• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asm-0707

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Elongation factor 1-alpha
Ensembl Gene: ENSAMXG00000002854.2
Ensembl Protein: ENSAMXP00000042576.1
Organism: Astyanax mexicanus
Taxa ID: 7994
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSAMXT00000032875.1ENSAMXP00000042576.1
UniProtA0A3B1JLH5, A0A3B1JLH5_ASTMX

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGKEKIHINI  VVIGHVDSGK  STTTGHLIYK  CGGIDKRTIE  KFEKEAAEMG  KGSFKYAWVL  60
61    DKLKAERERG  ITIDISLWKF  ETSKYYITII  DAPGHRDFIK  NMITGTSQAD  CAVLIVAAGV  120
121   GEFEAGISKN  GQTREHALLA  YTLGVKQLIV  AVNKMDSTEP  PYSEKRYDEI  VKEVSAYIKK  180
181   IGYSPAAVPF  VPISGWHGDN  MLESSSNMPW  FKGWKLDRKE  LHATGVTLLE  ALDTILPPTR  240
241   PTDKPLRLPL  QDVYKIGGIG  TVPVGRVETG  VLRPGMVVTF  APVNITTEVK  SVEMHHESLT  300
301   EALPGDNVGF  NVKNVSVKDI  RRGNVCGDSR  SDPPQEASGF  TAQVIILNHP  GQICAGYSPV  360
361   IDCHTAHIAC  KFAELKEKID  RRSGKKLEDN  PKNLKSGDAA  IVDMVPGKPM  CVESFSQYPP  420
421   LGRFAVRDMR  QTVAVGVIKN  VEKKVGGSGK  ITKSAQKAQK  AGK  463
Nucleotide CDS Sequence (FASTA)
1     ATGGGGAAGG  AAAAGATCCA  CATTAATATT  GTTGTGATTG  GCCATGTGGA  CTCTGGGAAG  60
61    TCCACCACCA  CCGGTCACCT  CATCTATAAG  TGTGGAGGCA  TTGACAAGAG  AACCATCGAG  120
121   AAATTTGAGA  AGGAGGCTGC  AGAGATGGGG  AAAGGATCCT  TTAAGTATGC  CTGGGTATTG  180
181   GACAAGCTAA  AGGCAGAGCG  AGAGAGAGGC  ATCACCATAG  ACATCTCTCT  CTGGAAATTT  240
241   GAGACTTCTA  AATACTACAT  TACCATCATA  GATGCTCCAG  GTCACAGAGA  TTTTATCAAG  300
301   AACATGATCA  CAGGGACTTC  CCAGGCAGAC  TGTGCCGTTT  TGATCGTGGC  AGCTGGCGTG  360
361   GGTGAATTTG  AAGCCGGCAT  CTCCAAGAAC  GGGCAGACAC  GCGAGCATGC  CCTACTAGCC  420
421   TACACTCTGG  GTGTTAAACA  GCTGATTGTA  GCTGTCAACA  AGATGGACTC  CACAGAGCCT  480
481   CCTTACAGCG  AGAAGCGCTA  TGATGAGATA  GTTAAGGAGG  TCAGCGCCTA  CATCAAGAAG  540
541   ATTGGCTACA  GCCCGGCGGC  CGTGCCCTTC  GTTCCCATTT  CAGGGTGGCA  TGGGGACAAC  600
601   ATGTTGGAGT  CCTCCTCTAA  TATGCCGTGG  TTTAAAGGCT  GGAAGCTGGA  CAGGAAGGAG  660
661   CTTCATGCTA  CAGGAGTCAC  CCTTCTGGAG  GCTCTGGACA  CTATCCTGCC  CCCCACACGG  720
721   CCCACAGACA  AACCCTTACG  TCTTCCCTTG  CAGGACGTCT  ACAAGATTGG  AGGTATTGGG  780
781   ACAGTGCCGG  TGGGAAGGGT  AGAGACTGGC  GTCCTGCGGC  CCGGCATGGT  GGTGACCTTC  840
841   GCCCCAGTCA  ACATCACCAC  GGAGGTGAAG  TCTGTGGAGA  TGCACCACGA  GTCTCTGACT  900
901   GAAGCTCTGC  CAGGGGATAA  CGTGGGCTTC  AACGTGAAGA  ATGTGTCAGT  GAAGGACATC  960
961   CGCAGGGGGA  ACGTGTGCGG  AGACAGCAGG  TCAGACCCAC  CCCAGGAGGC  CTCGGGGTTC  1020
1021  ACAGCACAGG  TTATTATTTT  GAATCACCCG  GGTCAGATCT  GTGCTGGTTA  CTCTCCTGTC  1080
1081  ATTGACTGCC  ACACGGCTCA  CATCGCCTGC  AAGTTCGCTG  AGCTGAAGGA  GAAGATTGAC  1140
1141  CGTCGCTCTG  GGAAGAAGCT  GGAGGACAAT  CCCAAGAACC  TGAAGTCTGG  AGATGCTGCG  1200
1201  ATCGTGGACA  TGGTCCCAGG  CAAACCCATG  TGTGTGGAGA  GCTTTTCTCA  GTACCCTCCT  1260
1261  CTGGGACGCT  TTGCTGTCCG  AGATATGAGG  CAGACCGTCG  CCGTCGGGGT  CATCAAGAAC  1320
1321  GTGGAAAAGA  AGGTGGGTGG  GAGCGGCAAA  ATCACCAAAT  CAGCACAGAA  AGCTCAGAAG  1380
1381  GCCGGCAAGT  GA  1392

▼ KEYWORD

ID
Family
Complete proteome
Elongation factor
GTP-binding
Nucleotide-binding
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Translation elongation factor activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Icp-2208Ictalurus punctatus96.110.0 925
LLPS-Dar-2675Danio rerio95.90.0 924
LLPS-Scf-0881Scleropages formosus95.250.0 917
LLPS-Mup-1483Mustela putorius furo94.540.0 828
LLPS-Fud-2462Fukomys damarensis94.420.0 849
LLPS-Leo-1630Lepisosteus oculatus94.380.0 911
LLPS-Mal-2112Mandrillus leucophaeus94.30.0 829
LLPS-Paa-0083Papio anubis94.170.0 907
LLPS-Bot-2222Bos taurus94.170.0 907
LLPS-Caj-1462Callithrix jacchus94.170.0 907
LLPS-Sus-0571Sus scrofa94.170.0 903
LLPS-Cea-0993Cercocebus atys94.170.0 907
LLPS-Aon-0720Aotus nancymaae94.170.0 907
LLPS-Maf-2342Macaca fascicularis94.170.0 907
LLPS-Chs-1440Chlorocebus sabaeus94.170.0 907
LLPS-Nol-3951Nomascus leucogenys94.170.0 907
LLPS-Cap-1547Cavia porcellus94.170.0 907
LLPS-Otg-2241Otolemur garnettii94.170.0 907
LLPS-Man-0643Macaca nemestrina94.170.0 907
LLPS-Pat-2178Pan troglodytes94.170.0 907
LLPS-Fec-2955Felis catus94.170.0 905
LLPS-Ict-4575Ictidomys tridecemlineatus94.090.0 831
LLPS-Ran-0200Rattus norvegicus93.950.0 905
LLPS-Sah-2199Sarcophilus harrisii93.950.0 908
LLPS-Mum-0726Mus musculus93.950.0 905
LLPS-Mea-0619Mesocricetus auratus93.950.0 904
LLPS-Ora-0021Ornithorhynchus anatinus93.950.0 908
LLPS-Tag-0967Taeniopygia guttata93.950.0 907
LLPS-Xet-2064Xenopus tropicalis93.950.0 908
LLPS-Fia-2591Ficedula albicollis93.950.0 908
LLPS-Pes-1254Pelodiscus sinensis93.950.0 907
LLPS-Tut-1304Tursiops truncatus93.740.0 897
LLPS-Anc-3596Anolis carolinensis93.740.0 907
LLPS-Gaga-0559Gallus gallus93.740.0 905
LLPS-Rhb-0380Rhinopithecus bieti93.520.0 899
LLPS-Loa-2715Loxodonta africana93.440.0 837
LLPS-Aim-2698Ailuropoda melanoleuca93.010.0 832
LLPS-Urm-1981Ursus maritimus93.010.0 832
LLPS-Hos-2069Homo sapiens92.210.0 884
LLPS-Anp-0246Anas platyrhynchos90.890.0 875
LLPS-Meg-2585Meleagris gallopavo90.890.0 875
LLPS-Mod-2181Monodelphis domestica90.890.0 873
LLPS-Ova-2121Ovis aries90.670.0 872
LLPS-Dio-0217Dipodomys ordii90.670.0 872
LLPS-Xim-1406Xiphophorus maculatus90.670.0 870
LLPS-Gog-1174Gorilla gorilla90.670.0 872
LLPS-Mam-0494Macaca mulatta90.670.0 872
LLPS-Caf-1529Canis familiaris90.670.0 872
LLPS-Poa-3031Pongo abelii90.670.0 872
LLPS-Eqc-1432Equus caballus90.670.0 872
LLPS-Orc-2866Oryctolagus cuniculus90.670.0 872
LLPS-Orn-1000Oreochromis niloticus90.670.0 873
LLPS-Pap-3872Pan paniscus90.670.0 872
LLPS-Pof-0581Poecilia formosa90.670.0 870
LLPS-Ten-1602Tetraodon nigroviridis90.650.0 872
LLPS-Myl-0197Myotis lucifugus90.460.0 872
LLPS-Cas-3574Carlito syrichta90.460.0 872
LLPS-Gaa-2233Gasterosteus aculeatus89.780.0 861
LLPS-Orl-1101Oryzias latipes89.350.0 861
LLPS-Lac-3741Latimeria chalumnae89.350.0 855
LLPS-Scm-0290Scophthalmus maximus88.990.0 796
LLPS-Tar-0687Takifugu rubripes88.70.0 837
LLPS-Cae-1606Caenorhabditis elegans83.840.0 810
LLPS-Drm-0656Drosophila melanogaster83.190.0 793
LLPS-Cis-1509Ciona savignyi82.750.0 782
LLPS-Cii-1838Ciona intestinalis82.530.0 788
LLPS-Miv-0526Microbotryum violaceum80.530.0 766
LLPS-Coo-0161Colletotrichum orbiculare79.910.0 764
LLPS-Dos-1004Dothistroma septosporum79.730.0 754
LLPS-Nec-1445Neurospora crassa79.690.0 766
LLPS-Sac-1187Saccharomyces cerevisiae79.680.0 748
LLPS-Cogr-0071Colletotrichum graminicola79.610.0 775
LLPS-Pyt-0448Pyrenophora teres79.480.0 764
LLPS-Scp-0321Schizosaccharomyces pombe79.420.0 755
LLPS-Beb-0492Beauveria bassiana79.390.0 775
LLPS-Scj-0167Schizosaccharomyces japonicus79.350.0 765
LLPS-Pytr-0366Pyrenophora triticirepentis79.350.0 766
LLPS-Mel-0450Melampsora laricipopulina79.250.0 763
LLPS-Scs-0035Sclerotinia sclerotiorum79.250.0 757
LLPS-Fus-0148Fusarium solani79.250.0 760
LLPS-Lem-1156Leptosphaeria maculans79.130.0 763
LLPS-Asg-0864Ashbya gossypii79.130.0 764
LLPS-Spr-1037Sporisorium reilianum79.080.0 777
LLPS-Kop-1070Komagataella pastoris79.030.0 753
LLPS-Fuv-1338Fusarium verticillioides79.030.0 759
LLPS-Trr-0140Trichoderma reesei78.810.0 754
LLPS-Nef-1081Neosartorya fischeri78.740.0 774
LLPS-Asfu-0115Aspergillus fumigatus78.590.0 761
LLPS-Pug-0332Puccinia graminis78.540.0 758
LLPS-Fuo-0468Fusarium oxysporum78.470.0 723
LLPS-Asc-0786Aspergillus clavatus78.430.0 764
LLPS-Trv-0177Trichoderma virens78.270.0 748
LLPS-Phn-1410Phaeosphaeria nodorum78.190.0 756
LLPS-Crn-0041Cryptococcus neoformans78.10.0 749
LLPS-Asf-0318Aspergillus flavus78.090.0 762
LLPS-Aso-0526Aspergillus oryzae77.730.0 759
LLPS-Scc-0584Schizosaccharomyces cryophilus77.730.0 754
LLPS-Yal-0190Yarrowia lipolytica77.70.0 744
LLPS-Cog-1446Colletotrichum gloeosporioides77.70.0 737
LLPS-Zyt-0398Zymoseptoria tritici77.650.0 739
LLPS-Usm-0916Ustilago maydis77.460.0 761
LLPS-Blg-0925Blumeria graminis77.430.0 740
LLPS-Asn-1218Aspergillus nidulans77.190.0 760
LLPS-Ast-0634Aspergillus terreus77.020.0 742
LLPS-Gas-0616Galdieria sulphuraria76.850.0 704
LLPS-Cym-0514Cyanidioschyzon merolae76.820.0 714
LLPS-Orni-1920Oryza nivara76.80.0 709
LLPS-Orb-1453Oryza barthii76.80.0 709
LLPS-Ori-0122Oryza indica76.80.0 709
LLPS-Org-1512Oryza glaberrima76.80.0 709
LLPS-Orbr-1059Oryza brachyantha76.80.0 709
LLPS-Ors-0930Oryza sativa76.80.0 709
LLPS-Orp-0316Oryza punctata76.630.0 704
LLPS-Zem-1334Zea mays76.580.0 705
LLPS-Brd-1791Brachypodium distachyon76.350.0 704
LLPS-Lep-2161Leersia perrieri76.350.0 707
LLPS-Glm-0124Glycine max76.350.0 707
LLPS-Sem-0171Selaginella moellendorffii76.350.0 708
LLPS-Put-0261Puccinia triticina76.330.0 724
LLPS-Sob-1702Sorghum bicolor76.130.0 702
LLPS-Ved-0320Verticillium dahliae75.970.0 736
LLPS-Sei-0820Setaria italica75.90.0 702
LLPS-Hea-1368Helianthus annuus75.90.0 704
LLPS-Via-1778Vigna angularis75.820.0 723
LLPS-Thc-1793Theobroma cacao75.810.0 719
LLPS-Php-2463Physcomitrella patens75.680.0 703
LLPS-Vir-1095Vigna radiata75.60.0 721
LLPS-Gor-2507Gossypium raimondii75.60.0 721
LLPS-Prp-1348Prunus persica75.450.0 699
LLPS-Met-0003Medicago truncatula75.430.0 714
LLPS-Coc-0924Corchorus capsularis75.380.0 718
LLPS-Viv-0600Vitis vinifera75.380.0 718
LLPS-Tru-0952Triticum urartu75.270.0 706
LLPS-Hov-0940Hordeum vulgare75.160.0 709
LLPS-Tra-2512Triticum aestivum75.160.0 707
LLPS-Mae-1663Manihot esculenta75.160.0 718
LLPS-Amt-1257Amborella trichopoda75.160.0 714
LLPS-Phv-1536Phaseolus vulgaris74.950.0 718
LLPS-Dac-0254Daucus carota74.620.0 704
LLPS-Sot-1266Solanum tuberosum74.570.0 712
LLPS-Sol-1712Solanum lycopersicum74.570.0 712
LLPS-Map-0651Magnaporthe poae74.510.0 728
LLPS-Nia-1021Nicotiana attenuata74.510.0 712
LLPS-Brn-1469Brassica napus74.40.0 707
LLPS-Bro-0690Brassica oleracea74.40.0 706
LLPS-Pot-1005Populus trichocarpa74.40.0 709
LLPS-Brr-2524Brassica rapa74.40.0 706
LLPS-Arl-2399Arabidopsis lyrata74.180.0 705
LLPS-Art-1043Arabidopsis thaliana74.180.0 706
LLPS-Gag-1009Gaeumannomyces graminis74.10.0 736
LLPS-Mao-0072Magnaporthe oryzae74.080.0 726