※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778

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No.	Status	DrLLPS ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		LLPS-Sus-4501	ENSSSCG00000034805.1	A0A287ANG1
2		LLPS-Sus-0984	ENSSSCG00000005935.3	A0A287B5S7	AGO2
3		LLPS-Sus-3623	ENSSSCG00000032986.1	A0A287AHC7	AKAP17A
4		LLPS-Sus-0377	ENSSSCG00000032655.1	A0A287BET5	ALYREF
5		LLPS-Sus-1473	ENSSSCG00000030058.2	I3LFK6	ANXA10
6		LLPS-Sus-1762	ENSSSCG00000004578.4	A0A286ZJV6	ANXA2
7		LLPS-Sus-3782	ENSSSCG00000009782.3	F1RFJ6	ARL6IP4
8		LLPS-Sus-2353	ENSSSCG00000011679.3	F1SKG2	ATR
9		LLPS-Sus-0592	ENSSSCG00000006756.3	I6L631	BCAS2
10		LLPS-Sus-2153	ENSSSCG00000030426.2	F1RQE0	C9orf78
11		LLPS-Sus-2687	ENSSSCG00000013633.3	F1S590	CARM1
12		LLPS-Sus-2002	ENSSSCG00000017477.3	A0A287BL32	CASC3
13		LLPS-Sus-4660	ENSSSCG00000029352.2	I3LG02	CCNL1
14		LLPS-Sus-0304	ENSSSCG00000010214.3	C0SW08	CDC2
15		LLPS-Sus-1818	ENSSSCG00000001708.3	F1RQS5	CDC5L
16		LLPS-Sus-2344	ENSSSCG00000016961.3	C9K505	CDK7
17		LLPS-Sus-0302	ENSSSCG00000005621.3	C9E1C9	CDK9
18		LLPS-Sus-4378	ENSSSCG00000012156.4	A0A287ARK6	CDKL5
19		LLPS-Sus-2224	ENSSSCG00000006519.3	F1RLJ5	CLK2
20		LLPS-Sus-3510	ENSSSCG00000015509.3	F1S705	COP1
21		LLPS-Sus-1029	ENSSSCG00000014435.3	A0A287ASJ4	CSNK1A1
22		LLPS-Sus-0026	ENSSSCG00000007337.3	F1SEK6	CTNNBL1
23		LLPS-Sus-1247	ENSSSCG00000026644.2	I3LR20	DDX46
24		LLPS-Sus-3690	ENSSSCG00000010135.3	A0A287BJV3	DGCR8
25		LLPS-Sus-2349	ENSSSCG00000013784.3	F1SCF5	DNAJB1
26		LLPS-Sus-0639	ENSSSCG00000004762.3	A0A287ALB8	DNAJC17
27		LLPS-Sus-2864	ENSSSCG00000015649.3	A0A287BJH6	DYRK3
28		LLPS-Sus-2933	ENSSSCG00000009134.3	F1S137	EGF
29		LLPS-Sus-1891	ENSSSCG00000002307.3	F2Z5J5	ERH
30		LLPS-Sus-3190	ENSSSCG00000014967.3	F1STI7	FAM76B
31		LLPS-Sus-3073	ENSSSCG00000036964.1	A0A287BB87	FAM83H
32		LLPS-Sus-2842	ENSSSCG00000011563.3	A0A286ZQA1	FANCD2
33		LLPS-Sus-4835	ENSSSCG00000001837.3	A0A287AD78	FANCI
34		LLPS-Sus-1981	ENSSSCG00000038526.1	A0A286ZYA7	FBXL18
35		LLPS-Sus-0518	ENSSSCG00000015815.4	K7GQJ1	FGFR1
36		LLPS-Sus-2823	ENSSSCG00000012992.3	F1RRI2	FRMD8
37		LLPS-Sus-0675	ENSSSCG00000030798.2	A0A287BPC6	FUS
38		LLPS-Sus-1597	ENSSSCG00000027139.2	I3LCE2	FYTTD1
39		LLPS-Sus-4774	ENSSSCG00000016763.3	F1SSE1	GLI3
40		LLPS-Sus-0173	ENSSSCG00000011889.4	I6YP72	GSK3B
41		LLPS-Sus-2132	ENSSSCG00000005096.3	F1SRU5	HIF1A
42		LLPS-Sus-4205	ENSSSCG00000003101.3	F1RM22	HIF3A
43		LLPS-Sus-1360	ENSSSCG00000026733.2	I3LHT2	HIPK2
44		LLPS-Sus-3475	ENSSSCG00000000288.3	A0A286ZPE3	HNRNPA1
45		LLPS-Sus-2441	ENSSSCG00000036350.1	A0A286ZI52	HNRNPA2B1
46		LLPS-Sus-0418	ENSSSCG00000022760.2	I3LQS0	HNRNPK
47		LLPS-Sus-3356	ENSSSCG00000009334.3	F1RST0	HSPH1
48		LLPS-Sus-0890	ENSSSCG00000028553.3	K7GS49	ILF2
49		LLPS-Sus-2155	ENSSSCG00000013638.4	K7GP99	ILF3
50		LLPS-Sus-3813	ENSSSCG00000015570.3	A0A287B5G3	IVNS1ABP
51		LLPS-Sus-2201	ENSSSCG00000029005.2	I3LS70	KPNA2
52		LLPS-Sus-1566	ENSSSCG00000016509.3	A0A287A3H0	LOC102162486
53		LLPS-Sus-1205	ENSSSCG00000007979.3	A0A287AC67	LUC7L
54		LLPS-Sus-3549	ENSSSCG00000003849.3	F1S766	MAGOH
55		LLPS-Sus-4688	ENSSSCG00000008316.3	F1SLE3	NAGK
56		LLPS-Sus-3331	ENSSSCG00000012613.4	F1RUA7	NKAP
57		LLPS-Sus-0557	ENSSSCG00000013107.3	B2CCY7	nmp-200
58		LLPS-Sus-0568	ENSSSCG00000023245.2	I3LSU1	NONO
59		LLPS-Sus-1222	ENSSSCG00000029154.2	F1RHW0	NOSIP
60		LLPS-Sus-1737	ENSSSCG00000005588.4	P79387	NR5A1
61		LLPS-Sus-0136	ENSSSCG00000017795.3	A0A286ZTW4	NSRP1
62		LLPS-Sus-2023	ENSSSCG00000038471.1	A0A287B415	NUAK2
63		LLPS-Sus-4629	ENSSSCG00000022866.2	I3LNX4	NXF1
64		LLPS-Sus-3834	ENSSSCG00000011549.3	F1SQF9	OGG1
65		LLPS-Sus-3239	ENSSSCG00000011713.3	F1SJN2	P2RY12
66		LLPS-Sus-0857	ENSSSCG00000027224.2	I3LEC2	PCBP1
67		LLPS-Sus-1815	ENSSSCG00000008996.3	F1RX38	PLRG1
68		LLPS-Sus-2898	ENSSSCG00000022828.2	F1SIQ0	PNN
69		LLPS-Sus-4517	ENSSSCG00000031123.1	A0A287BSX1	PPIG
70		LLPS-Sus-1333	ENSSSCG00000017817.3	F1RHH8	PRPF8
71		LLPS-Sus-2460	ENSSSCG00000005072.3	F1SSL6	PSMA3
72		LLPS-Sus-0940	ENSSSCG00000009569.3	A0A286ZKW2	PSPC1
73		LLPS-Sus-1420	ENSSSCG00000013421.3	A0A286ZKQ3	PTBP1
74		LLPS-Sus-3878	ENSSSCG00000005719.3	F1S0W0	RAPGEF1
75		LLPS-Sus-2186	ENSSSCG00000011134.3	F1RUL1	RBM17
76		LLPS-Sus-1330	ENSSSCG00000026700.2	I3LPP8	RBM23
77		LLPS-Sus-3639	ENSSSCG00000032739.1	I3LK87	RBMX2
78		LLPS-Sus-3934	ENSSSCG00000034728.1	A0A287B7J8	RNF151
79		LLPS-Sus-3521	ENSSSCG00000008048.3	F1RFA3	RNPS1
80		LLPS-Sus-0493	ENSSSCG00000000364.3	F1SPJ5	SARNP
81		LLPS-Sus-3885	ENSSSCG00000013021.3	A0A287AZ25	SF1
82		LLPS-Sus-1313	ENSSSCG00000010002.3	F1RFD3	SF3A1
83		LLPS-Sus-0201	ENSSSCG00000039757.1	A0A287AN25	SF3A2
84		LLPS-Sus-0016	ENSSSCG00000003643.3	F1SV40	SF3A3
85		LLPS-Sus-1559	ENSSSCG00000016075.3	F1SMZ9	SF3B1
86		LLPS-Sus-0045	ENSSSCG00000035690.1	A0A287A4F2	SFPQ
87		LLPS-Sus-2037	ENSSSCG00000004952.3	P84024	SMAD3
88		LLPS-Sus-1971	ENSSSCG00000008127.3	K9J4V0	SNRNP200
89		LLPS-Sus-2168	ENSSSCG00000022212.2	I3LN96	SNRNP35
90		LLPS-Sus-0583	ENSSSCG00000023792.2	A0A287AJ85	SNRNP70
91		LLPS-Sus-4620	ENSSSCG00000002998.3	A0A2C9F345	SNRPA
92		LLPS-Sus-1377	ENSSSCG00000005786.3	F1RWS8	SNRPA1
93		LLPS-Sus-3600	ENSSSCG00000037602.1	Q06A96	SNRPB2
94		LLPS-Sus-1664	ENSSSCG00000023674.2	A0A287BK71	SON
95		LLPS-Sus-3987	ENSSSCG00000020796.3	I3LA15	SPOP
96		LLPS-Sus-1394	ENSSSCG00000023304.2	A0A287BBC3	SRRM2
97		LLPS-Sus-0529	ENSSSCG00000017626.3	Q3YLA6	SRSF1
98		LLPS-Sus-2078	ENSSSCG00000036293.1	A0A287B770	SRSF10
99		LLPS-Sus-0701	ENSSSCG00000003791.2	F6Q230	SRSF11
100		LLPS-Sus-2139	ENSSSCG00000036592.1	Q06A98	SRSF2
101		LLPS-Sus-3978	ENSSSCG00000001564.3	F1RY92	SRSF3
102		LLPS-Sus-1616	ENSSSCG00000003589.3	A0A287BH67	SRSF4
103		LLPS-Sus-1586	ENSSSCG00000008484.3	A0A287ASZ5	SRSF7
104		LLPS-Sus-0524	ENSSSCG00000009906.3	F1RJJ0	SRSF9
105		LLPS-Sus-0271	ENSSSCG00000017403.3	A0A2C9F3G4	STAT3
106		LLPS-Sus-0220	ENSSSCG00000035842.1	A7WLH8	SUMO1
107		LLPS-Sus-2655	ENSSSCG00000025618.2	A5D9J3	TAP1
108		LLPS-Sus-3571	ENSSSCG00000005382.4	K7GSM3	TGFBR1
109		LLPS-Sus-2409	ENSSSCG00000030225.2	Q06AA7	TRA2B
110		LLPS-Sus-3640	ENSSSCG00000011767.3	A0A287AVL3	TTC14
111		LLPS-Sus-0014	ENSSSCG00000034815.1	I3W8V7	U2AF2
112		LLPS-Sus-3566	ENSSSCG00000011684.3	F1SKE6	U2SURP
113		LLPS-Sus-0947	ENSSSCG00000028228.2	A0A287BHC9	XPO1
114		LLPS-Sus-4004	ENSSSCG00000035505.1	A0A287AZ94	YTHDC1
115		LLPS-Sus-0074	ENSSSCG00000028035.2	F1S6B2	ZC3H11A
116		LLPS-Sus-4519	ENSSSCG00000004725.3	A0A287A687	ZNF106
117		LLPS-Sus-3310	ENSSSCG00000040959.1	A0A286ZKV2	ZNF131
118		LLPS-Sus-3889	ENSSSCG00000037875.1	A0A287BSM5	ZNF688