DrLLPS - Data resource of LLPS

LLPS-Xet-1344
srsf1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Serine/arginine-rich splicing factor 1; Splicing factor, arginine/serine-rich 1
Gene Name:	srsf1, sfrs1
Ensembl Gene:	ENSXETG00000008954.3
Ensembl Protein:	ENSXETP00000019608.2
Organism:	Xenopus tropicalis
Taxa ID:	8364
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Chromatin, Nuclear speckle, Nuclear stress body, Nucleolus, Stress granule, Chromatoid body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-2451	Q6PDM2	Client	Chromatin, Nuclear speckle, Nucleolus, Chromatoid body	89.23	3e-91	277
Homo sapiens	LLPS-Hos-1134	Q07955	Client	Nuclear speckle, Nuclear stress body, Nucleolus, Stress granule	89.23	3e-91	277

▼ FUNCTION

May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSXETT00000019608.2	ENSXETP00000019608.2
Ensembl	ENSXETT00000062041.1	ENSXETP00000058636.1
UniProt		Q6DII2, SRSF1_XENTR
GeneBank	BC075558	AAH75558.1
RefSeq	NM_001006918.1	NP_001006919.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 SAHRRSVWLP TPFLFLLNPS PFKSIKLDMS GGGVIRGPAG NNDCRIYVGN LPPDIRTKDI 60 61 EDVFYKYGAI RDIDLKNRRG GPPFAFVEFE DPRDAEDAVY GRDGYDYDGY RLRVEFPRSG 120 121 RGAGGRGGAP RGRYGPPSRR SEYRVVVSGL PPSGSWQDLK DHMREAGDVC YADVFRDGTG 180 181 VVEFVRKEDM TYAVRKLDNT KFRSHEGETA YIRVKVDGPR SPSYGRSRSR SRSRSRSRSR 240 241 SNSRSRSYSP RRSRGSPRYS PRHSRSRSRT 270
Nucleotide CDS Sequence (FASTA)
1 ATGTCAGGGG GCGGCGTGAT TAGGGGGCCG GCGGGTAACA ACGATTGCCG TATCTATGTT 60 61 GGCAATCTGC CGCCAGACAT CCGCACCAAG GACATTGAGG ACGTTTTCTA CAAGTATGGG 120 121 GCCATTCGGG ACATAGACCT AAAGAACCGC AGAGGGGGCC CGCCATTCGC CTTTGTGGAA 180 181 TTCGAAGATC CAAGGGATGC AGAAGATGCT GTCTATGGTA GAGATGGCTA TGATTATGAT 240 241 GGCTATCGCT TGCGTGTTGA GTTTCCAAGA AGTGGGCGAG GAGCTGGAGG CAGAGGTGGT 300 301 GGTGGTGGTG GCGGCGGCGG AGGAGGAGGT GGTGGAGGCG GCGGCGGCGG TGGTGGTGGT 360 361 GGCGGCGGAG GAGGAGCTCC CCGAGGGAGA TATGGACCTC CATCAAGACG TTCAGAATAC 420 421 AGAGTGGTTG TGTCAGGGTT GCCTCCAAGT GGCAGCTGGC AGGATTTAAA GGATCACATG 480 481 CGTGAAGCAG GTGATGTATG TTATGCCGAT GTGTTCCGAG ATGGTACTGG AGTTGTGGAG 540 541 TTTGTGAGGA AAGAAGATAT GACATATGCA GTACGGAAGC TGGATAACAC TAAATTTAGG 600 601 TCTCATGAGG GAGAGACTGC CTACATTCGT GTTAAGGTAG ATGGTCCAAG AAGTCCCAGC 660 661 TATGGAAGAT CGCGGTCACG CAGCCGCAGT CGTAGCAGGA GCCGTAGTAG AAGCAACAGT 720 721 CGCAGCCGAA GTTACTCTCC AAGAAGAAGC CGTGGTTCTC CACGCTACTC TCCTCGCCAC 780 781 AGCAGATCTC GCTCTCGTAC ATAA 804

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0677	Repeat
KW-0694	RNA-binding

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0016607	Cellular Component	Nuclear speck
GO:0003723	Molecular Function	RNA binding
GO:0045292	Biological Process	MRNA cis splicing, via spliceosome
GO:0000381	Biological Process	Regulation of alternative mRNA splicing, via spliceosome

▼ KEGG

xtr:448766

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Meg-2121	Meleagris gallopavo	100.0	7e-25	101
LLPS-Fia-1605	Ficedula albicollis	100.0	5e-31	121
LLPS-Tag-2386	Taeniopygia guttata	98.68	3e-46	159
LLPS-Tut-0652	Tursiops truncatus	97.37	3e-43	152
LLPS-Myl-2359	Myotis lucifugus	93.12	3e-87	267
LLPS-Aim-0087	Ailuropoda melanoleuca	92.06	5e-92	279
LLPS-Sah-4056	Sarcophilus harrisii	91.33	3e-92	280
LLPS-Gaga-3514	Gallus gallus	91.28	2e-92	280
LLPS-Mod-0906	Monodelphis domestica	90.81	3e-84	261
LLPS-Poa-3274	Pongo abelii	90.77	2e-91	278
LLPS-Caf-0040	Canis familiaris	90.77	2e-91	278
LLPS-Cap-2500	Cavia porcellus	90.77	2e-91	278
LLPS-Eqc-2624	Equus caballus	90.77	4e-91	277
LLPS-Mam-3610	Macaca mulatta	90.77	2e-91	278
LLPS-Cas-1742	Carlito syrichta	90.77	2e-91	278
LLPS-Anc-2220	Anolis carolinensis	90.77	5e-90	274
LLPS-Nol-0452	Nomascus leucogenys	90.77	2e-91	278
LLPS-Ict-1365	Ictidomys tridecemlineatus	90.77	2e-91	278
LLPS-Hos-1134	Homo sapiens	90.77	2e-91	278
LLPS-Pat-1059	Pan troglodytes	90.77	2e-91	278
LLPS-Urm-1562	Ursus maritimus	90.77	2e-91	278
LLPS-Pap-0426	Pan paniscus	90.77	2e-91	278
LLPS-Fec-1311	Felis catus	90.77	2e-91	278
LLPS-Man-0581	Macaca nemestrina	90.77	2e-91	278
LLPS-Loa-2111	Loxodonta africana	90.77	4e-91	277
LLPS-Otg-3359	Otolemur garnettii	90.77	4e-92	280
LLPS-Rhb-2099	Rhinopithecus bieti	90.77	2e-91	278
LLPS-Dio-3799	Dipodomys ordii	90.77	2e-91	278
LLPS-Bot-1743	Bos taurus	90.77	2e-91	278
LLPS-Ran-1234	Rattus norvegicus	90.77	4e-91	277
LLPS-Paa-1197	Papio anubis	90.77	2e-91	278
LLPS-Mal-3635	Mandrillus leucophaeus	90.77	4e-91	277
LLPS-Mup-3182	Mustela putorius furo	90.77	4e-91	277
LLPS-Maf-1091	Macaca fascicularis	90.77	2e-91	278
LLPS-Mum-2451	Mus musculus	90.77	2e-91	278
LLPS-Mea-4222	Mesocricetus auratus	90.77	2e-91	278
LLPS-Sus-0529	Sus scrofa	90.77	2e-91	278
LLPS-Cea-1735	Cercocebus atys	90.77	2e-91	278
LLPS-Aon-1081	Aotus nancymaae	90.77	2e-91	278
LLPS-Gog-0595	Gorilla gorilla	90.77	2e-91	278
LLPS-Fud-3879	Fukomys damarensis	90.77	2e-91	278
LLPS-Caj-2205	Callithrix jacchus	90.77	2e-91	278
LLPS-Leo-1373	Lepisosteus oculatus	90.72	1e-92	281
LLPS-Dar-2399	Danio rerio	90.62	5e-90	274
LLPS-Scf-0434	Scleropages formosus	90.62	1e-91	278
LLPS-Orc-0704	Oryctolagus cuniculus	90.22	1e-81	260
LLPS-Ere-1044	Erinaceus europaeus	90.22	3e-83	258
LLPS-Ova-3115	Ovis aries	89.95	2e-89	272
LLPS-Chs-1049	Chlorocebus sabaeus	89.74	5e-90	274
LLPS-Icp-1570	Ictalurus punctatus	89.69	8e-92	278
LLPS-Orn-2292	Oreochromis niloticus	87.77	2e-86	265
LLPS-Gaa-1460	Gasterosteus aculeatus	87.64	3e-80	247
LLPS-Pof-3992	Poecilia formosa	87.3	4e-86	264
LLPS-Scm-1170	Scophthalmus maximus	87.3	3e-86	265
LLPS-Xim-1139	Xiphophorus maculatus	87.3	4e-86	264
LLPS-Orl-0120	Oryzias latipes	87.3	4e-86	264
LLPS-Tar-2383	Takifugu rubripes	86.56	8e-84	258
LLPS-Asm-1683	Astyanax mexicanus	86.29	2e-88	270
LLPS-Ten-2072	Tetraodon nigroviridis	86.24	2e-85	262
LLPS-Lac-2460	Latimeria chalumnae	83.81	2e-91	278
LLPS-Pes-0886	Pelodiscus sinensis	83.76	1e-76	240
LLPS-Cii-1332	Ciona intestinalis	78.95	2e-36	133
LLPS-Cis-0022	Ciona savignyi	72.37	5e-33	124
LLPS-Drm-0643	Drosophila melanogaster	67.2	2e-61	201
LLPS-Php-1019	Physcomitrella patens	64.81	3e-13	72.4
LLPS-Cae-0817	Caenorhabditis elegans	62.05	8e-57	189
LLPS-Bro-0596	Brassica oleracea	60.69	1e-43	156
LLPS-Lep-0861	Leersia perrieri	60.28	1e-30	120
LLPS-Tra-1099	Triticum aestivum	60.22	2e-42	152
LLPS-Brn-1324	Brassica napus	60.12	1e-43	154
LLPS-Arl-0414	Arabidopsis lyrata	59.66	7e-41	148
LLPS-Hov-0039	Hordeum vulgare	59.12	1e-41	151
LLPS-Brr-1694	Brassica rapa	59.09	6e-41	147
LLPS-Sem-0122	Selaginella moellendorffii	58.76	1e-39	144
LLPS-Orp-1879	Oryza punctata	58.56	1e-40	147
LLPS-Orgl-1864	Oryza glumaepatula	58.56	2e-40	149
LLPS-Orb-0901	Oryza barthii	58.56	3e-41	151
LLPS-Art-0553	Arabidopsis thaliana	58.52	3e-39	144
LLPS-Orni-2176	Oryza nivara	58.01	5e-40	149
LLPS-Mua-1295	Musa acuminata	57.87	3e-41	151
LLPS-Orm-1642	Oryza meridionalis	57.8	6e-41	150
LLPS-Pot-0308	Populus trichocarpa	57.78	2e-38	141
LLPS-Viv-1897	Vitis vinifera	57.54	5e-39	142
LLPS-Orbr-1319	Oryza brachyantha	57.54	4e-39	145
LLPS-Hea-0582	Helianthus annuus	57.47	1e-37	140
LLPS-Thc-1215	Theobroma cacao	56.82	2e-38	143
LLPS-Brd-0789	Brachypodium distachyon	56.67	1e-40	147
LLPS-Gor-0677	Gossypium raimondii	56.25	1e-39	145
LLPS-Prp-1931	Prunus persica	56.18	6e-39	143
LLPS-Org-0614	Oryza glaberrima	56.18	8e-38	140
LLPS-Nia-0872	Nicotiana attenuata	56.11	1e-36	137
LLPS-Sot-1461	Solanum tuberosum	56.0	3e-37	140
LLPS-Sei-1706	Setaria italica	55.87	4e-41	149
LLPS-Dac-1517	Daucus carota	55.87	2e-37	140
LLPS-Glm-0327	Glycine max	55.74	4e-36	135
LLPS-Mae-2587	Manihot esculenta	55.68	5e-38	141
LLPS-Met-1705	Medicago truncatula	55.68	4e-41	149
LLPS-Sol-0408	Solanum lycopersicum	55.56	7e-27	108
LLPS-Ors-0735	Oryza sativa	55.31	8e-40	146
LLPS-Ori-2054	Oryza indica	55.31	1e-39	146
LLPS-Coc-1084	Corchorus capsularis	55.25	4e-40	147
LLPS-Tru-0093	Triticum urartu	55.14	5e-41	149
LLPS-Orr-1107	Oryza rufipogon	55.06	1e-40	145
LLPS-Amt-2066	Amborella trichopoda	54.64	2e-40	147
LLPS-Phv-1367	Phaseolus vulgaris	54.3	2e-35	133
LLPS-Vir-1995	Vigna radiata	52.81	3e-35	135
LLPS-Cus-2248	Cucumis sativus	51.79	9e-35	132
LLPS-Chr-1562	Chlamydomonas reinhardtii	45.45	2e-27	112
LLPS-Abg-0921	Absidia glauca	40.61	1e-22	99.0

LLPS-Xet-1344srsf1

Protein Sequence

Nucleotide Sequence

LLPS-Xet-1344
srsf1