LLPS-Asc-0980
ACLA_015700
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Serine/threonine-protein kinase Tel1 |
| Gene Name: | ACLA_015700 |
| Ensembl Gene: | ACLA_015700 |
| Ensembl Protein: | EAW13128 |
| Organism: | Aspergillus clavatus |
| Taxa ID: | 344612 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| DNA damage foci, Nucleolus, Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAW13128 | EAW13128 |
| UniProt | A1CBL0, A1CBL0_ASPCL | |
| GeneBank | DS027049 | EAW13128.1 |
| RefSeq | XM_001274553.1 | XP_001274554.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQVTLDKAI ALLSSERLKE RSDSLADLKH ILQQTKTSSK LTSLNDKACH KIFESLFRFI 60 61 SVEKSLYNKA SSKGASGSRL SACASVIRTA VDVFLRNLRT KSIRAIVDHI TEILQVPGEG 120 121 LWEHLSADYL KCLTTLLHYP PHVEHLGANE WEKVLNFCLT SVGAEGEGNS QPNVRDSHSS 180 181 ILDDYVGVSP RSTSRRTSTL ALREKQSGDK RAAGEAIVCI QLLVATPIAP VQAFAEKVLQ 240 241 GLTAFLKSSS IAGSEHQAAF SSINTVVMRV LFGQSDLVRN FLLELIPVIR HLWSTKLGGL 300 301 KDELLVTVML CVIVLTDATR REPTESLSLL TENLLDTLYS EYIRRPEKDI LQIDELIFHR 360 361 ETSSQTHDLT LQPRLEVSRS EHNWTVVWIM AKLMKLSEEL TKRLSPSTGA VPSKKQRFTS 420 421 AYDEVFKDAV MSSGNKRVCA LQLIPILLQD HVDMESKASL LQRLIPCIID DNNIISSWTM 480 481 VAIASIASDT DAAASLSLKK YWQQTWNLTS RASTSQNTSR AACNLMGSIL QFDLLEYSVV 540 541 AETTASMLAS MNLNAPSIIS DASLGLWATL TRLGAQTSPG SASSASKQIC SWLREAWTIG 600 601 TVADRVQTAQ IAAFARPLDL LNLFLACTNR QCKLPKLQYR GPGGLVAKGW HFYRSNQELL 660 661 EYLFHINGLL GPTSTHEKNQ PLTLQFASRQ DPNDDIILDM LQAKADIFLQ TWRLLSENKT 720 721 HHVTVDIFQI LSSFCIVVAM YTECLPEQNT SRIENLHKNC QQLWENLCSF MASREVTYTQ 780 781 SCLELLCPLL AQDCGLGRKD SVIANSLYKL TPPLTKVLET YRQDQKQLLS CPDQESMELD 840 841 DPLMQSHDLL AENMCIINLN REHRPPFQDS ATFQRSMTIR LSLFQLGFAC TPFSETSATG 900 901 PLIEYLTNLD EADLLSARHF LPHIYQACSV MDRSCLLDLL EDMGEKCLQT YQLERCENSQ 960 961 ILCIRVLSSF VKAWTNGVGD HLTDSASDIY NWFTDVLLAK GRASSQVLIA FSRLLKEIFG 1020 1021 VNATYTSGHS SPSPRTSLFT ILRESDILTK FNVGNLIPLL FGHFPLKNHD AIFDDVLDSL 1080 1081 PRDPDWDEGI ALRLLILAKI ASQWHTLLRR SIYHMFETPA QVPHSLWYAE KCVRDVATIL 1140 1141 GLEDARQLFR LFSSQILYTW TETQSITSMP FSIFGYPTIE DMLVDVQDEI VGQIMMRANE 1200 1201 HEADELSSRM GTPFVELLAT SFHKAEAYSI ARDISTPPGQ GSQPKGVENR LKKILGADRF 1260 1261 VDLIEKQFPQ VIATFFGSLD QYEQIERAFA KRPNFQAALN VLKSITAKSF SKAMLPANQQ 1320 1321 PSFRARYLLD ELDFLCRRSG YELDTIWTPT LATYVCRTLL ESIHPALGSL HACSIIRKIR 1380 1381 ILMCIAGPVM LRDYPCEMLL HGLRPFLTDI YCAEDALGLF WYLLEAGRPY LIDNPGFTAG 1440 1441 ISVSTLLYLR KFLTSFPAGT MQESQTTSSL ANIRRFLDWF EDFLSNYESN NLSGEGQALF 1500 1501 QRLVDSSRKI SATGNESDGM DERDLLLEVI RDRNSKTNLL SHSISDHILS LLCTDFKSLP 1560 1561 SYQYDYIGEG DDAIANSVAL CQTLQDFNPT TEYRLWAAQV IGRVFAATGR ISDVLTREQS 1620 1621 STLFEPQMVR LHLDVFCQSK ARILQILCNM LQKSNPLEVG LVERTLQLII STLAVSPEFE 1680 1681 SYGDTIPPSW LKALIWSPYQ CPSIALRASE VRKHDALVGW TTGMSAERWA RSIGLFLSRA 1740 1741 ASKDPVIGPL ITILHVIPHL AAQILPYILH DVLLTELEGE AGVRQTISEI FRQGLHEVDD 1800 1801 SSIPHVRLIL NCILYLRNQP RPQEATIVER DEWLDIDFAQ ASKAAKICRL PKTSLLFLEI 1860 1861 QASRVVSGSR RSSLAKYEPP PEILHEIFRN VDDPDLFYGV QQSSSLESVM GTLEHESSGL 1920 1921 KNLLFQSAQY DSAIQMSEDT NANASGLLRA LNSTNLQGIA NSLSSYVGGT KGSSVSFESM 1980 1981 MQAAINLRQW DIPVSPLNLS PSAALFRAFQ SLNSSRTLLE VSSSVKESLL AISDSLASTS 2040 2041 RSAMSLRTAM RDLGIVTEIS DMLSAKSSEE INEVWKEVAQ RNTWLKTTRQ VEVIHYILNC 2100 2101 HEALFSSIKR KRYLKSAIGL SDQEAQLLEV QVIRQSLEIT RSHGIPQASL KSAVCLSKLA 2160 2161 NSCAMQGINI EGAAKFDLAN VLWDQGEMAA SIRMLQQLDS QNDIHKQAIP ISRPELLVTL 2220 2221 GHHVAEARLE KPEAIIQGYL APAVKELKNR SGGGEAGRVY HGFAIFCDQQ LQNPDGLEDF 2280 2281 KRVEQLRNRK EKEVLALEDM MKRAEGKERD ALRHYRTKTK QWFDLDDREY QRLRRSREAF 2340 2341 LQQCLENYLL CLKESDNYNA DALRFCAIWL DKSDSDIANK AVSKYLNQVP SRKFAPLMNQ 2400 2401 LTSRLLDTSD EFQNMLFALI FRICVEHPFH GMYQIFASSK SKGGKDQSAL SRNRAANKLV 2460 2461 DYLRNDKRIG PTWVTVHNAN INYVRFAVER LDEKVKSGAK VQLKKFLTGQ RLEQDASTQR 2520 2521 LPPPTMKIEI RLDCDYSDVP KLVRYHPEFT VASGVSAPKI VTAVASDGHK YKQLFKGGND 2580 2581 DLRQDAIMEQ VFEQVSSLLK DHQATQQRKL GIRTYKVLPL TSNAGIIEFV PHTIPLHDYL 2640 2641 MPAHQKYFPK DMKPSVCRKH ISDVQTRSFE QRVKTFRQVT EHFHPVMRYF FMEKFNNPDD 2700 2701 WFSKRLAYTR STAAISILGH VLGLGDRHGH NILLDERTGE VVHIDLGVAF EQGRVLPVPE 2760 2761 VVPFRLTRDL VDGMGITKTE GVFRRCCEFT LEALRQESYS IMTILDVLRY DPLYSWTVSP 2820 2821 LRMKRMQDAQ EAGDGPPMIP GGAEDQRSAN EPSEADRALT VVAKKLSKTL SVTATVNELI 2880 2881 QQATDERNLA VLYCGMYLLL AVIQ 2904 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromosome, telomeric region | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | Protein serine/threonine kinase activity | |
Biological Process | Cellular response to DNA damage stimulus | |
Biological Process | Chromatin organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Map-0914 | Magnaporthe poae | 81.63 | 6e-13 | 79.7 |
| LLPS-Nef-0662 | Neosartorya fischeri | 80.25 | 0.0 | 3860 |
| LLPS-Asfu-0771 | Aspergillus fumigatus | 78.38 | 0.0 | 3783 |
| LLPS-Asf-0236 | Aspergillus flavus | 71.03 | 0.0 | 2981 |
| LLPS-Aso-0725 | Aspergillus oryzae | 66.43 | 0.0 | 3825 |
| LLPS-Ast-0506 | Aspergillus terreus | 66.07 | 0.0 | 3672 |
| LLPS-Asn-1254 | Aspergillus nidulans | 65.78 | 0.0 | 2945 |
| LLPS-Fuo-1125 | Fusarium oxysporum | 52.86 | 0.0 | 808 |
| LLPS-Ict-2539 | Ictidomys tridecemlineatus | 49.24 | 1e-69 | 266 |
| LLPS-Cii-1682 | Ciona intestinalis | 47.33 | 7e-69 | 241 |
| LLPS-Chr-0209 | Chlamydomonas reinhardtii | 45.24 | 7e-57 | 224 |
| LLPS-Tum-0137 | Tuber melanosporum | 42.91 | 0.0 | 1341 |
| LLPS-Scs-0608 | Sclerotinia sclerotiorum | 42.57 | 0.0 | 1563 |
| LLPS-Gag-0167 | Gaeumannomyces graminis | 42.02 | 0.0 | 1559 |
| LLPS-Osl-0264 | Ostreococcus lucimarinus | 41.07 | 6e-83 | 286 |
| LLPS-Fuv-0878 | Fusarium verticillioides | 40.73 | 0.0 | 1396 |
| LLPS-Blg-1147 | Blumeria graminis | 40.65 | 0.0 | 1433 |
| LLPS-Mel-1326 | Melampsora laricipopulina | 39.08 | 1e-62 | 225 |
| LLPS-Phn-1273 | Phaeosphaeria nodorum | 38.98 | 0.0 | 1380 |
| LLPS-Art-2992 | Arabidopsis thaliana | 38.81 | 2e-53 | 213 |
| LLPS-Cus-1073 | Cucumis sativus | 38.56 | 9e-118 | 394 |
| LLPS-Trv-0145 | Trichoderma virens | 38.48 | 0.0 | 1541 |
| LLPS-Arl-2275 | Arabidopsis lyrata | 38.46 | 4e-53 | 212 |
| LLPS-Cis-1637 | Ciona savignyi | 38.35 | 1e-68 | 245 |
| LLPS-Scj-0995 | Schizosaccharomyces japonicus | 38.13 | 3e-145 | 514 |
| LLPS-Trr-0661 | Trichoderma reesei | 38.04 | 0.0 | 1455 |
| LLPS-Fus-1259 | Fusarium solani | 37.88 | 0.0 | 1504 |
| LLPS-Cogr-1511 | Colletotrichum graminicola | 37.27 | 0.0 | 1588 |
| LLPS-Zyt-0206 | Zymoseptoria tritici | 37.09 | 0.0 | 1260 |
| LLPS-Coo-0915 | Colletotrichum orbiculare | 36.97 | 0.0 | 1693 |
| LLPS-Ved-1405 | Verticillium dahliae | 36.6 | 0.0 | 1707 |
| LLPS-Cog-1137 | Colletotrichum gloeosporioides | 36.51 | 0.0 | 1697 |
| LLPS-Beb-0672 | Beauveria bassiana | 36.31 | 1e-53 | 214 |
| LLPS-Nec-0391 | Neurospora crassa | 36.11 | 0.0 | 1644 |
| LLPS-Hov-1187 | Hordeum vulgare | 36.11 | 4e-107 | 390 |
| LLPS-Glm-0805 | Glycine max | 36.04 | 7e-113 | 409 |
| LLPS-Bro-1415 | Brassica oleracea | 35.7 | 3e-117 | 421 |
| LLPS-Pytr-1173 | Pyrenophora triticirepentis | 35.68 | 0.0 | 1677 |
| LLPS-Pyt-0669 | Pyrenophora teres | 35.64 | 0.0 | 1715 |
| LLPS-Mao-0347 | Magnaporthe oryzae | 35.62 | 0.0 | 1630 |
| LLPS-Phv-1001 | Phaseolus vulgaris | 35.56 | 3e-112 | 407 |
| LLPS-Sem-0085 | Selaginella moellendorffii | 35.48 | 6e-121 | 409 |
| LLPS-Lem-0344 | Leptosphaeria maculans | 35.46 | 0.0 | 1656 |
| LLPS-Via-1324 | Vigna angularis | 35.29 | 3e-113 | 406 |
| LLPS-Ors-1717 | Oryza sativa | 35.28 | 3e-53 | 202 |
| LLPS-Amt-0181 | Amborella trichopoda | 35.25 | 1e-115 | 404 |
| LLPS-Gor-1762 | Gossypium raimondii | 35.16 | 1e-117 | 424 |
| LLPS-Pug-1222 | Puccinia graminis | 35.14 | 2e-53 | 213 |
| LLPS-Met-0755 | Medicago truncatula | 34.93 | 4e-112 | 406 |
| LLPS-Pof-1541 | Poecilia formosa | 34.89 | 2e-124 | 447 |
| LLPS-Gog-2409 | Gorilla gorilla | 34.8 | 2e-127 | 456 |
| LLPS-Pot-1863 | Populus trichocarpa | 34.63 | 7e-54 | 214 |
| LLPS-Coc-0377 | Corchorus capsularis | 34.54 | 2e-114 | 401 |
| LLPS-Prp-1888 | Prunus persica | 34.52 | 1e-114 | 414 |
| LLPS-Thc-1221 | Theobroma cacao | 34.41 | 3e-112 | 407 |
| LLPS-Dac-0264 | Daucus carota | 34.36 | 8e-111 | 402 |
| LLPS-Tru-0207 | Triticum urartu | 34.34 | 7e-81 | 303 |
| LLPS-Fud-0929 | Fukomys damarensis | 34.34 | 5e-124 | 445 |
| LLPS-Sol-0591 | Solanum lycopersicum | 34.18 | 2e-113 | 410 |
| LLPS-Hea-0271 | Helianthus annuus | 34.17 | 5e-115 | 416 |
| LLPS-Yal-0651 | Yarrowia lipolytica | 34.16 | 3e-112 | 405 |
| LLPS-Orni-1691 | Oryza nivara | 34.08 | 3e-110 | 399 |
| LLPS-Orb-0589 | Oryza barthii | 33.86 | 2e-108 | 394 |
| LLPS-Mae-1475 | Manihot esculenta | 33.85 | 3e-114 | 412 |
| LLPS-Ora-2505 | Ornithorhynchus anatinus | 33.77 | 9e-55 | 214 |
| LLPS-Orgl-1108 | Oryza glumaepatula | 33.73 | 8e-103 | 375 |
| LLPS-Mua-0722 | Musa acuminata | 33.73 | 2e-107 | 390 |
| LLPS-Viv-1660 | Vitis vinifera | 33.64 | 1e-114 | 400 |
| LLPS-Brn-3303 | Brassica napus | 33.62 | 3e-109 | 382 |
| LLPS-Org-0046 | Oryza glaberrima | 33.5 | 3e-81 | 290 |
| LLPS-Orbr-1044 | Oryza brachyantha | 33.42 | 2e-107 | 390 |
| LLPS-Orr-1185 | Oryza rufipogon | 33.25 | 2e-107 | 391 |
| LLPS-Ori-2163 | Oryza indica | 33.25 | 8e-108 | 392 |
| LLPS-Gas-0357 | Galdieria sulphuraria | 33.2 | 2e-88 | 328 |
| LLPS-Php-1969 | Physcomitrella patens | 33.07 | 7e-114 | 412 |
| LLPS-Chc-0381 | Chondrus crispus | 33.06 | 3e-79 | 298 |
| LLPS-Sob-1267 | Sorghum bicolor | 33.03 | 2e-106 | 387 |
| LLPS-Drm-0429 | Drosophila melanogaster | 33.03 | 4e-87 | 324 |
| LLPS-Dos-0357 | Dothistroma septosporum | 33.0 | 0.0 | 1394 |
| LLPS-Scc-0179 | Schizosaccharomyces cryophilus | 32.73 | 1e-160 | 564 |
| LLPS-Sei-1505 | Setaria italica | 32.7 | 6e-103 | 365 |
| LLPS-Scp-0629 | Schizosaccharomyces pombe | 32.58 | 2e-174 | 607 |
| LLPS-Brr-1110 | Brassica rapa | 32.24 | 9e-94 | 346 |
| LLPS-Zem-1234 | Zea mays | 32.19 | 4e-96 | 354 |
| LLPS-Myl-3544 | Myotis lucifugus | 31.47 | 9e-134 | 457 |
| LLPS-Put-0468 | Puccinia triticina | 31.37 | 9e-143 | 500 |
| LLPS-Spr-1088 | Sporisorium reilianum | 31.18 | 9e-143 | 506 |
| LLPS-Usm-1446 | Ustilago maydis | 31.18 | 3e-139 | 495 |
| LLPS-Asm-2661 | Astyanax mexicanus | 30.95 | 2e-135 | 482 |
| LLPS-Tag-0104 | Taeniopygia guttata | 30.7 | 2e-143 | 509 |
| LLPS-Lep-1243 | Leersia perrieri | 30.51 | 6e-55 | 218 |
| LLPS-Miv-1131 | Microbotryum violaceum | 30.44 | 4e-130 | 465 |
| LLPS-Xet-0621 | Xenopus tropicalis | 30.29 | 2e-140 | 499 |
| LLPS-Fia-2755 | Ficedula albicollis | 30.27 | 1e-136 | 486 |
| LLPS-Cas-0351 | Carlito syrichta | 30.15 | 1e-144 | 513 |
| LLPS-Scf-4171 | Scleropages formosus | 30.15 | 1e-56 | 224 |
| LLPS-Icp-2814 | Ictalurus punctatus | 30.13 | 4e-136 | 484 |
| LLPS-Crn-0090 | Cryptococcus neoformans | 30.12 | 2e-128 | 459 |
| LLPS-Mod-0875 | Monodelphis domestica | 30.1 | 7e-139 | 493 |
| LLPS-Caj-0534 | Callithrix jacchus | 30.05 | 2e-141 | 502 |
| LLPS-Gaa-0314 | Gasterosteus aculeatus | 30.02 | 4e-56 | 222 |
| LLPS-Gaga-3396 | Gallus gallus | 29.89 | 2e-137 | 489 |
| LLPS-Mup-0014 | Mustela putorius furo | 29.87 | 2e-142 | 505 |
| LLPS-Dar-0356 | Danio rerio | 29.86 | 6e-136 | 484 |
| LLPS-Sah-0051 | Sarcophilus harrisii | 29.86 | 2e-139 | 496 |
| LLPS-Urm-0328 | Ursus maritimus | 29.85 | 4e-141 | 501 |
| LLPS-Sac-0648 | Saccharomyces cerevisiae | 29.84 | 9e-119 | 428 |
| LLPS-Anp-0094 | Anas platyrhynchos | 29.73 | 4e-139 | 494 |
| LLPS-Orp-0797 | Oryza punctata | 29.7 | 7e-54 | 214 |
| LLPS-Rhb-2627 | Rhinopithecus bieti | 29.7 | 3e-141 | 501 |
| LLPS-Aon-1585 | Aotus nancymaae | 29.7 | 1e-139 | 496 |
| LLPS-Xim-1040 | Xiphophorus maculatus | 29.68 | 6e-56 | 221 |
| LLPS-Orn-2068 | Oreochromis niloticus | 29.65 | 2e-57 | 226 |
| LLPS-Aim-3254 | Ailuropoda melanoleuca | 29.65 | 4e-141 | 501 |
| LLPS-Ten-1496 | Tetraodon nigroviridis | 29.62 | 2e-127 | 455 |
| LLPS-Cap-0760 | Cavia porcellus | 29.62 | 3e-141 | 501 |
| LLPS-Sus-1154 | Sus scrofa | 29.55 | 2e-142 | 505 |
| LLPS-Orc-1700 | Oryctolagus cuniculus | 29.53 | 4e-140 | 498 |
| LLPS-Lac-0466 | Latimeria chalumnae | 29.5 | 1e-58 | 230 |
| LLPS-Mam-0882 | Macaca mulatta | 29.47 | 2e-141 | 502 |
| LLPS-Man-2619 | Macaca nemestrina | 29.47 | 2e-141 | 502 |
| LLPS-Paa-1380 | Papio anubis | 29.47 | 2e-141 | 502 |
| LLPS-Ran-3270 | Rattus norvegicus | 29.47 | 2e-140 | 498 |
| LLPS-Cea-1207 | Cercocebus atys | 29.47 | 9e-142 | 503 |
| LLPS-Caf-2749 | Canis familiaris | 29.44 | 1e-137 | 489 |
| LLPS-Scm-3174 | Scophthalmus maximus | 29.41 | 1e-56 | 223 |
| LLPS-Mal-0322 | Mandrillus leucophaeus | 29.41 | 1e-141 | 502 |
| LLPS-Maf-0037 | Macaca fascicularis | 29.41 | 2e-141 | 502 |
| LLPS-Chs-0338 | Chlorocebus sabaeus | 29.41 | 2e-141 | 502 |
| LLPS-Mea-2828 | Mesocricetus auratus | 29.37 | 7e-142 | 503 |
| LLPS-Dio-3298 | Dipodomys ordii | 29.3 | 1e-55 | 220 |
| LLPS-Meg-1999 | Meleagris gallopavo | 29.26 | 6e-59 | 231 |
| LLPS-Pes-0748 | Pelodiscus sinensis | 29.25 | 5e-133 | 474 |
| LLPS-Asg-0388 | Ashbya gossypii | 29.25 | 4e-123 | 442 |
| LLPS-Mum-0950 | Mus musculus | 29.11 | 3e-139 | 495 |
| LLPS-Ova-1088 | Ovis aries | 29.07 | 2e-139 | 496 |
| LLPS-Kop-0432 | Komagataella pastoris | 29.06 | 3e-138 | 491 |
| LLPS-Loa-1272 | Loxodonta africana | 29.04 | 3e-140 | 498 |
| LLPS-Nol-1839 | Nomascus leucogenys | 29.02 | 1e-137 | 489 |
| LLPS-Hos-0566 | Homo sapiens | 29.02 | 2e-140 | 499 |
| LLPS-Bot-1781 | Bos taurus | 29.0 | 1e-139 | 496 |
| LLPS-Pap-1192 | Pan paniscus | 28.95 | 5e-140 | 497 |
| LLPS-Brd-0898 | Brachypodium distachyon | 28.95 | 2e-107 | 390 |
| LLPS-Otg-2150 | Otolemur garnettii | 28.9 | 3e-133 | 475 |
| LLPS-Pat-1650 | Pan troglodytes | 28.87 | 6e-140 | 497 |
| LLPS-Fec-1933 | Felis catus | 28.77 | 4e-138 | 491 |
| LLPS-Poa-3639 | Pongo abelii | 28.68 | 2e-134 | 479 |
| LLPS-Eqc-1738 | Equus caballus | 28.6 | 2e-136 | 486 |