Rattus norvegicus      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 46 genes.  Reviewed (14 or Unreviewed (32

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ran-0011
ENSRNOG00000042458.3
F1LN29
2
LLPS-Ran-0023
ENSRNOG00000000204.7
3
LLPS-Ran-0049
ENSRNOG00000009152.7
Q5M9G3
Caprin1
4
LLPS-Ran-0045
ENSRNOG00000009432.4
P68101
Eif2s1
5
LLPS-Ran-0010
ENSRNOG00000052343.3
P63074
Eif4e
6
LLPS-Ran-0016
ENSRNOG00000023601.6
O09032
Elavl4
7
LLPS-Ran-0041
ENSRNOG00000057464.1
Q80WE1
Fmr1
8
LLPS-Ran-0004
ENSRNOG00000011175.8
A7VJC2
Hnrnpa2b1
9
LLPS-Ran-0026
ENSRNOG00000046794.1
Q91V33
Khdrbs1
10
LLPS-Ran-0046
ENSRNOG00000020155.7
P49185
Mapk8
11
LLPS-Ran-0025
ENSRNOG00000003689.6
Q5FVM4
Nono
12
LLPS-Ran-0047
ENSRNOG00000020782.7
Q4KLH4
Pspc1
13
LLPS-Ran-0032
ENSRNOG00000058461.1
A0A0G2K8K0
Sfpq
14
LLPS-Ran-0040
ENSRNOG00000007781.6
Q9ET50
Stau1
15
LLPS-Ran-3202
ENSRNOG00000019062.6
16
LLPS-Ran-0467
ENSRNOG00000036687.3
D3ZXH7
Alyref
17
LLPS-Ran-3628
ENSRNOG00000015999.6
P60825
Cirbp
18
LLPS-Ran-2711
ENSRNOG00000033169.5
A0A0G2K3Y6
Cpeb4
19
LLPS-Ran-1195
ENSRNOG00000006652.6
Q641Y8
Ddx1
20
LLPS-Ran-0361
ENSRNOG00000023383.6
A0A0G2K719
Ddx3x
21
LLPS-Ran-1250
ENSRNOG00000030680.4
Q6AYI1
Ddx5
22
LLPS-Ran-2672
ENSRNOG00000009439.6
P62630
Eef1a1
23
LLPS-Ran-4017
ENSRNOG00000013393.6
D3ZUV3
Eif2a
24
LLPS-Ran-0996
ENSRNOG00000017447.5
Q6P685
Eif2s2
25
LLPS-Ran-3380
ENSRNOG00000060048.2
C9WPN6
Eif2s3y
26
LLPS-Ran-0538
ENSRNOG00000009437.7
A0A140UHY3
Ewsr1
27
LLPS-Ran-1306
ENSRNOG00000051480.1
Q5XI81
Fxr1
28
LLPS-Ran-2098
ENSRNOG00000011876.7
B1H2A6
Fxr2
29
LLPS-Ran-0914
ENSRNOG00000013186.6
D3ZYS7
G3bp1
30
LLPS-Ran-1271
ENSRNOG00000036839.4
P04256
Hnrnpa1
31
LLPS-Ran-1556
ENSRNOG00000003645.8
Q9QX81
Hnrnpab
32
LLPS-Ran-0717
ENSRNOG00000002292.8
Q9JJ54
Hnrnpd
33
LLPS-Ran-1109
ENSRNOG00000033790.4
Q6IMY8
Hnrnpu
34
LLPS-Ran-4414
ENSRNOG00000039876.4
F1M3H8
LOC681410
35
LLPS-Ran-3319
ENSRNOG00000018273.7
P13383
Ncl
36
LLPS-Ran-a066
ENSRNOG00000019435.6
Q9ESQ7
Psd
37
LLPS-Ran-2156
ENSRNOG00000005387.6
Q925G0
Rbm3
38
LLPS-Ran-1200
ENSRNOG00000013328.8
F1M9Y9
Rbpms
39
LLPS-Ran-4788
ENSRNOG00000001618.7
D4AAK5
Ripk4
40
LLPS-Ran-0241
ENSRNOG00000016896.8
P21531
Rpl3
41
LLPS-Ran-2523
ENSRNOG00000004813.5
Q6AYT3
Rtcb
42
LLPS-Ran-2594
ENSRNOG00000000340.7
Q6QI16
Rtraf
43
LLPS-Ran-0395
ENSRNOG00000007992.6
Q4KM38
Srsf10
44
LLPS-Ran-3957
ENSRNOG00000010124.7
D3ZQG6
Trim2
45
LLPS-Ran-4223
ENSRNOG00000018356.6
O70277
Trim3
46
LLPS-Ran-3645
ENSRNOG00000036833.4
B2RYC6
Zfp385a