Homo sapiens      Sam68 nuclear body


※ Sam68 nuclear body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Sam68 nuclear bodies (SNBs) is a kind of these bodies located in Nucleus, Its component of Nucleic acids or RNPs are Chloroplast-specific mRNAs Long non-coding RNA, and it is related to mRNAs trafficking through the nucleus (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID:27838525


There are 13 genes.  Reviewed (13 or Unreviewed (0

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-2438
ENSG00000135486.17
P09651
HNRNPA1
2
LLPS-Hos-2022
ENSG00000138668.18
Q14103
HNRNPD
3
LLPS-Hos-1907
ENSG00000165119.20
P61978
HNRNPK
4
LLPS-Hos-2742
ENSG00000104824.17
P14866
HNRNPL
5
LLPS-Hos-2491
ENSG00000121774.17
Q07666
KHDRBS1
6
LLPS-Hos-0205
ENSG00000112232.8
Q5VWX1
KHDRBS2
7
LLPS-Hos-2453
ENSG00000131773.13
O75525
KHDRBS3
8
LLPS-Hos-1885
ENSG00000198042.10
Q9BXY0
MAK16
9
LLPS-Hos-0440
ENSG00000129460.15
Q8NEJ9
NGDN
10
LLPS-Hos-1909
ENSG00000147274.14
P38159
RBMX
11
LLPS-Hos-0485
ENSG00000172062.16
Q16637
SMN2
12
LLPS-Hos-1918
ENSG00000140332.15
Q04726
TLE3
13
LLPS-Hos-0718
ENSG00000083896.12
Q96MU7
YTHDC1