• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Xet-1061
spop

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Speckle-type POZ protein
Gene Name: spop
Ensembl Gene: ENSXETG00000027799.2
Ensembl Protein: ENSXETP00000057841.2
Organism: Xenopus tropicalis
Taxa ID: 8364
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear specklePredicted from orthologs(View)

▼ FUNCTION

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSRVPSPPPP  AEMSSGPVAE  SWCYTQIKVV  KFSYMWTINN  FSFCREEMGE  VIKSSTFSSG  60
61    ANDKLKWCLR  VNPKGLDEES  KDYLSLYLLL  VSCPKSEVRA  KFKFSILNAK  GEETKAMATE  120
121   SQRAYRFVQG  KDWGFKKFIR  RDFLLDEANG  LLPDDKLTLF  CEVSVVQDSV  NISGQNTMNM  180
181   VKVPECRLAD  ELGGLWENSR  FTDCCLCVAG  QEFQAHKAIL  AARSPVFSAM  FEHEMEESKK  240
241   NRVEIKDVEP  DVFKEMMCFI  YTGKASNLDK  MADDLLAAAD  KYALERLKVM  CEEALCSNLS  300
301   VENAAEILIL  ADLHSADQLK  TQAVDFINYH  ASDVMETSGW  KSMVVSHPHL  VAEAYRSLAS  360
361   AQCPFLGPPR  KRLKQS  376
Nucleotide CDS Sequence (FASTA)
1     ATGTCGCGAG  TACCCAGTCC  CCCTCCCCCG  GCTGAGATGT  CCAGTGGCCC  TGTGGCAGAA  60
61    AGCTGGTGCT  ATACTCAGAT  TAAAGTTGTC  AAGTTTTCCT  ACATGTGGAC  CATCAACAAC  120
121   TTTAGCTTTT  GCCGAGAGGA  GATGGGGGAG  GTGATCAAGA  GCTCAACCTT  CTCTTCGGGC  180
181   GCCAATGACA  AACTCAAATG  GTGCTTGCGT  GTTAACCCCA  AGGGACTGGA  TGAGGAGAGT  240
241   AAAGATTATC  TATCCCTCTA  CCTACTGTTG  GTTAGTTGTC  CAAAGAGTGA  AGTGCGCGCC  300
301   AAGTTTAAAT  TCTCCATTCT  AAATGCCAAG  GGAGAGGAAA  CCAAAGCAAT  GGCCACAGAG  360
361   AGTCAGCGTG  CCTACCGGTT  CGTTCAGGGG  AAGGACTGGG  GCTTCAAGAA  ATTTATCCGC  420
421   AGGGACTTTT  TACTTGATGA  GGCCAATGGC  CTGCTTCCGG  ATGACAAACT  AACTCTGTTT  480
481   TGTGAGGTTA  GTGTGGTGCA  GGACTCTGTC  AACATTTCTG  GCCAGAACAC  AATGAACATG  540
541   GTCAAAGTCC  CAGAATGCCG  CCTTGCAGAT  GAACTTGGAG  GACTGTGGGA  GAACTCTCGT  600
601   TTCACGGACT  GCTGTCTGTG  TGTGGCTGGC  CAAGAATTCC  AGGCACACAA  AGCCATCCTG  660
661   GCAGCACGGT  CTCCTGTGTT  TAGCGCAATG  TTTGAGCATG  AAATGGAAGA  GAGTAAAAAG  720
721   AATCGTGTGG  AGATAAAAGA  CGTGGAACCG  GACGTGTTTA  AAGAAATGAT  GTGTTTCATC  780
781   TACACGGGGA  AAGCCTCCAA  CCTTGACAAA  ATGGCTGATG  ATTTATTGGC  TGCAGCAGAC  840
841   AAGTATGCTC  TAGAACGCCT  CAAAGTGATG  TGCGAGGAAG  CGCTTTGCAG  TAACCTGTCA  900
901   GTAGAAAATG  CAGCAGAAAT  CCTGATCTTG  GCTGACTTAC  ACAGTGCAGA  TCAGCTGAAA  960
961   ACGCAGGCTG  TGGACTTCAT  CAATTACCAT  GCCTCTGATG  TCATGGAAAC  CTCTGGATGG  1020
1021  AAGTCTATGG  TGGTCTCTCA  CCCACACCTG  GTAGCAGAAG  CATACCGCTC  GCTAGCATCC  1080
1081  GCCCAGTGCC  CCTTTCTGGG  CCCTCCACGC  AAACGCCTGA  AGCAATCCTA  A  1131

▼ KEYWORD

ID
Family
Complete proteome
Nucleus
Reference proteome
Ubl conjugation pathway

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cul3-RING ubiquitin ligase complex
Cellular Component
Cytoplasm
Cellular Component
Nuclear speck
Cellular Component
Nucleus
Molecular Function
Ubiquitin protein ligase binding
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process
Protein ubiquitination
Biological Process
Regulation of proteolysis
Biological Process
Ubiquitin-dependent protein catabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Anp-2648Anas platyrhynchos98.40.0 703
LLPS-Pes-0109Pelodiscus sinensis98.40.0 703
LLPS-Gaga-3929Gallus gallus98.40.0 703
LLPS-Hos-3594Homo sapiens98.140.0 702
LLPS-Pat-3009Pan troglodytes98.140.0 702
LLPS-Pap-0180Pan paniscus98.140.0 702
LLPS-Urm-1950Ursus maritimus98.140.0 702
LLPS-Fec-4766Felis catus98.140.0 702
LLPS-Otg-4451Otolemur garnettii98.140.0 702
LLPS-Orc-2614Oryctolagus cuniculus98.140.0 702
LLPS-Rhb-2797Rhinopithecus bieti98.140.0 702
LLPS-Poa-4084Pongo abelii98.140.0 702
LLPS-Caf-4480Canis familiaris98.140.0 702
LLPS-Eqc-4551Equus caballus98.140.0 702
LLPS-Mam-3945Macaca mulatta98.140.0 702
LLPS-Cas-1729Carlito syrichta98.140.0 702
LLPS-Anc-2448Anolis carolinensis98.140.0 702
LLPS-Nol-4156Nomascus leucogenys98.140.0 702
LLPS-Maf-3080Macaca fascicularis98.140.0 702
LLPS-Mum-1361Mus musculus98.140.0 702
LLPS-Sus-3987Sus scrofa98.140.0 702
LLPS-Aon-4430Aotus nancymaae98.140.0 702
LLPS-Cea-2882Cercocebus atys98.140.0 702
LLPS-Sah-3423Sarcophilus harrisii98.140.0 701
LLPS-Caj-1874Callithrix jacchus98.140.0 702
LLPS-Dio-0154Dipodomys ordii98.140.0 702
LLPS-Bot-4379Bos taurus98.140.0 702
LLPS-Ran-3642Rattus norvegicus98.140.0 702
LLPS-Mal-3295Mandrillus leucophaeus98.140.0 702
LLPS-Paa-4383Papio anubis98.140.0 702
LLPS-Mup-2464Mustela putorius furo98.140.0 702
LLPS-Loa-3675Loxodonta africana97.880.0 697
LLPS-Ova-3779Ovis aries97.880.0 697
LLPS-Cap-1838Cavia porcellus97.870.0 700
LLPS-Ict-1108Ictidomys tridecemlineatus97.870.0 701
LLPS-Tut-1749Tursiops truncatus97.870.0 701
LLPS-Leo-0563Lepisosteus oculatus97.610.0 698
LLPS-Myl-1614Myotis lucifugus97.610.0 697
LLPS-Lac-0725Latimeria chalumnae97.340.0 697
LLPS-Scf-0798Scleropages formosus97.070.0 696
LLPS-Icp-3615Ictalurus punctatus96.540.0 692
LLPS-Dar-4280Danio rerio96.010.0 686
LLPS-Pof-3901Poecilia formosa95.740.0 687
LLPS-Orn-3217Oreochromis niloticus95.740.0 687
LLPS-Orl-1515Oryzias latipes95.740.0 687
LLPS-Xim-0641Xiphophorus maculatus95.740.0 687
LLPS-Asm-3565Astyanax mexicanus95.530.0 686
LLPS-Gaa-0907Gasterosteus aculeatus95.480.0 686
LLPS-Ten-0750Tetraodon nigroviridis94.950.0 682
LLPS-Tar-2567Takifugu rubripes94.950.0 682
LLPS-Man-3419Macaca nemestrina94.410.0 664
LLPS-Meg-0898Meleagris gallopavo93.910.0 690
LLPS-Aim-0973Ailuropoda melanoleuca93.420.0 687
LLPS-Fud-0488Fukomys damarensis89.450.0 653
LLPS-Scm-2888Scophthalmus maximus86.710.0 667
LLPS-Chs-3745Chlorocebus sabaeus84.646e-160 458
LLPS-Mod-2012Monodelphis domestica84.530.0 588
LLPS-Tag-2811Taeniopygia guttata82.40.0 612
LLPS-Fia-0293Ficedula albicollis81.980.0 610
LLPS-Ere-1026Erinaceus europaeus80.432e-166 476
LLPS-Ora-1698Ornithorhynchus anatinus80.20.0 594
LLPS-Gog-1253Gorilla gorilla79.950.0 595
LLPS-Mea-3346Mesocricetus auratus79.70.0 592
LLPS-Drm-0578Drosophila melanogaster79.260.0 560
LLPS-Cii-1752Ciona intestinalis77.360.0 527
LLPS-Cis-1666Ciona savignyi71.572e-179 512
LLPS-Orgl-0853Oryza glumaepatula34.057e-42 160
LLPS-Orm-1922Oryza meridionalis33.71e-38 151
LLPS-Prp-2512Prunus persica33.582e-0962.8
LLPS-Tra-0480Triticum aestivum33.441e-33 133
LLPS-Amt-1711Amborella trichopoda33.331e-1476.6
LLPS-Php-2475Physcomitrella patens33.336e-45 165
LLPS-Viv-0832Vitis vinifera33.245e-37 143
LLPS-Hea-0101Helianthus annuus33.242e-39 150
LLPS-Gor-1388Gossypium raimondii32.872e-39 150
LLPS-Orni-1561Oryza nivara32.866e-0755.5
LLPS-Sob-1986Sorghum bicolor32.81e-43 161
LLPS-Art-1982Arabidopsis thaliana32.795e-40 152
LLPS-Met-1628Medicago truncatula32.761e-35 140
LLPS-Ors-2127Oryza sativa32.613e-39 149
LLPS-Org-0929Oryza glaberrima32.611e-39 150
LLPS-Orb-1863Oryza barthii32.613e-38 150
LLPS-Ori-2216Oryza indica32.614e-39 148
LLPS-Cus-2078Cucumis sativus32.553e-44 163
LLPS-Orp-2168Oryza punctata32.489e-37 142
LLPS-Orr-1177Oryza rufipogon32.482e-38 147
LLPS-Glm-1596Glycine max32.477e-35 137
LLPS-Mae-2364Manihot esculenta32.392e-34 136
LLPS-Thc-2330Theobroma cacao32.385e-43 160
LLPS-Sei-2515Setaria italica32.341e-35 138
LLPS-Coc-1833Corchorus capsularis32.259e-41 154
LLPS-Hov-0434Hordeum vulgare32.21e-35 139
LLPS-Vir-1298Vigna radiata32.182e-33 133
LLPS-Pot-1394Populus trichocarpa32.124e-0961.6
LLPS-Orbr-0475Oryza brachyantha32.127e-0960.8
LLPS-Bro-1698Brassica oleracea32.14e-40 152
LLPS-Brn-2818Brassica napus32.14e-40 152
LLPS-Phv-1483Phaseolus vulgaris32.081e-33 134
LLPS-Dac-1047Daucus carota31.972e-35 137
LLPS-Brd-0661Brachypodium distachyon31.962e-43 160
LLPS-Brr-2838Brassica rapa31.892e-41 155
LLPS-Tru-1311Triticum urartu31.652e-40 151
LLPS-Zem-1368Zea mays31.622e-38 147
LLPS-Arl-2482Arabidopsis lyrata31.591e-38 149
LLPS-Sol-1634Solanum lycopersicum31.584e-39 149
LLPS-Mua-0765Musa acuminata31.582e-39 150
LLPS-Sot-2017Solanum tuberosum31.588e-38 145
LLPS-Sem-0041Selaginella moellendorffii31.452e-44 164
LLPS-Nia-2315Nicotiana attenuata31.184e-37 144
LLPS-Lep-0707Leersia perrieri31.031e-41 155
LLPS-Cae-0342Caenorhabditis elegans31.019e-40 151
LLPS-Via-1930Vigna angularis30.071e-1168.2