LLPS-Xet-3045
eif2ak4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 2 alpha kinase 4 |
| Gene Name: | eif2ak4 |
| Ensembl Gene: | ENSXETG00000002204.3 |
| Ensembl Protein: | ENSXETP00000004685.3 |
| Organism: | Xenopus tropicalis |
| Taxa ID: | 8364 |
| LLPS Type: | Regulator |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSXETT00000004685.3 | ENSXETP00000004685.3 |
| Ensembl | ENSXETT00000014386.3 | ENSXETP00000014386.3 |
| Ensembl | ENSXETT00000066083.1 | ENSXETP00000058997.1 |
| UniProt | F7BH85, F7BH85_XENTR | |
| GeneBank | AAMC01063664, AAMC01063665, AAMC01063663 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAGGRGNALL PIELSPQGGL RPTPPACDPP ETYSHRQENE LEVLESIYSG DFADLRKNSA 60 61 WKVQQPPEVI IALRPQGNEV HVKVDLWVKC PQNYPDVPPE IKLKNIQGLS NENVNSLTSS 120 121 LEDLAKQLCG EVMIYQLADH VQCFLTEYNH PPPKSFHEEM LKNLQKQQEK LALEEERRMQ 180 181 EIKMKEEQTR REILNEIVAK QVSRIRDKEF LPTVLQKERI ENANLMCQEN VNKINNTGKT 240 241 TTAASDGSLP DHGGTNRNRP HSAGRSKRDR QYSVCLTDDS TPFEVLTFDI GCSGQIVVHR 300 301 GKCLGKDELL GKSVYNGLET ASGHFVVIYE WVLQWQKKMG KFLTNQEKEK IEKCKKQIQG 360 361 TETEFSSLIK LSHPNIVHYL AMRIKEKEDS ISVGIIAEHV NGTKLSSYLE QGVPVPLDQL 420 421 RHYTAQLLSA LDYLHSNSVV HKVMCASSVL VTADGKVKLT DYSLSKRLAD ICKEDVFEQT 480 481 KVRFSEDALP SKSGKKGDIW KLGLLLLSLS QGNIAKEYPV KVPSDLPADF QDFLQKCVCL 540 541 EDKERWTTQQ LLSHSFLNPP PEKSPVTEEC SDDYPGDCTE TVIPRSSVSN STFHIESQRQ 600 601 FSRYFNEFEE LQMLGKGAFG AVIKVQNKLD GCYYAVKRVQ INPASKQFRR IKGEVTLLSR 660 661 LNHENIVRYY NAWIEKHEHP TISPKCEAHE EKKVTVKPEQ IVKNDLGLLD DIEENAPAPI 720 721 LTSSVEWSTS CERSSSAHCT NGDQDSKEGV FSPSFLPGTD SDSEIIFENE DDISPDQDEE 780 781 YDKNNVEDRK AGANEIVTQA VHYLYIQMEY CEKSTLRDTI DQGLYMDVGR LWRLFREILD 840 841 GLTYIHEQGM IHRDLKPVNI FLDSEDHVKI GDFGLATDHP ASYTESAQGE EDQAHSDLVK 900 901 VDPEGKLTGM VGTALYVSPE VQGNTKASYN QKVDLYSLGI ILFEMSYRPM DTSSERISVL 960 961 SRLRQQALIV FPSDFENPEN EKQKKVITWL LNHDPASRPT AMELLKCDLL PPPQLEESEL 1020 1021 HEVLHHTLAN IDGKAYRTMM SQIFAQRISP AMDYTYDSDI LKGIFSVRSA RLHHHVCEAV 1080 1081 CRIFKRHGAV KLHAPLLMPR GKAGFDNSES ACFMDHSGML VTLPYNLRIS FARFVARNNI 1140 1141 TSLKRYSIER VFRPRKLNRC HPKELTECAF DIITSAANCY LPIAETIYTI YEIIQEFPVL 1200 1201 QERNYSIYVN HTSLLKAILL HCGVPEDKLT QVYNILYDAM IEKLTKREVE AKFCNLSLSE 1260 1261 NSFQLSRLYR FIEQKGDLPD LEAMMVPLTK QKTGVGVLAK QGLKDLEGVI GLVKRLGIKL 1320 1321 QIVVNFGLVY KMQQHSGIVF QFVAFIKRRQ RTVPEILAAG GRYDHLISQF RGPQTGAMGL 1380 1381 PCAVGVSIAI DKISAALSTA EEHVMISSCD LLVVSAGQMS LNRAIGITQK LWAAGITAEI 1440 1441 MYEWSESQDE LQDYCKCSGI SYAAIISDKE GNHIKLKTFE KERQSEKRIL ESDLVDLLVQ 1500 1501 KLRIRVLEER NNSMAEGNSG GPFPRGASSS SKVVSAFHIN QDITIPSFCP PQSPKEVELH 1560 1561 SLDPQVLTKL QTLITNFQQR NGEIEILAVD LPKETIQNLL ALEQCADEQV FNASVKMLMS 1620 1621 RLPKQRYLKS VFDEIYTIKI EKRVPVLVLY SYKDDYYKIL F 1661 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGGCG GCCGGGGAAA TGCACTTCTT CCTATTGAGC TCAGCCCGCA AGGGGGTCTG 60 61 CGCCCTACTC CGCCTGCCTG TGACCCCCCT GAAACTTATT CCCACCGGCA GGAGAATGAG 120 121 CTGGAGGTCC TGGAATCCAT CTATAGTGGG GATTTCGCGG ATCTGCGCAA GAACTCTGCC 180 181 TGGAAGGTAC AGCAGCCTCC AGAAGTCATC ATTGCCTTAC GTCCTCAGGG AAATGAGGTT 240 241 CATGTCAAGG TGGATTTATG GGTAAAATGC CCTCAGAACT ATCCTGATGT TCCTCCTGAA 300 301 ATAAAGCTGA AGAACATCCA GGGGTTGTCC AATGAAAATG TGAACTCTCT GACATCAAGC 360 361 TTGGAAGATT TAGCAAAACA GCTTTGTGGA GAGGTAATGA TATACCAGCT TGCGGATCAT 420 421 GTGCAGTGTT TTCTTACAGA GTATAACCAT CCACCTCCTA AATCCTTTCA TGAGGAGATG 480 481 TTAAAAAACC TTCAGAAGCA GCAGGAGAAG CTTGCTCTTG AAGAAGAGAG ACGAATGCAA 540 541 GAGATAAAGA TGAAAGAAGA GCAGACGAGA CGGGAAATCC TTAATGAAAT CCAGAAGCGA 600 601 GAAGAAGAGA AAAAGGAAGA AAAAAGAAGG AAGGAAGTAG CAAAACAGGA ACGGATTGAA 660 661 AACGCTAATC TAATGTGCCA AGAGAATGTA AATAAGATTA ATAATACAGG CAAGACAACA 720 721 ACAGCTGCCT CGGATGGGTC ACTTCCTGAT CATGGAGGAA CCAACAGAAA TCGGCCACAT 780 781 TCAGCAGGAC GCTCAAAGCG GGACCGACAG TATTCGGTGT GCCTCACTGA TGACTCAACC 840 841 CCATTTGAAG TGTTAACCTT TGATATTGGA TGCAGTGGGC AAATTGTTGT TCACAGAGGA 900 901 AAGTGCCTGG GGAAAGATGA GCTGCTGGGT AAATCTGTTT ACAATGGCTT GGAAACTGCT 960 961 TCAGGACATT TTGTTGTAAT CTATGAATGG GTTCTCCAGT GGCAGAAAAA GATGGGCAAG 1020 1021 TTTCTTACTA ATCAA 1035 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Maf-4561 | Macaca fascicularis | 66.67 | 3e-46 | 187 |
| LLPS-Mea-0491 | Mesocricetus auratus | 66.63 | 0.0 | 1090 |
| LLPS-Anp-1397 | Anas platyrhynchos | 66.54 | 0.0 | 2018 |
| LLPS-Pes-0614 | Pelodiscus sinensis | 66.47 | 0.0 | 2083 |
| LLPS-Meg-1916 | Meleagris gallopavo | 65.97 | 0.0 | 2003 |
| LLPS-Anc-2336 | Anolis carolinensis | 65.84 | 0.0 | 2051 |
| LLPS-Gaga-2351 | Gallus gallus | 65.44 | 0.0 | 2056 |
| LLPS-Fia-2038 | Ficedula albicollis | 64.75 | 0.0 | 1845 |
| LLPS-Tag-3516 | Taeniopygia guttata | 64.63 | 0.0 | 2005 |
| LLPS-Mod-3623 | Monodelphis domestica | 64.35 | 0.0 | 1983 |
| LLPS-Nol-0305 | Nomascus leucogenys | 64.31 | 0.0 | 1948 |
| LLPS-Hos-3593 | Homo sapiens | 64.31 | 0.0 | 1993 |
| LLPS-Pat-4610 | Pan troglodytes | 64.31 | 0.0 | 1993 |
| LLPS-Gog-2483 | Gorilla gorilla | 64.31 | 0.0 | 1992 |
| LLPS-Pap-2984 | Pan paniscus | 64.29 | 0.0 | 1984 |
| LLPS-Caj-4706 | Callithrix jacchus | 64.25 | 0.0 | 1982 |
| LLPS-Chs-2274 | Chlorocebus sabaeus | 64.13 | 0.0 | 1979 |
| LLPS-Sah-3244 | Sarcophilus harrisii | 64.12 | 0.0 | 1917 |
| LLPS-Aon-3315 | Aotus nancymaae | 64.09 | 0.0 | 1983 |
| LLPS-Paa-1799 | Papio anubis | 64.04 | 0.0 | 1980 |
| LLPS-Cea-3486 | Cercocebus atys | 64.04 | 0.0 | 1979 |
| LLPS-Mam-4488 | Macaca mulatta | 63.98 | 0.0 | 1978 |
| LLPS-Man-2890 | Macaca nemestrina | 63.98 | 0.0 | 1976 |
| LLPS-Mal-4188 | Mandrillus leucophaeus | 63.92 | 0.0 | 1975 |
| LLPS-Myl-0123 | Myotis lucifugus | 63.9 | 0.0 | 1912 |
| LLPS-Orc-3881 | Oryctolagus cuniculus | 63.69 | 0.0 | 1935 |
| LLPS-Ova-1846 | Ovis aries | 63.5 | 0.0 | 1936 |
| LLPS-Sus-4823 | Sus scrofa | 63.43 | 0.0 | 1967 |
| LLPS-Ran-2003 | Rattus norvegicus | 63.4 | 0.0 | 1959 |
| LLPS-Bot-1736 | Bos taurus | 63.38 | 0.0 | 1916 |
| LLPS-Cap-0225 | Cavia porcellus | 63.28 | 0.0 | 1955 |
| LLPS-Mum-0683 | Mus musculus | 63.25 | 0.0 | 1939 |
| LLPS-Eqc-4154 | Equus caballus | 63.24 | 0.0 | 1952 |
| LLPS-Tut-2332 | Tursiops truncatus | 63.2 | 0.0 | 1929 |
| LLPS-Otg-4635 | Otolemur garnettii | 63.05 | 0.0 | 1937 |
| LLPS-Ict-4678 | Ictidomys tridecemlineatus | 62.93 | 0.0 | 1925 |
| LLPS-Fec-1250 | Felis catus | 62.67 | 0.0 | 1932 |
| LLPS-Ora-3137 | Ornithorhynchus anatinus | 62.58 | 0.0 | 1869 |
| LLPS-Loa-1746 | Loxodonta africana | 62.37 | 0.0 | 1854 |
| LLPS-Dio-2081 | Dipodomys ordii | 61.93 | 0.0 | 1820 |
| LLPS-Caf-0311 | Canis familiaris | 61.87 | 0.0 | 1912 |
| LLPS-Rhb-1253 | Rhinopithecus bieti | 61.74 | 0.0 | 1861 |
| LLPS-Urm-2758 | Ursus maritimus | 61.46 | 0.0 | 1823 |
| LLPS-Mup-4201 | Mustela putorius furo | 61.19 | 0.0 | 1897 |
| LLPS-Asm-3474 | Astyanax mexicanus | 60.73 | 0.0 | 1380 |
| LLPS-Poa-3149 | Pongo abelii | 60.02 | 0.0 | 1795 |
| LLPS-Icp-3232 | Ictalurus punctatus | 59.45 | 0.0 | 1490 |
| LLPS-Tar-2577 | Takifugu rubripes | 58.97 | 0.0 | 1744 |
| LLPS-Ten-3135 | Tetraodon nigroviridis | 58.45 | 0.0 | 1767 |
| LLPS-Pof-2726 | Poecilia formosa | 58.06 | 0.0 | 1765 |
| LLPS-Orl-2138 | Oryzias latipes | 57.95 | 0.0 | 1711 |
| LLPS-Scm-3274 | Scophthalmus maximus | 57.87 | 0.0 | 1746 |
| LLPS-Orn-4039 | Oreochromis niloticus | 57.81 | 0.0 | 1763 |
| LLPS-Scf-0843 | Scleropages formosus | 57.59 | 0.0 | 1740 |
| LLPS-Xim-1525 | Xiphophorus maculatus | 57.49 | 0.0 | 1757 |
| LLPS-Gaa-1843 | Gasterosteus aculeatus | 57.25 | 0.0 | 1662 |
| LLPS-Lac-0461 | Latimeria chalumnae | 56.75 | 0.0 | 1437 |
| LLPS-Leo-1575 | Lepisosteus oculatus | 56.7 | 0.0 | 612 |
| LLPS-Via-2366 | Vigna angularis | 55.41 | 2e-14 | 83.6 |
| LLPS-Phv-1041 | Phaseolus vulgaris | 54.05 | 2e-14 | 83.2 |
| LLPS-Glm-1554 | Glycine max | 54.05 | 5e-14 | 82.0 |
| LLPS-Sob-1388 | Sorghum bicolor | 53.75 | 2e-15 | 86.7 |
| LLPS-Prp-0447 | Prunus persica | 53.33 | 5e-14 | 82.4 |
| LLPS-Pot-1473 | Populus trichocarpa | 53.33 | 4e-14 | 82.4 |
| LLPS-Mae-0895 | Manihot esculenta | 53.33 | 6e-14 | 82.0 |
| LLPS-Amt-1281 | Amborella trichopoda | 53.33 | 1e-13 | 80.9 |
| LLPS-Hea-0893 | Helianthus annuus | 53.33 | 1e-14 | 84.3 |
| LLPS-Sem-1202 | Selaginella moellendorffii | 53.25 | 3e-14 | 82.8 |
| LLPS-Orni-2140 | Oryza nivara | 52.94 | 3e-06 | 56.6 |
| LLPS-Met-2447 | Medicago truncatula | 52.7 | 1e-13 | 81.3 |
| LLPS-Bro-2052 | Brassica oleracea | 52.56 | 4e-14 | 82.4 |
| LLPS-Brr-1444 | Brassica rapa | 52.56 | 5e-14 | 82.0 |
| LLPS-Orr-1982 | Oryza rufipogon | 52.5 | 4e-15 | 85.5 |
| LLPS-Org-1439 | Oryza glaberrima | 52.5 | 5e-15 | 85.5 |
| LLPS-Zem-1828 | Zea mays | 52.5 | 6e-15 | 85.1 |
| LLPS-Orbr-1677 | Oryza brachyantha | 52.5 | 5e-15 | 85.5 |
| LLPS-Orgl-1929 | Oryza glumaepatula | 52.5 | 5e-15 | 85.5 |
| LLPS-Lep-1221 | Leersia perrieri | 52.5 | 5e-15 | 85.5 |
| LLPS-Hov-2025 | Hordeum vulgare | 52.5 | 4e-15 | 85.9 |
| LLPS-Sei-0479 | Setaria italica | 52.5 | 4e-15 | 85.5 |
| LLPS-Tra-1613 | Triticum aestivum | 52.5 | 4e-15 | 85.9 |
| LLPS-Orb-1777 | Oryza barthii | 52.5 | 6e-15 | 85.1 |
| LLPS-Ori-2360 | Oryza indica | 52.5 | 4e-15 | 85.5 |
| LLPS-Gor-2324 | Gossypium raimondii | 52.0 | 2e-13 | 80.1 |
| LLPS-Art-3058 | Arabidopsis thaliana | 52.0 | 1e-13 | 81.3 |
| LLPS-Arl-1309 | Arabidopsis lyrata | 52.0 | 9e-14 | 81.3 |
| LLPS-Brd-1099 | Brachypodium distachyon | 51.72 | 5e-16 | 88.6 |
| LLPS-Cus-2185 | Cucumis sativus | 51.28 | 3e-14 | 81.3 |
| LLPS-Usm-1294 | Ustilago maydis | 48.1 | 7e-17 | 91.7 |
| LLPS-Spr-0993 | Sporisorium reilianum | 48.1 | 2e-16 | 90.1 |
| LLPS-Php-2252 | Physcomitrella patens | 48.0 | 2e-13 | 80.1 |
| LLPS-Coc-2100 | Corchorus capsularis | 47.83 | 1e-14 | 84.0 |
| LLPS-Put-1204 | Puccinia triticina | 47.46 | 1e-08 | 64.7 |
| LLPS-Cym-0838 | Cyanidioschyzon merolae | 45.57 | 1e-12 | 77.4 |
| LLPS-Brn-1576 | Brassica napus | 43.14 | 5e-11 | 72.4 |
| LLPS-Dar-1504 | Danio rerio | 38.83 | 2e-28 | 129 |
| LLPS-Fud-4434 | Fukomys damarensis | 37.5 | 6e-27 | 124 |
| LLPS-Scp-0201 | Schizosaccharomyces pombe | 35.25 | 2e-11 | 73.6 |
| LLPS-Aso-0377 | Aspergillus oryzae | 33.88 | 8e-08 | 62.0 |
| LLPS-Asf-1110 | Aspergillus flavus | 33.88 | 8e-08 | 62.0 |
| LLPS-Aim-4073 | Ailuropoda melanoleuca | 33.69 | 1e-45 | 181 |
| LLPS-Cae-1676 | Caenorhabditis elegans | 33.08 | 4e-08 | 63.2 |
| LLPS-Scj-0288 | Schizosaccharomyces japonicus | 32.79 | 2e-10 | 70.5 |
| LLPS-Scc-1566 | Schizosaccharomyces cryophilus | 32.79 | 1e-10 | 70.9 |
| LLPS-Miv-0751 | Microbotryum violaceum | 32.77 | 5e-07 | 59.3 |
| LLPS-Cog-1497 | Colletotrichum gloeosporioides | 32.74 | 1e-75 | 283 |
| LLPS-Mua-0677 | Musa acuminata | 32.43 | 5e-35 | 145 |
| LLPS-Map-0534 | Magnaporthe poae | 32.33 | 2e-06 | 57.0 |
| LLPS-Cogr-1397 | Colletotrichum graminicola | 32.28 | 4e-73 | 275 |
| LLPS-Ast-0916 | Aspergillus terreus | 32.23 | 2e-08 | 63.9 |
| LLPS-Tum-0794 | Tuber melanosporum | 32.23 | 1e-78 | 292 |
| LLPS-Beb-1556 | Beauveria bassiana | 32.18 | 3e-75 | 281 |
| LLPS-Cas-2643 | Carlito syrichta | 32.15 | 6e-41 | 166 |
| LLPS-Mao-0686 | Magnaporthe oryzae | 32.14 | 2e-74 | 279 |
| LLPS-Pyt-0878 | Pyrenophora teres | 32.09 | 2e-77 | 288 |
| LLPS-Asni-0966 | Aspergillus niger | 32.09 | 2e-09 | 67.0 |
| LLPS-Asn-1089 | Aspergillus nidulans | 32.03 | 2e-09 | 67.4 |
| LLPS-Orp-0205 | Oryza punctata | 31.93 | 4e-44 | 180 |
| LLPS-Asfu-0862 | Aspergillus fumigatus | 31.9 | 5e-07 | 59.3 |
| LLPS-Coo-1118 | Colletotrichum orbiculare | 31.54 | 8e-72 | 270 |
| LLPS-Trv-1296 | Trichoderma virens | 31.49 | 1e-78 | 293 |
| LLPS-Sac-1083 | Saccharomyces cerevisiae | 31.45 | 3e-06 | 56.6 |
| LLPS-Lem-1030 | Leptosphaeria maculans | 31.39 | 1e-09 | 68.2 |
| LLPS-Tru-0475 | Triticum urartu | 31.19 | 4e-40 | 167 |
| LLPS-Nef-1152 | Neosartorya fischeri | 31.01 | 5e-07 | 59.3 |
| LLPS-Asc-1480 | Aspergillus clavatus | 30.77 | 3e-07 | 60.1 |
| LLPS-Scs-0849 | Sclerotinia sclerotiorum | 30.6 | 1e-68 | 260 |
| LLPS-Asg-1504 | Ashbya gossypii | 30.25 | 5e-06 | 55.8 |
| LLPS-Drm-2384 | Drosophila melanogaster | 30.19 | 0.0 | 597 |
| LLPS-Fuo-1522 | Fusarium oxysporum | 30.12 | 1e-74 | 280 |
| LLPS-Dos-1463 | Dothistroma septosporum | 30.09 | 3e-22 | 109 |
| LLPS-Phn-1011 | Phaeosphaeria nodorum | 29.92 | 6e-60 | 231 |
| LLPS-Pytr-1319 | Pyrenophora triticirepentis | 29.79 | 3e-07 | 60.1 |
| LLPS-Kop-0918 | Komagataella pastoris | 29.02 | 1e-104 | 374 |
| LLPS-Crn-1481 | Cryptococcus neoformans | 28.43 | 7e-18 | 95.1 |
| LLPS-Gag-1436 | Gaeumannomyces graminis | 28.42 | 3e-90 | 329 |
| LLPS-Blg-1449 | Blumeria graminis | 28.38 | 6e-100 | 359 |
| LLPS-Cii-1289 | Ciona intestinalis | 28.32 | 8e-33 | 140 |
| LLPS-Pug-1335 | Puccinia graminis | 27.06 | 4e-93 | 338 |
| LLPS-Zyt-1537 | Zymoseptoria tritici | 26.89 | 1e-88 | 323 |
| LLPS-Thc-2081 | Theobroma cacao | 26.74 | 2e-43 | 178 |
| LLPS-Nia-0634 | Nicotiana attenuata | 26.64 | 3e-46 | 183 |
| LLPS-Sol-1893 | Solanum lycopersicum | 26.58 | 9e-40 | 163 |
| LLPS-Fuv-1110 | Fusarium verticillioides | 26.34 | 1e-16 | 90.5 |