LLPS-Art-2377
GEN1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Flap endonuclease GEN-like 1
Gene Name: GEN1, At1g01880, F22M8.2
Ensembl Gene: AT1G01880
Ensembl Protein: AT1G01880.3
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGVGGNFWDL  LRPYAQQQGF  DFLRNKRVAV  DLSFWIVQHE  TAVKGFVLKP  HLRLTFFRTI  60
61    NLFSKFGAYP  VFVVDGTPSP  LKSQARISRF  FRSSGIDTCN  LPVIKDGVSV  ERNKLFSEWV  120
121   RECVELLELL  GIPVLKANGE  AEALCAQLNS  QGFVDACITP  DSDAFLFGAM  CVIKDIKPNS  180
181   REPFECYHMS  HIESGLGLKR  KHLIAISLLV  GNDYDSGGVL  GIGVDKALRI  VREFSEDQVL  240
241   ERLQDIGNGL  QPAVPGGIKS  GDDGEEFRSE  MKKRSPHCSR  CGHLGSKRTH  FKSSCEHCGC  300
301   DSGCIKKPLG  FRCECSFCSK  DRDLREQKKT  NDWWIKVCDK  IALAPEFPNR  KIIELYLSDG  360
361   LMTGDGSSMS  WGTPDTGMLV  DLMVFKLHWD  PSYVRKMLLP  MLSTIYLREK  ARNNTGYALL  420
421   CDQYEFHSIK  CIKTRYGHQS  FVIRWRKPKS  TSGYSHSHSE  PEESIVVLEE  EEESVDPLDG  480
481   LNEPQVQNDN  GDCFLLTDEC  IGLVQSAFPD  ETEHFLHEKK  LRESKKKNVS  EEETATPRAT  540
541   TMGVQRSITD  FYRSAKKAAA  GQSIETGGSS  KASAEKKRQA  TSTSSSNLTK  SVRRRLLFG  599
Nucleotide CDS Sequence (FASTA)
1     ATGCGGTTTA  GGGTTTTGCA  GTTTGGAGCG  TACCCGGTTT  TTGTGGTTGA  TGGAACACCA  60
61    TCACCTTTGA  AATCTCAGGC  GAGAATCTCC  AGGTTTTTCC  GTTCTTCTGG  AATTGATACT  120
121   TGTAATCTAC  CTGTGATTAA  AGATGGTGTC  TCGGTTGAGA  GAAACAAGCT  GTTTTCTGAA  180
181   TGGGTTAGGG  AATGTGTGGA  GCTACTCGAA  TTGCTCGGTA  TTCCGGTGCT  GAAAGCTAAT  240
241   GGTGAGGCTG  AAGCTCTCTG  TGCACAGTTA  AACAGCCAAG  GTTTTGTGGA  TGCTTGCATT  300
301   ACTCCTGATA  GTGATGCTTT  CCTTTTTGGT  GCTATGTGCG  TGATCAAAGA  CATCAAGCCT  360
361   AATTCAAGAG  AACCTTTTGA  ATGCTACCAT  ATGTCACATA  TCGAGTCTGG  CCTCGGTTTG  420
421   AAGCGGAAAC  ACTTGATTGC  TATTTCTCTA  TTGGTGGGAA  ACGATTATGA  TTCAGGCGGT  480
481   GTTCTTGGGA  TTGGTGTGGA  TAAAGCACTG  CGCATTGTTC  GTGAGTTTTC  TGAAGACCAA  540
541   GTACTTGAAA  GACTACAGGA  CATTGGAAAT  GGGTTGCAAC  CTGCAGTTCC  TGGTGGAATC  600
601   AAATCCGGGG  ATGATGGTGA  AGAATTCCGC  TCAGAGATGA  AAAAAAGATC  TCCTCACTGT  660
661   TCCCGTTGTG  GACACCTGGG  CAGCAAGAGA  ACTCATTTTA  AGTCCTCTTG  TGAGCACTGC  720
721   GGTTGTGATA  GTGGTTGCAT  TAAAAAACCA  TTAGGGTTTA  GATGTGAATG  CTCCTTTTGT  780
781   TCCAAGGATC  GAGATTTAAG  GGAACAAAAG  AAAACCAATG  ATTGGTGGAT  CAAAGTCTGC  840
841   GATAAGATTG  CTCTAGCGCC  AGAGTTTCCC  AACAGAAAGA  TTATTGAACT  TTATCTATCC  900
901   GATGGTTTGA  TGACAGGAGA  TGGATCGTCA  ATGTCTTGGG  GAACTCCTGA  TACTGGAATG  960
961   CTAGTGGATC  TCATGGTTTT  CAAACTGCAC  TGGGACCCAT  CTTATGTTAG  AAAAATGTTG  1020
1021  CTTCCGATGC  TGTCGACCAT  TTATCTGAGA  GAAAAGGCAA  GAAACAACAC  AGGATACGCT  1080
1081  TTGTTGTGTG  ATCAATACGA  ATTTCATTCA  ATCAAGTGCA  TAAAAACTAG  ATATGGGCAT  1140
1141  CAGTCCTTTG  TAATAAGGTG  GAGAAAACCC  AAATCTACAA  GTGGTTATAG  TCATAGTCAC  1200
1201  AGCGAGCCAG  AAGAATCAAT  TGTTGTATTG  GAAGAAGAAG  AAGAGTCTGT  TGATCCGTTG  1260
1261  GATGGTTTAA  ATGAACCTCA  GGTGCAAAAT  GATAATGGTG  ACTGCTTCTT  GCTAACTGAT  1320
1321  GAATGCATAG  GACTTGTTCA  GTCTGCTTTC  CCTGATGAAA  CAGAGCATTT  TCTACATGAG  1380
1381  AAGAAACTGA  GAGAGTCGAA  AAAGAAGAAT  GTTTCTGAAG  AAGAAACAGC  AACACCAAGA  1440
1441  GCAACAACAA  TGGGTGTACA  AAGAAGCATT  ACCGATTTCT  ACCGTTCAGC  GAAGAAAGCA  1500
1501  GCAGCAGGTC  AAAGTATAGA  GACAGGCGGG  AGTTCAAAAG  CTTCTGCGGA  AAAGAAGAGA  1560
1561  CAGGCAACTT  CTACTAGTAG  TAGTAACCTT  ACAAAGTCGG  TCAGGCGTCG  TCTCTTGTTT  1620
1621  GGATAG  1626

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
DNA damage
DNA repair
Endonuclease
Hydrolase
Magnesium
Metal-binding
Nuclease
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
5'-3' exodeoxyribonuclease activity
Molecular Function
5'-flap endonuclease activity
Molecular Function
Crossover junction endodeoxyribonuclease activity
Molecular Function
Double-stranded DNA binding
Molecular Function
Flap endonuclease activity
Molecular Function
Metal ion binding
Molecular Function
Single-stranded DNA binding
Biological Process
DNA repair
Biological Process
Pollen development

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-2533Arabidopsis lyrata90.380.01059
LLPS-Bro-2303Brassica oleracea77.80.0 905
LLPS-Brn-0931Brassica napus77.360.0 890
LLPS-Brr-1376Brassica rapa76.960.0 909
LLPS-Pot-0074Populus trichocarpa57.950.0 663
LLPS-Prp-1875Prunus persica57.890.0 680
LLPS-Mae-0669Manihot esculenta55.430.0 630
LLPS-Nia-1550Nicotiana attenuata54.890.0 628
LLPS-Sei-1791Setaria italica54.792e-164 484
LLPS-Thc-2192Theobroma cacao54.550.0 629
LLPS-Sot-1374Solanum tuberosum54.250.0 630
LLPS-Gor-0049Gossypium raimondii54.110.0 625
LLPS-Coc-1227Corchorus capsularis54.10.0 641
LLPS-Hea-0239Helianthus annuus53.930.0 596
LLPS-Met-0837Medicago truncatula53.760.0 644
LLPS-Sol-0441Solanum lycopersicum53.760.0 625
LLPS-Dac-1929Daucus carota52.680.0 614
LLPS-Via-2401Vigna angularis52.370.0 600
LLPS-Vir-0150Vigna radiata52.210.0 594
LLPS-Phv-1856Phaseolus vulgaris52.20.0 601
LLPS-Cus-0058Cucumis sativus51.970.0 602
LLPS-Glm-0794Glycine max51.230.0 590
LLPS-Mua-2349Musa acuminata50.40.0 583
LLPS-Sob-1678Sorghum bicolor48.980.0 580
LLPS-Orgl-1057Oryza glumaepatula48.750.0 573
LLPS-Orr-0190Oryza rufipogon48.670.0 573
LLPS-Ors-0476Oryza sativa48.670.0 573
LLPS-Orb-0420Oryza barthii48.590.0 568
LLPS-Org-1119Oryza glaberrima48.590.0 568
LLPS-Orni-0663Oryza nivara48.440.0 572
LLPS-Ori-0790Oryza indica48.440.0 572
LLPS-Zem-1437Zea mays48.280.0 567
LLPS-Lep-1777Leersia perrieri48.130.0 573
LLPS-Orp-0255Oryza punctata47.990.0 558
LLPS-Orm-1761Oryza meridionalis47.980.0 570
LLPS-Tra-0112Triticum aestivum47.460.0 555
LLPS-Orbr-1100Oryza brachyantha47.420.0 561
LLPS-Brd-0825Brachypodium distachyon47.280.0 555
LLPS-Amt-2255Amborella trichopoda45.264e-179 529
LLPS-Tru-0853Triticum urartu43.92e-131 403
LLPS-Sem-0751Selaginella moellendorffii42.82e-110 349
LLPS-Meg-1597Meleagris gallopavo41.942e-43 160
LLPS-Orn-2919Oreochromis niloticus40.375e-41 153
LLPS-Scm-1869Scophthalmus maximus38.531e-35 137
LLPS-Dar-4056Danio rerio37.794e-37 142
LLPS-Cis-1409Ciona savignyi37.783e-24 105
LLPS-Hov-0777Hordeum vulgare37.74e-31 133
LLPS-Sah-1488Sarcophilus harrisii37.51e-36 140
LLPS-Tar-3696Takifugu rubripes37.331e-36 140
LLPS-Php-1388Physcomitrella patens36.461e-114 363
LLPS-Viv-0151Vitis vinifera35.459e-32 133
LLPS-Scf-3703Scleropages formosus35.166e-33 130
LLPS-Ten-1981Tetraodon nigroviridis33.331e-44 174
LLPS-Nec-0556Neurospora crassa32.63e-1994.0
LLPS-Coo-0055Colletotrichum orbiculare32.64e-1993.6
LLPS-Ict-0100Ictidomys tridecemlineatus32.491e-21 101
LLPS-Ova-0866Ovis aries32.472e-1994.4
LLPS-Asf-1404Aspergillus flavus32.316e-1582.4
LLPS-Aso-1510Aspergillus oryzae32.319e-1581.6
LLPS-Aim-3905Ailuropoda melanoleuca32.245e-56 207
LLPS-Eqc-4667Equus caballus32.15e-57 211
LLPS-Myl-2294Myotis lucifugus32.076e-2199.4
LLPS-Paa-0443Papio anubis32.079e-2095.5
LLPS-Bot-2572Bos taurus32.071e-1995.1
LLPS-Tut-1192Tursiops truncatus32.071e-1995.5
LLPS-Gog-2575Gorilla gorilla32.078e-2095.5
LLPS-Aon-3219Aotus nancymaae32.071e-1995.1
LLPS-Cea-1265Cercocebus atys32.079e-2095.5
LLPS-Chs-0899Chlorocebus sabaeus32.078e-2095.1
LLPS-Maf-0185Macaca fascicularis32.079e-2095.5
LLPS-Mea-0852Mesocricetus auratus32.071e-21 101
LLPS-Nol-2261Nomascus leucogenys32.079e-2095.5
LLPS-Cas-1133Carlito syrichta32.075e-2199.4
LLPS-Mam-1545Macaca mulatta32.079e-2095.5
LLPS-Poa-0768Pongo abelii32.078e-2095.5
LLPS-Rhb-4199Rhinopithecus bieti32.071e-1995.5
LLPS-Orc-0575Oryctolagus cuniculus32.077e-2095.9
LLPS-Man-2691Macaca nemestrina32.079e-2095.5
LLPS-Hos-0295Homo sapiens32.078e-2095.5
LLPS-Pap-0468Pan paniscus32.078e-2095.5
LLPS-Pat-0485Pan troglodytes32.078e-2095.5
LLPS-Mup-3097Mustela putorius furo31.865e-1890.1
LLPS-Pyt-0008Pyrenophora teres31.799e-1992.0
LLPS-Pytr-0753Pyrenophora triticirepentis31.792e-1891.7
LLPS-Anc-4015Anolis carolinensis31.734e-51 194
LLPS-Ran-3939Rattus norvegicus31.652e-21 100
LLPS-Dio-2286Dipodomys ordii31.655e-1993.2
LLPS-Mum-1654Mus musculus31.652e-21 100
LLPS-Caf-1324Canis familiaris31.652e-1994.4
LLPS-Mod-2146Monodelphis domestica31.653e-23 105
LLPS-Fec-2873Felis catus31.652e-2097.8
LLPS-Urm-0409Ursus maritimus31.655e-2199.4
LLPS-Blg-0124Blumeria graminis31.618e-1786.7
LLPS-Cii-1283Ciona intestinalis31.51e-53 199
LLPS-Phn-0829Phaeosphaeria nodorum31.444e-1684.7
LLPS-Fuv-1008Fusarium verticillioides31.381e-1892.0
LLPS-Chr-0596Chlamydomonas reinhardtii31.337e-1890.1
LLPS-Otg-2523Otolemur garnettii31.282e-57 212
LLPS-Pof-2097Poecilia formosa31.231e-52 192
LLPS-Fud-0817Fukomys damarensis31.221e-1995.1
LLPS-Sus-0666Sus scrofa31.223e-2096.7
LLPS-Asfu-0800Aspergillus fumigatus31.222e-1892.0
LLPS-Cap-2194Cavia porcellus31.228e-2095.9
LLPS-Cogr-0326Colletotrichum graminicola31.24e-1890.9
LLPS-Ast-1497Aspergillus terreus31.164e-1583.2
LLPS-Nef-0871Neosartorya fischeri31.058e-1582.0
LLPS-Gaga-0195Gallus gallus30.973e-1993.6
LLPS-Anp-0270Anas platyrhynchos30.971e-1892.0
LLPS-Asni-1077Aspergillus niger30.969e-2095.5
LLPS-Asm-0753Astyanax mexicanus30.892e-1994.7
LLPS-Crn-0475Cryptococcus neoformans30.871e-1687.0
LLPS-Mal-0375Mandrillus leucophaeus30.82e-1994.4
LLPS-Fia-1618Ficedula albicollis30.82e-1994.7
LLPS-Icp-2601Ictalurus punctatus30.795e-57 211
LLPS-Xet-2455Xenopus tropicalis30.773e-57 210
LLPS-Lac-3127Latimeria chalumnae30.674e-56 208
LLPS-Trv-0220Trichoderma virens30.544e-1684.7
LLPS-Fus-0361Fusarium solani30.544e-1890.9
LLPS-Zyt-0203Zymoseptoria tritici30.538e-1786.7
LLPS-Miv-0171Microbotryum violaceum30.521e-1583.2
LLPS-Xim-1023Xiphophorus maculatus30.516e-49 187
LLPS-Gaa-0922Gasterosteus aculeatus30.491e-2098.6
LLPS-Trr-0609Trichoderma reesei30.48e-1684.0
LLPS-Tag-2635Taeniopygia guttata30.388e-1992.4
LLPS-Cog-0632Colletotrichum gloeosporioides30.331e-1892.0
LLPS-Beb-0696Beauveria bassiana30.252e-1892.0
LLPS-Ved-0019Verticillium dahliae30.091e-1789.4
LLPS-Put-0960Puccinia triticina30.095e-1580.1
LLPS-Lem-0965Leptosphaeria maculans30.047e-1890.5
LLPS-Spr-0902Sporisorium reilianum29.922e-1582.4
LLPS-Asc-0727Aspergillus clavatus29.832e-1789.0
LLPS-Orl-1715Oryzias latipes29.818e-56 207
LLPS-Gas-0144Galdieria sulphuraria29.668e-1683.6
LLPS-Cae-1279Caenorhabditis elegans29.652e-1479.7
LLPS-Dos-1012Dothistroma septosporum29.652e-1582.4
LLPS-Pes-0376Pelodiscus sinensis29.653e-1788.2
LLPS-Map-0262Magnaporthe poae29.412e-1788.6
LLPS-Asn-0735Aspergillus nidulans29.413e-1788.2
LLPS-Gag-0290Gaeumannomyces graminis29.298e-1786.7
LLPS-Usm-0027Ustilago maydis29.11e-1479.7
LLPS-Mao-0135Magnaporthe oryzae28.991e-1685.9
LLPS-Asg-1164Ashbya gossypii28.917e-1684.0
LLPS-Osl-0082Ostreococcus lucimarinus28.841e-1583.2
LLPS-Leo-3445Lepisosteus oculatus28.793e-49 183
LLPS-Mel-0715Melampsora laricipopulina28.785e-1787.0
LLPS-Drm-1232Drosophila melanogaster28.422e-38 154
LLPS-Cym-0423Cyanidioschyzon merolae27.982e-1479.3
LLPS-Scc-0387Schizosaccharomyces cryophilus27.191e-1479.7