Caenorhabditis elegans      Chromatoid body


※ Chromatoid body introduction

    A single large granule of nuage, presents in post-meiotic spermatids is called the chromatoid body (1). Multiple proteins and some mRNAs have been found to localized to the chromatoid body including mouse VASA homolog , tudor-domain containing 1 (TDRD1), tudor-domain containing 6 (TDRD6), and tudor-domain containing 7 (TDRD7) , transition protein 2 (Tnp2), RANBP9, as a known MVH interactor also localizes to it. Its formation is related to the coalescence of intermitochondrial cement granules. In fact, the formation of the chromatoid body is not required for microRNA biogenesis, but might be important for its action on target mRNAs (1). In mice, the chromatoid body is a structure resembles Gp, TDRD6 plays a role in establishing the body and the localization of piRNA pathway components to this body (2).

Reference
1. Woodruff, J. B., Hyman, A. A., & Boke, E. (2018) Organization and Function of Non-dynamic Biomolecular Condensates. Trends Biochem Sci, 43(2), 81-94. PMID: 30086300
2. Ma, L., Buchold, G. M., Greenbaum, M. P., Roy, A., Burns, K. H., Zhu, H., et al. (2009) GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet, 5(9), e1000635. PMID: 19730684


There are 35 genes.  Reviewed (5 or Unreviewed (30

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Cae-0354
WBGene00000079
Q9U3D6
adr-1
2
LLPS-Cae-0017
WBGene00003902
Q9U302
pab-1
3
LLPS-Cae-0070
WBGene00004178
P90786
prg-1
4
LLPS-Cae-0266
WBGene00004387
Q21832
rnp-4
5
LLPS-Cae-0226
WBGene00004477
P48156
rps-8
6
LLPS-Cae-1168
WBGene00000106
O16720
alg-2
7
LLPS-Cae-1259
WBGene00007628
Q09464
C16C10.8
8
LLPS-Cae-1438
WBGene00017771
Q8MNR9
CELE_F25B4.8
9
LLPS-Cae-1203
WBGene00012343
G5EDE4
CELE_W08E3.2
10
LLPS-Cae-1956
WBGene00021260
Q9BKX8
CELE_Y22D7AR.6
11
LLPS-Cae-1753
WBGene00012995
H1UBJ9
CELE_Y48C3A.14
12
LLPS-Cae-1416
WBGene00021748
Q965Q9
CELE_Y50D4C.3
13
LLPS-Cae-0799
WBGene00021938
Q9N341
CELE_Y55F3BR.1
14
LLPS-Cae-0759
WBGene00022029
Q9BL61
CELE_Y65B4A.6
15
LLPS-Cae-1971
WBGene00000785
P43509
cpr-5
16
LLPS-Cae-0621
WBGene00010964
P24893
ctc-1
17
LLPS-Cae-1019
WBGene00017121
P19974
cyc-2.1
18
LLPS-Cae-0955
WBGene00000915
Q18688
daf-21
19
LLPS-Cae-0120
WBGene00000939
P34529
dcr-1
20
LLPS-Cae-0963
WBGene00021551
Q8ITV6
edc-4
21
LLPS-Cae-1010
WBGene00020373
H2KYJ6
gpx-6
22
LLPS-Cae-0458
WBGene00001875
P62784
his-67
23
LLPS-Cae-0530
WBGene00012769
B9WRU1
hrpu-1
24
LLPS-Cae-0651
WBGene00002061
O61955
ife-3
25
LLPS-Cae-2024
WBGene00022696
Q20255
ift-139
26
LLPS-Cae-1012
WBGene00002076
A0A131MBF9
imb-2
27
LLPS-Cae-0667
WBGene00013880
Q23295
mppb-1
28
LLPS-Cae-0736
WBGene00004423
Q19162
rpl-11.2
29
LLPS-Cae-0615
WBGene00004436
O01868
rpl-24.1
30
LLPS-Cae-1290
WBGene00004439
Q20647
rpl-25.2
31
LLPS-Cae-0598
WBGene00004483
P48150
rps-14
32
LLPS-Cae-1733
WBGene00004705
Q9XTZ2
rsp-8
33
LLPS-Cae-1062
WBGene00004880
O76512
smg-2
34
LLPS-Cae-1589
WBGene00004884
Q9BL68
smg-6
35
LLPS-Cae-1767
WBGene00006933
Q21053
vps-35