LLPS-Via-1403
LR48_Vigan05g172900
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | AP-2 complex subunit alpha |
| Gene Name: | LR48_Vigan05g172900 |
| Ensembl Gene: | LR48_Vigan05g172900 |
| Ensembl Protein: | KOM44124 |
| Organism: | Vigna angularis |
| Taxa ID: | 3914 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | KOM44124 | KOM44124 |
| UniProt | A0A0L9UNL0, A0A0L9UNL0_PHAAN | |
| GeneBank | CM003375 | KOM44124.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLYIYMLGYD VDFGHMEAVS LISAPKYPEK QVGYIVTSSL LNENHDFLRL AINTVRNDII 60 61 GRNETFQCLA LTMVGNIGGR EFAESLAPDV QKLLISSSCR PLVRKKAALC LLRLYRKNPD 120 121 VVNVDGWADR MAQLLDERDL GVLTSSMSLL VALVSNNHEA YWSCLPKCIK ILERLARNLD 180 181 IPQEYTYYGI PSPWLQVKTM RALQYFPTIE DPNARRSLFE VLQRILMGTD VVKNVNKNNA 240 241 SHAVLFEALA LVMHLDAEKE MMSQCVALLG KFIAVREPNI RYLGLENMTR MLMVTDIQDI 300 301 IKRHQAQIIT SLKDPDISIR RRALDLLYGM CDVSNAKDIV EELLQYLSTA EFAMREELSL 360 361 KAAILAEKFA PDLSWYVDVI LQLIDKAGDF VSDDIWFRVV QFVTNNEDLQ PYAAAKAREY 420 421 LDKPAIHETM VKVSAYILGE FGHLLARRPG CSPKEIFGII HEKLPTVSTS TISILLSTYA 480 481 KILMHSQPPD PELQNQIWTI FKKYESSIEV EIQQRAVEYF ALSRKGAALM DILAEMPKFP 540 541 ERQSALIKKA EDTEVDTAEQ SAIRLRAQQL SQTSNALVVT EQSHANGTPP GGQLSLVKIP 600 601 SMSSNVDDTS ADGRLSQENG TLSKVDSQPP SGDFLGDLLG PLAIEGPPSI NIHTRSSSNS 660 661 GLEGTVVEAT AIVPAGEQTN SVQPIGNIAE RFHALCVKDS GVLYEDPYIQ IGIKAEWRAH 720 721 LGHLVLFLGN KNTSPLVSVQ ALILPPTHLK MELSLVPETI PPRAQVQCPL EVINLHPSRD 780 781 VAVLDFSYMF GNDRVRGVRP LPLPEMANLF SSYHITVSPG LDPNPNNLVA STTFYSESTR 840 841 AMLCLIRIET DPADRTQLRM TVASGDPTLT FELKEFIKDQ LVSIPTPIAI RPTQLAPASP 900 901 VAQPSSAPAS LTDPGAMLAA LL 922 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTTTATA TATACATGCT TGGCTATGAT GTGGATTTTG GTCACATGGA GGCTGTTTCT 60 61 CTTATATCTG CCCCAAAGTA TCCTGAAAAA CAGGTCGGAT ACATTGTAAC TTCAAGTTTG 120 121 CTTAATGAAA ATCATGACTT TCTCAGGTTG GCTATAAATA CAGTGCGCAA TGATATCATT 180 181 GGTCGTAATG AAACCTTCCA GTGTCTAGCA TTGACTATGG TTGGAAATAT TGGTGGGAGA 240 241 GAATTTGCTG AGTCCTTAGC ACCTGACGTG CAAAAGTTGC TGATATCAAG CAGTTGCAGA 300 301 CCACTCGTCA GAAAAAAAGC TGCATTGTGT TTGCTACGTC TGTACAGGAA AAATCCTGAT 360 361 GTTGTTAATG TAGATGGATG GGCGGATCGG ATGGCACAAC TTTTGGATGA ACGAGATCTT 420 421 GGTGTTTTGA CATCTTCTAT GAGCCTTCTT GTTGCATTGG TATCAAACAA CCACGAGGCA 480 481 TACTGGAGTT GTCTTCCCAA GTGTATCAAA ATTTTAGAGC GGCTTGCTAG GAACCTGGAT 540 541 ATCCCTCAAG AATACACTTA CTATGGTATC CCGTCTCCCT GGCTTCAGGT CAAAACAATG 600 601 AGGGCTCTTC AATATTTTCC TACAATTGAA GATCCTAATG CCAGAAGGTC ACTGTTTGAG 660 661 GTCTTACAAA GGATACTGAT GGGAACTGAT GTTGTAAAAA ATGTGAACAA AAATAATGCA 720 721 TCCCATGCTG TTCTTTTTGA AGCCCTTGCT CTGGTGATGC ATCTTGATGC CGAAAAAGAG 780 781 ATGATGTCTC AATGCGTGGC TCTTCTTGGA AAATTTATTG CTGTCCGTGA ACCAAACATC 840 841 CGGTATCTTG GCTTGGAGAA TATGACTAGA ATGTTGATGG TTACTGATAT ACAAGATATC 900 901 ATAAAAAGAC ATCAAGCTCA GATTATTACC TCATTGAAAG ATCCTGACAT CAGTATTCGG 960 961 AGGCGTGCTC TAGATTTGCT TTATGGCATG TGTGATGTTT CAAATGCAAA GGATATAGTT 1020 1021 GAAGAACTAC TGCAGTATCT CAGCACAGCA GAGTTTGCAA TGCGTGAGGA ATTGTCACTT 1080 1081 AAAGCGGCTA TTCTAGCTGA GAAGTTTGCA CCAGACCTTT CATGGTACGT TGATGTAATT 1140 1141 CTTCAATTAA TTGACAAGGC TGGAGATTTT GTTAGTGATG ATATATGGTT TCGGGTGGTG 1200 1201 CAGTTTGTTA CAAACAATGA AGATTTACAG CCTTATGCTG CGGCAAAAGC GCGAGAGTAT 1260 1261 CTTGACAAAC CTGCTATACA CGAGACAATG GTTAAGGTCA GTGCATACAT CCTTGGAGAG 1320 1321 TTTGGACACC TTCTAGCCAG ACGACCTGGA TGCAGTCCAA AGGAAATATT TGGCATTATA 1380 1381 CATGAGAAGC TTCCTACTGT ATCGACTTCT ACTATTTCTA TTCTTTTGTC TACATATGCT 1440 1441 AAAATTCTGA TGCACAGTCA ACCACCAGAC CCTGAATTAC AAAATCAGAT ATGGACAATA 1500 1501 TTTAAGAAAT ATGAAAGCTC AATTGAAGTT GAAATACAGC AAAGAGCTGT CGAATATTTT 1560 1561 GCATTGAGTA GAAAAGGTGC AGCTCTAATG GACATATTGG CCGAAATGCC TAAATTCCCC 1620 1621 GAACGACAGT CTGCTTTGAT TAAAAAGGCT GAAGACACTG AAGTTGACAC TGCAGAACAA 1680 1681 AGTGCCATAA GGTTACGAGC TCAACAGCTA TCTCAAACAT CAAATGCTTT GGTTGTAACA 1740 1741 GAACAAAGTC ATGCTAATGG AACTCCTCCT GGTGGCCAAC TTAGCCTTGT AAAAATTCCC 1800 1801 AGCATGAGCA GTAATGTGGA TGATACCTCA GCAGATGGAA GATTATCCCA GGAAAATGGG 1860 1861 ACTTTGAGTA AAGTAGATTC TCAACCTCCT TCAGGAGATT TCCTTGGTGA TCTCTTGGGT 1920 1921 CCATTGGCTA TTGAAGGCCC TCCCAGTATC AATATCCACA CTCGGTCAAG CTCTAATTCA 1980 1981 GGATTGGAAG GAACTGTGGT TGAAGCCACA GCCATAGTAC CTGCTGGAGA ACAGACCAAT 2040 2041 TCGGTGCAGC CAATTGGAAA TATTGCTGAA AGGTTTCATG CTTTGTGCGT GAAGGATAGT 2100 2101 GGTGTTCTAT ACGAGGATCC CTACATTCAG ATTGGTATTA AGGCAGAATG GAGAGCTCAC 2160 2161 CTTGGACATC TTGTTCTTTT CTTGGGAAAC AAGAACACTT CTCCTCTTGT CTCTGTTCAA 2220 2221 GCTTTAATAT TGCCTCCCAC ACATTTGAAG ATGGAGCTCT CTCTAGTACC AGAAACCATA 2280 2281 CCTCCCCGGG CACAAGTGCA ATGCCCACTT GAGGTCATTA ATCTCCATCC AAGCAGGGAT 2340 2341 GTCGCTGTTC TTGATTTCTC CTACATGTTT GGTAACGATA GGGTTAGAGG TGTTAGGCCA 2400 2401 CTTCCACTGC CTGAAATGGC AAACTTATTC AGCAGTTACC ACATAACAGT TTCCCCTGGC 2460 2461 CTTGATCCCA ATCCAAACAA TCTCGTTGCG AGTACAACAT TTTATTCAGA AAGTACTAGG 2520 2521 GCAATGCTTT GTTTAATAAG AATTGAGACA GACCCAGCTG ACAGAACCCA GCTGCGAATG 2580 2581 ACAGTTGCTT CAGGGGACCC AACACTAACA TTTGAGCTGA AGGAGTTCAT CAAAGACCAA 2640 2641 TTAGTGAGCA TTCCCACTCC TATCGCAATT CGTCCGACAC AGCTAGCTCC AGCATCTCCA 2700 2701 GTGGCTCAAC CCAGCAGTGC TCCCGCATCC TTGACGGATC CTGGGGCAAT GCTGGCTGCT 2760 2761 CTTTTATGA 2769 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | AP-2 adaptor complex | |
Molecular Function | Clathrin adaptor activity | |
Biological Process | Clathrin-dependent endocytosis | |
Biological Process | Intracellular protein transport |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Vir-1220 | Vigna radiata | 95.12 | 0.0 | 1806 |
| LLPS-Ors-0800 | Oryza sativa | 92.49 | 0.0 | 656 |
| LLPS-Phv-1686 | Phaseolus vulgaris | 91.19 | 0.0 | 1727 |
| LLPS-Glm-1214 | Glycine max | 90.36 | 0.0 | 1689 |
| LLPS-Met-1855 | Medicago truncatula | 86.17 | 0.0 | 1637 |
| LLPS-Cus-1266 | Cucumis sativus | 84.44 | 0.0 | 1495 |
| LLPS-Thc-1202 | Theobroma cacao | 84.0 | 0.0 | 1573 |
| LLPS-Prp-0803 | Prunus persica | 83.66 | 0.0 | 1559 |
| LLPS-Mae-0708 | Manihot esculenta | 83.18 | 0.0 | 1540 |
| LLPS-Viv-0539 | Vitis vinifera | 83.16 | 0.0 | 1538 |
| LLPS-Pot-1462 | Populus trichocarpa | 82.83 | 0.0 | 1538 |
| LLPS-Gor-2066 | Gossypium raimondii | 82.28 | 0.0 | 1514 |
| LLPS-Coc-0697 | Corchorus capsularis | 80.8 | 0.0 | 1531 |
| LLPS-Nia-0864 | Nicotiana attenuata | 80.16 | 0.0 | 1521 |
| LLPS-Sol-1799 | Solanum lycopersicum | 80.06 | 0.0 | 1516 |
| LLPS-Hea-1904 | Helianthus annuus | 77.94 | 0.0 | 1497 |
| LLPS-Mua-0400 | Musa acuminata | 77.28 | 0.0 | 1462 |
| LLPS-Amt-0489 | Amborella trichopoda | 77.15 | 0.0 | 1474 |
| LLPS-Dac-2331 | Daucus carota | 76.75 | 0.0 | 1450 |
| LLPS-Zem-0005 | Zea mays | 74.87 | 0.0 | 1420 |
| LLPS-Sei-1375 | Setaria italica | 74.52 | 0.0 | 1435 |
| LLPS-Orgl-0690 | Oryza glumaepatula | 74.07 | 0.0 | 1429 |
| LLPS-Org-0426 | Oryza glaberrima | 74.07 | 0.0 | 1426 |
| LLPS-Sob-0725 | Sorghum bicolor | 74.0 | 0.0 | 1429 |
| LLPS-Lep-0588 | Leersia perrieri | 73.77 | 0.0 | 1437 |
| LLPS-Orbr-1750 | Oryza brachyantha | 73.76 | 0.0 | 1425 |
| LLPS-Orp-0164 | Oryza punctata | 73.62 | 0.0 | 1417 |
| LLPS-Brd-1987 | Brachypodium distachyon | 73.08 | 0.0 | 1405 |
| LLPS-Tra-0733 | Triticum aestivum | 71.54 | 0.0 | 1370 |
| LLPS-Orni-1499 | Oryza nivara | 71.21 | 0.0 | 1370 |
| LLPS-Hov-0089 | Hordeum vulgare | 71.15 | 0.0 | 1339 |
| LLPS-Orr-2102 | Oryza rufipogon | 71.14 | 0.0 | 1369 |
| LLPS-Ori-1338 | Oryza indica | 70.08 | 0.0 | 1190 |
| LLPS-Tru-0097 | Triticum urartu | 67.8 | 0.0 | 1199 |
| LLPS-Orb-0192 | Oryza barthii | 67.04 | 0.0 | 1251 |
| LLPS-Sem-0989 | Selaginella moellendorffii | 65.47 | 0.0 | 1211 |
| LLPS-Php-0214 | Physcomitrella patens | 65.2 | 0.0 | 1232 |
| LLPS-Ved-0481 | Verticillium dahliae | 48.88 | 5e-144 | 445 |
| LLPS-Ast-0246 | Aspergillus terreus | 48.09 | 6e-152 | 479 |
| LLPS-Cogr-0406 | Colletotrichum graminicola | 47.78 | 5e-167 | 520 |
| LLPS-Chr-0396 | Chlamydomonas reinhardtii | 46.62 | 7e-160 | 506 |
| LLPS-Dos-0930 | Dothistroma septosporum | 46.2 | 1e-153 | 484 |
| LLPS-Asc-0174 | Aspergillus clavatus | 46.0 | 1e-160 | 502 |
| LLPS-Bot-3453 | Bos taurus | 44.44 | 9e-147 | 467 |
| LLPS-Tut-0022 | Tursiops truncatus | 44.27 | 2e-147 | 467 |
| LLPS-Aim-1871 | Ailuropoda melanoleuca | 44.27 | 8e-148 | 468 |
| LLPS-Sus-3863 | Sus scrofa | 44.09 | 4e-146 | 464 |
| LLPS-Cas-0906 | Carlito syrichta | 44.09 | 4e-150 | 474 |
| LLPS-Urm-2138 | Ursus maritimus | 44.09 | 6e-148 | 469 |
| LLPS-Otg-2684 | Otolemur garnettii | 44.09 | 2e-147 | 467 |
| LLPS-Loa-2693 | Loxodonta africana | 44.07 | 3e-143 | 456 |
| LLPS-Paa-1886 | Papio anubis | 44.06 | 3e-146 | 464 |
| LLPS-Mal-3651 | Mandrillus leucophaeus | 44.06 | 6e-146 | 464 |
| LLPS-Cea-2938 | Cercocebus atys | 44.06 | 8e-146 | 463 |
| LLPS-Maf-3254 | Macaca fascicularis | 44.06 | 6e-146 | 464 |
| LLPS-Hos-4616 | Homo sapiens | 44.06 | 9e-146 | 463 |
| LLPS-Gaa-2844 | Gasterosteus aculeatus | 44.01 | 9e-148 | 469 |
| LLPS-Poa-0079 | Pongo abelii | 43.96 | 1e-147 | 463 |
| LLPS-Xim-1759 | Xiphophorus maculatus | 43.94 | 1e-143 | 457 |
| LLPS-Ten-3489 | Tetraodon nigroviridis | 43.91 | 8e-144 | 457 |
| LLPS-Aon-4794 | Aotus nancymaae | 43.88 | 1e-143 | 457 |
| LLPS-Chs-1873 | Chlorocebus sabaeus | 43.88 | 1e-143 | 457 |
| LLPS-Mod-0200 | Monodelphis domestica | 43.55 | 3e-145 | 462 |
| LLPS-Fec-1693 | Felis catus | 43.52 | 1e-147 | 469 |
| LLPS-Cae-1642 | Caenorhabditis elegans | 42.91 | 6e-141 | 450 |
| LLPS-Cis-1716 | Ciona savignyi | 42.52 | 1e-131 | 427 |
| LLPS-Nol-2536 | Nomascus leucogenys | 41.37 | 6e-127 | 413 |
| LLPS-Fuo-0739 | Fusarium oxysporum | 41.23 | 1e-178 | 551 |
| LLPS-Beb-0372 | Beauveria bassiana | 41.16 | 2e-168 | 524 |
| LLPS-Ora-1673 | Ornithorhynchus anatinus | 39.75 | 6e-37 | 142 |
| LLPS-Miv-0591 | Microbotryum violaceum | 37.78 | 0.0 | 566 |
| LLPS-Crn-1275 | Cryptococcus neoformans | 37.7 | 2e-173 | 539 |
| LLPS-Eqc-0394 | Equus caballus | 37.59 | 1e-162 | 509 |
| LLPS-Trr-0659 | Trichoderma reesei | 36.75 | 2e-176 | 545 |
| LLPS-Lem-0421 | Leptosphaeria maculans | 36.52 | 1e-170 | 529 |
| LLPS-Asm-1646 | Astyanax mexicanus | 36.07 | 2e-166 | 517 |
| LLPS-Yal-0843 | Yarrowia lipolytica | 36.05 | 4e-141 | 451 |
| LLPS-Meg-2316 | Meleagris gallopavo | 35.59 | 6e-165 | 513 |
| LLPS-Zyt-0671 | Zymoseptoria tritici | 35.47 | 6e-176 | 542 |
| LLPS-Scj-0129 | Schizosaccharomyces japonicus | 35.36 | 3e-106 | 356 |
| LLPS-Lac-2525 | Latimeria chalumnae | 35.32 | 3e-168 | 523 |
| LLPS-Sah-2822 | Sarcophilus harrisii | 35.27 | 1e-163 | 510 |
| LLPS-Drm-0054 | Drosophila melanogaster | 35.25 | 1e-169 | 526 |
| LLPS-Icp-3337 | Ictalurus punctatus | 35.24 | 4e-166 | 516 |
| LLPS-Mup-2789 | Mustela putorius furo | 35.21 | 5e-165 | 515 |
| LLPS-Mea-4405 | Mesocricetus auratus | 35.2 | 2e-161 | 504 |
| LLPS-Tag-3052 | Taeniopygia guttata | 35.18 | 2e-161 | 504 |
| LLPS-Cap-3664 | Cavia porcellus | 35.13 | 2e-160 | 501 |
| LLPS-Orc-1248 | Oryctolagus cuniculus | 35.13 | 1e-163 | 510 |
| LLPS-Ict-3205 | Ictidomys tridecemlineatus | 35.1 | 3e-162 | 506 |
| LLPS-Scm-3508 | Scophthalmus maximus | 35.09 | 3e-164 | 513 |
| LLPS-Cii-2188 | Ciona intestinalis | 35.07 | 1e-149 | 474 |
| LLPS-Fud-4299 | Fukomys damarensis | 35.06 | 4e-160 | 501 |
| LLPS-Caj-3017 | Callithrix jacchus | 35.03 | 3e-163 | 510 |
| LLPS-Man-4446 | Macaca nemestrina | 35.03 | 9e-163 | 509 |
| LLPS-Anp-1600 | Anas platyrhynchos | 35.03 | 3e-163 | 509 |
| LLPS-Ova-0082 | Ovis aries | 34.96 | 2e-165 | 514 |
| LLPS-Caf-1989 | Canis familiaris | 34.95 | 4e-165 | 515 |
| LLPS-Gaga-2998 | Gallus gallus | 34.93 | 4e-164 | 512 |
| LLPS-Fia-0339 | Ficedula albicollis | 34.93 | 1e-164 | 513 |
| LLPS-Anc-1023 | Anolis carolinensis | 34.92 | 1e-168 | 524 |
| LLPS-Ran-0823 | Rattus norvegicus | 34.91 | 8e-167 | 520 |
| LLPS-Dio-3082 | Dipodomys ordii | 34.89 | 2e-163 | 511 |
| LLPS-Mum-3278 | Mus musculus | 34.74 | 2e-162 | 507 |
| LLPS-Pes-3101 | Pelodiscus sinensis | 34.74 | 7e-166 | 516 |
| LLPS-Myl-3116 | Myotis lucifugus | 34.62 | 4e-156 | 491 |
| LLPS-Orn-1052 | Oreochromis niloticus | 34.57 | 5e-163 | 508 |
| LLPS-Dar-2452 | Danio rerio | 34.5 | 5e-166 | 517 |
| LLPS-Xet-3095 | Xenopus tropicalis | 34.46 | 5e-161 | 503 |
| LLPS-Pat-3632 | Pan troglodytes | 34.43 | 4e-162 | 507 |
| LLPS-Pap-3307 | Pan paniscus | 34.43 | 4e-162 | 507 |
| LLPS-Gog-1434 | Gorilla gorilla | 34.38 | 2e-155 | 489 |
| LLPS-Tar-1888 | Takifugu rubripes | 34.33 | 5e-159 | 498 |
| LLPS-Pof-0250 | Poecilia formosa | 34.14 | 3e-164 | 512 |
| LLPS-Rhb-4054 | Rhinopithecus bieti | 34.0 | 6e-144 | 457 |
| LLPS-Orl-3513 | Oryzias latipes | 33.99 | 2e-161 | 506 |
| LLPS-Mam-1612 | Macaca mulatta | 33.16 | 3e-148 | 471 |
| LLPS-Kop-1329 | Komagataella pastoris | 30.0 | 1e-55 | 211 |
| LLPS-Leo-2321 | Lepisosteus oculatus | 25.38 | 1e-31 | 137 |