LLPS-Poa-4281
MDC1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mediator of DNA damage checkpoint 1 |
| Gene Name: | MDC1 |
| Ensembl Gene: | ENSPPYG00000016418.2 |
| Ensembl Protein: | ENSPPYP00000018356.2 |
| Organism: | Pongo abelii |
| Taxa ID: | 9601 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| DNA damage foci, OPT domain | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPPYT00000019090.2 | ENSPPYP00000018356.2 |
| UniProt | H2PIG1, H2PIG1_PONAB | |
| GeneBank | ABGA01234924, ABGA01234923, ABGA01234922, ABGA01234921 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEDTQAIDWD VEEEEETEQS SESLRCNMEP VGRLHIFSGA HGPEKDFPLH LGKNVVGRMP 60 61 DCSVALPFPS ISKQHAEIEI LAWDKAPILR DCGSLNGTQI LRPPKVLSPG VSHRLRDQEL 120 121 ILFADLLCQY HRLYVSLPFV SRGPLTVEET PRVQGGTQPQ RLLLAEDSEE EVDFLSERLM 180 181 VKKSRTTSSS VIVPESDEEG HSPVLGSLGP PFAFNMNSDT DVEEGQQPAT EEASSAARRG 240 241 ATIEAEQSEA EVVTEIQLEK DQPLVKERDD DTKVKRGAGN GVVPAGVILE RSQPPGEDSD 300 301 TDVDDDSRPG RPAEVHLERA QPFGFIDSDT DAEEEGIPAT PVVIPMKKRK IFHGVGTRGP 360 361 GAPGLTHLQE SQAGSDTDVE EGNAPQAVPL EKSQASMVIN SDTDDEEEVS AALTLARLKE 420 421 SQPAIWNRDA EEDMAQRVVL LQRSQTTTER DSDTDVEEEE LPVENREAVL KGHTKIRALV 480 481 RAHSEKDQPP FGDSVEADKS SPGIHLERSQ ASTTVDINTQ VEEEVPPGSA IIHIKKHQVS 540 541 VEGTNQTDVK AVGGPAKLLV VSLEEAWPPH GDCEIGAEEG TSLAASAVAD VRKSQLPAEG 600 601 DAGAEWAATV LKQERAHEVG AQGGPPVAQV EQDLPISREN LTDLVVDTDT LGESTQPQRE 660 661 GAQVPTGRER EQHVGGTKDS EDNYGDSEDL DLQATQCFLE NQGLEGTLDE PWEVLATQPF 720 721 CLRESEDSET QPSDTHLEAY GPCLSPPRAI PGDQHPESPV HTEPMGIQGR GRQTVDKVMG 780 781 IPKETAERVG PERGPLERET EKLLPERQTD VTGEEELTKG IQDREQKQLL ARDTQRQESD 840 841 KNGKSASPER DWESLKVEIE TSEEIQEKQV KKQTLPSKAY EREVERPVAD RECEPAEKAS 900 901 RGDQESPDAC LPPTVPEAPA PPQKPLNSQS RKHLAPQPLL SPLLPSIKPT IHKTRQDGSQ 960 961 EAAETPLSSE LEPFYPKPKI ITRKSSRMTP FPATSAAPEP HPSTSTAQPV TPKPTSQATR 1020 1021 SKTNRSSVKT SEPVVPAAPE LQPSTSTDQP VTSEPTSQVT RGRKNRSSVK TPETVVPTAL 1080 1081 ELQPSTSTDR PVTSEPTSQA TRGRKNRSSV KTPEPVVPTA PELQPSTSTD QPVTSERTSQ 1140 1141 ATRGRKNRSS VKTNKSSVKT PETVVPTAPK LQPSTSTDQP ITPEPTSQAT RGRKNRSSVK 1200 1201 TPETVVPTAP KLQPSTSTDQ PVTPEPTSQA TRGRTNRSSV KTPETVVPTA PELQPSTSTD 1260 1261 QPLTPEPTSQ ATRGRTDRSS VKTPETVVPT APELQASAST DQPVTSEPTS RTTRGRKNRS 1320 1321 SVKTPETVVP TAPELQPSTS IDQPVTPEPT SRATRGRTNR SSVKNPESIV PIAPELQPST 1380 1381 SRNQLVTPEP TSRATRGRTN RSSVKTPEPV VPIAPEPHPT TSTDQPVTPK LTSRATRRRT 1440 1441 NRSSVKTPKP VEPAASDLEP FTPTDQPVTP EAIAQGGQSK TLRSSTVRAM PLPTTPEFQS 1500 1501 PVTTDQPISP EPIPQPSCIK SQRATGNPGS LAAPIDRKPC SAPLEPKSQA SRNQRWGAVR 1560 1561 AAESLTAIPE PASPQLLETP THASQIQKVE PAGRSRFTLE LQPKASQSRK RSLATMDSPP 1620 1621 HQKQPQRGEV SQKTVIIKEE EEDTAEKPAK EEDVVTPKPG KRKRDQAEEE PNRIPSRSLR 1680 1681 RTKLNQESTA PKVLFTGVVD ARGEQAVLAL GGSLAGSAAE ASHLVTDRIR RTVKFLCALG 1740 1741 RGIPILSLDW LHQSRKAGFF LSPDEYVVTD PEQEKNFGFS LQDALSRARE RRLLEGYEIY 1800 1801 VTPGVQPPPL QMGEIISCCG GTYLPSMPRS YKPQRVVITC PQDFPRCSIP LRVGLPLLSP 1860 1861 EFLLTGVLKQ EAKPEAFVLS PLEMSST 1887 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGACA CCCAGGCTAT TGACTGGGAT GTTGAAGAAG AGGAGGAGAC AGAGCAATCC 60 61 AGTGAATCCT TGAGGTGTAA CATGGAGCCA GTAGGGCGGC TACATATCTT TAGTGGTGCC 120 121 CATGGACCAG AAAAAGATTT CCCACTACAC CTTGGGAAGA ATGTGGTAGG CCGAATGCCT 180 181 GACTGCTCTG TGGCCCTGCC CTTTCCATCT ATCTCCAAAC AACATGCAGA GATTGAAATC 240 241 TTAGCCTGGG ACAAGGCACC TATCCTCCGA GACTGTGGGA GCCTTAATGG TACTCAAATC 300 301 CTGAGACCTC CTAAGGTTTT GAGCCCTGGG GTGAGTCACC GTCTGAGGGA CCAGGAATTG 360 361 ATTCTCTTTG CTGACTTGCT CTGCCAGTAC CATCGCCTGT ATGTCTCTCT GCCCTTTGTC 420 421 TCCCGGGGCC CTCTGACAGT AGAAGAGACA CCCAGGGTAC AGGGAGGAAC TCAACCCCAG 480 481 AGGCTTCTGT TGGCTGAGGA CTCGGAGGAG GAAGTAGATT TTCTTTCTGA AAGGCTCATG 540 541 GTAAAAAAAT CAAGGACCAC ATCTTCCTCT GTGATAGTTC CAGAGAGTGA TGAAGAGGGG 600 601 CACTCCCCTG TCCTGGGCAG CCTTGGGCCG CCTTTTGCCT TCAATATGAA CAGTGACACA 660 661 GATGTGGAAG AAGGTCAGCA ACCAGCCACA GAGGAGGCCT CCTCAGCTGC CAGAAGAGGT 720 721 GCCACTATAG AGGCAGAGCA GTCTGAAGCT GAAGTTGTAA CTGAAATCCA GCTTGAAAAG 780 781 GATCAGCCTT TAGTGAAGGA GAGGGACGAT GATACAAAAG TCAAGAGGGG TGCAGGGAAT 840 841 GGGGTGGTTC CAGCTGGGGT GATTCTGGAG AGGAGCCAAC CTCCTGGAGA GGACAGTGAC 900 901 ACAGATGTGG ATGATGACAG CAGGCCTGGA AGGCCAGCTG AGGTCCATTT GGAAAGGGCT 960 961 CAGCCTTTTG GCTTCATCGA CAGCGACACT GATGCGGAAG AAGAGGGGAT CCCAGCAACC 1020 1021 CCAGTTGTCA TTCCTATGAA GAAGAGGAAG ATCTTCCATG GAGTTGGTAC AAGGGGTCCT 1080 1081 GGAGCACCAG GCCTGACCCA TCTGCAGGAG AGCCAGGCTG GTAGTGATAC AGATGTGGAG 1140 1141 GAAGGCAATG CCCCACAGGC TGTCCCTCTG GAGAAAAGCC AAGCTTCCAT GGTTATCAAC 1200 1201 AGCGATACAG ATGACGAGGA AGAAGTCTCA GCAGCGCTGA CTTTGGCACG TCTGAAAGAG 1260 1261 AGCCAGCCTG CTATATGGAA CAGAGATGCA GAAGAGGACA TGGCCCAACG TGTGGTCCTT 1320 1321 CTGCAGCGTA GCCAAACCAC CACTGAGAGA GACAGTGACA CAGACGTGGA GGAGGAAGAG 1380 1381 CTCCCGGTGG AAAATAGAGA AGCTGTCCTC AAGGGTCACA CAAAGATTAG AGCCCTTGTT 1440 1441 AGAGCACATT CAGAAAAGGA CCAACCTCCT TTTGGGGACA GTGTGGAAGC AGATAAGAGC 1500 1501 TCACCTGGGA TCCACCTGGA GAGAAGCCAA GCCTCCACCA CAGTGGACAT CAACACACAA 1560 1561 GTGGAGGAGG AAGTTCCGCC AGGGTCAGCC ATTATACATA TAAAGAAGCA TCAGGTGTCT 1620 1621 GTGGAGGGGA CAAATCAAAC AGATGTGAAA GCAGTTGGGG GACCAGCAAA GCTGCTTGTG 1680 1681 GTATCTCTAG AGGAAGCCTG GCCTCCGCAT GGGGACTGTG AAATAGGTGC GGAGGAGGGC 1740 1741 ACCTCCTTAG CAGCCTCAGC AGTTGCAGAT GTAAGAAAGA GCCAGCTTCC AGCAGAAGGG 1800 1801 GATGCTGGGG CAGAGTGGGC TGCAACTGTT CTTAAGCAGG AGAGAGCTCA TGAGGTGGGG 1860 1861 GCCCAGGGTG GGCCACCTGT GGCACAAGTG GAGCAGGACC TCCCTATCTC AAGAGAGAAC 1920 1921 CTCACAGATC TGGTGGTGGA CACAGACACT CTAGGGGAAT CCACCCAGCC ACAGAGAGAG 1980 1981 GGAGCCCAGG TCCCCACAGG AAGGGAGAGA GAACAACATG TGGGTGGGAC CAAGGACTCT 2040 2041 GAAGACAACT ATGGTGATTC TGAAGATCTG GACCTACAAG CTACCCAGTG CTTTCTGGAG 2100 2101 AATCAGGGCC TGGAAGGTAC CCTAGATGAA CCATGGGAGG TCCTGGCTAC ACAGCCATTC 2160 2161 TGTCTGAGAG AGTCTGAGGA CTCTGAGACC CAGCCTTCTG ACACCCACCT TGAGGCCTAT 2220 2221 GGACCTTGCC TGTCTCCACC TAGGGCAATA CCAGGAGACC AACATCCAGA GAGCCCAGTT 2280 2281 CACACAGAGC CAATGGGGAT TCAAGGCAGA GGGAGGCAGA CTGTGGATAA AGTCATGGGT 2340 2341 ATACCAAAAG AAACAGCAGA GAGGGTGGGC CCTGAGAGAG GGCCATTGGA GAGAGAGACT 2400 2401 GAGAAACTGC TACCAGAAAG ACAGACAGAT GTGACAGGAG AGGAAGAATT AACCAAGGGG 2460 2461 ATACAGGACA GAGAACAAAA ACAGTTGTTA GCTAGAGACA CCCAGAGACA AGAATCTGAC 2520 2521 AAAAATGGGA AAAGTGCAAG TCCTGAAAGA GATTGGGAGA GTTTGAAGGT AGAAATTGAG 2580 2581 ACATCCGAGG AAATACAAGA GAAACAAGTA AAGAAGCAGA CCCTTCCAAG CAAAGCATAT 2640 2641 GAGAGAGAAG TAGAGAGACC AGTAGCAGAC AGAGAGTGCG AGCCAGCCGA GAAGGCTTCC 2700 2701 AGGGGCGATC AGGAATCTCC AGATGCTTGT CTGCCTCCTA CAGTGCCTGA AGCCCCAGCC 2760 2761 CCACCCCAAA AGCCCCTTAA CTCTCAGAGC CGGAAACATC TTGCACCTCA GCCCCTTCTT 2820 2821 TCTCCCCTTT TACCTTCTAT CAAGCCAACC ATTCATAAGA CCAGGCAAGA TGGGAGTCAG 2880 2881 GAAGCTGCAG AGACTCCCTT GTCCTCAGAG CTGGAGCCTT TCTACCCAAA GCCTAAAATC 2940 2941 ATAACTCGAA AGTCCTCCAG GATGACACCC TTTCCAGCTA CCTCTGCTGC CCCTGAGCCC 3000 3001 CACCCTTCCA CCTCCACAGC CCAGCCAGTC ACTCCCAAGC CCACATCTCA GGCCACTAGG 3060 3061 AGCAAGACAA ATAGGTCCTC TGTCAAGACC TCTGAACCAG TTGTCCCCGC AGCCCCTGAG 3120 3121 CTCCAGCCTT CCACCTCCAC AGACCAGCCT GTCACCTCTG AGCCCACATC TCAGGTTACT 3180 3181 AGGGGAAGAA AAAATAGATC TTCTGTTAAG ACCCCTGAAA CAGTTGTGCC CACAGCCCTT 3240 3241 GAGCTCCAGC CTTCCACCTC CACCGACCGA CCTGTCACCT CTGAGCCCAC ATCTCAGGCT 3300 3301 ACTAGGGGAA GAAAAAATAG ATCCTCTGTC AAGACCCCTG AACCAGTTGT CCCCACAGCC 3360 3361 CCTGAGCTCC AGCCTTCCAC CTCCACAGAC CAGCCTGTCA CCTCTGAACG CACATCTCAG 3420 3421 GCTACTAGGG GAAGAAAAAA TAGATCCTCT GTCAAGACCA ATAAGTCCTC TGTCAAGACC 3480 3481 CCTGAAACAG TTGTCCCCAC AGCCCCTAAG CTCCAGCCTT CCACCTCCAC AGACCAGCCT 3540 3541 ATCACCCCTG AGCCCACATC TCAGGCTACT AGGGGAAGAA AAAATAGATC CTCTGTCAAG 3600 3601 ACCCCTGAAA CAGTTGTCCC CACAGCCCCT AAGCTCCAGC CTTCCACTTC CACAGACCAA 3660 3661 CCTGTCACTC CTGAGCCCAC ATCTCAGGCC ACCAGGGGCA GGACAAATAG ATCCTCTGTG 3720 3721 AAGACCCCTG AAACAGTTGT CCCTACAGCC CCTGAGCTTC AGCCTTCCAC CTCCACAGAC 3780 3781 CAGCCTCTTA CCCCTGAGCC TACATCTCAG GCTACTAGGG GAAGAACAGA TAGATCCTCT 3840 3841 GTCAAGACTC CTGAAACAGT TGTCCCCACA GCCCCTGAGC TACAGGCTTC TGCCTCCACA 3900 3901 GACCAGCCTG TCACCTCTGA GCCCACATCT CGGACCACTA GGGGAAGAAA AAATCGGTCC 3960 3961 TCTGTCAAGA CCCCTGAAAC AGTTGTGCCC ACAGCCCCTG AGCTCCAGCC TTCCACCTCC 4020 4021 ATAGACCAAC CTGTCACCCC TGAGCCCACA TCTCGGGCCA CTAGGGGCAG GACAAATAGG 4080 4081 TCCTCTGTCA AGAACCCTGA ATCAATTGTC CCTATAGCCC CTGAGCTTCA GCCTTCCACC 4140 4141 TCCAGAAACC AGCTTGTCAC CCCTGAGCCC ACATCTCGGG CCACTAGAGG CAGGACAAAT 4200 4201 AGATCCTCTG TCAAGACCCC TGAACCAGTT GTCCCCATAG CCCCTGAGCC CCATCCTACC 4260 4261 ACCTCCACAG ACCAGCCTGT CACCCCCAAG CTCACATCTA GGGCCACTAG GAGAAGGACA 4320 4321 AATAGGTCCT CTGTCAAGAC TCCCAAACCA GTTGAACCAG CAGCCTCTGA TCTTGAGCCT 4380 4381 TTTACCCCCA CAGACCAGCC TGTCACCCCT GAGGCCATAG CTCAGGGTGG TCAGAGCAAA 4440 4441 ACACTGAGGT CTTCCACAGT AAGAGCTATG CCGCTTCCTA CCACCCCTGA ATTCCAATCT 4500 4501 CCTGTCACCA CAGACCAGCC TATTTCCCCT GAGCCTATTC CTCAACCCAG TTGCATCAAG 4560 4561 AGTCAGAGAG CCACTGGGAA TCCTGGCTCC CTCGCAGCTC CCATTGACCG TAAGCCTTGC 4620 4621 TCTGCACCCT TGGAACCTAA ATCCCAGGCC TCAAGGAACC AAAGATGGGG AGCAGTGAGA 4680 4681 GCAGCTGAAT CCCTTACAGC CATTCCTGAG CCTGCCTCTC CCCAGCTTCT TGAGACACCA 4740 4741 ACTCATGCCT CCCAGATCCA AAAGGTGGAA CCAGCAGGTA GATCTAGGTT CACCCTGGAG 4800 4801 CTCCAGCCTA AGGCCTCTCA AAGCCGCAAG AGGTCTTTAG CTACCATGGA TTCACCACCA 4860 4861 CATCAAAAAC AGCCCCAAAG AGGGGAAGTC TCCCAGAAGA CAGTGATTAT CAAGGAAGAG 4920 4921 GAAGAAGATA CTGCAGAGAA GCCAGCGAAG GAAGAGGATG TCGTGACTCC AAAACCAGGC 4980 4981 AAGAGAAAGA GAGACCAGGC AGAGGAGGAG CCCAACAGAA TACCAAGCCG CAGCCTCCGA 5040 5041 CGGACCAAAC TTAACCAAGA ATCAACAGCC CCCAAAGTGC TCTTCACAGG AGTGGTGGAT 5100 5101 GCTCGGGGAG AGCAGGCTGT GCTGGCACTG GGGGGAAGTC TGGCTGGTTC AGCGGCAGAG 5160 5161 GCTTCCCACC TGGTCACTGA TCGCATCCGC CGGACAGTCA AGTTCCTGTG TGCCCTGGGG 5220 5221 CGGGGAATCC CCATTCTGTC CCTGGACTGG CTGCATCAGT CCCGCAAGGC TGGTTTCTTC 5280 5281 TTATCACCGG ATGAATATGT GGTGACCGAC CCTGAGCAAG AGAAGAACTT TGGCTTTAGC 5340 5341 CTTCAAGACG CACTGAGCCG GGCTCGGGAG CGAAGGCTGC TAGAGGGCTA TGAGATCTAT 5400 5401 GTGACCCCTG GAGTCCAGCC ACCACCACTT CAGATGGGAG AGATCATTAG CTGCTGTGGA 5460 5461 GGCACATACC TACCCAGCAT GCCTCGGTCC TATAAGCCAC AGAGAGTTGT GATCACATGC 5520 5521 CCTCAGGACT TCCCTCGTTG CTCCATTCCA CTGCGGGTTG GGCTGCCCCT CCTCTCGCCT 5580 5581 GAGTTCCTGC TGACTGGAGT GCTGAAGCAG GAAGCCAAGC CAGAGGCCTT TGTCCTTTCC 5640 5641 CCTTTGGAGA TGTCATCCAC CTGA 5664 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-1854 | Homo sapiens | 93.03 | 0.0 | 1664 |
| LLPS-Maf-3383 | Macaca fascicularis | 90.47 | 0.0 | 1613 |
| LLPS-Man-1502 | Macaca nemestrina | 90.26 | 0.0 | 1608 |
| LLPS-Mam-1159 | Macaca mulatta | 90.26 | 0.0 | 1612 |
| LLPS-Mal-4733 | Mandrillus leucophaeus | 90.14 | 0.0 | 1143 |
| LLPS-Rhb-3998 | Rhinopithecus bieti | 88.97 | 0.0 | 1582 |
| LLPS-Pat-4050 | Pan troglodytes | 81.93 | 0.0 | 2945 |
| LLPS-Caj-4217 | Callithrix jacchus | 81.43 | 0.0 | 1408 |
| LLPS-Paa-0117 | Papio anubis | 77.73 | 0.0 | 2548 |
| LLPS-Loa-4478 | Loxodonta africana | 70.85 | 9e-158 | 534 |
| LLPS-Otg-3536 | Otolemur garnettii | 69.51 | 0.0 | 1097 |
| LLPS-Caf-3846 | Canis familiaris | 67.38 | 0.0 | 908 |
| LLPS-Eqc-3787 | Equus caballus | 65.34 | 0.0 | 2118 |
| LLPS-Urm-1618 | Ursus maritimus | 64.06 | 0.0 | 1033 |
| LLPS-Ova-3628 | Ovis aries | 62.85 | 0.0 | 935 |
| LLPS-Fec-1175 | Felis catus | 61.6 | 0.0 | 1884 |
| LLPS-Scm-0148 | Scophthalmus maximus | 53.89 | 3e-51 | 205 |
| LLPS-Dar-3633 | Danio rerio | 49.52 | 4e-50 | 201 |
| LLPS-Scf-3651 | Scleropages formosus | 42.91 | 4e-44 | 181 |