LLPS-Ran-1575
Hdac1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Histone deacetylase 1
Gene Name: Hdac1
Ensembl Gene: ENSRNOG00000009568.6
Ensembl Protein: ENSRNOP00000012854.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatin, DNA damage foci, Nucleolus, PML nuclear body, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAQTQGTKRK  VCYYYDGDVG  NYYYGQGHPM  KPHRIRMTHN  LLLNYGLYRK  MEIYRPHKAN  60
61    AEEMTKYHSD  DYIKFLRSIR  PDNMSEYSKQ  MQRFNVGEDC  PVFDGLFEFC  QLSTGGSVAS  120
121   AVKLNKQQTD  IAVNWAGGLH  HAKKSEASGF  CYVNDIVLAI  LELLKYHQRV  LYIDIDIHHG  180
181   DGVEEAFYTT  DRVMTVSFHK  YGEYFPGTGD  LRDIGAGKGK  YYAVNYPLRD  GIDDESYEAI  240
241   FKPVMSKVME  MFQPSAVVLQ  CGSDSLSGDR  LGCFNLTIKG  HAKCVEFVKS  FNLPMLMLGG  300
301   GGYTIRNVAR  CWTYETAVAL  DTEIPNELPY  NDYFEYFGPD  FKLHISPSNM  TNQNTNEYLE  360
361   KIKQRLFENL  RMLPHAPGVQ  MQAIPEDAIP  EESGDEDEED  PDKRISICSS  DKRIACEEEF  420
421   SDSDEEGEGG  RKNSSNFKKA  KRVKTEDEKE  KDPEEKKEVT  EEEKTKEEKP  EAKGVKEEVK  480
481   MA  482
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCAGA  CTCAGGGCAC  CAAGAGGAAA  GTCTGTTACT  ACTACGACGG  GGATGTTGGA  60
61    AACTACTATT  ATGGACAAGG  GCACCCAATG  AAGCCTCACC  GAATCCGAAT  GACTCATAAT  120
121   TTGCTGCTCA  ACTATGGTCT  CTACCGAAAA  ATGGAAATCT  ATCGTCCTCA  CAAAGCCAAC  180
181   GCTGAGGAGA  TGACCAAGTA  CCACAGCGAC  GACTACATCA  AGTTCTTGCG  TTCTATTCGC  240
241   CCAGACAATA  TGTCTGAATA  CAGCAAGCAG  ATGCAGAGAT  TCAACGTGGG  TGAGGACTGT  300
301   CCGGTATTTG  ATGGCTTGTT  TGAGTTCTGT  CAGTTGTCCA  CGGGTGGCTC  TGTCGCGAGT  360
361   GCTGTGAAAC  TCAATAAGCA  GCAGACGGAC  ATCGCTGTGA  ACTGGGCTGG  GGGCCTGCAC  420
421   CATGCGAAGA  AGTCTGAAGC  ATCCGGCTTC  TGTTACGTCA  ATGATATTGT  CTTGGCCATC  480
481   CTGGAACTGC  TAAAGTATCA  CCAGAGGGTG  CTGTATATTG  ACATTGACAT  TCACCATGGC  540
541   GATGGCGTGG  AAGAGGCCTT  CTATACCACA  GACCGGGTCA  TGACTGTGTC  CTTTCATAAA  600
601   TACGGAGAGT  ACTTCCCAGG  AACTGGGGAC  CTACGGGATA  TTGGGGCTGG  CAAAGGCAAG  660
661   TACTACGCCG  TTAACTACCC  ACTGCGAGAT  GGCATTGATG  ATGAGTCCTA  TGAAGCCATC  720
721   TTTAAGCCAG  TCATGTCCAA  AGTAATGGAG  ATGTTCCAGC  CTAGTGCAGT  GGTCCTACAG  780
781   TGCGGCTCAG  ACTCCCTGTC  TGGGGATCGG  CTAGGTTGCT  TCAATCTGAC  CATCAAAGGA  840
841   CATGCCAAGT  GTGTGGAGTT  CGTGAAGAGT  TTCAACTTGC  CGATGCTAAT  GTTGGGAGGA  900
901   GGTGGCTATA  CCATCCGTAA  TGTCGCTCGG  TGCTGGACTT  ACGAGACAGC  TGTGGCCCTG  960
961   GACACAGAGA  TCCCTAATGA  GCTACCATAC  AATGACTACT  TTGAATACTT  TGGACCAGAT  1020
1021  TTCAAGCTTC  ACATCAGCCC  TTCCAATATG  ACTAACCAGA  ACACTAATGA  ATACCTGGAG  1080
1081  AAGATCAAGC  AGCGGCTCTT  TGAGAACTTG  AGAATGCTGC  CCCATGCCCC  TGGGGTCCAA  1140
1141  ATGCAGGCCA  TCCCAGAGGA  TGCCATCCCA  GAAGAGAGCG  GTGATGAGGA  TGAGGAAGAC  1200
1201  CCTGACAAAC  GAATTTCCAT  CTGCTCCTCT  GACAAACGCA  TTGCCTGTGA  GGAGGAATTC  1260
1261  TCTGATTCTG  ATGAGGAGGG  AGAAGGAGGT  CGCAAGAACT  CTTCTAACTT  CAAAAAAGCC  1320
1321  AAAAGAGTCA  AAACAGAAGA  TGAAAAAGAA  AAAGATCCCG  AGGAGAAAAA  AGAAGTCACA  1380
1381  GAAGAGGAGA  AAACCAAGGA  GGAGAAGCCA  GAAGCCAAAG  GGGTCAAAGA  AGAGGTCAAG  1440
1441  ATGGCCTGA  1449

▼ KEYWORD

ID
Family
Acetylation
Biological rhythms
Chromatin regulator
Complete proteome
Hydrolase
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome
Repressor
S-nitrosylation
Transcription
Transcription regulation
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromatin
Cellular Component
Heterochromatin
Cellular Component
Histone deacetylase complex
Cellular Component
Neuron projection
Cellular Component
Neuronal cell body
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
NuRD complex
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Protein-containing complex
Cellular Component
Sin3-type complex
Cellular Component
Transcription factor complex
Molecular Function
Chromatin binding
Molecular Function
Deacetylase activity
Molecular Function
DNA-binding transcription factor activity
Molecular Function
E-box binding
Molecular Function
Histone deacetylase activity
Molecular Function
Krueppel-associated box domain binding
Molecular Function
NAD-dependent histone deacetylase activity (H3-K14 specific)
Molecular Function
Promoter-specific chromatin binding
Molecular Function
Protein-containing complex binding
Molecular Function
RNA polymerase II repressing transcription factor binding
Molecular Function
Transcription corepressor activity
Molecular Function
Transcription factor binding
Molecular Function
Transcription regulatory region sequence-specific DNA binding
Biological Process
Cellular response to oxidative stress
Biological Process
Cellular response to tumor necrosis factor
Biological Process
Circadian regulation of gene expression
Biological Process
Embryonic digit morphogenesis
Biological Process
Endoderm development
Biological Process
Epidermal cell differentiation
Biological Process
Eyelid development in camera-type eye
Biological Process
Fungiform papilla formation
Biological Process
Hair follicle placode formation
Biological Process
Hippocampus development
Biological Process
Histone H3 deacetylation
Biological Process
Histone H4 deacetylation
Biological Process
Negative regulation of canonical Wnt signaling pathway
Biological Process
Negative regulation of cell population proliferation
Biological Process
Negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process
Negative regulation of insulin secretion
Biological Process
Negative regulation of intrinsic apoptotic signaling pathway
Biological Process
Negative regulation of neuron apoptotic process
Biological Process
Negative regulation of peptidyl-lysine acetylation
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Negative regulation of transcription, DNA-templated
Biological Process
Neuron differentiation
Biological Process
Odontogenesis of dentin-containing tooth
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process
Positive regulation of interleukin-1 production
Biological Process
Positive regulation of oligodendrocyte differentiation
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Positive regulation of tumor necrosis factor production
Biological Process
Positive regulation of type B pancreatic cell apoptotic process
Biological Process
Positive regulation of tyrosine phosphorylation of STAT protein
Biological Process
Response to amphetamine
Biological Process
Response to caffeine
Biological Process
Response to drug
Biological Process
Response to hyperoxia
Biological Process
Response to lipopolysaccharide

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-1267Mus musculus99.790.0 835
LLPS-Mam-0862Macaca mulatta99.760.0 807
LLPS-Man-0881Macaca nemestrina99.760.0 810
LLPS-Ict-3242Ictidomys tridecemlineatus99.690.0 647
LLPS-Cas-0322Carlito syrichta99.590.0 833
LLPS-Otg-1104Otolemur garnettii99.590.0 834
LLPS-Ova-1923Ovis aries99.590.0 831
LLPS-Chs-2253Chlorocebus sabaeus99.560.0 818
LLPS-Tut-1638Tursiops truncatus99.530.0 756
LLPS-Pap-0264Pan paniscus99.380.0 834
LLPS-Pat-1168Pan troglodytes99.380.0 834
LLPS-Cea-0582Cercocebus atys99.380.0 834
LLPS-Maf-0754Macaca fascicularis99.380.0 834
LLPS-Caf-0836Canis familiaris99.320.0 818
LLPS-Nol-0785Nomascus leucogenys99.170.0 830
LLPS-Cap-3488Cavia porcellus99.170.0 832
LLPS-Fec-0990Felis catus99.170.0 828
LLPS-Hos-0070Homo sapiens99.170.0 834
LLPS-Mal-0408Mandrillus leucophaeus99.170.0 834
LLPS-Caj-2429Callithrix jacchus99.170.0 833
LLPS-Fud-1317Fukomys damarensis99.170.0 836
LLPS-Gog-0520Gorilla gorilla99.170.0 834
LLPS-Sus-0983Sus scrofa99.170.0 825
LLPS-Urm-1664Ursus maritimus99.10.0 820
LLPS-Myl-3579Myotis lucifugus99.10.0 819
LLPS-Sah-2250Sarcophilus harrisii98.990.0 622
LLPS-Orc-1184Oryctolagus cuniculus98.960.0 830
LLPS-Aon-0757Aotus nancymaae98.960.0 833
LLPS-Eqc-0226Equus caballus98.760.0 827
LLPS-Mup-2619Mustela putorius furo98.760.0 827
LLPS-Aim-3628Ailuropoda melanoleuca98.140.0 815
LLPS-Loa-2283Loxodonta africana98.130.0 823
LLPS-Bot-2610Bos taurus97.290.0 809
LLPS-Gaga-0417Gallus gallus95.930.0 806
LLPS-Anp-1140Anas platyrhynchos95.90.0 791
LLPS-Meg-3213Meleagris gallopavo95.880.0 787
LLPS-Tag-0350Taeniopygia guttata95.480.0 804
LLPS-Anc-2277Anolis carolinensis95.480.0 803
LLPS-Fia-2124Ficedula albicollis95.160.0 785
LLPS-Dio-4209Dipodomys ordii95.020.0 772
LLPS-Scm-0831Scophthalmus maximus94.470.0 749
LLPS-Mod-4318Monodelphis domestica94.290.0 776
LLPS-Pof-1250Poecilia formosa94.230.0 750
LLPS-Rhb-2981Rhinopithecus bieti93.980.0 777
LLPS-Ten-1996Tetraodon nigroviridis93.750.0 745
LLPS-Xet-1787Xenopus tropicalis93.670.0 773
LLPS-Leo-2012Lepisosteus oculatus93.670.0 772
LLPS-Scf-2988Scleropages formosus93.390.0 769
LLPS-Gaa-1684Gasterosteus aculeatus93.270.0 748
LLPS-Xim-3205Xiphophorus maculatus92.130.0 758
LLPS-Dar-2530Danio rerio92.030.0 760
LLPS-Orn-1776Oreochromis niloticus91.910.0 756
LLPS-Pes-2499Pelodiscus sinensis91.910.0 784
LLPS-Icp-3157Ictalurus punctatus91.80.0 759
LLPS-Paa-4804Papio anubis91.630.0 736
LLPS-Orl-0119Oryzias latipes91.240.0 753
LLPS-Ere-0743Erinaceus europaeus91.080.0 736
LLPS-Tar-2918Takifugu rubripes91.080.0 745
LLPS-Ora-2502Ornithorhynchus anatinus91.040.0 729
LLPS-Asm-1830Astyanax mexicanus90.890.0 744
LLPS-Mea-0720Mesocricetus auratus90.520.0 741
LLPS-Poa-2413Pongo abelii90.290.0 736
LLPS-Cii-0886Ciona intestinalis88.80.0 706
LLPS-Cis-1284Ciona savignyi82.550.0 705
LLPS-Drm-2032Drosophila melanogaster82.110.0 709
LLPS-Cae-1608Caenorhabditis elegans70.720.0 583
LLPS-Gor-1338Gossypium raimondii69.970.0 546
LLPS-Ori-0917Oryza indica69.950.0 541
LLPS-Sob-1286Sorghum bicolor69.710.0 547
LLPS-Orp-0639Oryza punctata69.710.0 550
LLPS-Tra-2091Triticum aestivum69.710.0 571
LLPS-Brd-0444Brachypodium distachyon69.710.0 570
LLPS-Hov-0580Hordeum vulgare69.710.0 571
LLPS-Met-2183Medicago truncatula69.710.0 548
LLPS-Sem-1857Selaginella moellendorffii69.530.0 550
LLPS-Orbr-0499Oryza brachyantha69.450.0 550
LLPS-Vir-0883Vigna radiata69.450.0 549
LLPS-Sei-0987Setaria italica69.450.0 547
LLPS-Via-1426Vigna angularis69.450.0 548
LLPS-Glm-0976Glycine max69.450.0 549
LLPS-Osl-1151Ostreococcus lucimarinus69.250.0 560
LLPS-Orr-0198Oryza rufipogon69.250.0 551
LLPS-Ors-0324Oryza sativa69.250.0 551
LLPS-Orgl-0527Oryza glumaepatula69.250.0 551
LLPS-Orni-1609Oryza nivara69.250.0 544
LLPS-Orb-0749Oryza barthii69.250.0 552
LLPS-Nia-0020Nicotiana attenuata69.190.0 543
LLPS-Phv-0596Phaseolus vulgaris69.190.0 545
LLPS-Thc-1698Theobroma cacao69.190.0 542
LLPS-Lep-0160Leersia perrieri69.080.0 540
LLPS-Orm-0001Oryza meridionalis69.070.0 546
LLPS-Asf-0447Aspergillus flavus69.060.0 578
LLPS-Pot-1271Populus trichocarpa69.030.0 540
LLPS-Map-1331Magnaporthe poae68.990.0 561
LLPS-Mae-1878Manihot esculenta68.950.0 538
LLPS-Cus-1473Cucumis sativus68.930.0 541
LLPS-Sot-1062Solanum tuberosum68.930.0 542
LLPS-Nef-1460Neosartorya fischeri68.780.0 573
LLPS-Asc-1660Aspergillus clavatus68.780.0 573
LLPS-Gag-1066Gaeumannomyces graminis68.720.0 560
LLPS-Sol-0178Solanum lycopersicum68.670.0 541
LLPS-Zem-0391Zea mays68.570.0 536
LLPS-Asfu-0978Aspergillus fumigatus68.510.0 571
LLPS-Trv-1493Trichoderma virens68.440.0 553
LLPS-Trr-0531Trichoderma reesei68.440.0 548
LLPS-Cog-0886Colletotrichum gloeosporioides68.440.0 557
LLPS-Abg-0575Absidia glauca68.420.0 562
LLPS-Prp-0981Prunus persica68.410.0 537
LLPS-Coo-0930Colletotrichum orbiculare68.160.0 560
LLPS-Amt-1667Amborella trichopoda68.150.0 536
LLPS-Viv-2270Vitis vinifera68.050.0 536
LLPS-Php-0014Physcomitrella patens67.960.0 568
LLPS-Asn-1288Aspergillus nidulans67.960.0 570
LLPS-Asni-1271Aspergillus niger67.960.0 571
LLPS-Bro-2885Brassica oleracea67.890.0 532
LLPS-Brr-0974Brassica rapa67.890.0 531
LLPS-Art-1543Arabidopsis thaliana67.890.0 531
LLPS-Arl-0220Arabidopsis lyrata67.890.0 531
LLPS-Brn-0251Brassica napus67.890.0 533
LLPS-Tum-0986Tuber melanosporum67.610.0 553
LLPS-Beb-0714Beauveria bassiana67.60.0 550
LLPS-Mao-0923Magnaporthe oryzae67.60.0 551
LLPS-Chc-1121Chondrus crispus67.40.0 543
LLPS-Fus-0195Fusarium solani67.320.0 548
LLPS-Dac-0743Daucus carota67.270.0 535
LLPS-Hea-2429Helianthus annuus67.130.0 530
LLPS-Ved-1165Verticillium dahliae67.040.0 558
LLPS-Scs-0289Sclerotinia sclerotiorum67.020.0 559
LLPS-Dos-0537Dothistroma septosporum66.940.0 557
LLPS-Phn-0383Phaeosphaeria nodorum66.860.0 533
LLPS-Zyt-0759Zymoseptoria tritici66.760.0 546
LLPS-Fuv-0361Fusarium verticillioides66.760.0 545
LLPS-Cogr-0489Colletotrichum graminicola66.750.0 557
LLPS-Kop-1448Komagataella pastoris66.390.0 545
LLPS-Ast-1131Aspergillus terreus66.30.0 540
LLPS-Nec-0442Neurospora crassa66.20.0 539
LLPS-Yal-1460Yarrowia lipolytica65.930.0 543
LLPS-Blg-0870Blumeria graminis65.750.0 550
LLPS-Asg-0779Ashbya gossypii65.280.0 541
LLPS-Coc-0535Corchorus capsularis65.270.0 548
LLPS-Sac-0904Saccharomyces cerevisiae65.090.0 534
LLPS-Scp-0043Schizosaccharomyces pombe64.720.0 530
LLPS-Pyt-0876Pyrenophora teres64.090.0 530
LLPS-Lac-0882Latimeria chalumnae64.010.0 528