DrLLPS - Data resource of LLPS

LLPS-Xet-1065
h2afv

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Histone H2A.V; H2A.F/Z
Gene Name:	h2afv, TGas096d24.1
Ensembl Gene:	ENSXETG00000001258.2
Ensembl Protein:	ENSXETP00000002709.2
Organism:	Xenopus tropicalis
Taxa ID:	8364
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Histone locus body, Nucleolus, Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-2234	Q71UI9	Client	Nucleolus, Stress granule	100.00	2e-73	221
Drosophila melanogaster	LLPS-Drm-0075	P08985	Client	Histone locus body	96.97	2e-62	194

▼ FUNCTION

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSXETT00000002709.2	ENSXETP00000002709.2
UniProt		Q5BJ65, H2AV_XENTR, Q28FN8
GeneBank	BC091605, CR761860	CAJ81609.1, AAH91605.1
RefSeq	NM_001016178.2	NP_001016178.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE 60 61 YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG 120 121 KKGQQKTA 128
Nucleotide CDS Sequence (FASTA)
1 ATGGCTGGTG GAAAGGCTGG GAAAGACAGT GGAAAAGCTA AGGCCAAGGC AGTATCTCGC 60 61 TCCCAAAGGG CAGGACTGCA GTTCCCTGTG GGCCGTATCC ACAGACACTT GAAGACCCGT 120 121 ACCACAAGCC ACGGAAGAGT TGGTGCTACT GCAGCTGTTT ACAGTGCTGC CATCCTGGAA 180 181 TATCTTACTG CTGAGGTGTT GGAGTTGGCA GGAAATGCCT CCAAGGATCT GAAAGTGAAA 240 241 CGTATCACTC CTCGGCACTT GCAGCTAGCC ATTCGTGGGG ATGAGGAGCT GGATTCTCTG 300 301 ATCAAAGCGA CCATTGCTGG AGGAGGTGTC ATTCCTCATA TCCACAAGTC TCTGATTGGA 360 361 AAGAAGGGAC AGCAAAAAAC CGCATAA 387

▼ KEYWORD

ID	Family
KW-0007	Acetylation
KW-0158	Chromosome
KW-0181	Complete proteome
KW-0238	DNA-binding
KW-1017	Isopeptide bond
KW-0544	Nucleosome core
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0000790	Cellular Component	Nuclear chromatin
GO:0000786	Cellular Component	Nucleosome
GO:0003677	Molecular Function	DNA binding
GO:0046982	Molecular Function	Protein heterodimerization activity
GO:0006325	Biological Process	Chromatin organization

▼ KEGG

xtr:548932

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-0058	Rattus norvegicus	100.0	2e-73	221
LLPS-Paa-2038	Papio anubis	100.0	2e-73	221
LLPS-Mal-0565	Mandrillus leucophaeus	100.0	2e-73	221
LLPS-Myl-0616	Myotis lucifugus	100.0	3e-73	221
LLPS-Ova-3090	Ovis aries	100.0	3e-73	221
LLPS-Aim-0089	Ailuropoda melanoleuca	100.0	3e-73	221
LLPS-Mup-1417	Mustela putorius furo	100.0	2e-73	222
LLPS-Xim-2310	Xiphophorus maculatus	100.0	8e-67	204
LLPS-Tar-1865	Takifugu rubripes	100.0	2e-73	221
LLPS-Gaa-1289	Gasterosteus aculeatus	100.0	2e-73	221
LLPS-Bot-3797	Bos taurus	100.0	2e-73	221
LLPS-Scf-2815	Scleropages formosus	100.0	3e-73	221
LLPS-Gog-2098	Gorilla gorilla	100.0	3e-58	182
LLPS-Fud-0361	Fukomys damarensis	100.0	3e-73	221
LLPS-Asm-3648	Astyanax mexicanus	100.0	1e-72	220
LLPS-Icp-0038	Ictalurus punctatus	100.0	2e-73	221
LLPS-Caj-1078	Callithrix jacchus	100.0	2e-73	221
LLPS-Mea-0355	Mesocricetus auratus	100.0	2e-73	221
LLPS-Mum-0096	Mus musculus	100.0	2e-73	221
LLPS-Maf-1453	Macaca fascicularis	100.0	2e-73	221
LLPS-Ora-2547	Ornithorhynchus anatinus	100.0	3e-73	221
LLPS-Chs-1274	Chlorocebus sabaeus	100.0	2e-73	221
LLPS-Orl-2854	Oryzias latipes	100.0	2e-70	221
LLPS-Aon-3941	Aotus nancymaae	100.0	2e-73	221
LLPS-Sah-2515	Sarcophilus harrisii	100.0	2e-73	221
LLPS-Cea-3074	Cercocebus atys	100.0	2e-73	221
LLPS-Leo-1133	Lepisosteus oculatus	100.0	3e-73	221
LLPS-Sus-1052	Sus scrofa	100.0	2e-73	221
LLPS-Cas-0677	Carlito syrichta	100.0	2e-73	221
LLPS-Gaga-0240	Gallus gallus	100.0	2e-73	221
LLPS-Ict-1391	Ictidomys tridecemlineatus	100.0	2e-73	221
LLPS-Nol-0022	Nomascus leucogenys	100.0	2e-73	221
LLPS-Anc-1174	Anolis carolinensis	100.0	2e-73	221
LLPS-Tag-1472	Taeniopygia guttata	100.0	3e-73	221
LLPS-Caf-1689	Canis familiaris	100.0	2e-73	221
LLPS-Ten-0537	Tetraodon nigroviridis	100.0	2e-73	221
LLPS-Poa-0928	Pongo abelii	100.0	2e-73	221
LLPS-Eqc-0147	Equus caballus	100.0	3e-73	221
LLPS-Cap-0543	Cavia porcellus	100.0	2e-73	221
LLPS-Mam-0086	Macaca mulatta	100.0	2e-73	221
LLPS-Otg-3747	Otolemur garnettii	100.0	3e-73	221
LLPS-Pes-0407	Pelodiscus sinensis	100.0	2e-73	221
LLPS-Fia-0009	Ficedula albicollis	100.0	3e-73	221
LLPS-Orc-3540	Oryctolagus cuniculus	100.0	3e-73	221
LLPS-Rhb-1846	Rhinopithecus bieti	100.0	2e-73	221
LLPS-Orn-0401	Oreochromis niloticus	100.0	2e-73	221
LLPS-Pap-0871	Pan paniscus	100.0	2e-73	221
LLPS-Pof-2286	Poecilia formosa	100.0	2e-73	221
LLPS-Pat-2113	Pan troglodytes	100.0	2e-73	221
LLPS-Hos-2234	Homo sapiens	100.0	2e-73	221
LLPS-Dar-2147	Danio rerio	100.0	9e-73	220
LLPS-Lac-0627	Latimeria chalumnae	100.0	8e-72	218
LLPS-Mod-0832	Monodelphis domestica	100.0	2e-73	221
LLPS-Fec-0831	Felis catus	100.0	2e-73	221
LLPS-Man-2090	Macaca nemestrina	100.0	2e-73	221
LLPS-Loa-1041	Loxodonta africana	100.0	3e-73	221
LLPS-Anp-3139	Anas platyrhynchos	99.11	2e-71	216
LLPS-Urm-1911	Ursus maritimus	99.09	3e-72	218
LLPS-Meg-1088	Meleagris gallopavo	99.09	3e-72	219
LLPS-Ere-0596	Erinaceus europaeus	99.02	2e-66	204
LLPS-Dio-0347	Dipodomys ordii	99.0	6e-65	199
LLPS-Scm-0577	Scophthalmus maximus	98.18	6e-72	218
LLPS-Drm-0075	Drosophila melanogaster	98.1	3e-67	206
LLPS-Tut-1162	Tursiops truncatus	97.2	9e-67	204
LLPS-Cii-0796	Ciona intestinalis	96.33	3e-69	211
LLPS-Cis-1346	Ciona savignyi	96.33	4e-69	211
LLPS-Dac-2059	Daucus carota	93.27	2e-63	196
LLPS-Sot-1063	Solanum tuberosum	92.31	2e-62	194
LLPS-Sol-1464	Solanum lycopersicum	92.31	2e-62	194
LLPS-Nia-1750	Nicotiana attenuata	92.31	1e-62	194
LLPS-Cae-1285	Caenorhabditis elegans	90.57	6e-61	190
LLPS-Gor-2565	Gossypium raimondii	90.38	2e-61	191
LLPS-Php-0459	Physcomitrella patens	90.29	7e-60	187
LLPS-Hea-2245	Helianthus annuus	89.81	2e-63	197
LLPS-Hov-1675	Hordeum vulgare	89.47	3e-54	174
LLPS-Sei-1343	Setaria italica	89.42	1e-59	187
LLPS-Thc-1052	Theobroma cacao	89.42	6e-61	190
LLPS-Sem-0605	Selaginella moellendorffii	89.42	2e-60	189
LLPS-Coc-1623	Corchorus capsularis	89.42	6e-61	190
LLPS-Prp-1095	Prunus persica	89.42	2e-60	189
LLPS-Mae-0644	Manihot esculenta	88.89	1e-62	194
LLPS-Pot-0246	Populus trichocarpa	88.89	2e-62	194
LLPS-Cus-2123	Cucumis sativus	88.46	3e-60	188
LLPS-Brn-0386	Brassica napus	88.46	5e-61	190
LLPS-Bro-0280	Brassica oleracea	88.46	1e-60	191
LLPS-Viv-1612	Vitis vinifera	88.46	9e-61	189
LLPS-Brr-0763	Brassica rapa	88.46	5e-61	190
LLPS-Vir-1414	Vigna radiata	88.3	6e-53	169
LLPS-Chr-0782	Chlamydomonas reinhardtii	88.07	6e-61	190
LLPS-Met-1400	Medicago truncatula	87.96	1e-61	192
LLPS-Brd-0674	Brachypodium distachyon	87.96	3e-61	191
LLPS-Via-1184	Vigna angularis	87.96	3e-62	193
LLPS-Orgl-0860	Oryza glumaepatula	87.96	9e-62	192
LLPS-Lep-0572	Leersia perrieri	87.96	2e-61	191
LLPS-Mua-1276	Musa acuminata	87.96	3e-62	193
LLPS-Orni-0555	Oryza nivara	87.96	9e-62	192
LLPS-Glm-0067	Glycine max	87.96	4e-62	193
LLPS-Orb-0090	Oryza barthii	87.96	9e-62	192
LLPS-Ori-1940	Oryza indica	87.96	9e-62	192
LLPS-Zem-1028	Zea mays	87.96	2e-62	194
LLPS-Org-1745	Oryza glaberrima	87.96	9e-62	192
LLPS-Orr-0523	Oryza rufipogon	87.96	9e-62	192
LLPS-Orm-1453	Oryza meridionalis	87.96	9e-62	192
LLPS-Orbr-1739	Oryza brachyantha	87.96	2e-61	191
LLPS-Sob-1659	Sorghum bicolor	87.96	2e-62	194
LLPS-Phv-1146	Phaseolus vulgaris	87.96	5e-62	192
LLPS-Ors-1331	Oryza sativa	87.96	9e-62	192
LLPS-Arl-0042	Arabidopsis lyrata	87.85	3e-61	191
LLPS-Tra-0738	Triticum aestivum	87.04	5e-61	190
LLPS-Art-0925	Arabidopsis thaliana	86.54	5e-60	187
LLPS-Osl-0195	Ostreococcus lucimarinus	86.11	3e-59	186
LLPS-Tru-0301	Triticum urartu	86.11	3e-60	188
LLPS-Amt-0403	Amborella trichopoda	84.85	5e-54	171
LLPS-Abg-0403	Absidia glauca	83.33	2e-55	176
LLPS-Miv-0021	Microbotryum violaceum	83.02	1e-57	182
LLPS-Chc-0654	Chondrus crispus	81.08	1e-58	185
LLPS-Scj-0988	Schizosaccharomyces japonicus	78.43	4e-51	165
LLPS-Scp-0280	Schizosaccharomyces pombe	78.43	1e-51	167
LLPS-Scc-0419	Schizosaccharomyces cryophilus	78.43	9e-52	167
LLPS-Spr-1080	Sporisorium reilianum	78.38	2e-57	181
LLPS-Cym-0658	Cyanidioschyzon merolae	77.06	1e-53	171
LLPS-Usm-0458	Ustilago maydis	76.15	5e-56	177
LLPS-Gag-0384	Gaeumannomyces graminis	75.73	4e-49	160
LLPS-Crn-1065	Cryptococcus neoformans	74.07	6e-53	170
LLPS-Beb-1319	Beauveria bassiana	74.07	2e-49	161
LLPS-Zyt-0505	Zymoseptoria tritici	73.39	2e-50	163
LLPS-Map-0468	Magnaporthe poae	73.15	6e-49	159
LLPS-Yal-0104	Yarrowia lipolytica	73.15	6e-49	159
LLPS-Nec-0970	Neurospora crassa	72.73	1e-49	161
LLPS-Coo-0731	Colletotrichum orbiculare	72.73	6e-50	162
LLPS-Fuv-1357	Fusarium verticillioides	72.73	4e-49	160
LLPS-Ved-0535	Verticillium dahliae	72.73	3e-50	163
LLPS-Cogr-0487	Colletotrichum graminicola	72.73	8e-50	162
LLPS-Trv-0202	Trichoderma virens	72.73	8e-50	162
LLPS-Fuo-0174	Fusarium oxysporum	72.73	4e-49	160
LLPS-Cog-0992	Colletotrichum gloeosporioides	72.73	6e-50	162
LLPS-Trr-0290	Trichoderma reesei	72.73	9e-50	162
LLPS-Fus-1228	Fusarium solani	72.73	2e-49	161
LLPS-Lem-1560	Leptosphaeria maculans	72.22	1e-48	159
LLPS-Scs-0020	Sclerotinia sclerotiorum	72.22	5e-49	160
LLPS-Dos-0879	Dothistroma septosporum	72.22	4e-49	160
LLPS-Asf-1036	Aspergillus flavus	71.3	6e-48	157
LLPS-Aso-0144	Aspergillus oryzae	71.3	6e-48	157
LLPS-Asni-0510	Aspergillus niger	71.3	6e-48	157
LLPS-Asn-0570	Aspergillus nidulans	71.3	6e-48	157
LLPS-Asc-0247	Aspergillus clavatus	71.3	6e-48	157
LLPS-Phn-1041	Phaeosphaeria nodorum	71.3	6e-48	157

LLPS-Xet-1065h2afv

Protein Sequence

Nucleotide Sequence

LLPS-Xet-1065
h2afv