LLPS-Art-0742
ADF2

▼ OVERVIEW

Status: Reviewed
Protein Name: Actin-depolymerizing factor 2
Gene Name: ADF2, At3g46000, F16L2_210
Ensembl Gene: AT3G46000
Ensembl Protein: AT3G46000.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (PubMed:15563618, PubMed:19794115). Required for normal cell growth, plant development, cell organ expansion and flowering. Essential for root-knot nematode infection (PubMed:19794115).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLCFLPLDVS  KLKSKSFYKV  ANAASGMAVH  DDCKLKFMEL  KAKRTFRTIV  YKIEDKQVIV  60
61    EKLGEPEQSY  DDFAASLPAD  DCRYCIYDFD  FVTAENCQKS  KIFFIAWSPD  TAKVRDKMIY  120
121   ASSKDRFKRE  LDGIQVELQA  TDPTEMGLDV  FKSRTN  156
Nucleotide CDS Sequence (FASTA)
1     ATGGCAAACG  CGGCATCGGG  AATGGCTGTG  CATGATGATT  GCAAGCTGAA  ATTTATGGAA  60
61    CTGAAGGCGA  AAAGAACATT  CCGTACCATA  GTCTACAAGA  TTGAGGATAA  GCAAGTGATT  120
121   GTAGAGAAAC  TCGGTGAACC  TGAACAATCA  TATGATGACT  TTGCAGCTAG  TCTTCCAGCT  180
181   GATGATTGCC  GATATTGCAT  TTACGATTTC  GACTTTGTCA  CTGCGGAGAA  CTGCCAGAAG  240
241   AGCAAGATCT  TCTTCATTGC  ATGGTCTCCG  GACACTGCCA  AAGTGAGAGA  CAAGATGATT  300
301   TACGCGAGCT  CTAAAGATAG  GTTCAAGAGA  GAACTAGATG  GAATTCAAGT  GGAACTTCAA  360
361   GCTACTGATC  CAACAGAAAT  GGGTCTTGAT  GTTTTCAAAA  GCCGCACCAA  CTAA  414

▼ KEYWORD

ID
Family
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Phosphoprotein
Plant defense
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Actin cytoskeleton
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Molecular Function
Actin binding
Biological Process
Actin filament depolymerization
Biological Process
Defense response

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Interaction
iRefIndex
Physicochemical
Compute pI/MwAAindex
Function
PIRSF
Localization
COMPARTMENTS
Expression
ArrayExpress

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-1850Arabidopsis lyrata98.544e-96 281
LLPS-Bro-0699Brassica oleracea94.893e-92 271
LLPS-Brr-0040Brassica rapa94.894e-92 271
LLPS-Brn-0635Brassica napus94.898e-92 271
LLPS-Dac-0335Daucus carota86.766e-84 250
LLPS-Glm-2373Glycine max84.891e-83 249
LLPS-Coc-0435Corchorus capsularis84.784e-83 248
LLPS-Gor-1796Gossypium raimondii84.176e-84 250
LLPS-Mae-2492Manihot esculenta82.866e-81 244
LLPS-Sol-2059Solanum lycopersicum81.291e-79 239
LLPS-Mua-2484Musa acuminata81.063e-74 225
LLPS-Nia-0674Nicotiana attenuata80.585e-79 238
LLPS-Cus-0426Cucumis sativus79.867e-79 237
LLPS-Sot-0426Solanum tuberosum79.865e-79 237
LLPS-Vir-0246Vigna radiata79.431e-78 237
LLPS-Hea-0340Helianthus annuus79.143e-77 233
LLPS-Met-2276Medicago truncatula77.75e-76 230
LLPS-Pot-1973Populus trichocarpa75.164e-80 243
LLPS-Sei-1934Setaria italica72.661e-66 206
LLPS-Orm-1002Oryza meridionalis72.063e-66 213
LLPS-Orr-0148Oryza rufipogon71.324e-66 213
LLPS-Orni-0198Oryza nivara71.324e-66 213
LLPS-Orb-0007Oryza barthii71.324e-66 213
LLPS-Ori-0754Oryza indica71.324e-66 213
LLPS-Tra-0064Triticum aestivum71.013e-69 213
LLPS-Lep-0653Leersia perrieri70.294e-66 213
LLPS-Sob-0272Sorghum bicolor69.345e-68 209
LLPS-Thc-0491Theobroma cacao69.344e-68 210
LLPS-Tru-0525Triticum urartu69.125e-64 205
LLPS-Brd-0236Brachypodium distachyon67.883e-67 209
LLPS-Php-0291Physcomitrella patens66.22e-59 187
LLPS-Hov-0731Hordeum vulgare60.145e-56 181
LLPS-Orc-3287Oryctolagus cuniculus44.941e-1677.0
LLPS-Osl-0637Ostreococcus lucimarinus43.22e-31 115
LLPS-Crn-0544Cryptococcus neoformans41.541e-27 106
LLPS-Mal-0524Mandrillus leucophaeus40.433e-1676.6
LLPS-Chc-0364Chondrus crispus37.041e-2293.6
LLPS-Pes-3492Pelodiscus sinensis36.693e-1882.0
LLPS-Cym-0268Cyanidioschyzon merolae36.52e-2395.5
LLPS-Sah-1038Sarcophilus harrisii35.971e-1677.8
LLPS-Nol-0943Nomascus leucogenys35.512e-1677.4
LLPS-Caf-3295Canis familiaris35.511e-1677.4
LLPS-Eqc-0325Equus caballus35.512e-1677.0
LLPS-Otg-4483Otolemur garnettii35.513e-1676.3
LLPS-Hos-1866Homo sapiens35.512e-1677.4
LLPS-Pat-1397Pan troglodytes35.513e-1677.0
LLPS-Pap-2115Pan paniscus35.513e-1677.0
LLPS-Urm-4054Ursus maritimus35.511e-1677.4
LLPS-Aim-1556Ailuropoda melanoleuca35.512e-1677.4
LLPS-Mup-2627Mustela putorius furo35.511e-1677.4
LLPS-Myl-0634Myotis lucifugus35.511e-1677.4
LLPS-Ran-0954Rattus norvegicus35.511e-1677.4
LLPS-Dio-1582Dipodomys ordii35.513e-1676.3
LLPS-Bot-2045Bos taurus35.513e-1676.3
LLPS-Tut-1549Tursiops truncatus35.513e-1676.3
LLPS-Caj-3794Callithrix jacchus35.511e-1677.4
LLPS-Mum-4902Mus musculus35.513e-1677.4
LLPS-Mea-2696Mesocricetus auratus35.511e-1677.4
LLPS-Chs-3764Chlorocebus sabaeus35.513e-1676.3
LLPS-Chr-0315Chlamydomonas reinhardtii35.483e-29 114
LLPS-Gog-3077Gorilla gorilla35.464e-1779.3
LLPS-Ten-1500Tetraodon nigroviridis35.297e-1880.9
LLPS-Anc-0774Anolis carolinensis35.13e-1779.3
LLPS-Tag-1720Taeniopygia guttata33.996e-1778.6
LLPS-Gaga-3902Gallus gallus33.995e-1778.6
LLPS-Meg-0335Meleagris gallopavo33.996e-1778.6
LLPS-Ict-4126Ictidomys tridecemlineatus33.772e-1779.7
LLPS-Mam-3235Macaca mulatta33.772e-1779.7
LLPS-Poa-0519Pongo abelii33.772e-1779.7
LLPS-Cap-2863Cavia porcellus33.772e-1779.7
LLPS-Man-4290Macaca nemestrina33.772e-1779.7
LLPS-Loa-1998Loxodonta africana33.772e-1779.7
LLPS-Fec-3635Felis catus33.772e-1779.7
LLPS-Paa-4704Papio anubis33.772e-1779.7
LLPS-Ere-1041Erinaceus europaeus33.774e-1779.0
LLPS-Sus-2850Sus scrofa33.772e-1779.7
LLPS-Aon-1686Aotus nancymaae33.772e-1779.7
LLPS-Cea-1169Cercocebus atys33.772e-1779.7
LLPS-Maf-0977Macaca fascicularis33.772e-1779.7