LLPS-Cae-1285
htz-1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Histone H2A.V; H2A.F/Z
Gene Name: htz-1, R08C7.3
Ensembl Gene: WBGene00019947
Ensembl Protein: R08C7.3.2
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatin, Histone locus body, NucleolusPredicted from orthologs(View)

▼ FUNCTION

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblR08C7.3.2R08C7.3.2
EnsemblR08C7.3.1R08C7.3.1
EnsemblR08C7.3.3R08C7.3.3
UniProtQ27511, H2AV_CAEEL
GeneBankFO081646CCD73086.1
RefSeqNM_068168.6NP_500569.1
Entrez177212

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAGGKGKAGK  DSGKSKSKVV  SRSARAGLQF  PVGRIHRFLK  QRTTSSGRVG  ATAAVYSAAI  60
61    LEYLTAEVLE  LAGNASKDLK  VKRITPRHLH  LAIRGDEELD  TLIKATIAGG  GVIPHIHRYL  120
121   MNKKGAPVPG  KPGAPGQGPQ  140
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGGAG  GAAAAGGAAA  GGCCGGAAAG  GACTCCGGAA  AGTCCAAATC  GAAGGTCGTA  60
61    TCGAGAAGTG  CTCGCGCTGG  ACTCCAATTC  CCTGTCGGAC  GTATCCATCG  TTTCTTGAAG  120
121   CAGAGAACCA  CTTCCAGCGG  ACGTGTCGGA  GCTACTGCCG  CAGTATACAG  CGCTGCCATC  180
181   CTCGAATATC  TCACCGCCGA  AGTCCTCGAG  TTGGCCGGTA  ACGCCTCCAA  GGATCTTAAG  240
241   GTGAAGCGTA  TCACCCCAAG  ACATCTTCAT  CTTGCTATCA  GAGGAGACGA  AGAGCTCGAC  300
301   ACTCTCATCA  AGGCCACCAT  CGCCGGAGGA  GGAGTCATCC  CACACATCCA  TCGTTATTTG  360
361   ATGAACAAGA  AGGGAGCCCC  AGTCCCAGGA  AAGCCAGGAG  CTCCAGGACA  AGGACCACAA  420
421   TAA  423

▼ KEYWORD

ID
Family
Acetylation
Chromosome
Complete proteome
DNA-binding
Isopeptide bond
Nucleosome core
Nucleus
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromatin
Cellular Component
Condensed chromosome
Cellular Component
Nuclear chromatin
Cellular Component
Nucleosome
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
Protein heterodimerization activity
Biological Process
Chromatin organization
Biological Process
Negative regulation of cell fate specification
Biological Process
Negative regulation of transcription, DNA-templated

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Interaction
MIST
Physicochemical
Compute pI/MwAAindex
Localization
NLSdb

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scm-1881Scophthalmus maximus94.121e-47 157
LLPS-Gog-2098Gorilla gorilla94.054e-48 157
LLPS-Ere-0596Erinaceus europaeus92.639e-56 177
LLPS-Osl-0195Ostreococcus lucimarinus91.675e-57 181
LLPS-Prp-0805Prunus persica91.674e-57 181
LLPS-Ten-1180Tetraodon nigroviridis91.583e-55 176
LLPS-Cis-1346Ciona savignyi91.587e-55 176
LLPS-Drm-0075Drosophila melanogaster91.585e-55 176
LLPS-Xim-2310Xiphophorus maculatus91.499e-54 172
LLPS-Tut-1162Tursiops truncatus91.47e-54 172
LLPS-Dio-0347Dipodomys ordii91.31e-52 168
LLPS-Otg-3189Otolemur garnettii90.623e-55 176
LLPS-Sob-1831Sorghum bicolor90.626e-56 178
LLPS-Pes-0407Pelodiscus sinensis90.623e-55 176
LLPS-Orbr-1739Oryza brachyantha90.626e-56 178
LLPS-Phv-1146Phaseolus vulgaris90.623e-56 179
LLPS-Orc-3540Oryctolagus cuniculus90.623e-55 176
LLPS-Mae-0644Manihot esculenta90.625e-56 178
LLPS-Fia-0517Ficedula albicollis90.623e-55 176
LLPS-Orn-0401Oreochromis niloticus90.623e-55 176
LLPS-Nia-0631Nicotiana attenuata90.626e-57 180
LLPS-Rhb-1846Rhinopithecus bieti90.623e-55 176
LLPS-Hos-1401Homo sapiens90.623e-55 176
LLPS-Meg-1088Meleagris gallopavo90.623e-55 176
LLPS-Dar-3247Danio rerio90.623e-55 176
LLPS-Pof-2286Poecilia formosa90.623e-55 176
LLPS-Pat-0393Pan troglodytes90.623e-55 176
LLPS-Pap-0871Pan paniscus90.623e-55 176
LLPS-Urm-1911Ursus maritimus90.623e-55 176
LLPS-Mod-1117Monodelphis domestica90.624e-55 176
LLPS-Fec-0540Felis catus90.623e-55 176
LLPS-Lac-0627Latimeria chalumnae90.621e-54 175
LLPS-Gor-0875Gossypium raimondii90.622e-55 176
LLPS-Man-2090Macaca nemestrina90.623e-55 176
LLPS-Anp-0169Anas platyrhynchos90.624e-55 176
LLPS-Loa-1041Loxodonta africana90.624e-55 175
LLPS-Xet-1065Xenopus tropicalis90.623e-55 176
LLPS-Gaga-0518Gallus gallus90.623e-55 176
LLPS-Cas-0677Carlito syrichta90.623e-55 176
LLPS-Anc-1174Anolis carolinensis90.623e-55 176
LLPS-Nol-0022Nomascus leucogenys90.623e-55 176
LLPS-Zem-0517Zea mays90.627e-56 177
LLPS-Ict-1391Ictidomys tridecemlineatus90.623e-55 176
LLPS-Tag-1220Taeniopygia guttata90.623e-55 176
LLPS-Coc-0194Corchorus capsularis90.628e-56 177
LLPS-Poa-1180Pongo abelii90.623e-55 176
LLPS-Caf-1689Canis familiaris90.623e-55 176
LLPS-Cap-0543Cavia porcellus90.623e-55 176
LLPS-Eqc-0147Equus caballus90.624e-55 175
LLPS-Mam-0086Macaca mulatta90.623e-55 176
LLPS-Hea-2725Helianthus annuus90.626e-57 180
LLPS-Thc-1101Theobroma cacao90.629e-56 177
LLPS-Fud-0361Fukomys damarensis90.624e-55 176
LLPS-Asm-0179Astyanax mexicanus90.623e-55 176
LLPS-Caj-3048Callithrix jacchus90.623e-55 176
LLPS-Icp-1956Ictalurus punctatus90.623e-55 176
LLPS-Cii-0796Ciona intestinalis90.625e-55 175
LLPS-Maf-1453Macaca fascicularis90.623e-55 176
LLPS-Mum-0205Mus musculus90.623e-55 176
LLPS-Mea-0355Mesocricetus auratus90.623e-55 176
LLPS-Glm-1112Glycine max90.622e-56 179
LLPS-Ora-2547Ornithorhynchus anatinus90.624e-55 175
LLPS-Chs-1274Chlorocebus sabaeus90.623e-55 176
LLPS-Orl-2854Oryzias latipes90.623e-52 174
LLPS-Sus-0564Sus scrofa90.623e-55 176
LLPS-Leo-1167Lepisosteus oculatus90.623e-55 176
LLPS-Aon-3941Aotus nancymaae90.623e-55 176
LLPS-Cea-3074Cercocebus atys90.623e-55 176
LLPS-Sah-2515Sarcophilus harrisii90.623e-55 176
LLPS-Ran-0058Rattus norvegicus90.623e-55 176
LLPS-Tra-0738Triticum aestivum90.629e-56 177
LLPS-Brd-0674Brachypodium distachyon90.628e-56 177
LLPS-Paa-0195Papio anubis90.623e-55 176
LLPS-Mal-0565Mandrillus leucophaeus90.623e-55 176
LLPS-Aim-2612Ailuropoda melanoleuca90.623e-55 176
LLPS-Mup-0078Mustela putorius furo90.623e-55 176
LLPS-Ova-3090Ovis aries90.624e-55 175
LLPS-Myl-0616Myotis lucifugus90.624e-55 175
LLPS-Via-1184Vigna angularis90.622e-56 179
LLPS-Tar-1865Takifugu rubripes90.623e-55 176
LLPS-Gaa-0212Gasterosteus aculeatus90.623e-55 176
LLPS-Lep-0572Leersia perrieri90.626e-56 178
LLPS-Scf-1076Scleropages formosus90.623e-55 176
LLPS-Bot-3797Bos taurus90.623e-55 176
LLPS-Viv-1409Vitis vinifera89.581e-55 177
LLPS-Pot-0246Populus trichocarpa89.584e-55 176
LLPS-Dac-2094Daucus carota89.583e-55 176
LLPS-Sol-0133Solanum lycopersicum89.583e-54 174
LLPS-Met-1400Medicago truncatula89.586e-55 175
LLPS-Sei-1343Setaria italica89.583e-55 176
LLPS-Sot-2265Solanum tuberosum89.586e-56 177
LLPS-Ors-1331Oryza sativa88.541e-53 172
LLPS-Org-1745Oryza glaberrima88.541e-53 172
LLPS-Tru-0301Triticum urartu88.549e-55 175
LLPS-Orr-0523Oryza rufipogon88.541e-53 172
LLPS-Orm-1453Oryza meridionalis88.541e-53 172
LLPS-Php-1675Physcomitrella patens88.541e-54 174
LLPS-Mua-2213Musa acuminata88.542e-54 174
LLPS-Orni-0555Oryza nivara88.541e-53 172
LLPS-Sem-0067Selaginella moellendorffii88.546e-55 175
LLPS-Orb-0090Oryza barthii88.541e-53 172
LLPS-Ori-1940Oryza indica88.541e-53 172
LLPS-Arl-0042Arabidopsis lyrata88.543e-54 173
LLPS-Orgl-0860Oryza glumaepatula88.541e-53 172
LLPS-Hov-1675Hordeum vulgare88.38e-53 171
LLPS-Bro-2821Brassica oleracea87.54e-54 173
LLPS-Chr-0782Chlamydomonas reinhardtii87.52e-54 174
LLPS-Amt-0403Amborella trichopoda87.14e-52 167
LLPS-Vir-1414Vigna radiata87.15e-51 165
LLPS-Brr-1915Brassica rapa86.466e-54 172
LLPS-Art-0631Arabidopsis thaliana86.468e-54 172
LLPS-Brn-0601Brassica napus86.466e-54 172
LLPS-Cus-0066Cucumis sativus86.461e-53 172
LLPS-Chc-0654Chondrus crispus82.987e-50 163
LLPS-Miv-0021Microbotryum violaceum81.252e-50 164
LLPS-Scj-0988Schizosaccharomyces japonicus81.055e-49 160
LLPS-Abg-0403Absidia glauca80.212e-50 164
LLPS-Beb-1319Beauveria bassiana80.07e-48 157
LLPS-Scc-0419Schizosaccharomyces cryophilus80.04e-49 160
LLPS-Scp-0280Schizosaccharomyces pombe80.05e-49 160
LLPS-Spr-1080Sporisorium reilianum79.177e-49 160
LLPS-Trr-0290Trichoderma reesei78.951e-47 157
LLPS-Fus-1228Fusarium solani78.952e-47 156
LLPS-Trv-0202Trichoderma virens78.951e-47 157
LLPS-Fuo-0174Fusarium oxysporum78.953e-47 155
LLPS-Map-0468Magnaporthe poae78.952e-47 156
LLPS-Gag-0384Gaeumannomyces graminis78.955e-47 155
LLPS-Fuv-1357Fusarium verticillioides78.953e-47 155
LLPS-Nec-0970Neurospora crassa78.952e-47 156
LLPS-Zyt-0505Zymoseptoria tritici78.952e-47 156
LLPS-Cog-0992Colletotrichum gloeosporioides77.892e-46 154
LLPS-Ved-0535Verticillium dahliae77.897e-47 155
LLPS-Dos-0879Dothistroma septosporum77.891e-46 154
LLPS-Cogr-0487Colletotrichum graminicola77.892e-46 154
LLPS-Coo-0731Colletotrichum orbiculare77.892e-46 154
LLPS-Scs-0020Sclerotinia sclerotiorum77.891e-46 154
LLPS-Kop-0570Komagataella pastoris77.892e-45 151
LLPS-Nef-0002Neosartorya fischeri76.841e-45 152
LLPS-Asfu-0262Aspergillus fumigatus76.841e-45 152
LLPS-Asn-0570Aspergillus nidulans76.841e-45 152
LLPS-Asni-0510Aspergillus niger76.841e-45 152
LLPS-Asc-0247Aspergillus clavatus76.841e-45 152
LLPS-Crn-1065Cryptococcus neoformans76.841e-47 157
LLPS-Asf-1036Aspergillus flavus76.841e-45 152
LLPS-Aso-0144Aspergillus oryzae76.841e-45 152
LLPS-Usm-0458Ustilago maydis76.049e-48 157
LLPS-Cym-0658Cyanidioschyzon merolae76.045e-48 157
LLPS-Ast-0447Aspergillus terreus75.794e-44 147
LLPS-Yal-0104Yarrowia lipolytica74.749e-45 149