LLPS-Mum-3984
Atmin
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | ATM interactor; ATM/ATR-substrate CHK2-interacting zinc finger protein; ASCIZ |
| Gene Name: | Atmin, Kiaa0431 |
| Ensembl Gene: | ENSMUSG00000047388.10 |
| Ensembl Protein: | ENSMUSP00000104727.3 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| DNA damage foci | Predicted from orthologs | (View) |
▼ FUNCTION
| Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000109099.3 | ENSMUSP00000104727.3 |
| UniProt | Q6P9S1, ATMIN_MOUSE, Q05CB1, Q80U05, Q8C311 | |
| GeneBank | BC060631, BC027752, AC162858, AK122281, AK087334 | , BAC65563.1, AAH27752.1, AAH60631.1, BAC39849.1 |
| RefSeq | NM_177700.4 | NP_808368.3 |
| Entrez | 234776 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAATEAAAAD SAGPAPGVPA TPASTRGAAA ASSPWRPPES RLQGSRPRPA RARAAAPVPP 60 61 ARELIQPTVS ELSRAVRTNI LCTVRGCGKI LPNSPALNMH LVKSHRLQDG IVNPTIRKDL 120 121 TTAPKFYCCP IKGCPRGPDR PFSQFSLVKQ HFMKMHAEKK HKCSKCSNSY GTEWDLKRHE 180 181 EDCGKTFQCT CGCPYASRTA LQSHIYRTGH EIPAEHRDPP SKKRKMESYL QNQKLSSKTT 240 241 EPLSDQAAPR QDAAEPDAPE VKPAASLEDS CSAHTKKQSV ATPPRCPQKL LLPKPKVALV 300 301 KLPVMQFSPV PVFVPTAESS AQPVVLGVDH SSAAGTVHLV PLSVGALILS LDSEACSLKE 360 361 SLPLSKIISP VVEPMNTGVQ VNLGKSLCSP LQEVGSVCQR TSISSSNVQT DLTYASANLI 420 421 PSAQWLGPDS SVSSCSQTDL SFDSQVSLPV SVHTQTLVPS SKVTSSIAAQ TDAFIDACFQ 480 481 PGGVSRETQT SRMQNRTNDS VPVGHTGLCG DIFESVHASY SVPTDTIMSS SLVAETGTHG 540 541 LPPQSDPKIL GQVMEKSAPV LNFSTQNGLL PAHTMTDNQT QTIDLLSDLE NILSSNLPGQ 600 601 TLDNRSLLSD TNPGPDAQLP AGSAQNSGID FDIEEFLSAS NIQTQTEESE LSSMSTEPVL 660 661 ESLDIETQTD VLLSDPSTQP YGFRAGSGFL GLEMFDTQTQ TDLNFFLDSS PHLPLGSILK 720 721 HSSFSMSTDS SDTETQTEGA CPARHLPALE SKVQLSSTET QTMSSGFEPL GNLFLTSNET 780 781 QTAMDDFLLA DLAWNTMESQ FSSVETQTCA ELHAVSSF 818 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCCA CGGAGGCGGC GGCGGCCGAT TCTGCGGGTC CGGCCCCGGG TGTCCCGGCC 60 61 ACGCCGGCGA GCACGCGGGG AGCCGCCGCC GCCTCTAGCC CGTGGAGGCC GCCCGAGTCG 120 121 CGACTGCAAG GCAGCCGGCC GAGACCGGCC AGGGCTCGGG CCGCGGCCCC GGTGCCACCG 180 181 GCCCGGGAGC TGATCCAGCC GACTGTGAGC GAGCTGTCCC GGGCTGTGCG CACCAATATT 240 241 CTGTGCACCG TGCGCGGCTG CGGCAAGATC CTGCCCAACA GCCCTGCGCT CAACATGCAC 300 301 CTCGTCAAGA GCCACCGACT GCAGGATGGC ATAGTAAACC CGACAATAAG GAAAGACTTG 360 361 ACAACTGCAC CGAAATTCTA CTGTTGTCCA ATCAAAGGAT GTCCTCGAGG CCCCGACCGA 420 421 CCGTTTTCTC AGTTTTCTCT GGTTAAACAG CACTTTATGA AAATGCATGC AGAGAAGAAG 480 481 CACAAATGCA GTAAGTGCAG TAATTCCTAC GGCACCGAGT GGGACCTGAA AAGACACGAG 540 541 GAGGATTGTG GCAAGACCTT CCAGTGTACG TGCGGCTGTC CCTACGCCAG CAGAACCGCA 600 601 CTGCAGTCTC ACATCTACCG AACTGGCCAC GAGATCCCTG CAGAGCACAG AGACCCACCT 660 661 AGTAAAAAAA GGAAAATGGA AAGCTACCTG CAAAACCAAA AGTTGTCCAG TAAAACCACT 720 721 GAACCACTGA GCGACCAAGC AGCCCCGCGC CAAGATGCTG CTGAACCGGA TGCTCCGGAG 780 781 GTCAAGCCTG CAGCATCCCT CGAAGACTCC TGTAGCGCCC ACACCAAAAA GCAGAGCGTC 840 841 GCGACGCCTC CCCGGTGTCC CCAGAAGTTG CTGTTACCAA AGCCCAAGGT GGCTCTGGTT 900 901 AAACTCCCAG TCATGCAGTT TTCCCCCGTG CCTGTCTTTG TGCCTACAGC GGAGTCCTCG 960 961 GCCCAGCCTG TGGTGTTAGG TGTGGATCAC AGTTCTGCAG CCGGTACTGT GCACTTAGTA 1020 1021 CCTCTGTCGG TAGGAGCCCT GATCCTCAGC CTGGACTCAG AGGCCTGCTC TCTGAAGGAG 1080 1081 AGCCTACCTC TCTCAAAAAT TATCAGTCCT GTTGTTGAGC CAATGAATAC AGGTGTTCAA 1140 1141 GTGAACTTGG GTAAAAGCCT GTGTAGTCCT TTACAAGAGG TAGGGAGTGT GTGTCAGAGG 1200 1201 ACCAGCATTT CCTCAAGCAA CGTGCAGACA GATCTGACCT ATGCCTCAGC CAACTTGATA 1260 1261 CCCTCTGCTC AGTGGCTCGG CCCTGATTCC TCTGTGTCAT CGTGTTCTCA GACTGACCTG 1320 1321 TCGTTTGATT CTCAAGTGTC CCTTCCTGTT AGTGTCCACA CCCAGACGTT GGTGCCCAGC 1380 1381 TCTAAGGTCA CTTCATCCAT AGCTGCTCAG ACAGATGCAT TTATAGACGC CTGTTTCCAG 1440 1441 CCTGGTGGGG TCTCCAGGGA AACCCAGACC AGCAGGATGC AGAACCGCAC AAACGACTCA 1500 1501 GTGCCAGTGG GCCACACTGG CTTGTGTGGG GACATTTTTG AAAGCGTGCA TGCGTCATAC 1560 1561 AGTGTGCCTA CTGACACCAT CATGAGTAGC AGCTTAGTTG CAGAGACAGG GACTCATGGT 1620 1621 CTGCCACCTC AGAGTGACCC TAAGATCTTA GGCCAAGTCA TGGAAAAGTC TGCACCCGTG 1680 1681 TTAAACTTCA GCACCCAGAA CGGCTTGCTT CCTGCACACA CCATGACAGA TAATCAGACC 1740 1741 CAAACCATAG ATCTGCTGAG CGACTTGGAA AACATCTTGT CAAGTAACCT GCCAGGTCAA 1800 1801 ACACTGGATA ACCGGAGTCT CTTGTCCGAC ACCAACCCCG GACCTGACGC CCAGCTCCCA 1860 1861 GCTGGCTCAG CGCAGAATTC TGGGATTGAT TTTGATATTG AAGAGTTCCT CTCAGCCTCC 1920 1921 AATATCCAGA CTCAGACTGA GGAGAGTGAG CTCAGCTCCA TGAGCACTGA GCCGGTCCTG 1980 1981 GAGTCCCTGG ACATCGAGAC GCAGACCGAC GTCCTCCTCT CAGATCCCTC CACACAGCCC 2040 2041 TATGGCTTCA GAGCGGGGTC AGGCTTCCTG GGCCTTGAGA TGTTCGACAC ACAGACACAA 2100 2101 ACAGACTTAA ACTTCTTCTT AGACAGTAGT CCTCACCTGC CCCTGGGCAG CATCCTGAAA 2160 2161 CACTCCAGCT TCTCCATGAG TACCGACTCC TCTGACACAG AGACCCAAAC TGAAGGAGCC 2220 2221 TGCCCTGCTC GGCACCTGCC TGCTCTGGAG AGCAAGGTCC AGTTGAGCAG CACAGAAACA 2280 2281 CAAACCATGA GTTCTGGCTT CGAGCCCCTG GGGAACTTGT TCCTCACCAG CAACGAAACT 2340 2341 CAGACAGCAA TGGATGACTT CCTTCTAGCC GATCTGGCCT GGAATACGAT GGAGTCCCAG 2400 2401 TTCAGCTCCG TGGAAACCCA GACATGCGCA GAGCTGCACG CTGTCTCCAG CTTCTGA 2457 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nuclear body | |
Molecular Function | Dynein complex binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Transcription regulatory region DNA binding | |
Biological Process | Cellular response to DNA damage stimulus | |
Biological Process | Motile cilium assembly | |
Biological Process | Positive regulation of gene expression | |
Biological Process | Positive regulation of non-motile cilium assembly | |
Biological Process | Positive regulation of transcription, DNA-templated |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-4652 | Rattus norvegicus | 91.07 | 0.0 | 1302 |
| LLPS-Ict-3732 | Ictidomys tridecemlineatus | 83.15 | 0.0 | 1112 |
| LLPS-Nol-2481 | Nomascus leucogenys | 80.71 | 0.0 | 1142 |
| LLPS-Gog-3159 | Gorilla gorilla | 80.58 | 0.0 | 1138 |
| LLPS-Orc-3013 | Oryctolagus cuniculus | 80.36 | 0.0 | 1056 |
| LLPS-Chs-2107 | Chlorocebus sabaeus | 80.17 | 0.0 | 1071 |
| LLPS-Myl-1200 | Myotis lucifugus | 80.08 | 0.0 | 1112 |
| LLPS-Cea-2521 | Cercocebus atys | 79.92 | 0.0 | 1144 |
| LLPS-Man-0788 | Macaca nemestrina | 79.8 | 0.0 | 1142 |
| LLPS-Mam-4075 | Macaca mulatta | 79.8 | 0.0 | 1142 |
| LLPS-Tut-0117 | Tursiops truncatus | 79.8 | 0.0 | 1027 |
| LLPS-Paa-3055 | Papio anubis | 79.8 | 0.0 | 1137 |
| LLPS-Hos-1515 | Homo sapiens | 79.67 | 0.0 | 1146 |
| LLPS-Caf-0599 | Canis familiaris | 79.57 | 0.0 | 1131 |
| LLPS-Cas-3570 | Carlito syrichta | 79.46 | 0.0 | 967 |
| LLPS-Loa-1567 | Loxodonta africana | 79.44 | 0.0 | 1148 |
| LLPS-Pat-2444 | Pan troglodytes | 79.42 | 0.0 | 1144 |
| LLPS-Rhb-4103 | Rhinopithecus bieti | 79.31 | 0.0 | 963 |
| LLPS-Sus-0594 | Sus scrofa | 79.19 | 0.0 | 1110 |
| LLPS-Poa-3569 | Pongo abelii | 79.01 | 0.0 | 961 |
| LLPS-Aim-4012 | Ailuropoda melanoleuca | 78.99 | 0.0 | 1041 |
| LLPS-Eqc-2441 | Equus caballus | 78.93 | 0.0 | 1120 |
| LLPS-Mal-2166 | Mandrillus leucophaeus | 78.86 | 0.0 | 954 |
| LLPS-Caj-4295 | Callithrix jacchus | 78.68 | 0.0 | 1130 |
| LLPS-Bot-2370 | Bos taurus | 78.68 | 0.0 | 1109 |
| LLPS-Otg-2349 | Otolemur garnettii | 78.44 | 0.0 | 1082 |
| LLPS-Fec-4262 | Felis catus | 78.43 | 0.0 | 1126 |
| LLPS-Mup-3859 | Mustela putorius furo | 78.25 | 0.0 | 1052 |
| LLPS-Dio-4000 | Dipodomys ordii | 78.03 | 0.0 | 1014 |
| LLPS-Urm-2108 | Ursus maritimus | 77.69 | 0.0 | 938 |
| LLPS-Cap-0310 | Cavia porcellus | 76.36 | 0.0 | 767 |
| LLPS-Mod-3167 | Monodelphis domestica | 72.82 | 0.0 | 1015 |
| LLPS-Sah-2705 | Sarcophilus harrisii | 72.56 | 0.0 | 1010 |
| LLPS-Pap-1835 | Pan paniscus | 71.54 | 0.0 | 949 |
| LLPS-Ova-3633 | Ovis aries | 71.5 | 0.0 | 972 |
| LLPS-Aon-2567 | Aotus nancymaae | 70.05 | 0.0 | 932 |
| LLPS-Gaga-2030 | Gallus gallus | 65.74 | 0.0 | 865 |
| LLPS-Pes-3314 | Pelodiscus sinensis | 64.87 | 0.0 | 822 |
| LLPS-Tag-3060 | Taeniopygia guttata | 64.68 | 0.0 | 848 |
| LLPS-Anp-2129 | Anas platyrhynchos | 64.44 | 0.0 | 801 |
| LLPS-Meg-2646 | Meleagris gallopavo | 64.32 | 0.0 | 793 |
| LLPS-Fia-1874 | Ficedula albicollis | 64.03 | 0.0 | 793 |
| LLPS-Anc-3494 | Anolis carolinensis | 61.32 | 0.0 | 795 |
| LLPS-Ora-2412 | Ornithorhynchus anatinus | 61.27 | 0.0 | 652 |
| LLPS-Lac-1278 | Latimeria chalumnae | 58.99 | 0.0 | 751 |
| LLPS-Leo-3622 | Lepisosteus oculatus | 55.73 | 0.0 | 682 |
| LLPS-Xet-2158 | Xenopus tropicalis | 53.48 | 0.0 | 677 |
| LLPS-Dar-3484 | Danio rerio | 51.91 | 0.0 | 579 |
| LLPS-Gaa-3003 | Gasterosteus aculeatus | 50.77 | 0.0 | 588 |
| LLPS-Orn-3776 | Oreochromis niloticus | 50.13 | 0.0 | 583 |
| LLPS-Icp-2504 | Ictalurus punctatus | 49.8 | 0.0 | 577 |
| LLPS-Pof-1385 | Poecilia formosa | 49.68 | 0.0 | 556 |
| LLPS-Asm-3060 | Astyanax mexicanus | 49.68 | 0.0 | 601 |
| LLPS-Xim-0887 | Xiphophorus maculatus | 49.23 | 0.0 | 558 |
| LLPS-Ten-1490 | Tetraodon nigroviridis | 48.65 | 3e-179 | 540 |
| LLPS-Tar-1929 | Takifugu rubripes | 48.07 | 4e-176 | 532 |
| LLPS-Orl-1393 | Oryzias latipes | 47.15 | 1e-175 | 533 |
| LLPS-Scf-2469 | Scleropages formosus | 41.64 | 7e-115 | 373 |
| LLPS-Brr-0544 | Brassica rapa | 40.24 | 4e-13 | 76.6 |
| LLPS-Bro-0044 | Brassica oleracea | 40.24 | 2e-13 | 77.8 |
| LLPS-Brn-2583 | Brassica napus | 40.24 | 1e-13 | 78.2 |
| LLPS-Art-1978 | Arabidopsis thaliana | 39.02 | 9e-13 | 75.9 |
| LLPS-Arl-2703 | Arabidopsis lyrata | 39.02 | 8e-13 | 75.9 |
| LLPS-Php-2301 | Physcomitrella patens | 35.37 | 2e-10 | 68.9 |
| LLPS-Vir-1064 | Vigna radiata | 35.37 | 2e-09 | 65.5 |
| LLPS-Cus-0701 | Cucumis sativus | 34.09 | 1e-12 | 75.1 |
| LLPS-Orr-2340 | Oryza rufipogon | 33.07 | 3e-10 | 67.8 |
| LLPS-Orp-0117 | Oryza punctata | 32.33 | 7e-11 | 69.7 |
| LLPS-Ors-1025 | Oryza sativa | 32.33 | 3e-11 | 70.9 |
| LLPS-Orbr-0934 | Oryza brachyantha | 32.33 | 4e-11 | 70.5 |
| LLPS-Orm-0633 | Oryza meridionalis | 32.33 | 3e-11 | 71.2 |
| LLPS-Org-0351 | Oryza glaberrima | 32.33 | 2e-11 | 71.2 |
| LLPS-Orb-0935 | Oryza barthii | 32.33 | 3e-11 | 70.9 |
| LLPS-Ori-1185 | Oryza indica | 32.33 | 4e-11 | 70.5 |
| LLPS-Orgl-2310 | Oryza glumaepatula | 32.33 | 2e-11 | 70.9 |
| LLPS-Nia-1485 | Nicotiana attenuata | 32.31 | 5e-11 | 70.1 |
| LLPS-Prp-1200 | Prunus persica | 32.31 | 7e-11 | 70.1 |
| LLPS-Brd-0747 | Brachypodium distachyon | 31.82 | 3e-12 | 73.9 |
| LLPS-Sei-1828 | Setaria italica | 31.58 | 2e-10 | 68.2 |
| LLPS-Amt-1148 | Amborella trichopoda | 31.54 | 6e-11 | 69.7 |
| LLPS-Coc-0270 | Corchorus capsularis | 31.5 | 3e-12 | 75.1 |
| LLPS-Thc-1783 | Theobroma cacao | 31.5 | 2e-12 | 74.3 |
| LLPS-Tru-1179 | Triticum urartu | 30.83 | 9e-11 | 68.9 |
| LLPS-Hov-1772 | Hordeum vulgare | 30.83 | 6e-11 | 69.7 |
| LLPS-Mae-1901 | Manihot esculenta | 30.77 | 6e-11 | 70.1 |
| LLPS-Viv-2512 | Vitis vinifera | 30.71 | 2e-11 | 71.6 |
| LLPS-Sol-0495 | Solanum lycopersicum | 30.71 | 2e-11 | 71.2 |
| LLPS-Mua-1818 | Musa acuminata | 30.71 | 6e-11 | 69.3 |
| LLPS-Hea-2247 | Helianthus annuus | 30.71 | 2e-11 | 71.6 |
| LLPS-Sot-0163 | Solanum tuberosum | 30.71 | 7e-12 | 72.8 |
| LLPS-Met-2180 | Medicago truncatula | 30.6 | 1e-10 | 69.3 |
| LLPS-Sem-1390 | Selaginella moellendorffii | 30.36 | 2e-09 | 61.2 |
| LLPS-Orni-0465 | Oryza nivara | 30.23 | 4e-11 | 70.5 |
| LLPS-Lep-1184 | Leersia perrieri | 30.23 | 4e-11 | 70.5 |
| LLPS-Pot-0322 | Populus trichocarpa | 29.92 | 8e-11 | 69.7 |
| LLPS-Tra-2405 | Triticum aestivum | 29.92 | 8e-11 | 69.7 |
| LLPS-Zem-1793 | Zea mays | 29.46 | 5e-11 | 69.3 |
| LLPS-Gor-2329 | Gossypium raimondii | 29.17 | 1e-10 | 68.9 |
| LLPS-Phv-1899 | Phaseolus vulgaris | 29.13 | 6e-10 | 67.0 |
| LLPS-Glm-1749 | Glycine max | 29.13 | 3e-10 | 67.8 |
| LLPS-Dac-2168 | Daucus carota | 29.13 | 2e-10 | 67.8 |
| LLPS-Via-0745 | Vigna angularis | 29.13 | 7e-10 | 66.6 |
| LLPS-Sob-1413 | Sorghum bicolor | 29.1 | 9e-10 | 66.6 |