LLPS-Hos-1771
FASTKD5
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | FAST kinase domain-containing protein 5, mitochondrial |
| Gene Name: | FASTKD5, KIAA1792 |
| Ensembl Gene: | ENSG00000215251.3 |
| Ensembl Protein: | ENSP00000369618.3 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Mitochondrial RNA granule | "...NLRX1 interacts with FASTKD5 and colocalizes with mitochondrial RNA granules." | HEK293 cells | 29932989 |
| Mitochondrial RNA granule | "...Composition of the MRGs." | N/A | 26953349 |
| Mitochondrial RNA granule | "...More recently, the three family members, namely FASTK, FASTKD2, and FASTKD5, have been reported to localize to mitochondrial RNA granules, which are considered centers for post-transcriptional RNA processing and ribosome biogenesis." | N/A | 27789713 |
▼ FUNCTION
| Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000380266.3 | ENSP00000369618.3 |
| UniProt | Q7L8L6, FAKD5_HUMAN, Q96JN3, Q9H5D1, Q9H8Y3 | |
| GeneBank | AL121891, BC011856, BC007413, AK023211, AK027215, AB058695 | AAH07413.1, BAB47421.1, BAB14464.1, AAH11856.1, BAB15696.1 |
| RefSeq | NM_021826.4 | NP_068598.1 |
| Entrez | 60493 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC HSAKKVKNIC 60 61 STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG VDEEDVEVFD SFENMRVFLQ 120 121 LRPEYRVHSY NASETSQLLS VSEGELILHK VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV 180 181 LLGSTSFALL CQLSVKKIQL FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN 240 241 MDQLLLVADL WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ 300 301 KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH LSSRSLVNIV 360 361 KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC SALRFLNEGV MNAVAASLPP 420 421 RVAHCRSKDV AKILWSFGTL NYKPPNAEEF YSSLISEIHR KMPEFNQYPE HLPTCLLGLA 480 481 FLEYFPVELI DFALSPGFVR LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE 540 541 GSELLWYLAE KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP 600 601 LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP GQQPMELENK 660 661 AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ FTNRNQYCYG SRDLLGLHNM 720 721 KRRQLARLGY RVVELSYWEW LPLLKRTRLE KLAFLHEKVF TSAL 764 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGCTA CTCTCAAGTC ATTAAAACTT GTAAGATACC GAGCATTTTG CAGTCCTTCT 60 61 GCCTTTGGTG CAGTCCGAAG TGTGTCATAC TGGAATGTGA GCAGCACACA GCATGGGGGA 120 121 CAGGACCCTC CAGAACACAT TAGCCTCTGC CATTCTGCCA AAAAAGTTAA GAACATATGT 180 181 AGCACCTTCT CTTCTCGGAG AATCCTGACA ACCAGCAGTG CCCACCCAGG TTTGGAATTC 240 241 AGCAAGACTT CTTCCTCTAA GGCCAGTACA TTGCAGCTGG GCTCACCCAG GGCCACAGGA 300 301 GTTGATGAAG AGGACGTAGA AGTGTTTGAT TCCTTTGAAA ACATGCGAGT TTTCCTACAG 360 361 CTAAGACCAG AATACCGTGT TCACAGCTAT AATGCATCTG AGACTTCTCA GCTCCTGTCT 420 421 GTTTCAGAAG GTGAACTAAT TTTGCACAAA GTCAGAGTTA ATCAAAATAA TCTCCAGGCT 480 481 CAAGTCATTG TTGATTATTT GTGTAAGCTG AGCTCTTTGC CTGCAGAGCA GCATCCTGTC 540 541 TTGCTGGGCA GTACCAGCTT TGCTCTGCTC TGCCAGCTGA GTGTGAAGAA GATACAGCTC 600 601 TTTGATACCC AAGATCTGAT CAATGTTTTG AAAGCTTTTG TCATTTTAGG AATCCCTCAC 660 661 TCCCATTCAA TGCTAGATGT GTATGAGACC AAGTGTTGCC ATCAGGTATG GGAGATGAAT 720 721 ATGGATCAGC TCCTTTTGGT GGCTGATCTC TGGAGGTACT TAGGCCGCAA AGTACCTAGG 780 781 TTTTTAAACA TTTTTTCTAG TTATCTTAAT TTGCACTGGA AGGATCTATC CTTGTCTCAG 840 841 CTAGTTCACT TAATTTATGT TATAGGTGAA AATCGTCAGG TATCCCAGGA CCTAATGCAA 900 901 AAATTGGAAT CATTGATCCT TAAATATATA GATTTGATCA ATTTGGAGGA GGTTGGTACC 960 961 ATCTGTTTGG GGTTCTTTAA ATCAAGTACT AATCTCTCTG AATTTGTCAT GCGGAAAATT 1020 1021 GGAGACTTGG CTTGTGCTAA CATTCAGCAT CTGAGTAGTC GCTCCTTAGT GAATATTGTT 1080 1081 AAAATGTTCC GTTTCACTCA CGTGGATCAC ATCAATTTCA TGAAGCAGAT TGGAGAGATA 1140 1141 GCTCCTCAGC GAATTCCTTC CCTGGGAGTT CAAGGTGTCA TGCACCTGAC TCTTTACTGC 1200 1201 TCGGCCTTAC GCTTCCTGAA TGAAGGAGTA ATGAATGCAG TGGCTGCGTC TTTGCCTCCT 1260 1261 AGAGTGGCAC ACTGTCGAAG TAAAGATGTT GCCAAGATTC TGTGGTCATT TGGAACTCTG 1320 1321 AATTATAAGC CACCCAATGC AGAAGAATTT TACTCCAGCC TGATAAGTGA GATTCACAGA 1380 1381 AAGATGCCTG AATTCAACCA GTACCCAGAA CACCTGCCCA CCTGCCTGCT GGGCCTGGCA 1440 1441 TTTTTGGAGT ACTTTCCAGT AGAGTTAATT GATTTCGCTC TCAGTCCAGG GTTTGTCAGG 1500 1501 TTAGCTCAGG AGAGAACTAA GTTTGACCTC CTTAAGGAAC TATATACCCT CGATGGTACA 1560 1561 GTTGGCATTG AGTGTCCAGA TTACAGAGGC AATCGTCTTA GTACTCACCT TCAGCAAGAG 1620 1621 GGGTCTGAAT TGCTGTGGTA TTTAGCAGAG AAGGATATGA ATTCAAAGCC TGAATTCTTA 1680 1681 GAAACTGTCT TTTTACTGGA GACCATGCTG GGGGGGCCCC AGTACGTCAA GCACCATATG 1740 1741 ATTTTGCCTC ATACCCGATC TTCTGACTTA GAGGTCCAGC TTGATGTTAA CCTGAAGCCA 1800 1801 TTACCATTTA ATAGAGAAGC CACGCCGGCT GAAAATGTAG CCAAATTAAG GCTTGAGCAT 1860 1861 GTGGGAGTCA GCCTTACAGA TGATTTGATG AATAAGTTAC TAAAAGGGAA AGCAAGAGGA 1920 1921 CATTTCCAGG GCAAAACTGA GTCAGAGCCT GGGCAGCAGC CCATGGAGTT GGAGAATAAG 1980 1981 GCAGCTGTAC CTCTGGGGGG CTTCCTTTGC AATGTAGCAG ATAAATCAGG GGCCATGGAG 2040 2041 ATGGCTGGCC TGTGCCCCGC AGCCTGCATG CAGACCCCAA GAATGAAGCT GGCTGTTCAG 2100 2101 TTCACAAACA GGAACCAGTA TTGCTATGGC TCCAGGGATC TCCTTGGACT GCACAATATG 2160 2161 AAGAGGCGGC AGCTGGCTCG GCTTGGCTAC CGTGTGGTAG AGTTATCCTA CTGGGAATGG 2220 2221 CTCCCACTAC TGAAACGAAC TCGCTTAGAA AAGTTGGCGT TTCTTCATGA GAAAGTATTC 2280 2281 ACCTCTGCTC TCTGA 2295 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial nucleoid | |
Cellular Component | Mitochondrion | |
Cellular Component | Ribonucleoprotein granule | |
Molecular Function | Protein kinase activity | |
Molecular Function | RNA binding | |
Molecular Function | RRNA binding | |
Biological Process | Cellular respiration | |
Biological Process | Mitochondrial RNA processing | |
Biological Process | MRNA processing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-4315 | Macaca mulatta | 94.63 | 0.0 | 1455 |
| LLPS-Nol-3501 | Nomascus leucogenys | 91.36 | 0.0 | 1402 |
| LLPS-Caj-0173 | Callithrix jacchus | 86.61 | 0.0 | 1345 |
| LLPS-Eqc-1665 | Equus caballus | 82.22 | 0.0 | 1282 |
| LLPS-Myl-0332 | Myotis lucifugus | 80.42 | 0.0 | 1261 |
| LLPS-Bot-4531 | Bos taurus | 79.87 | 0.0 | 1237 |
| LLPS-Otg-0448 | Otolemur garnettii | 79.35 | 0.0 | 1224 |
| LLPS-Orc-1943 | Oryctolagus cuniculus | 78.3 | 0.0 | 1206 |
| LLPS-Urm-4000 | Ursus maritimus | 77.46 | 0.0 | 1200 |
| LLPS-Aim-4094 | Ailuropoda melanoleuca | 76.7 | 0.0 | 1189 |
| LLPS-Mup-0852 | Mustela putorius furo | 76.44 | 0.0 | 1171 |
| LLPS-Caf-2884 | Canis familiaris | 76.08 | 0.0 | 1169 |
| LLPS-Dio-0200 | Dipodomys ordii | 75.95 | 0.0 | 1176 |
| LLPS-Mea-4231 | Mesocricetus auratus | 75.16 | 0.0 | 1176 |
| LLPS-Fud-1263 | Fukomys damarensis | 74.51 | 0.0 | 1148 |
| LLPS-Mum-3615 | Mus musculus | 73.46 | 0.0 | 1136 |
| LLPS-Cap-2160 | Cavia porcellus | 72.29 | 0.0 | 1100 |
| LLPS-Ora-0074 | Ornithorhynchus anatinus | 63.32 | 6e-157 | 468 |
| LLPS-Sah-2742 | Sarcophilus harrisii | 61.96 | 0.0 | 919 |
| LLPS-Pes-1897 | Pelodiscus sinensis | 54.35 | 0.0 | 699 |
| LLPS-Xet-2815 | Xenopus tropicalis | 52.36 | 0.0 | 704 |
| LLPS-Fia-2506 | Ficedula albicollis | 49.39 | 0.0 | 627 |
| LLPS-Lac-0504 | Latimeria chalumnae | 48.69 | 0.0 | 729 |
| LLPS-Tag-3150 | Taeniopygia guttata | 48.27 | 0.0 | 629 |
| LLPS-Meg-0915 | Meleagris gallopavo | 45.88 | 0.0 | 665 |
| LLPS-Gaa-2900 | Gasterosteus aculeatus | 43.79 | 1e-98 | 316 |
| LLPS-Ten-0727 | Tetraodon nigroviridis | 42.41 | 5e-96 | 309 |
| LLPS-Leo-3786 | Lepisosteus oculatus | 42.12 | 6e-82 | 272 |
| LLPS-Scf-1820 | Scleropages formosus | 39.82 | 1e-155 | 478 |
| LLPS-Tar-4002 | Takifugu rubripes | 39.55 | 1e-155 | 478 |
| LLPS-Asm-1838 | Astyanax mexicanus | 39.39 | 3e-155 | 476 |
| LLPS-Xim-2233 | Xiphophorus maculatus | 38.99 | 4e-156 | 478 |
| LLPS-Pof-0728 | Poecilia formosa | 38.74 | 7e-156 | 480 |
| LLPS-Icp-4037 | Ictalurus punctatus | 38.6 | 1e-160 | 491 |
| LLPS-Orl-2686 | Oryzias latipes | 37.17 | 1e-148 | 461 |
| LLPS-Orn-2046 | Oreochromis niloticus | 36.75 | 1e-154 | 477 |
| LLPS-Scm-2083 | Scophthalmus maximus | 36.09 | 6e-140 | 436 |
| LLPS-Gaga-3163 | Gallus gallus | 24.93 | 4e-13 | 77.4 |
| LLPS-Anp-1896 | Anas platyrhynchos | 23.94 | 3e-13 | 78.2 |
| LLPS-Aon-4165 | Aotus nancymaae | 23.32 | 5e-07 | 57.8 |
| LLPS-Anc-1676 | Anolis carolinensis | 22.89 | 8e-14 | 79.7 |
| LLPS-Dar-3383 | Danio rerio | 22.82 | 3e-16 | 87.0 |
| LLPS-Drm-0672 | Drosophila melanogaster | 22.54 | 6e-16 | 85.9 |
| LLPS-Ova-0362 | Ovis aries | 22.04 | 1e-15 | 85.5 |
| LLPS-Chs-4159 | Chlorocebus sabaeus | 21.84 | 2e-12 | 75.1 |
| LLPS-Pap-4550 | Pan paniscus | 21.84 | 2e-11 | 71.6 |
| LLPS-Pat-3681 | Pan troglodytes | 21.84 | 2e-11 | 71.6 |
| LLPS-Ran-2342 | Rattus norvegicus | 21.78 | 3e-13 | 77.8 |
| LLPS-Fec-3809 | Felis catus | 21.76 | 6e-13 | 76.6 |
| LLPS-Gog-4353 | Gorilla gorilla | 21.59 | 7e-11 | 70.1 |
| LLPS-Mal-3986 | Mandrillus leucophaeus | 21.58 | 1e-11 | 72.4 |
| LLPS-Paa-3531 | Papio anubis | 21.58 | 2e-11 | 72.0 |
| LLPS-Maf-3994 | Macaca fascicularis | 21.58 | 2e-11 | 72.0 |
| LLPS-Cea-0727 | Cercocebus atys | 21.58 | 1e-11 | 72.4 |
| LLPS-Man-0554 | Macaca nemestrina | 21.58 | 2e-11 | 72.0 |
| LLPS-Rhb-2810 | Rhinopithecus bieti | 21.11 | 1e-11 | 72.4 |
| LLPS-Ict-0883 | Ictidomys tridecemlineatus | 20.98 | 3e-08 | 61.6 |
| LLPS-Mod-3259 | Monodelphis domestica | 20.69 | 3e-09 | 64.7 |
| LLPS-Loa-3686 | Loxodonta africana | 19.9 | 1e-09 | 65.9 |