DrLLPS - Data resource of LLPS

LLPS-Bot-2045
CFL1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Cofilin-1; Cofilin, non-muscle isoform
Gene Name:	CFL1
Ensembl Gene:	ENSBTAG00000021455.6
Ensembl Protein:	ENSBTAP00000028602.5
Organism:	Bos taurus
Taxa ID:	9913
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule, Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1866	P23528	Client	Stress granule, Postsynaptic density	99.39	2e-114	330
Mus musculus	LLPS-Mum-4902	P18760	Client	Postsynaptic density	98.80	1e-113	330

▼ FUNCTION

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSBTAT00000028602.6	ENSBTAP00000028602.5
UniProt		Q5E9F7, COF1_BOVIN, Q3SZ74
GeneBank	BT020963, BC103077	AAX08980.1, AAI03078.1
RefSeq	NM_001015655.1	NP_001015655.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV 60 61 GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPECAP LKSKMIYASS 120 121 KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL 166
Nucleotide CDS Sequence (FASTA)
1 ATGGCCTCCG GTGTGGCTGT CTCTGATGGG GTCATCAAAG TGTTCAACGA CATGAAAGTG 60 61 CGTAAGTCGT CGACACCAGA GGAAGTGAAG AAGCGCAAGA AGGCGGTGCT CTTCTGCCTG 120 121 AGTGAGGACA AGAAGAACAT CATCCTGGAG GAGGGCAAGG AGATCCTGGT GGGTGACGTG 180 181 GGCCAGACGG TAGACGACCC CTATGCCACC TTTGTCAAGA TGCTGCCAGA CAAGGACTGC 240 241 CGCTACGCCC TCTACGATGC AACCTACGAG ACCAAGGAGA GCAAGAAGGA GGACCTGGTG 300 301 TTCATCTTCT GGGCCCCTGA GTGTGCACCC CTTAAGAGCA AAATGATCTA TGCCAGCTCC 360 361 AAGGACGCCA TCAAGAAGAA GCTGACGGGG ATCAAGCATG AATTACAAGC AAACTGCTAC 420 421 GAGGAGGTCA AGGACCGCTG CACCCTTGCA GAGAAGCTGG GGGGCAGCGC TGTCATCTCC 480 481 CTGGAGGGCA AGCCTTTGTG A 501

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0009	Actin-binding
KW-1003	Cell membrane
KW-0966	Cell projection
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-1017	Isopeptide bond
KW-0472	Membrane
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005911	Cellular Component	Cell-cell junction
GO:0030864	Cellular Component	Cortical actin cytoskeleton
GO:0030027	Cellular Component	Lamellipodium
GO:0031258	Cellular Component	Lamellipodium membrane
GO:0016363	Cellular Component	Nuclear matrix
GO:0032587	Cellular Component	Ruffle membrane
GO:0051015	Molecular Function	Actin filament binding
GO:0005102	Molecular Function	Signaling receptor binding
GO:0030043	Biological Process	Actin filament fragmentation
GO:0007010	Biological Process	Cytoskeleton organization
GO:0030010	Biological Process	Establishment of cell polarity
GO:0000281	Biological Process	Mitotic cytokinesis
GO:0001755	Biological Process	Neural crest cell migration
GO:0001842	Biological Process	Neural fold formation
GO:0044794	Biological Process	Positive regulation by host of viral process
GO:0030836	Biological Process	Positive regulation of actin filament depolymerization
GO:0006468	Biological Process	Protein phosphorylation
GO:0022604	Biological Process	Regulation of cell morphogenesis
GO:0061001	Biological Process	Regulation of dendritic spine morphogenesis
GO:0043200	Biological Process	Response to amino acid
GO:0009615	Biological Process	Response to virus

▼ KEGG

bta:534553

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ova-2840	Ovis aries	100.0	5e-116	333
LLPS-Mal-1676	Mandrillus leucophaeus	100.0	5e-116	334
LLPS-Paa-3930	Papio anubis	100.0	1e-115	333
LLPS-Dio-1582	Dipodomys ordii	100.0	7e-116	332
LLPS-Cea-3441	Cercocebus atys	100.0	5e-116	334
LLPS-Chs-3764	Chlorocebus sabaeus	100.0	6e-117	335
LLPS-Maf-2263	Macaca fascicularis	100.0	1e-115	333
LLPS-Cas-1223	Carlito syrichta	100.0	1e-115	333
LLPS-Mam-3138	Macaca mulatta	100.0	1e-115	333
LLPS-Otg-4483	Otolemur garnettii	100.0	6e-117	335
LLPS-Man-4497	Macaca nemestrina	100.0	1e-115	333
LLPS-Fec-3434	Felis catus	100.0	1e-115	333
LLPS-Caj-3794	Callithrix jacchus	99.4	7e-116	332
LLPS-Urm-4054	Ursus maritimus	99.4	7e-116	332
LLPS-Myl-0634	Myotis lucifugus	99.39	5e-115	330
LLPS-Aim-1556	Ailuropoda melanoleuca	99.39	4e-114	330
LLPS-Gog-3077	Gorilla gorilla	99.39	7e-115	331
LLPS-Nol-0943	Nomascus leucogenys	99.39	1e-114	331
LLPS-Cap-3690	Cavia porcellus	99.39	3e-114	330
LLPS-Eqc-0325	Equus caballus	99.39	3e-114	328
LLPS-Caf-3295	Canis familiaris	99.39	5e-115	330
LLPS-Hos-1866	Homo sapiens	99.39	2e-114	330
LLPS-Pap-2115	Pan paniscus	99.39	2e-114	330
LLPS-Pat-1397	Pan troglodytes	99.39	2e-114	330
LLPS-Aon-3140	Aotus nancymaae	99.35	2e-105	307
LLPS-Ran-0954	Rattus norvegicus	98.8	3e-115	331
LLPS-Tut-1549	Tursiops truncatus	98.8	9e-116	332
LLPS-Sus-2214	Sus scrofa	98.8	2e-115	332
LLPS-Mum-4902	Mus musculus	98.8	1e-113	329
LLPS-Mea-2696	Mesocricetus auratus	98.8	3e-115	331
LLPS-Mup-2627	Mustela putorius furo	98.79	3e-114	328
LLPS-Fud-1877	Fukomys damarensis	98.73	2e-108	316
LLPS-Orc-3287	Oryctolagus cuniculus	97.66	2e-87	259
LLPS-Sah-1038	Sarcophilus harrisii	97.58	4e-114	328
LLPS-Loa-3805	Loxodonta africana	96.97	2e-110	321
LLPS-Ict-2513	Ictidomys tridecemlineatus	95.06	1e-104	303
LLPS-Pes-3492	Pelodiscus sinensis	90.36	5e-108	312
LLPS-Anc-0774	Anolis carolinensis	81.93	1e-95	281
LLPS-Gaga-3902	Gallus gallus	81.33	5e-95	280
LLPS-Tag-1720	Taeniopygia guttata	81.21	5e-94	277
LLPS-Meg-0335	Meleagris gallopavo	81.21	5e-94	277
LLPS-Scf-0855	Scleropages formosus	80.72	3e-95	280
LLPS-Asm-3674	Astyanax mexicanus	80.72	1e-93	276
LLPS-Poa-0519	Pongo abelii	80.12	8e-94	276
LLPS-Dar-2484	Danio rerio	80.12	5e-93	275
LLPS-Ere-1041	Erinaceus europaeus	80.0	1e-92	273
LLPS-Rhb-3168	Rhinopithecus bieti	79.52	2e-91	270
LLPS-Xet-3061	Xenopus tropicalis	78.31	3e-87	260
LLPS-Ten-1500	Tetraodon nigroviridis	76.51	3e-89	265
LLPS-Fia-1992	Ficedula albicollis	72.73	8e-80	241
LLPS-Anp-2825	Anas platyrhynchos	72.73	8e-80	241
LLPS-Ora-2610	Ornithorhynchus anatinus	70.91	6e-79	238
LLPS-Mod-0766	Monodelphis domestica	70.91	3e-78	236
LLPS-Icp-1754	Ictalurus punctatus	48.78	5e-40	139
LLPS-Brn-0635	Brassica napus	44.94	1e-17	80.5
LLPS-Pot-1973	Populus trichocarpa	39.13	5e-20	88.2
LLPS-Dac-2166	Daucus carota	38.41	3e-20	86.7
LLPS-Glm-1551	Glycine max	38.18	6e-18	80.5
LLPS-Gor-2067	Gossypium raimondii	38.14	3e-18	81.6
LLPS-Mae-2492	Manihot esculenta	37.96	1e-19	86.7
LLPS-Mua-2325	Musa acuminata	37.61	8e-19	82.8
LLPS-Phv-1568	Phaseolus vulgaris	37.27	3e-18	81.6
LLPS-Sol-2059	Solanum lycopersicum	36.96	2e-20	87.8
LLPS-Nia-1574	Nicotiana attenuata	36.96	3e-19	84.3
LLPS-Art-1666	Arabidopsis thaliana	36.69	3e-18	81.6
LLPS-Crn-0544	Cryptococcus neoformans	36.55	3e-21	89.7
LLPS-Sei-1171	Setaria italica	36.23	2e-20	87.4
LLPS-Cus-0426	Cucumis sativus	36.23	8e-20	85.9
LLPS-Hea-0340	Helianthus annuus	36.23	4e-18	81.3
LLPS-Bro-1361	Brassica oleracea	36.23	1e-19	85.1
LLPS-Coc-0435	Corchorus capsularis	36.23	8e-19	83.6
LLPS-Brr-2208	Brassica rapa	36.23	2e-19	85.5
LLPS-Cym-0268	Cyanidioschyzon merolae	36.13	1e-17	80.5
LLPS-Vir-0246	Vigna radiata	35.77	1e-17	80.1
LLPS-Met-2276	Medicago truncatula	35.77	6e-18	80.9
LLPS-Tra-0064	Triticum aestivum	35.51	2e-18	82.4
LLPS-Brd-0236	Brachypodium distachyon	35.51	1e-19	86.3
LLPS-Sot-0426	Solanum tuberosum	35.51	1e-19	85.5
LLPS-Osl-0637	Ostreococcus lucimarinus	35.29	1e-20	87.8
LLPS-Tru-0525	Triticum urartu	35.04	2e-17	81.3
LLPS-Orbr-1196	Oryza brachyantha	34.97	9e-19	83.2
LLPS-Orp-1361	Oryza punctata	34.97	2e-18	84.0
LLPS-Sob-0272	Sorghum bicolor	34.78	2e-19	84.7
LLPS-Arl-1558	Arabidopsis lyrata	34.31	7e-18	80.9
LLPS-Org-0448	Oryza glaberrima	34.31	9e-18	80.1
LLPS-Chr-0315	Chlamydomonas reinhardtii	34.27	9e-19	85.1
LLPS-Orgl-1336	Oryza glumaepatula	33.57	1e-17	80.5
LLPS-Orni-0316	Oryza nivara	33.57	1e-17	80.5
LLPS-Ori-1514	Oryza indica	33.57	1e-17	80.5
LLPS-Orm-1793	Oryza meridionalis	33.57	1e-17	80.1
LLPS-Asf-0507	Aspergillus flavus	32.53	1e-18	83.2
LLPS-Zem-0291	Zea mays	32.17	1e-18	82.8
LLPS-Orr-1319	Oryza rufipogon	32.17	2e-18	82.4
LLPS-Hov-0731	Hordeum vulgare	31.94	2e-18	83.2

LLPS-Bot-2045CFL1

Protein Sequence

Nucleotide Sequence

LLPS-Bot-2045
CFL1