Homo sapiens      Mitochondrial RNA granule


※ Mitochondrial RNA granule introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Mitochondrial RNA granules is a kind of these bodies of spherical shape that located in mitochondria with mitochondrial mRNAs and mitochondrial ribosomes components and it’s proved to be related to the posttranscriptional RNA processing and biogenesis of mitochondrial ribosomes (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 42 genes.  Reviewed (42 or Unreviewed (0

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-0559
ENSG00000124608.4
Q5JTZ9
AARS2
2
LLPS-Hos-0287
ENSG00000117593.10
Q6PI48
DARS2
3
LLPS-Hos-2885
ENSG00000182810.6
Q9NUL7
DDX28
4
LLPS-Hos-1813
ENSG00000132153.14
Q7L2E3
DHX30
5
LLPS-Hos-0021
ENSG00000132591.11
O75616
ERAL1
6
LLPS-Hos-2417
ENSG00000164896.19
Q14296
FASTK
7
LLPS-Hos-2757
ENSG00000138399.17
Q53R41
FASTKD1
8
LLPS-Hos-2844
ENSG00000118246.13
Q9NYY8
FASTKD2
9
LLPS-Hos-1771
ENSG00000215251.3
Q7L8L6
FASTKD5
10
LLPS-Hos-0380
ENSG00000132463.13
Q12849
GRSF1
11
LLPS-Hos-1830
ENSG00000072506.12
Q99714
HSD17B10
12
LLPS-Hos-0611
ENSG00000100890.15
O15091
KIAA0391
13
LLPS-Hos-2060
ENSG00000156026.14
Q8NE86
MCU
14
LLPS-Hos-2462
ENSG00000082212.12
P23368
ME2
15
LLPS-Hos-1256
ENSG00000274853.2
Q6IN84
MRM1
16
LLPS-Hos-2583
ENSG00000122687.17
Q9UI43
MRM2
17
LLPS-Hos-1337
ENSG00000171861.10
Q9HC36
MRM3
18
LLPS-Hos-1820
ENSG00000115364.13
P49406
MRPL19
19
LLPS-Hos-0852
ENSG00000055950.16
Q8N983
MRPL43
20
LLPS-Hos-0322
ENSG00000136522.13
Q9HD33
MRPL47
21
LLPS-Hos-2156
ENSG00000113048.16
Q92552
MRPS27
22
LLPS-Hos-1626
ENSG00000102738.7
Q92665
MRPS31
23
LLPS-Hos-1964
ENSG00000125445.10
Q9Y2R9
MRPS7
24
LLPS-Hos-1747
ENSG00000135972.8
P82933
MRPS9
25
LLPS-Hos-2460
ENSG00000156469.8
Q96E29
MTERF3
26
LLPS-Hos-1420
ENSG00000107951.14
Q9NVV4
MTPAP
27
LLPS-Hos-1260
ENSG00000160703.15
Q86UT6
NLRX1
28
LLPS-Hos-1717
ENSG00000084092.6
Q8NC60
NOA1
29
LLPS-Hos-1285
ENSG00000105819.13
O75439
PMPCB
30
LLPS-Hos-1832
ENSG00000138035.14
Q8TCS8
PNPT1
31
LLPS-Hos-1409
ENSG00000099821.13
O00411
POLRMT
32
LLPS-Hos-0532
ENSG00000106246.17
O75127
PTCD1
33
LLPS-Hos-1101
ENSG00000049883.14
Q8WV60
PTCD2
34
LLPS-Hos-2324
ENSG00000156990.14
Q6P087
RPUSD3
35
LLPS-Hos-1694
ENSG00000165526.8
Q96CM3
RPUSD4
36
LLPS-Hos-1303
ENSG00000172340.14
Q96I99
SUCLG2
37
LLPS-Hos-0912
ENSG00000156502.13
Q8IYB8
SUPV3L1
38
LLPS-Hos-0141
ENSG00000029639.10
Q8WVM0
TFB1M
39
LLPS-Hos-1483
ENSG00000174173.6
Q7L0Y3
TRMT10C
40
LLPS-Hos-0946
ENSG00000167112.9
O95900
TRUB2
41
LLPS-Hos-0148
ENSG00000107815.9
Q96RR1
TWNK
42
LLPS-Hos-1593
ENSG00000136758.18
Q96TA2
YME1L1