• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aon-0832
PPP2R5A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
Gene Name: PPP2R5A
Ensembl Gene: ENSANAG00000030090.1
Ensembl Protein: ENSANAP00000024856.1
Organism: Aotus nancymaae
Taxa ID: 37293
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, OthersPredicted from orthologs(View)

▼ FUNCTION

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSSSPPAGA  ASAAISASEK  VDGFTRKSVR  KAQRQKRSQG  SSQFRSQGSQ  AELHPLPQLK  60
61    DATSNEQQEL  FCQKLQQCCV  LFDFMDSVSD  LKSKEIKRAT  LNELVEYVST  NRGVIVESAY  120
121   SDIVKMISAN  IFRTLPPSDN  PDFDPEEDEP  TLEASWPHIQ  LVYEFFLRFL  ESPDFQPSIA  180
181   KRYIDQKFVQ  QLLELFDSED  PRERDFLKTV  LHRIYGKFLG  LRAFIRKQIN  NIFLRFIYET  240
241   EHFNGVAELL  EILGSIINGF  ALPLKAEHKQ  FLMKVLIPMH  TAKGLALFHA  QLAYCVVQFL  300
301   EKDTTLTEPV  IRGLLKFWPK  TCSQKEVMFL  GEIEEILDVI  EPTQFKKIEE  PLFKQISKCV  360
361   SSSHFQVAER  ALYFWNNEYI  LSLIEENIDK  ILPIMFASLY  KISKEHWNPT  IVALVYNVLK  420
421   TLMEMNGKLF  DDLTSSYKAE  RQREKKKELE  REELWKKLEE  LKLKKALEKQ  NSAYNMHSIL  480
481   SNTSAE  486
Nucleotide CDS Sequence (FASTA)
1     ATGTCGTCGT  CGTCGCCGCC  AGCGGGGGCT  GCCAGCGCCG  CCATCTCGGC  CTCGGAGAAA  60
61    GTGGACGGCT  TTACCCGGAA  ATCGGTCCGC  AAGGCGCAGA  GGCAGAAGCG  CTCCCAGGGC  120
121   TCGTCGCAGT  TCCGCAGTCA  GGGCAGCCAG  GCAGAGCTGC  ACCCGCTGCC  CCAGCTCAAA  180
181   GATGCCACTT  CAAATGAACA  ACAGGAGCTT  TTCTGTCAGA  AGTTGCAGCA  GTGTTGTGTA  240
241   CTGTTTGATT  TCATGGACTC  TGTTTCAGAC  TTGAAGAGCA  AAGAAATTAA  AAGAGCAACA  300
301   CTGAATGAAC  TGGTTGAGTA  TGTTTCAACT  AATCGTGGTG  TAATTGTTGA  ATCAGCGTAT  360
361   TCTGATATAG  TAAAAATGAT  CAGTGCTAAC  ATCTTCCGTA  CACTTCCTCC  AAGTGATAAT  420
421   CCAGATTTTG  ATCCAGAAGA  GGATGAACCC  ACGCTTGAGG  CCTCTTGGCC  TCACATACAA  480
481   TTGGTATATG  AATTCTTCTT  GAGATTTTTG  GAGAGCCCCG  ATTTCCAGCC  TAGCATTGCA  540
541   AAGCGATACA  TTGACCAGAA  ATTCGTACAA  CAGCTCCTGG  AGCTTTTTGA  TAGTGAAGAT  600
601   CCCAGAGAAC  GTGACTTCCT  GAAGACTGTC  CTGCACCGAA  TTTATGGGAA  ATTTCTTGGA  660
661   TTAAGAGCAT  TCATCAGAAA  ACAGATTAAC  AACATTTTCC  TCAGGTTTAT  ATATGAAACA  720
721   GAACATTTCA  ATGGTGTTGC  TGAACTTCTT  GAAATATTAG  GAAGTATTAT  CAATGGCTTT  780
781   GCATTGCCAC  TGAAAGCAGA  ACATAAACAA  TTTCTAATGA  AGGTTCTTAT  TCCTATGCAT  840
841   ACTGCAAAAG  GATTAGCTTT  GTTTCATGCT  CAGCTAGCAT  ATTGTGTCGT  ACAGTTCCTG  900
901   GAGAAAGATA  CAACACTAAC  AGAGCCAGTG  ATCAGAGGAC  TGCTGAAATT  TTGGCCAAAA  960
961   ACCTGCAGTC  AGAAAGAGGT  GATGTTTTTA  GGAGAAATTG  AAGAAATCTT  AGATGTCATT  1020
1021  GAACCAACAC  AGTTCAAAAA  AATTGAAGAG  CCACTTTTCA  AGCAGATATC  GAAGTGTGTA  1080
1081  TCCAGTTCTC  ATTTTCAGGT  TGCAGAAAGG  GCACTGTACT  TCTGGAATAA  TGAATATATT  1140
1141  CTTAGTTTGA  TTGAGGAGAA  CATTGATAAA  ATTCTACCAA  TTATGTTTGC  CAGTTTGTAC  1200
1201  AAAATTTCCA  AAGAACACTG  GAATCCGACC  ATTGTAGCAC  TGGTATACAA  TGTGCTGAAA  1260
1261  ACCCTAATGG  AAATGAACGG  CAAGCTTTTC  GATGACCTTA  CTAGCTCATA  CAAAGCTGAA  1320
1321  AGACAGAGAG  AGAAAAAGAA  GGAATTGGAA  CGTGAAGAAT  TATGGAAAAA  ATTAGAGGAG  1380
1381  CTAAAGCTAA  AGAAAGCTCT  AGAAAAACAG  AATAGTGCTT  ACAACATGCA  CAGTATTCTC  1440
1441  AGCAATACAA  GTGCCGAATA  A  1461

▼ KEYWORD

ID
Family
Complete proteome
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cytosol
Cellular Component
M band
Cellular Component
Membrane
Cellular Component
Protein phosphatase type 2A complex
Cellular Component
Z disc
Molecular Function
Kinase binding
Molecular Function
Phosphoprotein phosphatase activity
Molecular Function
Protein phosphatase regulator activity
Biological Process
Negative regulation of lipid kinase activity
Biological Process
Negative regulation of protein localization to plasma membrane
Biological Process
Positive regulation of protein dephosphorylation
Biological Process
Signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-0881Pan troglodytes99.790.0 784
LLPS-Pap-0564Pan paniscus99.790.0 784
LLPS-Hos-2244Homo sapiens99.790.0 784
LLPS-Nol-0143Nomascus leucogenys99.790.0 784
LLPS-Poa-2852Pongo abelii99.790.0 784
LLPS-Gog-1756Gorilla gorilla99.790.0 784
LLPS-Man-0789Macaca nemestrina99.570.0 783
LLPS-Mam-0240Macaca mulatta99.570.0 783
LLPS-Cea-3275Cercocebus atys99.570.0 783
LLPS-Chs-0821Chlorocebus sabaeus99.570.0 783
LLPS-Maf-1180Macaca fascicularis99.570.0 783
LLPS-Mup-2005Mustela putorius furo99.570.0 782
LLPS-Mal-0244Mandrillus leucophaeus99.570.0 786
LLPS-Paa-1909Papio anubis99.570.0 783
LLPS-Otg-0595Otolemur garnettii99.520.0 766
LLPS-Caf-0673Canis familiaris99.50.0 693
LLPS-Fec-0031Felis catus99.360.0 782
LLPS-Urm-2166Ursus maritimus99.360.0 779
LLPS-Ict-0283Ictidomys tridecemlineatus99.360.0 781
LLPS-Aim-1607Ailuropoda melanoleuca99.360.0 781
LLPS-Eqc-1757Equus caballus99.280.0 758
LLPS-Caj-2078Callithrix jacchus99.150.0 780
LLPS-Sus-1058Sus scrofa99.150.0 780
LLPS-Ora-2045Ornithorhynchus anatinus99.050.0 760
LLPS-Ova-0059Ovis aries98.930.0 777
LLPS-Ran-3212Rattus norvegicus98.930.0 778
LLPS-Bot-1783Bos taurus98.930.0 777
LLPS-Cas-3776Carlito syrichta98.850.0 765
LLPS-Mum-3727Mus musculus98.720.0 776
LLPS-Tut-1008Tursiops truncatus98.720.0 779
LLPS-Loa-1889Loxodonta africana98.590.0 743
LLPS-Orc-0934Oryctolagus cuniculus98.50.0 774
LLPS-Myl-0205Myotis lucifugus98.50.0 778
LLPS-Fud-1201Fukomys damarensis98.350.0 731
LLPS-Cap-1203Cavia porcellus98.290.0 771
LLPS-Gaga-0999Gallus gallus97.610.0 751
LLPS-Fia-1623Ficedula albicollis97.370.0 749
LLPS-Pes-3706Pelodiscus sinensis97.370.0 750
LLPS-Tag-0516Taeniopygia guttata97.370.0 750
LLPS-Anp-1684Anas platyrhynchos97.140.0 756
LLPS-Meg-3091Meleagris gallopavo96.210.0 734
LLPS-Sah-0331Sarcophilus harrisii95.080.0 720
LLPS-Mod-3649Monodelphis domestica94.750.0 741
LLPS-Leo-2944Lepisosteus oculatus91.650.0 713
LLPS-Scf-2206Scleropages formosus90.770.0 672
LLPS-Anc-2398Anolis carolinensis90.690.0 698
LLPS-Ten-0142Tetraodon nigroviridis90.210.0 711
LLPS-Tar-2295Takifugu rubripes89.740.0 706
LLPS-Orn-3556Oreochromis niloticus89.260.0 703
LLPS-Scm-2272Scophthalmus maximus89.260.0 700
LLPS-Gaa-0005Gasterosteus aculeatus89.050.0 698
LLPS-Orl-3347Oryzias latipes88.540.0 694
LLPS-Mea-1457Mesocricetus auratus88.450.0 602
LLPS-Pof-0139Poecilia formosa88.070.0 696
LLPS-Xim-0352Xiphophorus maculatus88.070.0 696
LLPS-Asm-3403Astyanax mexicanus86.730.0 692
LLPS-Icp-2096Ictalurus punctatus85.340.0 679
LLPS-Dar-4175Danio rerio83.890.0 666
LLPS-Drm-1199Drosophila melanogaster80.10.0 603
LLPS-Lac-3334Latimeria chalumnae79.070.0 614
LLPS-Xet-2361Xenopus tropicalis78.150.0 610
LLPS-Rhb-4776Rhinopithecus bieti77.80.0 640
LLPS-Cae-0025Caenorhabditis elegans73.060.0 561
LLPS-Dio-2377Dipodomys ordii72.40.0 554
LLPS-Cii-0726Ciona intestinalis70.770.0 543
LLPS-Cogr-0646Colletotrichum graminicola62.987e-169 499
LLPS-Ved-0893Verticillium dahliae62.989e-170 500
LLPS-Fus-1121Fusarium solani62.724e-168 497
LLPS-Fuo-0538Fusarium oxysporum62.722e-168 497
LLPS-Spr-0068Sporisorium reilianum62.721e-169 503
LLPS-Usm-0679Ustilago maydis62.725e-170 504
LLPS-Coo-0735Colletotrichum orbiculare62.724e-168 497
LLPS-Fuv-0269Fusarium verticillioides62.723e-168 497
LLPS-Blg-0449Blumeria graminis62.722e-167 496
LLPS-Trr-0867Trichoderma reesei62.477e-168 495
LLPS-Zyt-0778Zymoseptoria tritici62.476e-168 493
LLPS-Cis-0238Ciona savignyi62.384e-156 463
LLPS-Beb-1557Beauveria bassiana62.211e-166 493
LLPS-Phn-1268Phaeosphaeria nodorum62.213e-167 495
LLPS-Dos-0788Dothistroma septosporum62.212e-166 493
LLPS-Mao-0286Magnaporthe oryzae62.215e-166 492
LLPS-Mel-0192Melampsora laricipopulina62.211e-168 503
LLPS-Nec-0026Neurospora crassa62.213e-167 495
LLPS-Pyt-0741Pyrenophora teres62.213e-167 495
LLPS-Trv-0008Trichoderma virens62.052e-165 489
LLPS-Miv-1418Microbotryum violaceum61.958e-167 497
LLPS-Crn-1474Cryptococcus neoformans61.955e-168 498
LLPS-Tum-1381Tuber melanosporum61.954e-165 489
LLPS-Lem-1458Leptosphaeria maculans61.952e-165 494
LLPS-Nef-0449Neosartorya fischeri61.72e-166 495
LLPS-Asc-0438Aspergillus clavatus61.73e-168 498
LLPS-Map-0754Magnaporthe poae61.548e-164 486
LLPS-Gag-1425Gaeumannomyces graminis61.541e-163 486
LLPS-Asfu-1465Aspergillus fumigatus61.443e-167 495
LLPS-Asn-0778Aspergillus nidulans61.443e-167 494
LLPS-Pug-0883Puccinia graminis61.181e-166 496
LLPS-Asf-1064Aspergillus flavus61.181e-167 492
LLPS-Aso-0959Aspergillus oryzae61.182e-166 493
LLPS-Ast-1097Aspergillus terreus60.936e-166 490
LLPS-Yal-0155Yarrowia lipolytica60.934e-159 478
LLPS-Abg-0932Absidia glauca60.932e-162 481
LLPS-Cog-1305Colletotrichum gloeosporioides60.413e-158 471
LLPS-Asni-0413Aspergillus niger60.155e-162 478
LLPS-Pytr-1574Pyrenophora triticirepentis59.92e-163 484
LLPS-Scc-1405Schizosaccharomyces cryophilus58.447e-155 459
LLPS-Scj-1519Schizosaccharomyces japonicus57.773e-149 444
LLPS-Scp-0033Schizosaccharomyces pombe57.144e-152 452
LLPS-Hea-2265Helianthus annuus56.073e-148 441
LLPS-Prp-2036Prunus persica55.57e-147 437
LLPS-Thc-1287Theobroma cacao55.51e-146 437
LLPS-Mae-1812Manihot esculenta55.354e-144 431
LLPS-Nia-0963Nicotiana attenuata55.242e-146 437
LLPS-Gor-1718Gossypium raimondii55.242e-145 434
LLPS-Sot-1520Solanum tuberosum55.241e-143 429
LLPS-Amt-1723Amborella trichopoda55.128e-144 430
LLPS-Sol-0025Solanum lycopersicum54.972e-145 434
LLPS-Coc-2044Corchorus capsularis54.715e-145 433
LLPS-Phv-0229Phaseolus vulgaris54.622e-144 431
LLPS-Cus-0807Cucumis sativus54.576e-144 430
LLPS-Viv-0534Vitis vinifera54.459e-144 429
LLPS-Sob-1991Sorghum bicolor54.335e-144 430
LLPS-Pot-0575Populus trichocarpa54.192e-145 434
LLPS-Php-2074Physcomitrella patens54.012e-144 432
LLPS-Sei-1991Setaria italica54.013e-146 435
LLPS-Sem-1106Selaginella moellendorffii53.091e-143 427