Latimeria chalumnae      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Lac-1369
ENSLACG00000004811.1
H3A6Y6
ATM
2
LLPS-Lac-1278
ENSLACG00000008127.2
M3XGW6
ATMIN
3
LLPS-Lac-0466
ENSLACG00000009886.1
H3ANL6
ATR
4
LLPS-Lac-1227
ENSLACG00000004570.1
H3A671
FUS
5
LLPS-Lac-0439
ENSLACG00000017684.1
H3BE02
H2AFX
6
LLPS-Lac-0196
ENSLACG00000014083.1
H3B272
PRKDC
7
LLPS-Lac-3436
ENSLACG00000017079.1
H3BBZ5
RAD51
8
LLPS-Lac-1108
ENSLACG00000003728.1
H3A3H1
RBM45
9
LLPS-Lac-0869
ENSLACG00000008674.2
H3AJL6
TP53BP1