Mandrillus leucophaeus      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mal-1539
ENSMLEG00000043648.1
A0A2K6AGQ7
2
LLPS-Mal-0322
ENSMLEG00000035852.1
A0A2K5Z7G4
ATM
3
LLPS-Mal-2166
ENSMLEG00000035981.1
A0A2K5Z796
ATMIN
4
LLPS-Mal-4390
ENSMLEG00000030611.1
A0A2K5YBU2
ATR
5
LLPS-Mal-0523
ENSMLEG00000038040.1
A0A2K5ZIM2
FUS
6
LLPS-Mal-0623
ENSMLEG00000005566.1
A0A2K5XDM8
H2AFX
7
LLPS-Mal-0408
ENSMLEG00000043256.1
A0A2K6AEA9
HDAC1
8
LLPS-Mal-4733
ENSMLEG00000023736.1
A0A2K5XPV0
MDC1
9
LLPS-Mal-3194
ENSMLEG00000033844.1
A0A2K5YUQ0
PRKDC
10
LLPS-Mal-0702
ENSMLEG00000028390.1
A0A2K5XYZ5
RAD51
11
LLPS-Mal-3889
ENSMLEG00000042404.1
A0A2K6A959
RBM45
12
LLPS-Mal-1487
ENSMLEG00000044033.1
A0A2K6AIZ7
TP53BP1