Rattus norvegicus      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ran-3270
ENSRNOG00000029773.5
D4ACL8
Atm
2
LLPS-Ran-4608
ENSRNOG00000010027.7
D3Z822
Atr
3
LLPS-Ran-0549
ENSRNOG00000023360.4
Q5PQK2
Fus
4
LLPS-Ran-1778
ENSRNOG00000010386.4
D3ZXP3
H2afx
5
LLPS-Ran-1575
ENSRNOG00000009568.6
Q4QQW4
Hdac1
6
LLPS-Ran-4652
ENSRNOG00000051838.1
A0A0G2K752
LOC680989
7
LLPS-Ran-3715
ENSRNOG00000025028.7
D3ZTN0
Prkdc
8
LLPS-Ran-2709
ENSRNOG00000033065.5
Q9JIL8
Rad50
9
LLPS-Ran-1257
ENSRNOG00000037302.3
B5DF04
Rad51
10
LLPS-Ran-1725
ENSRNOG00000010595.5
Q8CFD1
Rbm45
11
LLPS-Ran-0997
ENSRNOG00000013837.8
F1M842
Tp53bp1