LLPS-Yal-0009
PAC1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Nuclear distribution protein PAC1; Lissencephaly-1 homolog; LIS-1; nudF homolog |
| Gene Name: | PAC1, LIS1, YALI0B00902g |
| Ensembl Gene: | YALI0_B00902g |
| Ensembl Protein: | CAG82578 |
| Organism: | Yarrowia lipolytica |
| Taxa ID: | 284591 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CAG82578 | CAG82578 |
| UniProt | Q6CG48, LIS1_YARLI | |
| GeneBank | CR382128 | CAG82578.1 |
| RefSeq | XM_500364.1 | XP_500364.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MESLLTDKQR SDLETSIFGY VSRLTNDEAL LSQLAAVLSQ PSGSEPVPAD TLKANALLLE 60 61 KKWLSVIRLQ RKVMDLETRL EAAEREASST HKANGLGAGD PKTWLPKTSR FSLLHKQPVN 120 121 AVSFHPFHST LASACEDGNI RIWDYELGEI ETTIKAHTRG VLDVDFSQPD TGASRDKSHD 180 181 KPRADVSHAQ PRALLVSCSS DLTIRIWDPQ NEYANVKTLT GHDHTISAVK FTASGNHVIS 240 241 ASRDKTVRVW SVQSGYCVRT VHGHTDWVKS CAALNEEFIF SAGIDHVTRV SEFVSGDGKM 300 301 TLLGHEHVIE GVAVYPKSAA GCLAKLDKTS SYFVVSWSRD KTIRVWSSRG DPLLILRGHD 360 361 NWVRGVVLHP AGRYLVSVSD DKTMRCWDLE QGGRCIRVVD AHGHFVTCVA WAPNDVNGRV 420 421 RCLVATGGVD GQVKVWQ 437 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGTCGC TACTGACGGA TAAACAACGC AGCGACCTGG AAACCAGCAT TTTCGGATAC 60 61 GTCAGCCGGC TGACTAACGA CGAGGCGCTG CTGAGTCAGC TGGCGGCGGT TCTGAGTCAG 120 121 CCGTCGGGCT CCGAGCCCGT GCCTGCCGAC ACTCTCAAGG CCAACGCTTT ACTACTGGAA 180 181 AAGAAATGGT TATCGGTCAT AAGGCTTCAG CGCAAGGTGA TGGATTTGGA AACCCGTTTG 240 241 GAGGCGGCAG AGCGAGAAGC CTCTTCCACT CATAAGGCCA ACGGTCTGGG GGCTGGCGAC 300 301 CCGAAAACGT GGCTACCCAA AACTTCACGA TTCAGTCTGT TACATAAGCA GCCCGTGAAT 360 361 GCCGTGTCAT TTCATCCGTT TCATTCCACT CTGGCGTCGG CGTGCGAAGA TGGAAATATC 420 421 AGAATCTGGG ATTACGAGCT GGGCGAGATT GAAACGACGA TAAAGGCCCA TACGAGGGGG 480 481 GTGCTGGACG TGGACTTTAG TCAGCCGGAC ACGGGAGCGT CACGGGACAA ATCACATGAC 540 541 AAGCCACGTG CCGACGTATC ACACGCCCAG CCCCGAGCGC TCCTGGTCAG CTGCTCGTCG 600 601 GACCTCACCA TCCGAATATG GGACCCCCAA AACGAATACG CAAACGTCAA AACACTGACC 660 661 GGCCATGACC ACACAATCTC GGCGGTCAAA TTCACCGCGT CGGGGAACCA CGTCATTTCC 720 721 GCGTCACGTG ACAAGACGGT CCGCGTCTGG TCCGTGCAAT CGGGCTACTG CGTGCGAACG 780 781 GTCCACGGCC ACACAGACTG GGTCAAATCG TGCGCGGCGC TCAACGAAGA GTTCATCTTC 840 841 TCAGCAGGGA TCGATCACGT GACCCGCGTC AGCGAGTTTG TCTCCGGCGA CGGCAAGATG 900 901 ACGCTACTCG GCCACGAGCA CGTGATCGAG GGCGTTGCCG TCTACCCCAA GAGCGCCGCC 960 961 GGGTGTCTGG CCAAGCTCGA CAAGACGAGC TCGTACTTTG TCGTGTCGTG GTCACGTGAC 1020 1021 AAGACGATCC GGGTGTGGTC GTCACGTGGC GATCCTCTAC TAATTCTTCG GGGTCATGAC 1080 1081 AATTGGGTTA GGGGAGTTGT TCTTCATCCG GCCGGGCGGT ATTTGGTTTC TGTTTCTGAT 1140 1141 GACAAGACCA TGAGATGTTG GGATTTGGAG CAGGGCGGCC GGTGTATTAG GGTTGTTGAT 1200 1201 GCCCATGGGC ATTTTGTCAC GTGCGTGGCG TGGGCTCCGA ACGATGTCAA TGGTCGGGTT 1260 1261 CGGTGTCTTG TTGCCACTGG CGGTGTTGAT GGCCAAGTCA AGGTGTGGCA GTGA 1314 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic microtubule | |
Cellular Component | Kinetochore | |
Cellular Component | Microtubule associated complex | |
Cellular Component | Nuclear envelope | |
Cellular Component | Spindle pole | |
Molecular Function | Dynein complex binding | |
Molecular Function | Microtubule plus-end binding | |
Biological Process | Cell division | |
Biological Process | Establishment of mitotic spindle orientation | |
Biological Process | Microtubule organizing center organization | |
Biological Process | Microtubule sliding | |
Biological Process | Nuclear migration | |
Biological Process | Regulation of microtubule motor activity | |
Biological Process | Vesicle transport along microtubule |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scs-0009 | Sclerotinia sclerotiorum | 44.62 | 6e-112 | 344 |
| LLPS-Asf-0823 | Aspergillus flavus | 43.68 | 1e-108 | 335 |
| LLPS-Lem-0798 | Leptosphaeria maculans | 43.33 | 2e-120 | 366 |
| LLPS-Tum-0520 | Tuber melanosporum | 43.16 | 2e-115 | 353 |
| LLPS-Phn-0244 | Phaeosphaeria nodorum | 42.77 | 1e-118 | 362 |
| LLPS-Ved-1030 | Verticillium dahliae | 42.66 | 4e-105 | 327 |
| LLPS-Asfu-0547 | Aspergillus fumigatus | 42.13 | 2e-117 | 358 |
| LLPS-Pytr-0275 | Pyrenophora triticirepentis | 42.03 | 3e-118 | 360 |
| LLPS-Pyt-0095 | Pyrenophora teres | 41.82 | 1e-117 | 359 |
| LLPS-Blg-0031 | Blumeria graminis | 41.82 | 8e-116 | 354 |
| LLPS-Asc-0007 | Aspergillus clavatus | 41.51 | 2e-115 | 353 |
| LLPS-Cogr-0488 | Colletotrichum graminicola | 41.49 | 7e-113 | 347 |
| LLPS-Cog-0123 | Colletotrichum gloeosporioides | 41.32 | 9e-108 | 333 |
| LLPS-Leo-0026 | Lepisosteus oculatus | 41.31 | 8e-85 | 272 |
| LLPS-Crn-0295 | Cryptococcus neoformans | 41.08 | 7e-91 | 288 |
| LLPS-Coo-0396 | Colletotrichum orbiculare | 41.03 | 1e-108 | 335 |
| LLPS-Zyt-0898 | Zymoseptoria tritici | 40.91 | 9e-111 | 341 |
| LLPS-Pap-1791 | Pan paniscus | 40.81 | 1e-83 | 270 |
| LLPS-Pat-1867 | Pan troglodytes | 40.81 | 1e-83 | 270 |
| LLPS-Man-3506 | Macaca nemestrina | 40.81 | 2e-83 | 269 |
| LLPS-Loa-0835 | Loxodonta africana | 40.81 | 5e-84 | 270 |
| LLPS-Otg-1323 | Otolemur garnettii | 40.81 | 9e-84 | 270 |
| LLPS-Caf-0706 | Canis familiaris | 40.81 | 2e-83 | 269 |
| LLPS-Eqc-2177 | Equus caballus | 40.81 | 7e-84 | 270 |
| LLPS-Ict-3692 | Ictidomys tridecemlineatus | 40.81 | 8e-84 | 270 |
| LLPS-Maf-0816 | Macaca fascicularis | 40.81 | 2e-83 | 269 |
| LLPS-Gog-1943 | Gorilla gorilla | 40.81 | 1e-83 | 270 |
| LLPS-Paa-3460 | Papio anubis | 40.81 | 2e-83 | 268 |
| LLPS-Myl-2440 | Myotis lucifugus | 40.81 | 1e-83 | 270 |
| LLPS-Aim-3745 | Ailuropoda melanoleuca | 40.81 | 2e-83 | 269 |
| LLPS-Nef-0816 | Neosartorya fischeri | 40.78 | 1e-115 | 353 |
| LLPS-Map-0818 | Magnaporthe poae | 40.74 | 2e-109 | 338 |
| LLPS-Nec-0488 | Neurospora crassa | 40.63 | 7e-114 | 348 |
| LLPS-Gag-1129 | Gaeumannomyces graminis | 40.58 | 4e-109 | 337 |
| LLPS-Fud-0484 | Fukomys damarensis | 40.55 | 5e-83 | 268 |
| LLPS-Dos-0850 | Dothistroma septosporum | 40.25 | 2e-107 | 332 |
| LLPS-Mao-0668 | Magnaporthe oryzae | 40.21 | 1e-109 | 338 |
| LLPS-Beb-0146 | Beauveria bassiana | 40.04 | 1e-109 | 338 |
| LLPS-Cis-0436 | Ciona savignyi | 40.0 | 6e-80 | 259 |
| LLPS-Drm-0464 | Drosophila melanogaster | 39.73 | 5e-82 | 265 |
| LLPS-Mea-0891 | Mesocricetus auratus | 39.7 | 3e-72 | 238 |
| LLPS-Fuv-0395 | Fusarium verticillioides | 39.67 | 1e-108 | 335 |
| LLPS-Fuo-0440 | Fusarium oxysporum | 39.54 | 2e-109 | 337 |
| LLPS-Aso-1298 | Aspergillus oryzae | 39.37 | 4e-106 | 328 |
| LLPS-Tar-2543 | Takifugu rubripes | 39.29 | 4e-85 | 273 |
| LLPS-Chs-0091 | Chlorocebus sabaeus | 39.26 | 7e-76 | 247 |
| LLPS-Abg-0236 | Absidia glauca | 39.2 | 1e-96 | 303 |
| LLPS-Ten-0356 | Tetraodon nigroviridis | 39.15 | 8e-85 | 272 |
| LLPS-Trv-0054 | Trichoderma virens | 39.14 | 6e-105 | 326 |
| LLPS-Cii-1105 | Ciona intestinalis | 39.11 | 5e-80 | 260 |
| LLPS-Spr-0351 | Sporisorium reilianum | 39.1 | 8e-98 | 307 |
| LLPS-Gaa-0517 | Gasterosteus aculeatus | 39.1 | 1e-85 | 275 |
| LLPS-Asn-1241 | Aspergillus nidulans | 38.97 | 3e-100 | 313 |
| LLPS-Orn-1181 | Oreochromis niloticus | 38.88 | 1e-85 | 275 |
| LLPS-Dar-1289 | Danio rerio | 38.79 | 3e-84 | 271 |
| LLPS-Anp-1577 | Anas platyrhynchos | 38.79 | 1e-84 | 272 |
| LLPS-Fia-0310 | Ficedula albicollis | 38.79 | 1e-84 | 272 |
| LLPS-Gaga-0755 | Gallus gallus | 38.79 | 1e-84 | 272 |
| LLPS-Tag-1858 | Taeniopygia guttata | 38.79 | 2e-84 | 271 |
| LLPS-Miv-0361 | Microbotryum violaceum | 38.78 | 3e-93 | 295 |
| LLPS-Usm-0171 | Ustilago maydis | 38.72 | 3e-96 | 303 |
| LLPS-Fus-0311 | Fusarium solani | 38.67 | 1e-104 | 325 |
| LLPS-Pof-0361 | Poecilia formosa | 38.65 | 3e-86 | 276 |
| LLPS-Scm-2788 | Scophthalmus maximus | 38.65 | 4e-84 | 271 |
| LLPS-Orl-0107 | Oryzias latipes | 38.65 | 2e-85 | 274 |
| LLPS-Meg-0761 | Meleagris gallopavo | 38.57 | 4e-84 | 271 |
| LLPS-Trr-0871 | Trichoderma reesei | 38.55 | 7e-101 | 316 |
| LLPS-Cas-0711 | Carlito syrichta | 38.43 | 7e-84 | 270 |
| LLPS-Lac-3171 | Latimeria chalumnae | 38.39 | 5e-86 | 275 |
| LLPS-Scf-1544 | Scleropages formosus | 38.39 | 4e-84 | 271 |
| LLPS-Hos-0868 | Homo sapiens | 38.34 | 3e-84 | 271 |
| LLPS-Pes-2197 | Pelodiscus sinensis | 38.34 | 5e-84 | 270 |
| LLPS-Asm-2834 | Astyanax mexicanus | 38.34 | 4e-84 | 271 |
| LLPS-Icp-2263 | Ictalurus punctatus | 38.34 | 2e-84 | 271 |
| LLPS-Urm-0716 | Ursus maritimus | 38.12 | 5e-84 | 270 |
| LLPS-Fec-0352 | Felis catus | 38.12 | 5e-84 | 270 |
| LLPS-Rhb-0187 | Rhinopithecus bieti | 38.12 | 1e-83 | 269 |
| LLPS-Poa-0077 | Pongo abelii | 38.12 | 5e-84 | 270 |
| LLPS-Cap-0549 | Cavia porcellus | 38.12 | 5e-84 | 270 |
| LLPS-Mam-1347 | Macaca mulatta | 38.12 | 1e-83 | 269 |
| LLPS-Anc-1700 | Anolis carolinensis | 38.12 | 2e-81 | 263 |
| LLPS-Mum-0510 | Mus musculus | 38.12 | 5e-84 | 270 |
| LLPS-Ora-2318 | Ornithorhynchus anatinus | 38.12 | 5e-84 | 270 |
| LLPS-Cea-2643 | Cercocebus atys | 38.12 | 1e-83 | 269 |
| LLPS-Aon-1032 | Aotus nancymaae | 38.12 | 5e-84 | 270 |
| LLPS-Sus-1100 | Sus scrofa | 38.12 | 5e-84 | 270 |
| LLPS-Caj-3302 | Callithrix jacchus | 38.12 | 5e-84 | 270 |
| LLPS-Xim-1787 | Xiphophorus maculatus | 38.12 | 1e-84 | 272 |
| LLPS-Dio-2011 | Dipodomys ordii | 38.12 | 5e-84 | 270 |
| LLPS-Bot-2741 | Bos taurus | 38.12 | 5e-84 | 270 |
| LLPS-Ran-0516 | Rattus norvegicus | 38.12 | 5e-84 | 270 |
| LLPS-Mal-0368 | Mandrillus leucophaeus | 38.12 | 1e-83 | 269 |
| LLPS-Ova-0316 | Ovis aries | 38.12 | 5e-84 | 270 |
| LLPS-Mup-1981 | Mustela putorius furo | 38.12 | 5e-84 | 270 |
| LLPS-Xet-1516 | Xenopus tropicalis | 37.89 | 1e-83 | 269 |
| LLPS-Sah-3483 | Sarcophilus harrisii | 37.89 | 1e-82 | 267 |
| LLPS-Asni-0781 | Aspergillus niger | 37.71 | 5e-101 | 315 |
| LLPS-Mod-1241 | Monodelphis domestica | 37.67 | 3e-82 | 266 |
| LLPS-Tut-2058 | Tursiops truncatus | 37.67 | 8e-85 | 272 |
| LLPS-Mel-0215 | Melampsora laricipopulina | 37.47 | 6e-92 | 292 |
| LLPS-Ast-0653 | Aspergillus terreus | 37.23 | 2e-97 | 306 |
| LLPS-Pug-1357 | Puccinia graminis | 36.48 | 2e-91 | 291 |
| LLPS-Cae-0125 | Caenorhabditis elegans | 36.22 | 1e-81 | 264 |
| LLPS-Nol-1335 | Nomascus leucogenys | 36.09 | 9e-63 | 213 |
| LLPS-Put-0742 | Puccinia triticina | 34.87 | 2e-28 | 122 |
| LLPS-Php-2319 | Physcomitrella patens | 31.72 | 1e-12 | 72.4 |
| LLPS-Scj-0033 | Schizosaccharomyces japonicus | 31.3 | 1e-58 | 205 |
| LLPS-Lep-1671 | Leersia perrieri | 31.12 | 2e-27 | 115 |
| LLPS-Orp-2192 | Oryza punctata | 30.86 | 2e-27 | 115 |
| LLPS-Sob-1767 | Sorghum bicolor | 30.82 | 3e-26 | 111 |
| LLPS-Zem-1499 | Zea mays | 30.82 | 8e-26 | 110 |
| LLPS-Sei-1717 | Setaria italica | 30.82 | 4e-25 | 108 |
| LLPS-Brd-2494 | Brachypodium distachyon | 30.74 | 8e-14 | 76.3 |
| LLPS-Ors-1106 | Oryza sativa | 30.68 | 6e-27 | 114 |
| LLPS-Org-2252 | Oryza glaberrima | 30.68 | 6e-27 | 114 |
| LLPS-Hov-1642 | Hordeum vulgare | 30.3 | 8e-14 | 76.3 |
| LLPS-Tra-2832 | Triticum aestivum | 30.3 | 1e-13 | 75.5 |
| LLPS-Mua-0915 | Musa acuminata | 29.79 | 2e-27 | 115 |
| LLPS-Ori-1612 | Oryza indica | 29.72 | 2e-23 | 104 |
| LLPS-Chc-0712 | Chondrus crispus | 29.58 | 2e-25 | 114 |
| LLPS-Hea-1495 | Helianthus annuus | 29.44 | 5e-18 | 88.6 |
| LLPS-Kop-0105 | Komagataella pastoris | 29.44 | 2e-44 | 167 |
| LLPS-Mae-0054 | Manihot esculenta | 29.36 | 1e-16 | 84.3 |
| LLPS-Orc-2983 | Oryctolagus cuniculus | 29.21 | 5e-25 | 109 |
| LLPS-Osl-0673 | Ostreococcus lucimarinus | 28.0 | 4e-22 | 102 |
| LLPS-Sot-2109 | Solanum tuberosum | 27.98 | 4e-09 | 62.8 |
| LLPS-Viv-0598 | Vitis vinifera | 27.65 | 2e-21 | 98.2 |
| LLPS-Sol-0570 | Solanum lycopersicum | 27.27 | 7e-22 | 102 |
| LLPS-Pot-0047 | Populus trichocarpa | 26.73 | 2e-22 | 100 |
| LLPS-Asg-0956 | Ashbya gossypii | 26.72 | 2e-34 | 137 |
| LLPS-Vir-0994 | Vigna radiata | 26.65 | 7e-22 | 99.4 |
| LLPS-Glm-2511 | Glycine max | 25.68 | 5e-22 | 100 |