Cryptococcus neoformans P-body
※ P-body introduction P- (mRNA-processing) bodies are cytoplasmic granules that form in eukaryotic cells in response to numerous stresses to serve as sites of degradation and storage of mRNAs (1), which form through multiple protein-protein interactions analogous to a liquid-liquid phase separation (2). Functional P-bodies are critical for the DNA replication stress response in yeast (1), it consists of nontranslating mRNAs and the general translation repression and mRNA degradation machinery (2) and is associated with mRNA translation and degradation (3). Reference
1. Loll-Krippleber, R., & Brown, G. W. (2017) P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance. Nat Commun, 8(1), 558. PMID: 28916784
2. Rao, B. S., & Parker, R. (2017) Numerous interactions act redundantly to assemble a tunable size of P bodies in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 114(45), E9569-E9578. PMID: 29078371
3. Decker, C. J., & Parker, R. (2012) P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. Cold Spring Harb Perspect Biol, 4(9), a012286. PMID: 22763747
There are 258 genes. Reviewed (0)
or Unreviewed (258) 
※ P-body introduction P- (mRNA-processing) bodies are cytoplasmic granules that form in eukaryotic cells in response to numerous stresses to serve as sites of degradation and storage of mRNAs (1), which form through multiple protein-protein interactions analogous to a liquid-liquid phase separation (2). Functional P-bodies are critical for the DNA replication stress response in yeast (1), it consists of nontranslating mRNAs and the general translation repression and mRNA degradation machinery (2) and is associated with mRNA translation and degradation (3). Reference
1. Loll-Krippleber, R., & Brown, G. W. (2017) P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance. Nat Commun, 8(1), 558. PMID: 28916784
2. Rao, B. S., & Parker, R. (2017) Numerous interactions act redundantly to assemble a tunable size of P bodies in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 114(45), E9569-E9578. PMID: 29078371
3. Decker, C. J., & Parker, R. (2012) P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. Cold Spring Harb Perspect Biol, 4(9), a012286. PMID: 22763747
There are 258 genes. Reviewed (0)
or Unreviewed (258)