cell migration
GO:0018107	Biological Process	Peptidyl-threonine phosphorylation
GO:0032927	Biological Process	Positive regulation of activin receptor signaling pathway
GO:0010862	Biological Process	Positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0033574	Biological Process	Response to testosterone

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Maf-1038	Macaca fascicularis	100.0	9e-69	222
LLPS-Chs-1992	Chlorocebus sabaeus	100.0	1e-122	357
LLPS-Cea-2703	Cercocebus atys	100.0	1e-68	222
LLPS-Gog-1496	Gorilla gorilla	100.0	5e-69	223
LLPS-Mal-1916	Mandrillus leucophaeus	100.0	1e-68	222
LLPS-Paa-0909	Papio anubis	100.0	9e-69	222
LLPS-Pat-3436	Pan troglodytes	100.0	5e-69	223
LLPS-Pap-2408	Pan paniscus	100.0	4e-69	223
LLPS-Lac-1794	Latimeria chalumnae	100.0	5e-72	225
LLPS-Man-1942	Macaca nemestrina	100.0	9e-69	222
LLPS-Rhb-0880	Rhinopithecus bieti	100.0	9e-69	222
LLPS-Mam-0475	Macaca mulatta	100.0	9e-69	222
LLPS-Ict-0597	Ictidomys tridecemlineatus	100.0	1e-70	225
LLPS-Mea-1144	Mesocricetus auratus	99.47	6e-126	365
LLPS-Orl-2477	Oryzias latipes	99.47	4e-126	366
LLPS-Aon-1344	Aotus nancymaae	99.47	2e-126	367
LLPS-Sah-1271	Sarcophilus harrisii	99.47	3e-126	367
LLPS-Asm-2490	Astyanax mexicanus	99.47	1e-126	369
LLPS-Caj-0659	Callithrix jacchus	99.47	3e-126	367
LLPS-Icp-1099	Ictalurus punctatus	99.47	5e-126	365
LLPS-Xim-0324	Xiphophorus maculatus	99.47	5e-126	365
LLPS-Dio-2339	Dipodomys ordii	99.47	6e-126	365
LLPS-Gaa-1381	Gasterosteus aculeatus	99.47	4e-126	366
LLPS-Scf-0973	Scleropages formosus	99.47	5e-126	365
LLPS-Bot-0043	Bos taurus	99.47	6e-126	365
LLPS-Ran-1994	Rattus norvegicus	99.47	6e-126	365
LLPS-Aim-2801	Ailuropoda melanoleuca	99.47	2e-126	367
LLPS-Mup-3142	Mustela putorius furo	99.47	6e-126	365
LLPS-Myl-0924	Myotis lucifugus	99.47	2e-126	367
LLPS-Ova-1294	Ovis aries	99.47	3e-126	367
LLPS-Hos-3167	Homo sapiens	99.47	3e-126	367
LLPS-Dar-0003	Danio rerio	99.47	5e-126	365
LLPS-Pof-2039	Poecilia formosa	99.47	5e-126	365
LLPS-Urm-0591	Ursus maritimus	99.47	6e-125	364
LLPS-Fec-1105	Felis catus	99.47	3e-126	367
LLPS-Mod-1103	Monodelphis domestica	99.47	3e-126	366
LLPS-Scm-0017	Scophthalmus maximus	99.47	4e-127	373
LLPS-Loa-4069	Loxodonta africana	99.47	2e-126	367
LLPS-Otg-0419	Otolemur garnettii	99.47	6e-126	365
LLPS-Orc-0011	Oryctolagus cuniculus	99.47	6e-126	365
LLPS-Orn-1108	Oreochromis niloticus	99.47	5e-126	365
LLPS-Poa-0297	Pongo abelii	99.47	6e-126	365
LLPS-Cas-1491	Carlito syrichta	99.47	2e-126	367
LLPS-Anc-3113	Anolis carolinensis	99.47	2e-125	365
LLPS-Xet-1175	Xenopus tropicalis	99.39	6e-106	313
LLPS-Leo-1838	Lepisosteus oculatus	99.2	3e-88	267
LLPS-Sus-2440	Sus scrofa	99.19	4e-69	223
LLPS-Eqc-1200	Equus caballus	99.19	2e-69	224
LLPS-Tar-2952	Takifugu rubripes	98.41	4e-124	360
LLPS-Mum-2470	Mus musculus	97.67	1e-70	226
LLPS-Cap-2211	Cavia porcellus	96.88	3e-70	224
LLPS-Ten-0144	Tetraodon nigroviridis	96.3	2e-120	351
LLPS-Pes-0539	Pelodiscus sinensis	94.3	2e-115	339
LLPS-Fud-1642	Fukomys damarensis	93.94	1e-103	307
LLPS-Cii-0578	Ciona intestinalis	93.65	5e-119	348
LLPS-Cis-0533	Ciona savignyi	91.53	2e-114	336
LLPS-Drm-0476	Drosophila melanogaster	91.01	8e-117	343
LLPS-Nol-0197	Nomascus leucogenys	91.01	5e-109	323
LLPS-Cae-1351	Caenorhabditis elegans	80.95	5e-104	310
LLPS-Sot-0721	Solanum tuberosum	63.95	1e-58	196
LLPS-Sei-2488	Setaria italica	63.95	3e-57	192
LLPS-Via-0095	Vigna angularis	63.27	2e-58	194
LLPS-Met-1186	Medicago truncatula	63.27	2e-58	196
LLPS-Mel-0528	Melampsora laricipopulina	61.99	2e-66	216
LLPS-Crn-0628	Cryptococcus neoformans	61.05	5e-67	217
LLPS-Put-0896	Puccinia triticina	60.82	9e-66	213
LLPS-Viv-1788	Vitis vinifera	60.26	7e-58	194
LLPS-Pug-0139	Puccinia graminis	60.23	9e-66	214
LLPS-Sol-1181	Solanum lycopersicum	60.11	6e-75	238
LLPS-Mua-0157	Musa acuminata	60.11	3e-74	237
LLPS-Brn-1752	Brassica napus	59.78	2e-73	233
LLPS-Spr-1076	Sporisorium reilianum	59.66	5e-67	220
LLPS-Hov-0116	Hordeum vulgare	59.57	2e-74	236
LLPS-Scp-0922	Schizosaccharomyces pombe	59.46	1e-70	225
LLPS-Orb-0744	Oryza barthii	59.04	7e-74	235
LLPS-Ori-1438	Oryza indica	59.04	7e-74	235
LLPS-Orni-0228	Oryza nivara	59.04	7e-74	235
LLPS-Dac-1600	Daucus carota	59.04	5e-72	230
LLPS-Orgl-0175	Oryza glumaepatula	59.04	2e-72	231
LLPS-Lep-0486	Leersia perrieri	59.04	6e-73	232
LLPS-Chr-0492	Chlamydomonas reinhardtii	59.04	3e-70	226
LLPS-Tra-2034	Triticum aestivum	59.04	1e-72	231
LLPS-Brd-0809	Brachypodium distachyon	59.04	1e-73	234
LLPS-Arl-1099	Arabidopsis lyrata	59.04	3e-73	233
LLPS-Ors-2058	Oryza sativa	59.04	2e-72	231
LLPS-Orp-1492	Oryza punctata	59.04	7e-73	232
LLPS-Sob-0770	Sorghum bicolor	59.04	3e-73	233
LLPS-Orbr-2280	Oryza brachyantha	59.04	3e-73	231
LLPS-Orm-1873	Oryza meridionalis	59.04	1e-72	231
LLPS-Orr-0613	Oryza rufipogon	59.04	7e-74	235
LLPS-Org-1029	Oryza glaberrima	59.04	1e-73	235
LLPS-Brr-1025	Brassica rapa	58.6	9e-73	232
LLPS-Bro-0911	Brassica oleracea	58.6	9e-73	232
LLPS-Glm-0903	Glycine max	58.51	6e-75	238
LLPS-Cus-1687	Cucumis sativus	58.51	6e-71	228
LLPS-Phv-0807	Phaseolus vulgaris	58.51	4e-75	238
LLPS-Nia-0138	Nicotiana attenuata	58.51	3e-73	233
LLPS-Coc-1045	Corchorus capsularis	58.51	1e-72	232
LLPS-Zem-0985	Zea mays	58.51	6e-72	229
LLPS-Scc-0544	Schizosaccharomyces cryophilus	58.38	2e-69	221
LLPS-Sem-2119	Selaginella moellendorffii	58.2	1e-72	229
LLPS-Pot-1964	Populus trichocarpa	58.19	2e-66	216
LLPS-Php-0535	Physcomitrella patens	57.98	6e-73	233
LLPS-Art-2613	Arabidopsis thaliana	57.98	2e-71	228
LLPS-Usm-0397	Ustilago maydis	57.95	4e-65	216
LLPS-Cym-0512	Cyanidioschyzon merolae	57.45	1e-67	221
LLPS-Thc-1120	Theobroma cacao	57.45	2e-71	229
LLPS-Gor-0581	Gossypium raimondii	57.45	1e-71	229
LLPS-Mae-1261	Manihot esculenta	57.45	2e-71	228
LLPS-Prp-0407	Prunus persica	57.45	2e-71	228
LLPS-Scj-0397	Schizosaccharomyces japonicus	57.14	2e-66	214
LLPS-Osl-0367	Ostreococcus lucimarinus	56.52	1e-64	209
LLPS-Hea-0040	Helianthus annuus	56.38	2e-71	228
LLPS-Amt-1690	Amborella trichopoda	56.38	4e-71	225
LLPS-Abg-0108	Absidia glauca	54.7	9e-69	219
LLPS-Miv-0382	Microbotryum violaceum	54.19	3e-62	204
LLPS-Aso-0202	Aspergillus oryzae	54.14	5e-64	208
LLPS-Asn-1141	Aspergillus nidulans	53.59	3e-63	207
LLPS-Mao-0323	Magnaporthe oryzae	53.59	9e-63	206
LLPS-Ved-0231	Verticillium dahliae	53.33	6e-37	138
LLPS-Tru-0435	Triticum urartu	53.19	3e-57	195
LLPS-Pyt-0984	Pyrenophora teres	53.11	4e-55	195
LLPS-Lem-0642	Leptosphaeria maculans	53.04	3e-60	199
LLPS-Tum-1506	Tuber melanosporum	53.04	1e-59	201
LLPS-Ast-0718	Aspergillus terreus	53.04	1e-62	205
LLPS-Pytr-0902	Pyrenophora triticirepentis	53.04	6e-61	201
LLPS-Dos-0743	Dothistroma septosporum	53.04	4e-62	204
LLPS-Gas-1027	Galdieria sulphuraria	52.69	7e-63	205
LLPS-Asf-0184	Aspergillus flavus	52.66	1e-63	209
LLPS-Phn-0190	Phaeosphaeria nodorum	52.54	6e-59	195
LLPS-Asni-0968	Aspergillus niger	52.49	2e-61	202
LLPS-Zyt-0633	Zymoseptoria tritici	52.49	6e-63	206
LLPS-Nec-0256	Neurospora crassa	51.93	1e-60	201
LLPS-Cog-0752	Colletotrichum gloeosporioides	51.93	6e-57	204
LLPS-Cogr-0621	Colletotrichum graminicola	51.65	3e-60	199
LLPS-Gag-0525	Gaeumannomyces graminis	51.38	4e-60	199
LLPS-Map-0282	Magnaporthe poae	51.38	2e-60	200
LLPS-Blg-1204	Blumeria graminis	51.38	2e-60	199
LLPS-Trr-0082	Trichoderma reesei	51.38	2e-60	199
LLPS-Fus-1051	Fusarium solani	51.38	4e-60	199
LLPS-Kop-1199	Komagataella pastoris	50.9	2e-41	150
LLPS-Coo-0103	Colletotrichum orbiculare	50.83	1e-59	197
LLPS-Beb-0339	Beauveria bassiana	50.83	7e-60	197
LLPS-Trv-0565	Trichoderma virens	50.83	1e-55	200
LLPS-Sac-1548	Saccharomyces cerevisiae	49.73	3e-53	181
LLPS-Yal-0281	Yarrowia lipolytica	49.47	3e-56	189
LLPS-Asg-0379	Ashbya gossypii	48.35	3e-55	186
LLPS-Nef-0893	Neosartorya fischeri	47.96	3e-57	192
LLPS-Asfu-1223	Aspergillus fumigatus	47.96	4e-57	192
LLPS-Asc-0967	Aspergillus clavatus	47.29	7e-56	189
LLPS-Fuv-0323	Fusarium verticillioides	47.06	6e-47	166
LLPS-Fuo-0535	Fusarium oxysporum	47.06	6e-47	166
LLPS-Ora-1118	Ornithorhynchus anatinus	43.8	8e-27	107

LLPS-Caf-1335CSNK2B

Protein Sequence

Nucleotide Sequence

LLPS-Caf-1335
CSNK2B