Mus musculus      Sam68 nuclear body


※ Sam68 nuclear body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Sam68 nuclear bodies (SNBs) is a kind of these bodies located in Nucleus, Its component of Nucleic acids or RNPs are Chloroplast-specific mRNAs Long non-coding RNA, and it is related to mRNAs trafficking through the nucleus (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID:27838525


There are 12 genes.  Reviewed (5 or Unreviewed (7

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mum-2872
ENSMUSG00000046434.16
P49312
Hnrnpa1
2
LLPS-Mum-1345
ENSMUSG00000000568.15
Q60668
Hnrnpd
3
LLPS-Mum-2748
ENSMUSG00000021546.18
P61979
Hnrnpk
4
LLPS-Mum-0356
ENSMUSG00000028790.13
Q60749
Khdrbs1
5
LLPS-Mum-0797
ENSMUSG00000021645.16
P97801
Smn1
6
LLPS-Mum-1553
ENSMUSG00000026058.11
Q9WU01
Khdrbs2
7
LLPS-Mum-2598
ENSMUSG00000022332.8
Q9R226
Khdrbs3
8
LLPS-Mum-1221
ENSMUSG00000031578.5
Q8BGS0
Mak16
9
LLPS-Mum-0149
ENSMUSG00000022204.9
Q9DB96
Ngdn
10
LLPS-Mum-2641
ENSMUSG00000031134.16
Q9WV02
Rbmx
11
LLPS-Mum-4680
ENSMUSG00000032280.16
Q08122
Tle3
12
LLPS-Mum-0147
ENSMUSG00000035851.14
E9Q5K9
Ythdc1