Mus musculus      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 11 genes.  Reviewed (3 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mum-1848
ENSMUSG00000032409.15
Q9JKK8
Atr
2
LLPS-Mum-0246
ENSMUSG00000030795.18
P56959
Fus
3
LLPS-Mum-1911
ENSMUSG00000022672.8
P97313
Prkdc
4
LLPS-Mum-0950
ENSMUSG00000034218.16
Q62388
Atm
5
LLPS-Mum-3984
ENSMUSG00000047388.10
Q6P9S1
Atmin
6
LLPS-Mum-2725
ENSMUSG00000049932.3
P27661
H2afx
7
LLPS-Mum-1267
ENSMUSG00000028800.15
O09106
Hdac1
8
LLPS-Mum-0127
ENSMUSG00000020380.16
P70388
Rad50
9
LLPS-Mum-2256
ENSMUSG00000027323.10
Q08297
Rad51
10
LLPS-Mum-4212
ENSMUSG00000042369.8
Q8BHN5
Rbm45
11
LLPS-Mum-0380
ENSMUSG00000043909.16
P70399
Tp53bp1