LLPS-Crn-0476
MPG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mannose-1-phosphate guanyltransferase; GDP-mannose pyrophosphorylase; GTP-mannose-1-phosphate guanylyltransferase |
| Gene Name: | MPG1, PSA1, CNC03020 |
| Ensembl Gene: | CNC03020 |
| Ensembl Protein: | AAW42293 |
| Organism: | Cryptococcus neoformans |
| Taxa ID: | 214684 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AAW42293 | AAW42293 |
| UniProt | P0CO20, MPG1_CRYNJ, Q45T76, Q55VR7, Q5KKH2, Q5WQW2 | |
| GeneBank | AY426181, DQ116945, AE017343 | AAR84601.1, AAW42293.1, AAZ22401.1 |
| RefSeq | XM_569600.1 | XP_569600.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKALILVGGF GTRLRPLTLS WPKPLVEFCN KAMILHQIEA LVKAGVKDIV LAVNYRPEVM 60 61 VSVLKKTEEE FGINIHFSVE TEPLGTAGPL ALAREILGKD DSPFFVLNSD VTCVYPFEAF 120 121 RDFHIAHKCE GSIMVTKVAE PSAYGVVVTK PNSTVIDRFV EKPVEFVGNR INAGIYIFNP 180 181 SVLDRIELRP TSIEKEIFPA IAADQQLHSF DLQGFWMDVG QPKDFLAGTC LYLSHLTSQH 240 241 SPLLTDPSQN KWVYGGNVMV DPSAEIDPTA VIGPNVVIGP DAKIGPGVRL QRCVIMSNAT 300 301 VRDHSWIANS IVGWNSTVGR WTRVENITVL GDDVTIKDEL YVNGASVLPH KSISTSITEP 360 361 RIVM 364 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGGCTC TGATCCTCGT CGGTGGTTTC GGTACCCGGC TTAGGCCCTT GACCCTCTCG 60 61 TGGCCCAAGC CTCTCGTCGA GTTCTGCAAC AAGGCCATGA TCTTGCACCA AATCGAGGCT 120 121 CTTGTCAAGG CGGGTGTCAA GGACATCGTC CTCGCTGTCA ACTACCGACC AGAGGTCATG 180 181 GTCTCTGTAC TCAAAAAGAC TGAGGAGGAG TTTGGCATCA ACATCCACTT CAGCGTCGAA 240 241 ACCGAACCTC TCGGCACTGC GGGTCCCCTT GCTCTTGCTC GCGAAATCTT GGGCAAGGAC 300 301 GACTCTCCGT TCTTTGTTTT GAACTCTGAT GTCACCTGTG TCTATCCCTT TGAGGCTTTC 360 361 CGAGACTTCC ACATTGCCCA CAAGTGCGAA GGTTCCATCA TGGTCACCAA GGTCGCCGAG 420 421 CCTTCTGCCT ATGGTGTCGT GGTCACGAAG CCCAACTCCA CTGTGATTGA TCGATTCGTC 480 481 GAGAAGCCCG TTGAATTCGT TGGTAACAGG ATCAACGCTG GTATCTACAT ATTCAACCCC 540 541 AGCGTTTTGG ACAGGATTGA GCTCCGTCCC ACTTCTATCG AAAAAGAAAT CTTCCCCGCC 600 601 ATCGCCGCCG ACCAACAACT GCACTCCTTT GATCTTCAAG GGTTCTGGAT GGATGTCGGT 660 661 CAACCAAAAG ACTTCCTTGC CGGTACCTGC CTTTACCTTT CCCACCTCAC TTCTCAACAT 720 721 TCTCCCTTGT TGACTGATCC CTCTCAAAAC AAGTGGGTGT ATGGTGGTAA TGTGATGGTT 780 781 GACCCTTCTG CGGAAATCGA CCCCACAGCC GTCATCGGCC CCAATGTCGT TATTGGTCCC 840 841 GACGCGAAGA TTGGGCCTGG TGTCCGTCTC CAGCGATGTG TGATCATGTC CAACGCTACC 900 901 GTGCGAGACC ACTCCTGGAT TGCCAACTCC ATTGTCGGGT GGAACAGCAC GGTGGGGCGA 960 961 TGGACAAGAG TGGAGAACAT TACAGTGTTG GGTGACGATG TGACGATAAA GGACGAGCTC 1020 1021 TATGTCAATG GTGCTTCAGT GTTGCCCCAC AAGAGTATCT CTACCTCTAT CACTGAGCCC 1080 1081 CGTATTGTTA TGTAA 1095 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell tip | |
Cellular Component | Cytoplasm | |
Molecular Function | GTP binding | |
Molecular Function | Mannose-1-phosphate guanylyltransferase activity | |
Biological Process | Cell cycle | |
Biological Process | Cell wall mannoprotein biosynthetic process | |
Biological Process | Fungal-type cell wall biogenesis | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | Protein glycosylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mel-0977 | Melampsora laricipopulina | 75.82 | 0.0 | 574 |
| LLPS-Pug-0075 | Puccinia graminis | 75.27 | 0.0 | 573 |
| LLPS-Put-0182 | Puccinia triticina | 75.27 | 0.0 | 576 |
| LLPS-Scs-0258 | Sclerotinia sclerotiorum | 73.76 | 5e-132 | 386 |
| LLPS-Asn-0076 | Aspergillus nidulans | 72.33 | 0.0 | 544 |
| LLPS-Trr-1133 | Trichoderma reesei | 72.05 | 0.0 | 541 |
| LLPS-Nef-1418 | Neosartorya fischeri | 71.79 | 0.0 | 536 |
| LLPS-Asni-1250 | Aspergillus niger | 71.51 | 0.0 | 543 |
| LLPS-Aso-0627 | Aspergillus oryzae | 71.51 | 0.0 | 543 |
| LLPS-Asf-0597 | Aspergillus flavus | 71.51 | 0.0 | 543 |
| LLPS-Tum-0443 | Tuber melanosporum | 71.51 | 0.0 | 531 |
| LLPS-Asfu-0288 | Aspergillus fumigatus | 71.43 | 0.0 | 531 |
| LLPS-Zyt-0618 | Zymoseptoria tritici | 71.23 | 0.0 | 535 |
| LLPS-Fuv-0276 | Fusarium verticillioides | 70.68 | 0.0 | 530 |
| LLPS-Fuo-1121 | Fusarium oxysporum | 70.68 | 0.0 | 530 |
| LLPS-Fus-0670 | Fusarium solani | 70.41 | 0.0 | 527 |
| LLPS-Asc-0936 | Aspergillus clavatus | 70.39 | 0.0 | 529 |
| LLPS-Pyt-0346 | Pyrenophora teres | 70.25 | 0.0 | 533 |
| LLPS-Trv-0442 | Trichoderma virens | 70.14 | 0.0 | 530 |
| LLPS-Ast-0979 | Aspergillus terreus | 69.94 | 4e-169 | 482 |
| LLPS-Gag-0160 | Gaeumannomyces graminis | 69.86 | 0.0 | 526 |
| LLPS-Lem-0693 | Leptosphaeria maculans | 69.86 | 0.0 | 536 |
| LLPS-Ved-0433 | Verticillium dahliae | 69.86 | 0.0 | 525 |
| LLPS-Scp-0476 | Schizosaccharomyces pombe | 69.67 | 0.0 | 522 |
| LLPS-Map-1393 | Magnaporthe poae | 69.59 | 0.0 | 525 |
| LLPS-Mao-0402 | Magnaporthe oryzae | 69.59 | 0.0 | 529 |
| LLPS-Blg-0706 | Blumeria graminis | 69.59 | 0.0 | 523 |
| LLPS-Abg-0543 | Absidia glauca | 69.32 | 0.0 | 535 |
| LLPS-Dos-0820 | Dothistroma septosporum | 69.32 | 0.0 | 534 |
| LLPS-Cog-0102 | Colletotrichum gloeosporioides | 69.15 | 1e-180 | 513 |
| LLPS-Scj-0623 | Schizosaccharomyces japonicus | 69.13 | 0.0 | 520 |
| LLPS-Coo-0430 | Colletotrichum orbiculare | 69.04 | 0.0 | 515 |
| LLPS-Miv-0833 | Microbotryum violaceum | 68.96 | 0.0 | 526 |
| LLPS-Scc-0782 | Schizosaccharomyces cryophilus | 68.85 | 0.0 | 516 |
| LLPS-Nec-0837 | Neurospora crassa | 68.49 | 0.0 | 526 |
| LLPS-Yal-0846 | Yarrowia lipolytica | 67.58 | 0.0 | 523 |
| LLPS-Cogr-1303 | Colletotrichum graminicola | 67.05 | 2e-169 | 484 |
| LLPS-Pytr-0916 | Pyrenophora triticirepentis | 65.48 | 2e-169 | 483 |
| LLPS-Kop-0914 | Komagataella pastoris | 64.31 | 1e-173 | 495 |
| LLPS-Asg-0350 | Ashbya gossypii | 64.03 | 4e-169 | 483 |
| LLPS-Sac-0980 | Saccharomyces cerevisiae | 63.76 | 7e-170 | 486 |
| LLPS-Drm-1676 | Drosophila melanogaster | 60.99 | 3e-156 | 451 |
| LLPS-Mua-0015 | Musa acuminata | 60.82 | 9e-151 | 441 |
| LLPS-Gaa-0958 | Gasterosteus aculeatus | 60.82 | 1e-159 | 459 |
| LLPS-Scm-2282 | Scophthalmus maximus | 60.82 | 1e-159 | 459 |
| LLPS-Pof-0465 | Poecilia formosa | 60.66 | 2e-160 | 461 |
| LLPS-Nia-0021 | Nicotiana attenuata | 60.55 | 2e-153 | 444 |
| LLPS-Gaga-2596 | Gallus gallus | 60.55 | 7e-163 | 468 |
| LLPS-Scf-1120 | Scleropages formosus | 60.38 | 1e-158 | 457 |
| LLPS-Pot-0968 | Populus trichocarpa | 60.38 | 4e-150 | 435 |
| LLPS-Lac-2636 | Latimeria chalumnae | 60.38 | 6e-159 | 457 |
| LLPS-Sei-1095 | Setaria italica | 60.27 | 3e-151 | 442 |
| LLPS-Mae-0996 | Manihot esculenta | 60.27 | 1e-151 | 439 |
| LLPS-Zem-1449 | Zea mays | 60.27 | 2e-152 | 441 |
| LLPS-Xet-0551 | Xenopus tropicalis | 60.27 | 3e-159 | 458 |
| LLPS-Icp-1434 | Ictalurus punctatus | 60.11 | 2e-157 | 454 |
| LLPS-Xim-1069 | Xiphophorus maculatus | 60.11 | 9e-159 | 457 |
| LLPS-Orn-2303 | Oreochromis niloticus | 60.11 | 6e-159 | 457 |
| LLPS-Sol-1130 | Solanum lycopersicum | 60.0 | 3e-150 | 436 |
| LLPS-Glm-2010 | Glycine max | 60.0 | 1e-150 | 436 |
| LLPS-Hea-2649 | Helianthus annuus | 60.0 | 1e-148 | 434 |
| LLPS-Sob-0268 | Sorghum bicolor | 60.0 | 3e-152 | 441 |
| LLPS-Prp-0105 | Prunus persica | 60.0 | 2e-150 | 436 |
| LLPS-Thc-1433 | Theobroma cacao | 59.95 | 4e-149 | 432 |
| LLPS-Coc-0968 | Corchorus capsularis | 59.84 | 1e-150 | 436 |
| LLPS-Ten-3393 | Tetraodon nigroviridis | 59.84 | 4e-155 | 448 |
| LLPS-Sem-1590 | Selaginella moellendorffii | 59.73 | 7e-152 | 440 |
| LLPS-Sot-0649 | Solanum tuberosum | 59.73 | 6e-150 | 435 |
| LLPS-Via-0830 | Vigna angularis | 59.73 | 4e-150 | 435 |
| LLPS-Vir-1756 | Vigna radiata | 59.73 | 4e-150 | 435 |
| LLPS-Met-0384 | Medicago truncatula | 59.73 | 4e-150 | 435 |
| LLPS-Brd-1537 | Brachypodium distachyon | 59.73 | 2e-152 | 441 |
| LLPS-Asm-0425 | Astyanax mexicanus | 59.45 | 1e-156 | 452 |
| LLPS-Cus-1423 | Cucumis sativus | 59.45 | 6e-152 | 440 |
| LLPS-Gor-1336 | Gossypium raimondii | 59.45 | 1e-151 | 439 |
| LLPS-Phv-0373 | Phaseolus vulgaris | 59.45 | 2e-149 | 434 |
| LLPS-Leo-1644 | Lepisosteus oculatus | 59.34 | 8e-157 | 452 |
| LLPS-Anc-2552 | Anolis carolinensis | 59.34 | 3e-157 | 453 |
| LLPS-Cii-1035 | Ciona intestinalis | 59.24 | 9e-70 | 223 |
| LLPS-Ova-0905 | Ovis aries | 59.18 | 2e-154 | 446 |
| LLPS-Tra-0041 | Triticum aestivum | 59.18 | 1e-151 | 439 |
| LLPS-Amt-2064 | Amborella trichopoda | 59.18 | 1e-148 | 432 |
| LLPS-Orbr-1557 | Oryza brachyantha | 59.18 | 1e-146 | 426 |
| LLPS-Tag-1082 | Taeniopygia guttata | 58.98 | 1e-124 | 368 |
| LLPS-Orb-2015 | Oryza barthii | 58.9 | 8e-146 | 424 |
| LLPS-Ori-0788 | Oryza indica | 58.9 | 1e-145 | 424 |
| LLPS-Orni-1941 | Oryza nivara | 58.9 | 8e-146 | 424 |
| LLPS-Bot-1856 | Bos taurus | 58.9 | 2e-154 | 446 |
| LLPS-Orgl-0135 | Oryza glumaepatula | 58.9 | 8e-146 | 424 |
| LLPS-Dar-0929 | Danio rerio | 58.9 | 1e-155 | 449 |
| LLPS-Ors-0788 | Oryza sativa | 58.9 | 9e-146 | 424 |
| LLPS-Fec-0312 | Felis catus | 58.9 | 6e-154 | 445 |
| LLPS-Orr-1172 | Oryza rufipogon | 58.9 | 9e-146 | 424 |
| LLPS-Orm-0535 | Oryza meridionalis | 58.9 | 8e-146 | 424 |
| LLPS-Org-1456 | Oryza glaberrima | 58.9 | 8e-146 | 424 |
| LLPS-Orl-2257 | Oryzias latipes | 58.68 | 4e-134 | 395 |
| LLPS-Fud-3332 | Fukomys damarensis | 58.63 | 2e-152 | 441 |
| LLPS-Mup-3250 | Mustela putorius furo | 58.63 | 9e-153 | 442 |
| LLPS-Cap-0464 | Cavia porcellus | 58.63 | 4e-152 | 440 |
| LLPS-Eqc-2635 | Equus caballus | 58.63 | 1e-150 | 440 |
| LLPS-Orp-0152 | Oryza punctata | 58.54 | 5e-149 | 432 |
| LLPS-Mum-4576 | Mus musculus | 58.36 | 1e-153 | 444 |
| LLPS-Mea-3274 | Mesocricetus auratus | 58.36 | 9e-154 | 444 |
| LLPS-Mal-2370 | Mandrillus leucophaeus | 58.36 | 2e-152 | 441 |
| LLPS-Ran-0083 | Rattus norvegicus | 58.36 | 1e-153 | 444 |
| LLPS-Rhb-4206 | Rhinopithecus bieti | 58.36 | 3e-152 | 441 |
| LLPS-Poa-2292 | Pongo abelii | 58.36 | 1e-152 | 441 |
| LLPS-Nol-1325 | Nomascus leucogenys | 58.36 | 1e-152 | 441 |
| LLPS-Ict-3611 | Ictidomys tridecemlineatus | 58.36 | 1e-152 | 442 |
| LLPS-Orc-0543 | Oryctolagus cuniculus | 58.08 | 9e-153 | 442 |
| LLPS-Otg-3346 | Otolemur garnettii | 58.08 | 8e-152 | 439 |
| LLPS-Cas-0544 | Carlito syrichta | 58.08 | 3e-153 | 443 |
| LLPS-Bro-1038 | Brassica oleracea | 58.08 | 5e-147 | 427 |
| LLPS-Brn-1715 | Brassica napus | 57.92 | 5e-145 | 422 |
| LLPS-Dac-1424 | Daucus carota | 57.86 | 1e-127 | 377 |
| LLPS-Pes-2446 | Pelodiscus sinensis | 57.84 | 2e-75 | 239 |
| LLPS-Dio-1390 | Dipodomys ordii | 57.81 | 1e-151 | 439 |
| LLPS-Art-0554 | Arabidopsis thaliana | 57.81 | 5e-146 | 425 |
| LLPS-Php-0765 | Physcomitrella patens | 57.65 | 2e-143 | 418 |
| LLPS-Mod-2074 | Monodelphis domestica | 57.64 | 3e-148 | 431 |
| LLPS-Arl-2012 | Arabidopsis lyrata | 57.53 | 2e-145 | 424 |
| LLPS-Brr-2667 | Brassica rapa | 57.53 | 2e-146 | 426 |
| LLPS-Chr-1136 | Chlamydomonas reinhardtii | 57.49 | 8e-146 | 424 |
| LLPS-Cis-0710 | Ciona savignyi | 57.42 | 5e-148 | 430 |
| LLPS-Cae-0104 | Caenorhabditis elegans | 57.1 | 5e-142 | 415 |
| LLPS-Anp-2243 | Anas platyrhynchos | 56.98 | 2e-69 | 222 |
| LLPS-Hov-1505 | Hordeum vulgare | 56.89 | 3e-134 | 396 |
| LLPS-Lep-0542 | Leersia perrieri | 56.84 | 3e-122 | 367 |
| LLPS-Urm-2445 | Ursus maritimus | 56.49 | 2e-121 | 360 |
| LLPS-Fia-0207 | Ficedula albicollis | 56.47 | 7e-130 | 382 |
| LLPS-Gas-0127 | Galdieria sulphuraria | 55.07 | 2e-142 | 416 |
| LLPS-Tut-1269 | Tursiops truncatus | 54.87 | 4e-146 | 426 |
| LLPS-Aim-0315 | Ailuropoda melanoleuca | 54.85 | 1e-147 | 430 |
| LLPS-Caf-2999 | Canis familiaris | 54.59 | 3e-147 | 429 |
| LLPS-Cea-1222 | Cercocebus atys | 54.34 | 3e-146 | 426 |
| LLPS-Maf-4219 | Macaca fascicularis | 54.34 | 6e-147 | 428 |
| LLPS-Chs-1004 | Chlorocebus sabaeus | 54.34 | 4e-146 | 426 |
| LLPS-Caj-0603 | Callithrix jacchus | 54.34 | 1e-146 | 427 |
| LLPS-Gog-0501 | Gorilla gorilla | 54.34 | 3e-146 | 426 |
| LLPS-Paa-2195 | Papio anubis | 54.34 | 4e-146 | 426 |
| LLPS-Man-0814 | Macaca nemestrina | 54.34 | 6e-147 | 428 |
| LLPS-Hos-4237 | Homo sapiens | 54.34 | 1e-146 | 427 |
| LLPS-Pap-2042 | Pan paniscus | 54.34 | 2e-146 | 427 |
| LLPS-Pat-1523 | Pan troglodytes | 54.34 | 2e-146 | 427 |
| LLPS-Mam-0562 | Macaca mulatta | 54.34 | 6e-147 | 428 |
| LLPS-Cym-0349 | Cyanidioschyzon merolae | 54.12 | 1e-139 | 408 |
| LLPS-Aon-4166 | Aotus nancymaae | 54.08 | 1e-145 | 425 |
| LLPS-Loa-1597 | Loxodonta africana | 53.51 | 2e-134 | 395 |
| LLPS-Tru-1495 | Triticum urartu | 52.16 | 5e-143 | 419 |
| LLPS-Chc-0148 | Chondrus crispus | 51.37 | 7e-125 | 371 |
| LLPS-Ere-0591 | Erinaceus europaeus | 47.2 | 1e-58 | 195 |