Pongo abelii      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Poa-3639
ENSPPYG00000003845.2
H2NF74
ATM
2
LLPS-Poa-3569
ENSPPYG00000007583.2
A0A2J8VWT3
ATMIN
3
LLPS-Poa-1846
ENSPPYG00000014173.2
H2PBM9
ATR
4
LLPS-Poa-3631
ENSPPYG00000012974.2
Q5RDL0
DKFZp459H0661
5
LLPS-Poa-4281
ENSPPYG00000016418.2
H2PIG1
MDC1
6
LLPS-Poa-0935
ENSPPYG00000018573.1
H2PQ95
PRKDC
7
LLPS-Poa-2104
ENSPPYG00000015764.2
H2PGI2
RAD50
8
LLPS-Poa-0639
ENSPPYG00000006357.2
H2NMV0
RAD51
9
LLPS-Poa-1304
ENSPPYG00000006414.2
H2NN14
TP53BP1