LLPS-Ast-0506
ATEG_02002
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Serine/threonine-protein kinase Tel1 |
| Gene Name: | ATEG_02002 |
| Ensembl Gene: | ATEG_02002 |
| Ensembl Protein: | EAU36964 |
| Organism: | Aspergillus terreus |
| Taxa ID: | 341663 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| DNA damage foci, Nucleolus, Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAU36964 | EAU36964 |
| UniProt | Q0CWD2, Q0CWD2_ASPTN | |
| GeneBank | CH476596 | EAU36964.1 |
| RefSeq | XM_001211180.1 | XP_001211180.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVPSDGLLDV LCVDYTKCLT SILHYPPHLE HLGTSEWKKI LDSCLKIINV QNDEESSLLS 60 61 SSERRSTLDG YLASDRGSTP SRMTPTLPVR ERSKGNQSAI GEAVTCIQLL TTSSNAPIQD 120 121 HFDKVLRSLA KFLRPYHIPG ATHQAAIRSI NSVVMKVMFD QTEFIRMFLL DLIPTIQNLW 180 181 TTKLAGLKDG LLVTLMLCLI ILTDTVKREP SESLASIIES LTDVIFSEYT KRPDKEILQI 240 241 DEVTFYQTTS DHGERFSVWP RPESPKSEHN WTTIWIISNL MKLSEEIAAC LAPPRVVGEE 300 301 STKKPRPKSL IEDVHRDSVL ASGTRKLCAL QMIPFVSGQN VSVESKTSLL HRLIPNILDD 360 361 NGMVSSWTMI AIASLAGSPG VDSQALKAPW RQIWDLASRA STSQITSRAA CTLMNCLLQF 420 421 DLLEYSEVAE VTTSMLSSVN LSGPSTLSDA SLALWATTIR GIAQTNPGSV PNAVNQICAW 480 481 LRQSWTIGTT TDRLQTAQVA TFARPLDLLN TILATTNRPF EMPRSLLRGP TGLVAQGWLF 540 541 YYRSRQLLNY VFDLRGLTDF VEPWFQAETL SLDTFTRQDP NDNVVLDLLK AKSEAFLHAW 600 601 RSLSEDKSQN VTLDTMQILV SFCVLIALYT QCLPKNCASR LESLQENTHY LWGGLCSFLT 660 661 NRDHDFSQVF LTQISPLLGP DLYSPEAKSV VKQALSQLAP PLARVLETHR KSQQDTLLAQ 720 721 DEEPMDLDDP LMSSDDRLAE AMCIINMNRD ASSLIRDFAT FQRSVTIQLS VFERIHGSTH 780 781 SPEDEPSTGS LVDYLTDLDA ADLLSARAFL PHVYRACSWL DRPYLLRLLE DIGEKCLREY 840 841 ELERCENAHI LCIHMMHSFV KSWAIGESDD LSDSASDIYT WFIDVLLAKG RASPAVLAAF 900 901 VDLLGGLISC NASYAVGESD PSPRTGLFMI LKEGDISVKF DAGALIPKLF SQYPLTDHDA 960 961 IFDDVLESLP RDLDWVEGIA LRLFILAQLA SQWHTLLRRS IYHMFETPAQ APGSLWYAKK 1020 1021 CICRVSESLG LTDPKELFRL FSSQVLYTWM ETQTITSVPF SIFGYESIEE MLIDVQDEIV 1080 1081 GQIMMRARDD EGVELSNHLG TPFVELLGQS FYKAEAYSIA RDLSTPPGQG SQPKGVENRM 1140 1141 KKALGTDRFL RLIDQQFPQA VSTFFGALDQ HEQVERAFSK RPNFNAALSI MKCILGKSSS 1200 1201 NIALPPNQQP SFRARFLLDE LEFLCKRSGY ELETIWTPAL VSYICRTLLE SIHPALGSLH 1260 1261 ACAVIRKIRI LVCVAGDAVL SDYPLEMMLN ALHPFLTDPY CSEDALGIFW YLLEAGKAYL 1320 1321 METPGLMAGI AVSTLLSLGK FLAFAADESK IDSQSKSVSE KLREFLHWFE EYLETYESST 1380 1381 LNAEQQGLFR RLVASSNKRY ATDQIDEDRT ERDVLLEVLV DRISKNSLLT KPASNHIIKL 1440 1441 LCTDSMLPDD WQLDVTGNDE YAISSSVAIC QTLRNFETGS RYRLWAARII GRAFAATGTI 1500 1501 GGELLREQDQ ALFKYAHSSM AEFNFSKARI VEILCDMLQK STPREVGLVE RTLQLIVSNL 1560 1561 DKYPDFAPCR EVIPSSLMKA LAWAPYQCPA LPLPSEARGY CPRLAWHPHL PSAHWAREVG 1620 1621 LYLSKAATGD PVVGALSNLL FAMPDLAADL LPYILHDVLL AELHGEAQVR QEISAVFKQA 1680 1681 LREVDDTTVP HVRLIINCIL YLRNQPRPKE STIVQRDEWL DIDFAEASLA ANKCCLPKTA 1740 1741 LILLETHTSR VAHGARRSSV VRYEAPPEML HEIFKNIDDP DFFYGVQQNA SLSSVMETLE 1800 1801 RESSGFKNLL FQSAHYDSDI QMFGNGKALG VLGALNAVNL QGVANSMFSM AGGGSKDTSS 1860 1861 SFDSMLKAAT NLRQWDVPVS PLNPSPSATI FRVFQSLNTS SILEDAMSSI DESLLSILDL 1920 1921 ATSNSRSAMS LRTTMRVLGV MTEISDILRV RSAEEIESEW QKITVRNSWL KTTSVDEVGE 1980 1981 ILNSQEALFS SIKQRDYLKS AMNLSDRDAQ LLEVKAIRQS LAITRDHGIA QASLKSAVCL 2040 2041 SKLSEQCSAS GINVDGAAKF DLANVLWDQG EMTPSIQMLR QLREQNDLHT QAVPISRAEL 2100 2101 LVTLGHHVAE ARLEKPEAIV QEYLSQAVKE LRNSSAGEEA GRVYHGFAMF CDQQLQNPDG 2160 2161 LEDFKRVEQL RNRKEKEVRA LEDMMKSADG KERDALRYHR TKTKQWFDLD DREYQRLLRS 2220 2221 RESFLQQCLE NYLLCLKESE AYNNDALRFC ALWLDKSDSD IANQAVSKYL HEVPSRKFAP 2280 2281 LMNQLSSRLL DTSDEFQTML FALISRICVE HPFHGMYQIF ASSKSKGSKD ESALSRNRAA 2340 2341 GRLVDGLKND KRIGPTWVAV HNANINYVRF AIDRSIDKLK SGAKVPLKKL SAGQRLEQDA 2400 2401 ATQRLPPPTM HIDIRVDCDY SDIPKLVRYH PEFTIASGVS APKIVSAWAS NGQRYKQLFK 2460 2461 GGNDDLRQDA IMEQVFEQVS SLLKDHQATR QRNLGIRTYK VLPLTSNAGI IEFVPHTIPL 2520 2521 HDYLMPAHQR YYPKDMKPNV CRKHIADVQT RSFEQRVRTY RQVAEHFHPV MRYFFMENFN 2580 2581 NPDDWFGRRL SYTRSTAAIS ILGHVLGLGD RHGHNILLDE RTGEVVHIDL GVAFEQGRVL 2640 2641 PVPEVVPFRL TRDLVDGMGI TKTEGVFRRC CEFTLEALRQ ESYSIMTILD VLRYDPLYSW 2700 2701 TVSPLRMKKM QDASEAGGGP PVLPGAVDKR QTNEPSEADR ALTVVAKKLS KTLSVTATVN 2760 2761 ELIQQATDEK NLAVLYCGKS LFLVCDKRLA G 2791 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromosome, telomeric region | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | Protein serine/threonine kinase activity | |
Biological Process | Cellular response to DNA damage stimulus | |
Biological Process | Chromatin organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asf-0236 | Aspergillus flavus | 72.55 | 0.0 | 3046 |
| LLPS-Nef-0662 | Neosartorya fischeri | 69.29 | 0.0 | 3263 |
| LLPS-Asfu-0771 | Aspergillus fumigatus | 67.99 | 0.0 | 3213 |
| LLPS-Aso-0725 | Aspergillus oryzae | 67.88 | 0.0 | 3787 |
| LLPS-Asc-0980 | Aspergillus clavatus | 66.28 | 0.0 | 3690 |
| LLPS-Asn-1254 | Aspergillus nidulans | 65.63 | 0.0 | 2910 |
| LLPS-Fuo-1125 | Fusarium oxysporum | 52.74 | 0.0 | 800 |
| LLPS-Ict-2539 | Ictidomys tridecemlineatus | 47.89 | 1e-67 | 260 |
| LLPS-Cii-1682 | Ciona intestinalis | 46.1 | 7e-68 | 238 |
| LLPS-Chr-0209 | Chlamydomonas reinhardtii | 45.24 | 3e-56 | 222 |
| LLPS-Cogr-1511 | Colletotrichum graminicola | 43.55 | 0.0 | 1567 |
| LLPS-Coo-0915 | Colletotrichum orbiculare | 43.31 | 0.0 | 1558 |
| LLPS-Gag-0167 | Gaeumannomyces graminis | 43.14 | 0.0 | 1604 |
| LLPS-Scs-0608 | Sclerotinia sclerotiorum | 42.85 | 0.0 | 1576 |
| LLPS-Map-0914 | Magnaporthe poae | 42.65 | 0.0 | 1491 |
| LLPS-Nec-0391 | Neurospora crassa | 42.63 | 0.0 | 1545 |
| LLPS-Tum-0137 | Tuber melanosporum | 42.44 | 0.0 | 1310 |
| LLPS-Mao-0347 | Magnaporthe oryzae | 42.2 | 0.0 | 1537 |
| LLPS-Ved-1405 | Verticillium dahliae | 42.2 | 0.0 | 1560 |
| LLPS-Trv-0145 | Trichoderma virens | 42.13 | 0.0 | 1535 |
| LLPS-Fus-1259 | Fusarium solani | 41.91 | 0.0 | 1525 |
| LLPS-Beb-0671 | Beauveria bassiana | 41.72 | 0.0 | 1545 |
| LLPS-Osl-0264 | Ostreococcus lucimarinus | 41.38 | 1e-84 | 291 |
| LLPS-Trr-0661 | Trichoderma reesei | 40.94 | 0.0 | 1473 |
| LLPS-Blg-1147 | Blumeria graminis | 40.7 | 0.0 | 1474 |
| LLPS-Pytr-1173 | Pyrenophora triticirepentis | 40.08 | 0.0 | 1473 |
| LLPS-Fuv-0878 | Fusarium verticillioides | 40.01 | 0.0 | 1389 |
| LLPS-Lem-0344 | Leptosphaeria maculans | 39.66 | 0.0 | 1451 |
| LLPS-Phn-1273 | Phaeosphaeria nodorum | 38.88 | 0.0 | 1368 |
| LLPS-Cus-1073 | Cucumis sativus | 38.04 | 1e-112 | 379 |
| LLPS-Cis-1637 | Ciona savignyi | 37.9 | 7e-68 | 242 |
| LLPS-Cog-1137 | Colletotrichum gloeosporioides | 37.32 | 0.0 | 1675 |
| LLPS-Zem-1234 | Zea mays | 37.18 | 5e-94 | 347 |
| LLPS-Mel-1326 | Melampsora laricipopulina | 36.99 | 1e-59 | 216 |
| LLPS-Zyt-0206 | Zymoseptoria tritici | 36.66 | 0.0 | 1264 |
| LLPS-Gaga-3396 | Gallus gallus | 36.13 | 9e-125 | 447 |
| LLPS-Dos-0357 | Dothistroma septosporum | 35.88 | 0.0 | 1232 |
| LLPS-Glm-0805 | Glycine max | 35.57 | 1e-111 | 404 |
| LLPS-Pyt-0669 | Pyrenophora teres | 35.46 | 0.0 | 1644 |
| LLPS-Fia-2755 | Ficedula albicollis | 35.33 | 4e-123 | 442 |
| LLPS-Viv-0683 | Vitis vinifera | 35.25 | 4e-52 | 209 |
| LLPS-Sem-0085 | Selaginella moellendorffii | 35.01 | 8e-125 | 420 |
| LLPS-Via-1324 | Vigna angularis | 34.88 | 2e-112 | 403 |
| LLPS-Yal-0651 | Yarrowia lipolytica | 34.84 | 8e-114 | 410 |
| LLPS-Phv-1001 | Phaseolus vulgaris | 34.79 | 5e-110 | 399 |
| LLPS-Pug-1222 | Puccinia graminis | 34.12 | 1e-53 | 213 |
| LLPS-Art-2717 | Arabidopsis thaliana | 34.08 | 9e-111 | 402 |
| LLPS-Met-0755 | Medicago truncatula | 33.99 | 2e-108 | 394 |
| LLPS-Amt-0181 | Amborella trichopoda | 33.98 | 6e-113 | 396 |
| LLPS-Chc-0381 | Chondrus crispus | 33.96 | 3e-77 | 291 |
| LLPS-Scj-0995 | Schizosaccharomyces japonicus | 33.94 | 8e-167 | 582 |
| LLPS-Hea-0271 | Helianthus annuus | 33.9 | 3e-113 | 409 |
| LLPS-Hov-1187 | Hordeum vulgare | 33.68 | 9e-106 | 385 |
| LLPS-Lep-0321 | Leersia perrieri | 33.6 | 6e-104 | 379 |
| LLPS-Bro-1415 | Brassica oleracea | 33.55 | 7e-112 | 404 |
| LLPS-Coc-0377 | Corchorus capsularis | 33.38 | 2e-108 | 383 |
| LLPS-Gor-1762 | Gossypium raimondii | 33.33 | 1e-109 | 398 |
| LLPS-Prp-1888 | Prunus persica | 33.33 | 7e-110 | 399 |
| LLPS-Mua-0722 | Musa acuminata | 33.25 | 4e-106 | 385 |
| LLPS-Orni-1691 | Oryza nivara | 33.25 | 2e-107 | 390 |
| LLPS-Php-1969 | Physcomitrella patens | 33.25 | 7e-113 | 408 |
| LLPS-Pot-0957 | Populus trichocarpa | 33.16 | 2e-113 | 397 |
| LLPS-Arl-1029 | Arabidopsis lyrata | 33.12 | 3e-105 | 384 |
| LLPS-Mae-1475 | Manihot esculenta | 33.11 | 2e-109 | 397 |
| LLPS-Orb-0589 | Oryza barthii | 33.02 | 2e-105 | 384 |
| LLPS-Sol-0591 | Solanum lycopersicum | 32.82 | 1e-113 | 410 |
| LLPS-Dac-0264 | Daucus carota | 32.74 | 1e-107 | 391 |
| LLPS-Thc-1221 | Theobroma cacao | 32.74 | 2e-104 | 381 |
| LLPS-Ora-2505 | Ornithorhynchus anatinus | 32.73 | 1e-52 | 207 |
| LLPS-Tra-1036 | Triticum aestivum | 32.57 | 7e-108 | 392 |
| LLPS-Orr-1185 | Oryza rufipogon | 32.55 | 7e-104 | 379 |
| LLPS-Sei-1505 | Setaria italica | 32.52 | 2e-100 | 357 |
| LLPS-Orbr-1044 | Oryza brachyantha | 32.49 | 2e-105 | 384 |
| LLPS-Gas-0357 | Galdieria sulphuraria | 32.47 | 9e-83 | 310 |
| LLPS-Org-0046 | Oryza glaberrima | 32.46 | 1e-79 | 285 |
| LLPS-Ori-2163 | Oryza indica | 32.42 | 9e-105 | 382 |
| LLPS-Orgl-0266 | Oryza glumaepatula | 32.31 | 4e-52 | 209 |
| LLPS-Scc-0179 | Schizosaccharomyces cryophilus | 32.24 | 5e-164 | 573 |
| LLPS-Brn-3303 | Brassica napus | 32.22 | 4e-105 | 370 |
| LLPS-Sob-1267 | Sorghum bicolor | 32.14 | 4e-105 | 383 |
| LLPS-Brd-0898 | Brachypodium distachyon | 32.01 | 2e-102 | 374 |
| LLPS-Drm-0429 | Drosophila melanogaster | 31.98 | 2e-83 | 311 |
| LLPS-Brr-1372 | Brassica rapa | 31.9 | 1e-52 | 210 |
| LLPS-Miv-0599 | Microbotryum violaceum | 31.35 | 3e-65 | 252 |
| LLPS-Put-0468 | Puccinia triticina | 31.29 | 1e-134 | 474 |
| LLPS-Ors-0687 | Oryza sativa | 31.26 | 6e-93 | 343 |
| LLPS-Orp-0797 | Oryza punctata | 31.22 | 7e-52 | 207 |
| LLPS-Pof-0761 | Poecilia formosa | 31.01 | 2e-57 | 226 |
| LLPS-Spr-1088 | Sporisorium reilianum | 30.71 | 1e-139 | 496 |
| LLPS-Xim-1040 | Xiphophorus maculatus | 30.68 | 1e-56 | 224 |
| LLPS-Orl-1458 | Oryzias latipes | 30.54 | 2e-54 | 216 |
| LLPS-Myl-3544 | Myotis lucifugus | 30.51 | 4e-128 | 440 |
| LLPS-Crn-0090 | Cryptococcus neoformans | 30.3 | 4e-129 | 461 |
| LLPS-Usm-1446 | Ustilago maydis | 30.26 | 8e-135 | 480 |
| LLPS-Asg-0388 | Ashbya gossypii | 30.1 | 1e-120 | 434 |
| LLPS-Ten-3034 | Tetraodon nigroviridis | 30.09 | 3e-52 | 209 |
| LLPS-Tru-0207 | Triticum urartu | 29.94 | 1e-77 | 293 |
| LLPS-Scf-4171 | Scleropages formosus | 29.91 | 2e-56 | 223 |
| LLPS-Meg-1280 | Meleagris gallopavo | 29.91 | 3e-130 | 465 |
| LLPS-Mup-0014 | Mustela putorius furo | 29.83 | 6e-139 | 494 |
| LLPS-Caf-2749 | Canis familiaris | 29.66 | 2e-135 | 483 |
| LLPS-Fec-1933 | Felis catus | 29.54 | 1e-134 | 480 |
| LLPS-Asm-2661 | Astyanax mexicanus | 29.52 | 1e-131 | 470 |
| LLPS-Anp-0094 | Anas platyrhynchos | 29.52 | 1e-133 | 476 |
| LLPS-Fud-0929 | Fukomys damarensis | 29.47 | 4e-135 | 481 |
| LLPS-Tag-0104 | Taeniopygia guttata | 29.47 | 2e-137 | 488 |
| LLPS-Icp-2814 | Ictalurus punctatus | 29.38 | 2e-130 | 466 |
| LLPS-Cas-0351 | Carlito syrichta | 29.38 | 9e-138 | 489 |
| LLPS-Sus-1154 | Sus scrofa | 29.36 | 3e-139 | 494 |
| LLPS-Scm-3174 | Scophthalmus maximus | 29.36 | 2e-57 | 226 |
| LLPS-Cea-1207 | Cercocebus atys | 29.33 | 1e-136 | 486 |
| LLPS-Chs-0338 | Chlorocebus sabaeus | 29.33 | 1e-136 | 486 |
| LLPS-Maf-0037 | Macaca fascicularis | 29.33 | 2e-136 | 486 |
| LLPS-Mal-0322 | Mandrillus leucophaeus | 29.33 | 1e-136 | 486 |
| LLPS-Paa-1380 | Papio anubis | 29.33 | 4e-136 | 484 |
| LLPS-Orn-0729 | Oreochromis niloticus | 29.33 | 6e-135 | 481 |
| LLPS-Man-2619 | Macaca nemestrina | 29.33 | 3e-136 | 484 |
| LLPS-Urm-0328 | Ursus maritimus | 29.33 | 2e-136 | 486 |
| LLPS-Mam-0882 | Macaca mulatta | 29.33 | 2e-136 | 485 |
| LLPS-Rhb-2627 | Rhinopithecus bieti | 29.28 | 3e-136 | 485 |
| LLPS-Aim-3254 | Ailuropoda melanoleuca | 29.23 | 4e-136 | 484 |
| LLPS-Cap-0760 | Cavia porcellus | 29.2 | 5e-135 | 481 |
| LLPS-Ova-1088 | Ovis aries | 29.11 | 1e-134 | 479 |
| LLPS-Aon-1585 | Aotus nancymaae | 29.1 | 6e-136 | 484 |
| LLPS-Sac-0648 | Saccharomyces cerevisiae | 29.1 | 4e-117 | 422 |
| LLPS-Orc-1700 | Oryctolagus cuniculus | 29.08 | 4e-135 | 481 |
| LLPS-Caj-0534 | Callithrix jacchus | 29.07 | 3e-137 | 488 |
| LLPS-Gaa-0314 | Gasterosteus aculeatus | 29.07 | 7e-56 | 221 |
| LLPS-Abg-1561 | Absidia glauca | 29.01 | 7e-53 | 211 |
| LLPS-Lac-0466 | Latimeria chalumnae | 28.92 | 5e-56 | 221 |
| LLPS-Dar-0356 | Danio rerio | 28.89 | 2e-127 | 456 |
| LLPS-Mea-2828 | Mesocricetus auratus | 28.86 | 2e-138 | 492 |
| LLPS-Mum-0950 | Mus musculus | 28.84 | 7e-137 | 487 |
| LLPS-Eqc-1738 | Equus caballus | 28.79 | 5e-133 | 474 |
| LLPS-Pap-1192 | Pan paniscus | 28.77 | 1e-136 | 486 |
| LLPS-Sah-0051 | Sarcophilus harrisii | 28.69 | 2e-134 | 479 |
| LLPS-Hos-0566 | Homo sapiens | 28.69 | 4e-137 | 488 |
| LLPS-Pat-1650 | Pan troglodytes | 28.69 | 1e-136 | 486 |
| LLPS-Mod-0875 | Monodelphis domestica | 28.68 | 5e-136 | 484 |
| LLPS-Bot-1781 | Bos taurus | 28.66 | 1e-133 | 476 |
| LLPS-Pes-0748 | Pelodiscus sinensis | 28.62 | 6e-126 | 451 |
| LLPS-Dio-3298 | Dipodomys ordii | 28.6 | 4e-54 | 215 |
| LLPS-Scp-1419 | Schizosaccharomyces pombe | 28.57 | 2e-54 | 216 |
| LLPS-Xet-0621 | Xenopus tropicalis | 28.55 | 2e-129 | 463 |
| LLPS-Nol-1839 | Nomascus leucogenys | 28.54 | 4e-133 | 474 |
| LLPS-Ran-4608 | Rattus norvegicus | 28.52 | 9e-55 | 217 |
| LLPS-Otg-2150 | Otolemur garnettii | 28.39 | 2e-129 | 462 |
| LLPS-Gog-2409 | Gorilla gorilla | 28.25 | 2e-133 | 475 |
| LLPS-Loa-1272 | Loxodonta africana | 28.15 | 7e-138 | 490 |
| LLPS-Poa-3639 | Pongo abelii | 28.12 | 3e-130 | 465 |
| LLPS-Leo-0519 | Lepisosteus oculatus | 27.83 | 2e-52 | 209 |
| LLPS-Kop-0432 | Komagataella pastoris | 26.14 | 4e-138 | 491 |