• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Urm-3305
MTHFD2L

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
Gene Name: MTHFD2L
Ensembl Gene: ENSUMAG00000006704.1
Ensembl Protein: ENSUMAP00000008821.1
Organism: Ursus maritimus
Taxa ID: 29073
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAKQVQKEIQ  RGVESWISLG  NRRPYLSIIL  VGDDPASHTY  VRKKIRAASA  VGICSEIILK  60
61    PKDVSQEELL  DITDQLNMDP  RVSGILVQLP  LPDHVDERAV  CNGIAPEKDV  DGFHIINIGR  120
121   LCLDQHSLIP  ATASAVWEII  KRTGIETFGK  NVVVAGRSKN  VGMPIAMLLH  TDGEHERPGG  180
181   DATVTIAHRY  TPKEQLKIHT  QLADVIIVAA  GIPKLITCDM  VREGAAVIDV  GINYVHDPVT  240
241   GKTKLVGDVD  FEAVKKKASF  ITPVPGGVGP  MTVAMLLKNT  LLAAKKLIY  289
Nucleotide CDS Sequence (FASTA)
1     ATGGCCAAAC  AAGTCCAGAA  AGAAATACAG  AGAGGTGTGG  AATCATGGAT  TTCCCTCGGG  60
61    AACAGAAGAC  CTTACCTCAG  TATCATTTTA  GTGGGCGATG  ACCCAGCCAG  TCATACGTAT  120
121   GTCCGGAAGA  AGATCAGAGC  TGCCTCTGCT  GTAGGGATCT  GTAGTGAGAT  CATTCTAAAA  180
181   CCTAAGGATG  TTTCTCAGGA  AGAACTTTTG  GACATAACTG  ATCAATTGAA  TATGGACCCA  240
241   AGAGTCAGTG  GTATATTAGT  TCAGTTACCA  CTGCCAGACC  ATGTGGACGA  GCGAGCCGTG  300
301   TGCAATGGAA  TTGCCCCTGA  AAAAGATGTA  GATGGATTTC  ATATTATCAA  TATTGGAAGA  360
361   CTGTGCCTTG  ATCAGCATTC  TCTCATACCT  GCCACTGCCA  GTGCTGTTTG  GGAAATAATC  420
421   AAGAGAACAG  GAATTGAAAC  ATTTGGGAAG  AATGTGGTCG  TAGCTGGAAG  ATCCAAGAAT  480
481   GTAGGGATGC  CCATTGCCAT  GCTTTTACAC  ACTGATGGAG  AGCACGAACG  GCCAGGAGGT  540
541   GATGCAACGG  TGACAATAGC  TCACAGATAC  ACTCCCAAAG  AACAACTGAA  GATCCATACT  600
601   CAGCTGGCAG  ATGTTATCAT  AGTCGCTGCC  GGTATTCCCA  AGCTGATCAC  CTGTGATATG  660
661   GTTAGAGAAG  GCGCTGCCGT  AATTGACGTG  GGCATCAACT  ACGTCCATGA  CCCAGTGACG  720
721   GGAAAGACAA  AACTGGTTGG  AGATGTGGAC  TTCGAAGCTG  TTAAGAAGAA  GGCTAGCTTT  780
781   ATCACTCCGG  TTCCTGGAGG  TGTGGGACCC  ATGACCGTGG  CAATGCTTCT  GAAGAACACG  840
841   CTTCTGGCAG  CTAAAAAACT  CATTTACTAG  870

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-3826Ailuropoda melanoleuca98.960.0 551
LLPS-Caf-2369Canis familiaris97.580.0 545
LLPS-Fec-3952Felis catus96.890.0 538
LLPS-Cas-1286Carlito syrichta96.241e-89 270
LLPS-Eqc-3849Equus caballus96.198e-142 416
LLPS-Poa-2440Pongo abelii95.925e-123 357
LLPS-Mup-1191Mustela putorius furo95.850.0 536
LLPS-Gog-3356Gorilla gorilla94.460.0 533
LLPS-Hos-2779Homo sapiens94.460.0 535
LLPS-Chs-4671Chlorocebus sabaeus94.120.0 535
LLPS-Caj-4497Callithrix jacchus94.120.0 529
LLPS-Pat-3455Pan troglodytes94.120.0 530
LLPS-Pap-2810Pan paniscus94.120.0 530
LLPS-Rhb-3335Rhinopithecus bieti94.120.0 533
LLPS-Bot-4553Bos taurus93.430.0 527
LLPS-Paa-0544Papio anubis93.430.0 531
LLPS-Aon-0937Aotus nancymaae93.430.0 528
LLPS-Cea-2995Cercocebus atys93.430.0 532
LLPS-Mam-1905Macaca mulatta93.430.0 529
LLPS-Nol-1416Nomascus leucogenys93.430.0 530
LLPS-Ova-3939Ovis aries93.080.0 527
LLPS-Man-2169Macaca nemestrina93.080.0 529
LLPS-Mal-0706Mandrillus leucophaeus92.730.0 526
LLPS-Mum-3752Mus musculus92.670.0 527
LLPS-Ict-2419Ictidomys tridecemlineatus92.670.0 528
LLPS-Sus-2424Sus scrofa92.393e-179 504
LLPS-Loa-2570Loxodonta africana92.390.0 523
LLPS-Orc-1326Oryctolagus cuniculus91.940.0 524
LLPS-Otg-2799Otolemur garnettii91.350.0 515
LLPS-Ran-2092Rattus norvegicus90.840.0 518
LLPS-Myl-4437Myotis lucifugus86.456e-169 478
LLPS-Mod-1990Monodelphis domestica86.161e-173 489
LLPS-Fud-3289Fukomys damarensis85.122e-175 494
LLPS-Sah-1026Sarcophilus harrisii84.781e-171 486
LLPS-Anp-1445Anas platyrhynchos83.332e-156 446
LLPS-Pes-0352Pelodiscus sinensis83.076e-142 407
LLPS-Gaga-0866Gallus gallus82.76e-168 477
LLPS-Fia-3572Ficedula albicollis82.72e-168 478
LLPS-Anc-2619Anolis carolinensis80.599e-165 467
LLPS-Lac-2394Latimeria chalumnae77.661e-163 465
LLPS-Xet-0606Xenopus tropicalis77.378e-160 456
LLPS-Tag-3182Taeniopygia guttata75.691e-75 236
LLPS-Leo-1518Lepisosteus oculatus75.091e-153 441
LLPS-Tar-2912Takifugu rubripes73.633e-141 409
LLPS-Scf-2801Scleropages formosus72.533e-145 419
LLPS-Pof-3781Poecilia formosa72.169e-149 428
LLPS-Dar-2198Danio rerio72.162e-149 429
LLPS-Xim-3314Xiphophorus maculatus71.791e-148 427
LLPS-Asm-3406Astyanax mexicanus71.794e-149 429
LLPS-Orn-3684Oreochromis niloticus71.794e-145 419
LLPS-Orl-3764Oryzias latipes71.434e-143 414
LLPS-Mea-0861Mesocricetus auratus71.431e-144 418
LLPS-Scm-1185Scophthalmus maximus71.435e-143 414
LLPS-Icp-4137Ictalurus punctatus71.061e-148 427
LLPS-Cap-3831Cavia porcellus70.73e-142 411
LLPS-Ten-3062Tetraodon nigroviridis70.443e-140 405
LLPS-Dio-1385Dipodomys ordii70.333e-139 404
LLPS-Gaa-2255Gasterosteus aculeatus70.336e-146 421
LLPS-Meg-1684Meleagris gallopavo69.63e-145 418
LLPS-Drm-1432Drosophila melanogaster52.382e-94 288
LLPS-Trv-1187Trichoderma virens46.853e-54 194
LLPS-Sem-0487Selaginella moellendorffii46.741e-69 224
LLPS-Trr-0560Trichoderma reesei46.672e-55 197
LLPS-Yal-0784Yarrowia lipolytica46.467e-56 198
LLPS-Map-0253Magnaporthe poae46.215e-58 204
LLPS-Ved-1029Verticillium dahliae45.85e-54 193
LLPS-Tru-1040Triticum urartu45.287e-60 200
LLPS-Sol-1066Solanum lycopersicum45.264e-59 197
LLPS-Beb-0726Beauveria bassiana45.133e-59 209
LLPS-Cus-1837Cucumis sativus44.775e-59 199
LLPS-Gag-1502Gaeumannomyces graminis44.774e-55 197
LLPS-Tra-2005Triticum aestivum44.661e-59 199
LLPS-Glm-2663Glycine max44.44e-61 202
LLPS-Org-1888Oryza glaberrima44.41e-61 206
LLPS-Asfu-1298Aspergillus fumigatus44.41e-54 195
LLPS-Nef-1502Neosartorya fischeri44.44e-55 196
LLPS-Amt-1888Amborella trichopoda44.46e-63 207
LLPS-Sob-1014Sorghum bicolor44.42e-64 210
LLPS-Met-0382Medicago truncatula44.23e-63 207
LLPS-Mua-1716Musa acuminata44.23e-60 200
LLPS-Nia-0574Nicotiana attenuata44.24e-60 199
LLPS-Brd-0316Brachypodium distachyon44.043e-61 204
LLPS-Cogr-1031Colletotrichum graminicola44.041e-57 203
LLPS-Asf-1589Aspergillus flavus43.886e-54 194
LLPS-Fus-0110Fusarium solani43.881e-55 198
LLPS-Coc-0359Corchorus capsularis43.848e-61 203
LLPS-Phv-1647Phaseolus vulgaris43.846e-62 204
LLPS-Orgl-1184Oryza glumaepatula43.681e-62 206
LLPS-Orm-1592Oryza meridionalis43.685e-63 207
LLPS-Kop-1040Komagataella pastoris43.531e-53 192
LLPS-Fuv-1126Fusarium verticillioides43.534e-55 196
LLPS-Fuo-0768Fusarium oxysporum43.538e-56 198
LLPS-Ast-1552Aspergillus terreus43.536e-54 193
LLPS-Via-0722Vigna angularis43.487e-61 201
LLPS-Chc-1079Chondrus crispus43.326e-58 194
LLPS-Nec-0638Neurospora crassa43.322e-55 198
LLPS-Sei-1863Setaria italica43.323e-61 202
LLPS-Hov-2124Hordeum vulgare43.329e-62 204
LLPS-Ori-1753Oryza indica43.322e-61 202
LLPS-Orb-1306Oryza barthii43.322e-61 202
LLPS-Orni-2262Oryza nivara43.322e-61 202
LLPS-Orr-1650Oryza rufipogon43.322e-61 202
LLPS-Pot-1201Populus trichocarpa43.324e-58 194
LLPS-Orp-2128Oryza punctata43.325e-61 202
LLPS-Ors-1431Oryza sativa43.322e-61 202
LLPS-Spr-0078Sporisorium reilianum43.264e-50 183
LLPS-Usm-1140Ustilago maydis43.261e-49 181
LLPS-Asn-1266Aspergillus nidulans43.177e-55 196
LLPS-Chr-1469Chlamydomonas reinhardtii43.127e-59 198
LLPS-Brn-2091Brassica napus43.121e-58 196
LLPS-Hea-2000Helianthus annuus43.124e-58 194
LLPS-Bro-2634Brassica oleracea43.122e-59 198
LLPS-Asc-1399Aspergillus clavatus42.963e-53 191
LLPS-Coo-1353Colletotrichum orbiculare42.964e-56 199
LLPS-Orbr-1681Oryza brachyantha42.963e-60 200
LLPS-Aso-0383Aspergillus oryzae42.756e-51 185
LLPS-Brr-3057Brassica rapa42.759e-59 196
LLPS-Mae-2142Manihot esculenta42.755e-59 197
LLPS-Abg-1275Absidia glauca42.691e-50 184
LLPS-Dos-0919Dothistroma septosporum42.521e-49 181
LLPS-Thc-2396Theobroma cacao42.391e-56 191
LLPS-Viv-1717Vitis vinifera42.394e-58 195
LLPS-Pyt-1056Pyrenophora teres42.283e-47 174
LLPS-Osl-0189Ostreococcus lucimarinus42.242e-58 195
LLPS-Prp-1020Prunus persica42.034e-58 194
LLPS-Blg-1007Blumeria graminis41.941e-52 190
LLPS-Scj-0687Schizosaccharomyces japonicus41.99e-49 179
LLPS-Zyt-1230Zymoseptoria tritici41.881e-53 192
LLPS-Mao-0031Magnaporthe oryzae41.883e-56 200
LLPS-Miv-0389Microbotryum violaceum41.81e-47 176
LLPS-Arl-0173Arabidopsis lyrata41.675e-59 197
LLPS-Gas-1188Galdieria sulphuraria41.674e-57 192
LLPS-Asg-1091Ashbya gossypii41.581e-45 170
LLPS-Cym-0282Cyanidioschyzon merolae41.372e-51 180
LLPS-Art-1436Arabidopsis thaliana41.33e-58 195
LLPS-Scp-0866Schizosaccharomyces pombe41.283e-51 186
LLPS-Zem-1635Zea mays40.941e-59 199
LLPS-Lem-0713Leptosphaeria maculans40.793e-52 189
LLPS-Scs-0713Sclerotinia sclerotiorum40.794e-52 188
LLPS-Vir-1497Vigna radiata40.735e-49 170
LLPS-Maf-4779Macaca fascicularis40.557e-47 174
LLPS-Tum-0936Tuber melanosporum40.433e-50 182
LLPS-Phn-1206Phaeosphaeria nodorum40.437e-51 186
LLPS-Crn-1190Cryptococcus neoformans40.141e-44 167
LLPS-Scc-1034Schizosaccharomyces cryophilus40.071e-48 178
LLPS-Mel-0585Melampsora laricipopulina39.784e-45 168
LLPS-Cis-1752Ciona savignyi39.641e-44 167
LLPS-Dac-1359Daucus carota39.499e-51 174
LLPS-Cii-1940Ciona intestinalis38.571e-46 172
LLPS-Gor-0889Gossypium raimondii38.561e-54 186