DrLLPS - Data resource of LLPS

LLPS-Sus-0529
SRSF1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Serine/arginine-rich splicing factor 1; Splicing factor, arginine/serine-rich 1
Gene Name:	SRSF1, SFRS1
Ensembl Gene:	ENSSSCG00000017626.3
Ensembl Protein:	ENSSSCP00000045363.1
Organism:	Sus scrofa
Taxa ID:	9823
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Chromatin, Nuclear speckle, Nuclear stress body, Nucleolus, Stress granule, Chromatoid body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1134	Q07955	Client	Nuclear speckle, Nuclear stress body, Nucleolus, Stress granule	100.00	8e-95	286
Mus musculus	LLPS-Mum-2451	Q6PDM2	Client	Chromatin, Nuclear speckle, Nucleolus, Chromatoid body	100.00	8e-95	286

▼ FUNCTION

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSSSCT00000049897.1	ENSSSCP00000045363.1
Ensembl	ENSSSCT00000019188.3	ENSSSCP00000018680.2
Ensembl	ENSSSCT00000048013.1	ENSSSCP00000057405.1
Ensembl	ENSSSCT00000043811.1	ENSSSCP00000057414.1
UniProt		Q3YLA6, SRSF1_PIG
GeneBank	DQ098950, DQ098951	AAZ86088.1, AAZ86089.1
RefSeq	NM_001038007.1	NP_001033096.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE 60 61 FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE 120 121 NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF 180 181 RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR 240 241 HSRSRSHISE EMD 253
Nucleotide CDS Sequence (FASTA)
1 ATGTCGGGAG GTGGTGTGAT CCGTGGCCCG GCAGGGAACA ACGATTGCCG CATCTACGTG 60 61 GGTAACTTAC CTCCAGACAT CCGAACCAAG GACATTGAGG ACGTGTTCTA CAAATACGGT 120 121 GCTATCCGCG ACATCGACCT GAAGAATCGC CGCGGAGGAC CGCCCTTCGC CTTCGTTGAG 180 181 TTCGAGGACC CGCGAGACGC AGAAGACGCG GTGTATGGTC GCGACGGCTA TGATTACGAT 240 241 GGATACCGTC TGCGGGTGGA GTTTCCTCGA AGCGGCCGTG GTACCGGCCG AGGCGGCGGC 300 301 GGGGGTGGTG GCGGCGGGGC TCCCCGAGGG CGCTATGGCC CCCCATCCAG GCGTTCTGAA 360 361 AACAGAGTGG TTGTCTCTGG ACTGCCTCCA AGTGGAAGCT GGCAGGATTT GAAGGATCAC 420 421 ATGCGTGAAG CAGGTGATGT ATGTTATGCT GATGTTTACC GAGATGGCAC TGGTGTCGTG 480 481 GAGTTTGTAC GGAAAGAAGA TATGACCTAT GCAGTTCGAA AACTGGATAA CACTAAGTTT 540 541 AGATCTCATG AGGGAGAAAC TGCCTACATC CGGGTTAAAG TTGATGGGCC CAGAAGTCCA 600 601 AGTTATGGAA GATCTCGATC TCGAAGCCGT AGTCGTAGCA GAAGCCGTAG CAGAAGCAAC 660 661 AGCAGGAGTC GCAGTTATTC CCCAAGGAGA AGCAGAGGAT CACCACGCTA TTCTCCCCGT 720 721 CATAGCAGAT CTCGCTCTCG TACATAA 747

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-1017	Isopeptide bond
KW-0488	Methylation
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0677	Repeat
KW-0694	RNA-binding
KW-0747	Spliceosome
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0016607	Cellular Component	Nuclear speck
GO:0005654	Cellular Component	Nucleoplasm
GO:0005681	Cellular Component	Spliceosomal complex
GO:0003723	Molecular Function	RNA binding
GO:0000395	Biological Process	MRNA 5'-splice site recognition
GO:0045292	Biological Process	MRNA cis splicing, via spliceosome
GO:0000381	Biological Process	Regulation of alternative mRNA splicing, via spliceosome

▼ KEGG

ssc:654327

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Otg-3359	Otolemur garnettii	100.0	1e-95	288
LLPS-Orc-0704	Oryctolagus cuniculus	100.0	4e-85	268
LLPS-Rhb-2099	Rhinopithecus bieti	100.0	8e-95	286
LLPS-Urm-1562	Ursus maritimus	100.0	8e-95	286
LLPS-Pap-0426	Pan paniscus	100.0	8e-95	286
LLPS-Pat-1059	Pan troglodytes	100.0	8e-95	286
LLPS-Hos-1134	Homo sapiens	100.0	8e-95	286
LLPS-Fec-1311	Felis catus	100.0	8e-95	286
LLPS-Man-0581	Macaca nemestrina	100.0	8e-95	286
LLPS-Loa-2111	Loxodonta africana	100.0	2e-94	285
LLPS-Cas-1742	Carlito syrichta	100.0	8e-95	286
LLPS-Ict-1365	Ictidomys tridecemlineatus	100.0	8e-95	286
LLPS-Nol-0452	Nomascus leucogenys	100.0	8e-95	286
LLPS-Caf-0040	Canis familiaris	100.0	8e-95	286
LLPS-Poa-3274	Pongo abelii	100.0	8e-95	286
LLPS-Eqc-2624	Equus caballus	100.0	2e-94	285
LLPS-Cap-2500	Cavia porcellus	100.0	8e-95	286
LLPS-Mam-3610	Macaca mulatta	100.0	8e-95	286
LLPS-Gog-0595	Gorilla gorilla	100.0	8e-95	286
LLPS-Fud-3879	Fukomys damarensis	100.0	8e-95	286
LLPS-Caj-2205	Callithrix jacchus	100.0	8e-95	286
LLPS-Mea-4222	Mesocricetus auratus	100.0	8e-95	286
LLPS-Mum-2451	Mus musculus	100.0	8e-95	286
LLPS-Maf-1091	Macaca fascicularis	100.0	8e-95	286
LLPS-Cea-1735	Cercocebus atys	100.0	8e-95	286
LLPS-Aon-1081	Aotus nancymaae	100.0	8e-95	286
LLPS-Ran-1234	Rattus norvegicus	100.0	2e-94	285
LLPS-Ere-1044	Erinaceus europaeus	100.0	1e-86	266
LLPS-Mal-3635	Mandrillus leucophaeus	100.0	2e-94	285
LLPS-Paa-1197	Papio anubis	100.0	8e-95	286
LLPS-Myl-3687	Myotis lucifugus	100.0	2e-94	285
LLPS-Mup-3182	Mustela putorius furo	100.0	2e-94	285
LLPS-Tut-0652	Tursiops truncatus	100.0	2e-46	159
LLPS-Dio-3799	Dipodomys ordii	100.0	8e-95	286
LLPS-Bot-1743	Bos taurus	100.0	8e-95	286
LLPS-Chs-1049	Chlorocebus sabaeus	98.97	1e-93	283
LLPS-Gaga-3514	Gallus gallus	98.46	2e-92	280
LLPS-Anc-2220	Anolis carolinensis	97.95	7e-90	273
LLPS-Meg-2121	Meleagris gallopavo	97.92	2e-24	99.4
LLPS-Dar-2399	Danio rerio	96.88	6e-90	273
LLPS-Tag-2386	Taeniopygia guttata	96.05	2e-43	151
LLPS-Sah-4056	Sarcophilus harrisii	94.9	3e-91	276
LLPS-Aim-0087	Ailuropoda melanoleuca	94.36	7e-93	280
LLPS-Mod-0906	Monodelphis domestica	94.05	1e-83	259
LLPS-Leo-1373	Lepisosteus oculatus	91.79	7e-91	275
LLPS-Lac-2460	Latimeria chalumnae	91.15	4e-88	269
LLPS-Pes-0886	Pelodiscus sinensis	90.86	1e-76	239
LLPS-Pof-4024	Poecilia formosa	90.56	2e-78	241
LLPS-Icp-1570	Ictalurus punctatus	90.26	6e-90	273
LLPS-Gaa-1460	Gasterosteus aculeatus	90.0	3e-78	241
LLPS-Scf-0434	Scleropages formosus	89.69	8e-90	273
LLPS-Xet-1344	Xenopus tropicalis	89.23	3e-91	277
LLPS-Ova-3115	Ovis aries	89.23	1e-90	274
LLPS-Orl-1225	Oryzias latipes	89.12	2e-86	265
LLPS-Asm-1683	Astyanax mexicanus	88.83	5e-87	266
LLPS-Orn-2809	Oreochromis niloticus	88.72	1e-89	272
LLPS-Scm-0620	Scophthalmus maximus	86.14	8e-86	263
LLPS-Xim-4128	Xiphophorus maculatus	85.95	8e-76	241
LLPS-Ten-2072	Tetraodon nigroviridis	84.82	3e-84	259
LLPS-Tar-1375	Takifugu rubripes	84.82	4e-84	258
LLPS-Cii-1332	Ciona intestinalis	78.95	2e-35	130
LLPS-Fia-1605	Ficedula albicollis	76.92	2e-78	244
LLPS-Cis-0022	Ciona savignyi	74.32	2e-32	122
LLPS-Drm-0643	Drosophila melanogaster	66.67	5e-61	199
LLPS-Cae-0817	Caenorhabditis elegans	61.54	2e-55	185
LLPS-Pot-0308	Populus trichocarpa	59.44	1e-37	139
LLPS-Lep-0861	Leersia perrieri	59.31	4e-30	119
LLPS-Viv-1897	Vitis vinifera	58.66	1e-39	143
LLPS-Bro-1946	Brassica oleracea	58.29	2e-34	131
LLPS-Brr-3041	Brassica rapa	57.84	1e-34	131
LLPS-Brd-0789	Brachypodium distachyon	57.78	4e-40	145
LLPS-Orp-2382	Oryza punctata	57.63	1e-39	145
LLPS-Orm-1642	Oryza meridionalis	57.63	3e-39	145
LLPS-Orb-2396	Oryza barthii	57.63	2e-39	145
LLPS-Orgl-1540	Oryza glumaepatula	57.63	3e-39	145
LLPS-Glm-0327	Glycine max	57.38	9e-36	134
LLPS-Tru-0093	Triticum urartu	57.3	1e-40	147
LLPS-Mua-2036	Musa acuminata	56.98	2e-38	140
LLPS-Brn-1849	Brassica napus	56.84	2e-33	128
LLPS-Tra-1099	Triticum aestivum	56.83	6e-42	150
LLPS-Nia-1523	Nicotiana attenuata	56.67	2e-35	133
LLPS-Phv-1367	Phaseolus vulgaris	56.45	4e-35	132
LLPS-Mae-1980	Manihot esculenta	56.42	5e-36	134
LLPS-Hov-0641	Hordeum vulgare	56.42	1e-39	144
LLPS-Arl-0438	Arabidopsis lyrata	56.32	6e-34	130
LLPS-Thc-0814	Theobroma cacao	56.22	5e-39	143
LLPS-Art-1712	Arabidopsis thaliana	56.08	3e-34	130
LLPS-Sol-0408	Solanum lycopersicum	55.56	6e-26	105
LLPS-Sot-1501	Solanum tuberosum	55.43	2e-34	131
LLPS-Prp-1673	Prunus persica	55.36	8e-35	132
LLPS-Coc-2285	Corchorus capsularis	55.32	2e-37	137
LLPS-Orbr-1319	Oryza brachyantha	55.31	7e-38	141
LLPS-Gor-1720	Gossypium raimondii	55.31	2e-36	135
LLPS-Met-0143	Medicago truncatula	55.26	4e-33	129
LLPS-Org-0413	Oryza glaberrima	55.19	2e-38	142
LLPS-Orr-1107	Oryza rufipogon	54.95	3e-39	141
LLPS-Php-0185	Physcomitrella patens	54.92	2e-36	137
LLPS-Ors-0735	Oryza sativa	54.64	2e-38	142
LLPS-Ori-2054	Oryza indica	54.64	4e-38	142
LLPS-Hea-1202	Helianthus annuus	54.59	6e-33	129
LLPS-Dac-1280	Daucus carota	54.4	4e-33	126
LLPS-Orni-2176	Oryza nivara	54.1	7e-39	145
LLPS-Sei-0321	Setaria italica	54.1	4e-38	140
LLPS-Sem-0122	Selaginella moellendorffii	53.04	3e-37	137
LLPS-Cus-2248	Cucumis sativus	52.82	6e-34	129
LLPS-Vir-1995	Vigna radiata	51.96	2e-33	130
LLPS-Amt-2066	Amborella trichopoda	51.61	2e-38	141
LLPS-Chr-1562	Chlamydomonas reinhardtii	43.96	4e-26	108

LLPS-Sus-0529SRSF1

Protein Sequence

Nucleotide Sequence

LLPS-Sus-0529
SRSF1