• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Urm-1694
IFNG

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Interferon gamma
Gene Name: IFNG
Ensembl Gene: ENSUMAG00000020686.1
Ensembl Protein: ENSUMAP00000028473.1
Organism: Ursus maritimus
Taxa ID: 29073
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MNYTSYILAF  QLCVILCSSG  YYCQAMFFKE  IENLKEYFNA  SNPDVADGGP  LFLDILKNWR  60
61    EESDKTIIQS  QIVSFYLKLF  ENFKDNQVIQ  RSMDTIKEDM  LFKFFNSSTS  KRSDFLKLIQ  120
121   IPVNDMQVQR  KAINELIKVM  NDLSPRSNLR  KRKRSQNLFR  GRRASK  166
Nucleotide CDS Sequence (FASTA)
1     ATGAATTATA  CAAGCTATAT  CTTAGCTTTC  CAGCTTTGTG  TGATTTTGTG  TTCTTCTGGC  60
61    TATTACTGTC  AGGCCATGTT  TTTTAAAGAA  ATAGAAAACC  TGAAGGAATA  TTTTAATGCA  120
121   AGTAATCCAG  ATGTAGCAGA  TGGTGGCCCT  CTTTTCTTAG  ATATTTTGAA  GAACTGGAGA  180
181   GAGGAGAGTG  ACAAAACGAT  CATTCAAAGC  CAAATCGTCT  CCTTCTACTT  GAAACTGTTC  240
241   GAAAACTTTA  AAGATAACCA  GGTCATTCAA  AGGAGCATGG  ACACCATCAA  GGAGGACATG  300
301   CTTTTCAAGT  TCTTCAACAG  CAGTACCAGT  AAGCGGAGTG  ACTTCCTTAA  GCTGATTCAA  360
361   ATTCCCGTGA  ATGATATGCA  GGTTCAGCGC  AAAGCGATAA  ATGAACTCAT  CAAAGTGATG  420
421   AATGATCTCT  CACCAAGATC  TAACCTGAGG  AAGCGGAAAA  GGAGTCAGAA  TCTGTTTCGA  480
481   GGCCGCAGAG  CATCGAAATA  A  501

▼ KEYWORD


ID
Family
Antiviral defense
Complete proteome
Cytokine
Growth regulation
Reference proteome
Secreted
Signal

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Extracellular space
Molecular Function
Cytokine activity
Molecular Function
Interferon-gamma receptor binding
Biological Process
Defense response to virus
Biological Process
Immune response
Biological Process
Regulation of growth

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-2789Ailuropoda melanoleuca99.44e-118 338
LLPS-Caf-3531Canis familiaris92.771e-108 314
LLPS-Mup-4016Mustela putorius furo89.761e-106 309
LLPS-Fec-4008Felis catus87.435e-102 297
LLPS-Eqc-1704Equus caballus85.377e-99 289
LLPS-Tut-0024Tursiops truncatus78.921e-91 271
LLPS-Ova-2348Ovis aries78.791e-82 248
LLPS-Bot-0504Bos taurus77.581e-82 248
LLPS-Sus-3772Sus scrofa74.14e-85 254
LLPS-Loa-3924Loxodonta africana72.894e-84 252
LLPS-Poa-3947Pongo abelii67.473e-74 227
LLPS-Hos-0619Homo sapiens67.472e-74 227
LLPS-Pat-4837Pan troglodytes67.476e-74 226
LLPS-Pap-1234Pan paniscus67.476e-74 226
LLPS-Caj-2962Callithrix jacchus67.474e-75 229
LLPS-Gog-0629Gorilla gorilla67.472e-74 227
LLPS-Nol-4100Nomascus leucogenys66.872e-73 225
LLPS-Mam-2323Macaca mulatta66.273e-73 224
LLPS-Man-3098Macaca nemestrina66.273e-73 224
LLPS-Mal-1922Mandrillus leucophaeus66.272e-73 224
LLPS-Maf-2835Macaca fascicularis66.273e-73 224
LLPS-Chs-3746Chlorocebus sabaeus66.271e-73 225
LLPS-Paa-0529Papio anubis65.665e-72 221
LLPS-Aon-4735Aotus nancymaae65.663e-74 226
LLPS-Cea-1508Cercocebus atys65.661e-72 223
LLPS-Ict-2100Ictidomys tridecemlineatus65.221e-56 182
LLPS-Orc-3238Oryctolagus cuniculus65.061e-72 223
LLPS-Cas-3530Carlito syrichta64.461e-70 218
LLPS-Myl-4131Myotis lucifugus64.468e-66 205
LLPS-Rhb-1826Rhinopithecus bieti63.254e-68 211
LLPS-Otg-2819Otolemur garnettii63.251e-67 210
LLPS-Cap-4278Cavia porcellus60.711e-58 187
LLPS-Mea-3237Mesocricetus auratus60.252e-61 194
LLPS-Fud-2699Fukomys damarensis60.242e-60 191
LLPS-Ere-0246Erinaceus europaeus57.382e-40 139
LLPS-Sah-0835Sarcophilus harrisii47.561e-46 156
LLPS-Mum-4700Mus musculus46.798e-42 143
LLPS-Ran-4264Rattus norvegicus44.879e-45 151
LLPS-Ora-2221Ornithorhynchus anatinus39.733e-29 111
LLPS-Tag-3557Taeniopygia guttata39.022e-25 101
LLPS-Pes-2536Pelodiscus sinensis38.932e-2088.2
LLPS-Gaga-0446Gallus gallus37.822e-2395.9
LLPS-Fia-1554Ficedula albicollis37.86e-26 102
LLPS-Meg-0017Meleagris gallopavo36.972e-2395.9
LLPS-Anp-0867Anas platyrhynchos36.91e-2088.6
LLPS-Xet-0398Xenopus tropicalis31.854e-1162.0