Homo sapiens      Chromatoid body


※ Chromatoid body introduction

    A single large granule of nuage, presents in post-meiotic spermatids is called the chromatoid body (1). Multiple proteins and some mRNAs have been found to localized to the chromatoid body including mouse VASA homolog , tudor-domain containing 1 (TDRD1), tudor-domain containing 6 (TDRD6), and tudor-domain containing 7 (TDRD7) , transition protein 2 (Tnp2), RANBP9, as a known MVH interactor also localizes to it. Its formation is related to the coalescence of intermitochondrial cement granules. In fact, the formation of the chromatoid body is not required for microRNA biogenesis, but might be important for its action on target mRNAs (1). In mice, the chromatoid body is a structure resembles Gp, TDRD6 plays a role in establishing the body and the localization of piRNA pathway components to this body (2).

Reference
1. Woodruff, J. B., Hyman, A. A., & Boke, E. (2018) Organization and Function of Non-dynamic Biomolecular Condensates. Trends Biochem Sci, 43(2), 81-94. PMID: 30086300
2. Ma, L., Buchold, G. M., Greenbaum, M. P., Roy, A., Burns, K. H., Zhu, H., et al. (2009) GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet, 5(9), e1000635. PMID: 19730684


There are 105 genes.  Reviewed (71 or Unreviewed (34

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-1686
ENSG00000123908.11
Q9UKV8
AGO2
2
LLPS-Hos-0037
ENSG00000108349.16
O15234
CASC3
3
LLPS-Hos-0805
ENSG00000169714.16
P62633
CNBP
4
LLPS-Hos-2051
ENSG00000172115.8
P99999
CYCS
5
LLPS-Hos-0531
ENSG00000272886.5
Q9NPI6
DCP1A
6
LLPS-Hos-2503
ENSG00000079785.14
Q92499
DDX1
7
LLPS-Hos-0713
ENSG00000152670.18
Q9NQI0
DDX4
8
LLPS-Hos-0055
ENSG00000108654.14
P17844
DDX5
9
LLPS-Hos-2251
ENSG00000135829.16
Q08211
DHX9
10
LLPS-Hos-0870
ENSG00000100697.14
Q9UPY3
DICER1
11
LLPS-Hos-1721
ENSG00000038358.14
Q6P2E9
EDC4
12
LLPS-Hos-2726
ENSG00000156508.17
P68104
EEF1A1
13
LLPS-Hos-2247
ENSG00000161960.14
P60842
EIF4A1
14
LLPS-Hos-2188
ENSG00000141543.10
P38919
EIF4A3
15
LLPS-Hos-0768
ENSG00000151247.12
P06730
EIF4E
16
LLPS-Hos-2640
ENSG00000066044.14
Q15717
ELAVL1
17
LLPS-Hos-0808
ENSG00000182944.17
Q01844
EWSR1
18
LLPS-Hos-3685
ENSG00000167468.16
P36969
GPX4
19
LLPS-Hos-0101
ENSG00000197153.4
P68431
HIST1H3J
20
LLPS-Hos-2608
ENSG00000122566.21
P22626
HNRNPA2B1
21
LLPS-Hos-1188
ENSG00000170144.20
P51991
HNRNPA3
22
LLPS-Hos-2409
ENSG00000152795.17
O14979
HNRNPDL
23
LLPS-Hos-2794
ENSG00000169813.16
P52597
HNRNPF
24
LLPS-Hos-2896
ENSG00000169045.17
P31943
HNRNPH1
25
LLPS-Hos-0452
ENSG00000099783.11
P52272
HNRNPM
26
LLPS-Hos-0747
ENSG00000153187.19
Q00839
HNRNPU
27
LLPS-Hos-1993
ENSG00000080824.18
P07900
HSP90AA1
28
LLPS-Hos-0844
ENSG00000096384.19
P08238
HSP90AB1
29
LLPS-Hos-0145
ENSG00000204388.6
P0DMV9
HSPA1B
30
LLPS-Hos-1896
ENSG00000126803.9
P54652
HSPA2
31
LLPS-Hos-0450
ENSG00000136231.13
O00425
IGF2BP3
32
LLPS-Hos-0059
ENSG00000129351.17
Q12906
ILF3
33
LLPS-Hos-2491
ENSG00000121774.17
Q07666
KHDRBS1
34
LLPS-Hos-0198
ENSG00000134333.13
P00338
LDHA
35
LLPS-Hos-0207
ENSG00000145220.13
Q9NX58
LYAR
36
LLPS-Hos-2492
ENSG00000143194.12
Q96JY0
MAEL
37
LLPS-Hos-0280
ENSG00000111196.9
Q96A72
MAGOHB
38
LLPS-Hos-1736
ENSG00000115053.15
P19338
NCL
39
LLPS-Hos-0411
ENSG00000139350.11
Q8NHV4
NEDD1
40
LLPS-Hos-0089
ENSG00000070756.15
P11940
PABPC1
41
LLPS-Hos-2073
ENSG00000169564.6
Q15365
PCBP1
42
LLPS-Hos-1663
ENSG00000197111.15
Q15366
PCBP2
43
LLPS-Hos-2582
ENSG00000125207.7
Q96J94
PIWIL1
44
LLPS-Hos-0832
ENSG00000197181.11
Q8TC59
PIWIL2
45
LLPS-Hos-1285
ENSG00000105819.13
O75439
PMPCB
46
LLPS-Hos-2136
ENSG00000010017.12
Q96S59
RANBP9
47
LLPS-Hos-2036
ENSG00000239306.4
Q96PK6
RBM14
48
LLPS-Hos-0387
ENSG00000265241.6
Q9Y5S9
RBM8A
49
LLPS-Hos-1283
ENSG00000142676.14
P62913
RPL11
50
LLPS-Hos-0262
ENSG00000198242.13
P62750
RPL23A
51
LLPS-Hos-0810
ENSG00000114391.12
P83731
RPL24
52
LLPS-Hos-1000
ENSG00000164587.12
P62263
RPS14
53
LLPS-Hos-0178
ENSG00000142937.11
P62241
RPS8
54
LLPS-Hos-2376
ENSG00000157106.16
Q96Q15
SMG1
55
LLPS-Hos-0990
ENSG00000070366.13
Q86US8
SMG6
56
LLPS-Hos-1134
ENSG00000136450.12
Q07955
SRSF1
57
LLPS-Hos-1496
ENSG00000112081.16
P84103
SRSF3
58
LLPS-Hos-2013
ENSG00000083544.14
Q9H7E2
TDRD3
59
LLPS-Hos-0693
ENSG00000196116.7
Q8NHU6
TDRD7
60
LLPS-Hos-1144
ENSG00000083312.17
Q92973
TNPO1
61
LLPS-Hos-0196
ENSG00000090905.18
Q8NDV7
TNRC6A
62
LLPS-Hos-0908
ENSG00000025772.7
Q15785
TOMM34
63
LLPS-Hos-1197
ENSG00000100038.19
O95985
TOP3B
64
LLPS-Hos-1744
ENSG00000136527.17
P62995
TRA2B
65
LLPS-Hos-3547
ENSG00000075886.10
P0DPH8
TUBA3D
66
LLPS-Hos-2655
ENSG00000258947.6
Q13509
TUBB3
67
LLPS-Hos-1346
ENSG00000005007.12
Q92900
UPF1
68
LLPS-Hos-4588
ENSG00000124486.12
Q93008
USP9X
69
LLPS-Hos-0709
ENSG00000026025.15
P08670
VIM
70
LLPS-Hos-4545
ENSG00000069329.17
Q96QK1
VPS35
71
LLPS-Hos-0345
ENSG00000047188.15
Q9H6S0
YTHDC2
72
LLPS-Hos-2933
ENSG00000164113.10
Q96M93
ADAD1
73
LLPS-Hos-4218
ENSG00000140955.10
Q8NCV1
ADAD2
74
LLPS-Hos-3616
ENSG00000169129.14
Q8N4X5
AFAP1L2
75
LLPS-Hos-4956
ENSG00000147081.14
Q5JQC9
AKAP4
76
LLPS-Hos-3809
ENSG00000154438.7
Q8WWH4
ASZ1
77
LLPS-Hos-0128
ENSG00000166582.9
Q7Z7K6
CENPV
78
LLPS-Hos-3329
ENSG00000164733.20
P07858
CTSB
79
LLPS-Hos-3262
ENSG00000109832.13
Q9UHL0
DDX25
80
LLPS-Hos-4093
ENSG00000188316.13
A6NNW6
ENO4
81
LLPS-Hos-3570
ENSG00000205186.2
Q0Z7S8
FABP9
82
LLPS-Hos-3659
ENSG00000163820.14
Q9BQS8
FYCO1
83
LLPS-Hos-2032
ENSG00000146047.6
Q96A08
HIST1H2BA
84
LLPS-Hos-1834
ENSG00000158406.4
P62805
HIST4H4
85
LLPS-Hos-3205
ENSG00000176095.11
Q92551
IP6K1
86
LLPS-Hos-4853
ENSG00000185896.10
P11279
LAMP1
87
LLPS-Hos-3951
ENSG00000198804.2
P00395
MT-CO1
88
LLPS-Hos-4760
ENSG00000155087.3
Q14990
ODF1
89
LLPS-Hos-3490
ENSG00000164985.14
O75475
PSIP1
90
LLPS-Hos-3307
ENSG00000108961.13
Q9HD47
RANGRF
91
LLPS-Hos-4049
ENSG00000169413.2
Q93091
RNASE6
92
LLPS-Hos-3389
ENSG00000132972.18
Q9BXT8
RNF17
93
LLPS-Hos-3848
ENSG00000174015.9
Q8NA61
SPERT
94
LLPS-Hos-4911
ENSG00000196335.12
Q9BXU1
STK31
95
LLPS-Hos-2987
ENSG00000095627.9
Q9BXT4
TDRD1
96
LLPS-Hos-3900
ENSG00000162782.15
Q8NAT2
TDRD5
97
LLPS-Hos-2996
ENSG00000180113.15
O60522
TDRD6
98
LLPS-Hos-3161
ENSG00000156414.18
Q8NDG6
TDRD9
99
LLPS-Hos-1650
ENSG00000092850.11
Q9UIF3
TEKT2
100
LLPS-Hos-1815
ENSG00000163060.7
Q8WW24
TEKT4
101
LLPS-Hos-4129
ENSG00000070985.13
Q9NZQ8
TRPM5
102
LLPS-Hos-4682
ENSG00000123607.14
Q7Z4L5
TTC21B
103
LLPS-Hos-4321
ENSG00000165886.4
Q9HAC8
UBTD1
104
LLPS-Hos-4403
ENSG00000122958.14
O75436
VPS26A
105
LLPS-Hos-4190
ENSG00000006047.12
Q9Y2T7
YBX2