LLPS-Mum-0510
Pafah1b1

▼ OVERVIEW

Status: Reviewed
Protein Name: Platelet-activating factor acetylhydrolase IB subunit alpha; Lissencephaly-1 protein; LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha
Gene Name: Pafah1b1, Lis-1, Lis1, Pafaha
Ensembl Gene: ENSMUSG00000020745.15
Ensembl Protein: ENSMUSP00000021091.8
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others
PDB: 1VYH (C, A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A15473967, 11163260

▼ FUNCTION

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVLSQRQRDE  LNRAIADYLR  SNGYEEAYSV  FKKEAELDMN  EELDKKYAGL  LEKKWTSVIR  60
61    LQKKVMELES  KLNEAKEEFT  SGGPLGQKRD  PKEWIPRPPE  KYALSGHRSP  VTRVIFHPVF  120
121   SVMVSASEDA  TIKVWDYETG  DFERTLKGHT  DSVQDISFDH  SGKLLASCSA  DMTIKLWDFQ  180
181   GFECIRTMHG  HDHNVSSVAI  MPNGDHIVSA  SRDKTIKMWE  VQTGYCVKTF  TGHREWVRMV  240
241   RPNQDGTLIA  SCSNDQTVRV  WVVATKECKA  ELREHEHVVE  CISWAPESSY  SSISEATGSE  300
301   TKKSGKPGPF  LLSGSRDKTI  KMWDVSTGMC  LMTLVGHDNW  VRGVLFHSGG  KFILSCADDK  360
361   TLRVWDYKNK  RCMKTLNAHE  HFVTSLDFHK  TAPYVVTGSV  DQTVKVWECR  410
Nucleotide CDS Sequence (FASTA)
1     ATGGTGCTGT  CCCAGAGACA  ACGAGATGAA  CTAAATCGAG  CTATAGCAGA  TTATCTTCGT  60
61    TCAAATGGCT  ATGAAGAGGC  ATATTCCGTT  TTTAAAAAGG  AAGCTGAACT  AGATATGAAT  120
121   GAAGAATTAG  ATAAGAAGTA  TGCTGGTCTT  TTGGAAAAAA  AATGGACATC  TGTTATTAGA  180
181   TTACAAAAAA  AGGTAATGGA  ATTAGAATCA  AAACTAAATG  AAGCAAAAGA  AGAATTTACG  240
241   TCGGGTGGTC  CTCTTGGTCA  GAAACGGGAC  CCAAAAGAAT  GGATTCCCCG  TCCACCTGAG  300
301   AAATACGCAT  TGAGTGGTCA  TAGGAGTCCA  GTTACTCGAG  TCATTTTCCA  TCCTGTGTTC  360
361   AGTGTTATGG  TCTCTGCTTC  AGAGGATGCT  ACAATTAAGG  TGTGGGATTA  TGAGACTGGA  420
421   GATTTTGAGC  GAACTCTCAA  GGGCCATACA  GACTCTGTAC  AGGACATTTC  CTTTGACCAC  480
481   AGTGGCAAGC  TTCTGGCTTC  CTGTTCAGCA  GATATGACGA  TTAAATTATG  GGATTTTCAG  540
541   GGTTTTGAAT  GCATCAGAAC  CATGCACGGT  CACGATCACA  ATGTCTCTTC  AGTAGCCATC  600
601   ATGCCTAATG  GAGATCATAT  AGTGTCTGCC  TCAAGGGATA  AAACTATAAA  GATGTGGGAA  660
661   GTGCAAACTG  GCTACTGTGT  GAAGACATTC  ACAGGACACA  GAGAATGGGT  ACGTATGGTG  720
721   CGGCCAAATC  AGGATGGCAC  TCTGATAGCC  AGCTGTTCCA  ATGACCAGAC  TGTGCGTGTG  780
781   TGGGTTGTAG  CAACAAAGGA  ATGCAAGGCT  GAGCTCCGAG  AACATGAACA  TGTGGTGGAA  840
841   TGCATTTCCT  GGGCTCCAGA  AAGTTCATAT  TCTTCCATCT  CTGAAGCAAC  AGGATCTGAG  900
901   ACTAAAAAAA  GTGGCAAGCC  TGGACCTTTC  TTGCTATCTG  GTTCCAGAGA  CAAAACTATT  960
961   AAGATGTGGG  ACGTCAGTAC  TGGCATGTGC  CTTATGACTC  TTGTGGGTCA  TGATAACTGG  1020
1021  GTACGTGGAG  TTCTGTTCCA  TTCTGGGGGG  AAGTTTATTT  TGAGTTGTGC  TGATGACAAG  1080
1081  ACCCTCCGTG  TATGGGATTA  TAAGAACAAG  CGATGCATGA  AGACCCTCAA  TGCGCATGAA  1140
1141  CACTTTGTTA  CCTCCTTGGA  TTTCCATAAG  ACGGCACCCT  ATGTGGTTAC  TGGCAGTGTA  1200
1201  GATCAAACAG  TAAAGGTGTG  GGAGTGCCGT  TGA  1233

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Developmental protein
Differentiation
Direct protein sequencing
Lipid degradation
Lipid metabolism
Membrane
Microtubule
Mitosis
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transport
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Astral microtubule
Cellular Component
Axon
Cellular Component
Axon cytoplasm
Cellular Component
Cell cortex
Cellular Component
Central region of growth cone
Cellular Component
Centrosome
Cellular Component
Cytoplasm
Cellular Component
Cytoplasmic microtubule
Cellular Component
Cytosol
Cellular Component
Growth cone
Cellular Component
Kinesin complex
Cellular Component
Kinetochore
Cellular Component
Microtubule associated complex
Cellular Component
Microtubule cytoskeleton
Cellular Component
Motile cilium
Cellular Component
Neuron projection
Cellular Component
Neuronal cell body
Cellular Component
Nuclear envelope
Cellular Component
Nuclear membrane
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Stereocilium
Cellular Component
Vesicle
Molecular Function
Dynein complex binding
Molecular Function
Dynein intermediate chain binding
Molecular Function
Microtubule binding
Molecular Function
Microtubule plus-end binding
Molecular Function
Phosphoprotein binding
Molecular Function
Protein homodimerization activity
Molecular Function
Protein-containing complex binding
Biological Process
Acrosome assembly
Biological Process
Actin cytoskeleton organization
Biological Process
Adult locomotory behavior
Biological Process
Ameboidal-type cell migration
Biological Process
Auditory receptor cell development
Biological Process
Brain morphogenesis
Biological Process
Cell migration
Biological Process
Cerebral cortex development
Biological Process
Cerebral cortex neuron differentiation
Biological Process
Chemical synaptic transmission
Biological Process
Cochlea development
Biological Process
Corpus callosum morphogenesis
Biological Process
Cortical microtubule organization
Biological Process
Establishment of centrosome localization
Biological Process
Establishment of mitotic spindle orientation
Biological Process
Establishment of planar polarity of embryonic epithelium
Biological Process
Hippocampus development
Biological Process
Layer formation in cerebral cortex
Biological Process
Learning or memory
Biological Process
Lipid catabolic process
Biological Process
Maintenance of centrosome location
Biological Process
Microtubule cytoskeleton organization
Biological Process
Microtubule cytoskeleton organization involved in establishment of planar polarity
Biological Process
Microtubule organizing center organization
Biological Process
Microtubule sliding
Biological Process
Microtubule-based process
Biological Process
Negative regulation of JNK cascade
Biological Process
Negative regulation of neuron projection development
Biological Process
Neuroblast proliferation
Biological Process
Neuromuscular process controlling balance
Biological Process
Neuron migration
Biological Process
Nuclear envelope disassembly
Biological Process
Nuclear migration
Biological Process
Osteoclast development
Biological Process
Positive regulation of axon extension
Biological Process
Positive regulation of cellular component organization
Biological Process
Positive regulation of cytokine-mediated signaling pathway
Biological Process
Positive regulation of dendritic spine morphogenesis
Biological Process
Positive regulation of embryonic development
Biological Process
Positive regulation of mitotic cell cycle
Biological Process
Protein secretion
Biological Process
Regulation of GTPase activity
Biological Process
Regulation of microtubule cytoskeleton organization
Biological Process
Regulation of microtubule motor activity
Biological Process
Retrograde axonal transport
Biological Process
Stem cell division
Biological Process
Transmission of nerve impulse
Biological Process
Vesicle transport along microtubule

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-2011Dipodomys ordii100.00.0 856
LLPS-Bot-2741Bos taurus100.00.0 856
LLPS-Ran-0516Rattus norvegicus100.00.0 856
LLPS-Mup-1981Mustela putorius furo100.00.0 856
LLPS-Aim-3745Ailuropoda melanoleuca100.00.0 835
LLPS-Ova-0316Ovis aries100.00.0 856
LLPS-Ora-2318Ornithorhynchus anatinus100.00.0 856
LLPS-Sus-1100Sus scrofa100.00.0 856
LLPS-Aon-1032Aotus nancymaae100.00.0 856
LLPS-Caj-3302Callithrix jacchus100.00.0 856
LLPS-Poa-0077Pongo abelii100.00.0 856
LLPS-Cap-0549Cavia porcellus100.00.0 856
LLPS-Urm-0716Ursus maritimus100.00.0 856
LLPS-Fec-0352Felis catus100.00.0 856
LLPS-Tut-2058Tursiops truncatus99.760.0 853
LLPS-Hos-0868Homo sapiens99.760.0 855
LLPS-Mal-0368Mandrillus leucophaeus99.510.0 853
LLPS-Cea-2643Cercocebus atys99.510.0 853
LLPS-Mam-1347Macaca mulatta99.510.0 853
LLPS-Rhb-0187Rhinopithecus bieti99.510.0 853
LLPS-Chs-0091Chlorocebus sabaeus99.420.0 721
LLPS-Mod-1241Monodelphis domestica99.270.0 850
LLPS-Fud-0484Fukomys damarensis99.260.0 839
LLPS-Sah-3483Sarcophilus harrisii99.020.0 849
LLPS-Pes-2197Pelodiscus sinensis99.020.0 851
LLPS-Gaga-0755Gallus gallus98.780.0 850
LLPS-Pap-1791Pan paniscus98.780.0 842
LLPS-Anp-1577Anas platyrhynchos98.780.0 850
LLPS-Fia-0310Ficedula albicollis98.780.0 850
LLPS-Gog-1943Gorilla gorilla98.540.0 839
LLPS-Anc-1700Anolis carolinensis98.540.0 844
LLPS-Tag-1858Taeniopygia guttata98.540.0 847
LLPS-Meg-0761Meleagris gallopavo98.540.0 849
LLPS-Pat-1867Pan troglodytes98.540.0 839
LLPS-Caf-0706Canis familiaris98.530.0 840
LLPS-Paa-3460Papio anubis98.290.0 837
LLPS-Ict-3692Ictidomys tridecemlineatus98.290.0 838
LLPS-Myl-2440Myotis lucifugus98.280.0 838
LLPS-Cas-0711Carlito syrichta98.040.0 831
LLPS-Loa-0835Loxodonta africana98.040.0 837
LLPS-Otg-1323Otolemur garnettii97.80.0 837
LLPS-Xet-1516Xenopus tropicalis97.560.0 843
LLPS-Eqc-2177Equus caballus97.340.0 836
LLPS-Maf-0816Macaca fascicularis97.090.0 833
LLPS-Man-3506Macaca nemestrina97.090.0 833
LLPS-Lac-3171Latimeria chalumnae96.830.0 833
LLPS-Leo-0026Lepisosteus oculatus95.990.0 804
LLPS-Scf-1544Scleropages formosus95.850.0 830
LLPS-Asm-2834Astyanax mexicanus94.880.0 822
LLPS-Icp-2682Ictalurus punctatus94.630.0 820
LLPS-Orl-0107Oryzias latipes94.150.0 813
LLPS-Pof-0361Poecilia formosa93.660.0 813
LLPS-Scm-2788Scophthalmus maximus93.660.0 813
LLPS-Dar-1289Danio rerio93.410.0 816
LLPS-Ten-0356Tetraodon nigroviridis93.170.0 807
LLPS-Gaa-0517Gasterosteus aculeatus92.930.0 808
LLPS-Nol-1335Nomascus leucogenys92.930.0 712
LLPS-Orn-1181Oreochromis niloticus92.440.0 806
LLPS-Tar-2543Takifugu rubripes92.20.0 807
LLPS-Xim-1787Xiphophorus maculatus91.220.0 803
LLPS-Mea-0891Mesocricetus auratus83.760.0 663
LLPS-Cii-1105Ciona intestinalis71.050.0 634
LLPS-Drm-0464Drosophila melanogaster70.070.0 620
LLPS-Cis-0436Ciona savignyi69.510.0 635
LLPS-Cae-0125Caenorhabditis elegans57.420.0 519
LLPS-Abg-0236Absidia glauca55.933e-173 498
LLPS-Miv-0361Microbotryum violaceum50.111e-155 454
LLPS-Spr-0351Sporisorium reilianum50.08e-154 450
LLPS-Crn-0295Cryptococcus neoformans48.924e-136 404
LLPS-Nec-0488Neurospora crassa48.415e-129 387
LLPS-Tum-0520Tuber melanosporum48.395e-129 387
LLPS-Mel-0215Melampsora laricipopulina48.312e-142 421
LLPS-Cogr-0488Colletotrichum graminicola48.214e-128 385
LLPS-Pug-1357Puccinia graminis47.871e-141 419
LLPS-Blg-0031Blumeria graminis47.738e-125 376
LLPS-Pytr-0275Pyrenophora triticirepentis47.733e-127 382
LLPS-Usm-0171Ustilago maydis47.729e-147 432
LLPS-Pyt-0095Pyrenophora teres47.491e-126 381
LLPS-Phn-0244Phaeosphaeria nodorum47.268e-127 381
LLPS-Asfu-0547Aspergillus fumigatus47.196e-126 379
LLPS-Asc-0007Aspergillus clavatus47.033e-126 380
LLPS-Cog-0123Colletotrichum gloeosporioides46.812e-118 360
LLPS-Lem-0798Leptosphaeria maculans46.671e-126 381
LLPS-Coo-0396Colletotrichum orbiculare46.552e-119 362
LLPS-Fuo-0440Fusarium oxysporum46.411e-123 373
LLPS-Fuv-0395Fusarium verticillioides45.934e-122 369
LLPS-Asf-0823Aspergillus flavus45.698e-111 339
LLPS-Nef-0816Neosartorya fischeri45.571e-116 354
LLPS-Ved-1030Verticillium dahliae45.432e-119 362
LLPS-Gag-1129Gaeumannomyces graminis45.113e-120 364
LLPS-Mao-0668Magnaporthe oryzae45.081e-118 360
LLPS-Map-0818Magnaporthe poae45.053e-120 364
LLPS-Zyt-0898Zymoseptoria tritici44.742e-122 370
LLPS-Scs-0009Sclerotinia sclerotiorum44.712e-119 362
LLPS-Asni-0781Aspergillus niger44.561e-110 339
LLPS-Fus-0311Fusarium solani44.15e-117 356
LLPS-Aso-1298Aspergillus oryzae43.948e-108 332
LLPS-Trv-0054Trichoderma virens43.831e-123 373
LLPS-Dos-0850Dothistroma septosporum43.583e-120 364
LLPS-Trr-0871Trichoderma reesei43.312e-121 368
LLPS-Asn-1241Aspergillus nidulans42.542e-105 326
LLPS-Put-0742Puccinia triticina42.469e-49 181
LLPS-Ast-0653Aspergillus terreus41.812e-105 326
LLPS-Beb-0146Beauveria bassiana41.592e-119 363
LLPS-Chc-0561Chondrus crispus38.832e-1889.4
LLPS-Yal-0009Yarrowia lipolytica38.343e-91 289
LLPS-Php-2319Physcomitrella patens35.926e-1784.7
LLPS-Vir-0994Vigna radiata34.753e-1271.2
LLPS-Phv-1454Phaseolus vulgaris34.751e-1272.4
LLPS-Viv-0598Vitis vinifera34.671e-41 155
LLPS-Gor-2545Gossypium raimondii33.946e-39 147
LLPS-Met-0856Medicago truncatula33.92e-1168.9
LLPS-Glm-2511Glycine max33.93e-1168.2
LLPS-Hea-1495Helianthus annuus33.75e-42 156
LLPS-Zem-1499Zea mays33.634e-1270.9
LLPS-Sob-1767Sorghum bicolor33.633e-1271.2
LLPS-Hov-1642Hordeum vulgare33.331e-1890.1
LLPS-Sei-1717Setaria italica33.333e-1271.2
LLPS-Tra-2832Triticum aestivum33.332e-1889.4
LLPS-Sot-1154Solanum tuberosum33.212e-42 157
LLPS-Sol-0428Solanum lycopersicum33.212e-42 157
LLPS-Prp-2085Prunus persica32.738e-38 145
LLPS-Mae-0054Manihot esculenta32.57e-38 145
LLPS-Scj-0033Schizosaccharomyces japonicus32.343e-72 240
LLPS-Pot-0047Populus trichocarpa32.284e-38 145
LLPS-Thc-0178Theobroma cacao32.264e-38 145
LLPS-Cus-2080Cucumis sativus32.143e-37 143
LLPS-Lep-1671Leersia perrieri31.965e-48 172
LLPS-Orp-2192Oryza punctata31.822e-23 103
LLPS-Arl-2861Arabidopsis lyrata31.03e-28 117
LLPS-Mua-0915Musa acuminata30.995e-48 173
LLPS-Brd-2494Brachypodium distachyon30.941e-45 166
LLPS-Art-2692Arabidopsis thaliana30.572e-28 118
LLPS-Org-2252Oryza glaberrima30.53e-22 100
LLPS-Ors-1106Oryza sativa30.53e-22 100
LLPS-Bro-2983Brassica oleracea30.131e-28 118
LLPS-Brn-2608Brassica napus29.691e-28 118
LLPS-Brr-1568Brassica rapa29.691e-28 118
LLPS-Kop-0105Komagataella pastoris29.375e-46 171