LLPS-Maf-2835
EGM_03470
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Interferon gamma |
| Gene Name: | EGM_03470 |
| Ensembl Gene: | ENSMFAG00000043748.1 |
| Ensembl Protein: | ENSMFAP00000024297.1 |
| Organism: | Macaca fascicularis |
| Taxa ID: | 9541 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMFAT00000032436.1 | ENSMFAP00000024297.1 |
| UniProt | G7PHZ5, G7PHZ5_MACFA | |
| GeneBank | CM001286 | EHH66470.1 |
| RefSeq | NM_001287657.1 | NP_001274586.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GDPDVADNGT LFLDILRNWK 60 61 EESDRKIMQS QIVSFYFKLF KNFKDDQRIQ KSVETIKEDI NVKFFNSNKK KRDDFEKLTN 120 121 YSVTDSNVQR KAVHELIQVM AELSPAAKIG KRKRSQMFRG RRASQ 165 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAATACA CAAGTTATAT CTTGGCTTTT CAGCTCTGCA TTGTTTTGGG TTCTCTTGGC 60 61 TGTTACTGCC AGGACCCATA TGTAAAAGAA GCAGAAAACC TTAAGAAATA TTTTAATGCA 120 121 GGTGATCCAG ATGTAGCAGA TAATGGAACT CTTTTCTTAG ACATCTTGAG GAATTGGAAA 180 181 GAGGAGAGTG ACAGAAAAAT AATGCAGAGC CAAATTGTCT CCTTTTACTT CAAACTTTTT 240 241 AAAAACTTCA AAGATGACCA GAGGATCCAA AAGAGTGTGG AGACCATCAA GGAAGACATT 300 301 AATGTCAAGT TTTTCAATAG CAACAAAAAG AAACGGGATG ACTTTGAAAA GCTGACCAAT 360 361 TATTCGGTAA CTGACTCGAA TGTCCAACGC AAAGCAGTAC ATGAACTCAT CCAAGTGATG 420 421 GCTGAACTGT CGCCAGCAGC TAAAATAGGG AAGCGAAAAA GGAGTCAGAT GTTTCGAGGT 480 481 CGAAGAGCAT CCCAATAA 498 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Extracellular space | |
Molecular Function | Cytokine activity | |
Molecular Function | Interferon-gamma receptor binding | |
Biological Process | Cell cycle arrest | |
Biological Process | Defense response to virus | |
Biological Process | Extrinsic apoptotic signaling pathway | |
Biological Process | Interferon-gamma-mediated signaling pathway | |
Biological Process | Negative regulation of interleukin-17 production | |
Biological Process | Negative regulation of smooth muscle cell proliferation | |
Biological Process | Negative regulation of transcription, DNA-templated | |
Biological Process | Positive regulation of autophagy | |
Biological Process | Positive regulation of calcidiol 1-monooxygenase activity | |
Biological Process | Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response | |
Biological Process | Positive regulation of core promoter binding | |
Biological Process | Positive regulation of epithelial cell migration | |
Biological Process | Positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity | |
Biological Process | Positive regulation of fructose 1,6-bisphosphate metabolic process | |
Biological Process | Positive regulation of gene expression | |
Biological Process | Positive regulation of interleukin-12 production | |
Biological Process | Positive regulation of interleukin-23 production | |
Biological Process | Positive regulation of killing of cells of other organism | |
Biological Process | Positive regulation of membrane protein ectodomain proteolysis | |
Biological Process | Positive regulation of nitric oxide biosynthetic process | |
Biological Process | Positive regulation of osteoclast differentiation | |
Biological Process | Positive regulation of peptidyl-serine phosphorylation of STAT protein | |
Biological Process | Positive regulation of protein complex assembly | |
Biological Process | Positive regulation of protein deacetylation | |
Biological Process | Positive regulation of protein import into nucleus | |
Biological Process | Positive regulation of protein serine/threonine kinase activity | |
Biological Process | Positive regulation of smooth muscle cell apoptotic process | |
Biological Process | Positive regulation of tumor necrosis factor (ligand) superfamily member 11 production | |
Biological Process | Positive regulation of tyrosine phosphorylation of STAT protein | |
Biological Process | Regulation of growth | |
Biological Process | Regulation of insulin secretion | |
Biological Process | Regulation of protein ADP-ribosylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-2323 | Macaca mulatta | 100.0 | 3e-119 | 341 |
| LLPS-Man-3098 | Macaca nemestrina | 100.0 | 3e-119 | 341 |
| LLPS-Chs-3746 | Chlorocebus sabaeus | 99.39 | 4e-118 | 338 |
| LLPS-Mal-1922 | Mandrillus leucophaeus | 98.79 | 3e-117 | 336 |
| LLPS-Paa-0529 | Papio anubis | 98.18 | 1e-115 | 332 |
| LLPS-Cea-1508 | Cercocebus atys | 98.18 | 1e-116 | 334 |
| LLPS-Poa-3947 | Pongo abelii | 94.58 | 2e-111 | 321 |
| LLPS-Rhb-1826 | Rhinopithecus bieti | 94.55 | 1e-109 | 317 |
| LLPS-Nol-4100 | Nomascus leucogenys | 93.98 | 9e-111 | 319 |
| LLPS-Hos-0619 | Homo sapiens | 93.98 | 1e-110 | 319 |
| LLPS-Gog-0629 | Gorilla gorilla | 93.98 | 1e-110 | 319 |
| LLPS-Pap-1234 | Pan paniscus | 93.37 | 7e-110 | 317 |
| LLPS-Pat-4837 | Pan troglodytes | 93.37 | 7e-110 | 317 |
| LLPS-Caj-2962 | Callithrix jacchus | 88.55 | 3e-106 | 308 |
| LLPS-Aon-4735 | Aotus nancymaae | 87.35 | 3e-103 | 300 |
| LLPS-Eqc-1704 | Equus caballus | 66.87 | 1e-72 | 222 |
| LLPS-Orc-3238 | Oryctolagus cuniculus | 66.87 | 9e-72 | 220 |
| LLPS-Urm-1694 | Ursus maritimus | 66.27 | 3e-73 | 224 |
| LLPS-Aim-2789 | Ailuropoda melanoleuca | 66.27 | 4e-73 | 224 |
| LLPS-Cas-3530 | Carlito syrichta | 64.02 | 2e-70 | 217 |
| LLPS-Caf-3531 | Canis familiaris | 63.86 | 1e-70 | 217 |
| LLPS-Fec-4008 | Felis catus | 62.87 | 1e-67 | 209 |
| LLPS-Loa-3924 | Loxodonta africana | 62.65 | 4e-69 | 213 |
| LLPS-Mup-4016 | Mustela putorius furo | 62.65 | 1e-68 | 212 |
| LLPS-Tut-0024 | Tursiops truncatus | 61.45 | 8e-69 | 213 |
| LLPS-Ova-2348 | Ovis aries | 60.0 | 2e-58 | 186 |
| LLPS-Bot-0504 | Bos taurus | 59.39 | 6e-56 | 180 |
| LLPS-Sus-3772 | Sus scrofa | 57.23 | 9e-61 | 192 |
| LLPS-Otg-2819 | Otolemur garnettii | 56.1 | 9e-57 | 182 |
| LLPS-Ict-2100 | Ictidomys tridecemlineatus | 55.8 | 5e-47 | 157 |
| LLPS-Ere-0246 | Erinaceus europaeus | 55.74 | 2e-39 | 136 |
| LLPS-Myl-4131 | Myotis lucifugus | 55.15 | 9e-59 | 187 |
| LLPS-Fud-2699 | Fukomys damarensis | 54.82 | 8e-53 | 172 |
| LLPS-Cap-4278 | Cavia porcellus | 54.76 | 1e-49 | 164 |
| LLPS-Mea-3237 | Mesocricetus auratus | 52.5 | 3e-50 | 166 |
| LLPS-Sah-0835 | Sarcophilus harrisii | 43.04 | 5e-39 | 136 |
| LLPS-Mum-4700 | Mus musculus | 42.31 | 2e-37 | 132 |
| LLPS-Ran-4264 | Rattus norvegicus | 41.03 | 2e-40 | 140 |
| LLPS-Tag-3557 | Taeniopygia guttata | 35.15 | 6e-20 | 86.7 |
| LLPS-Pes-2536 | Pelodiscus sinensis | 34.87 | 1e-16 | 78.2 |
| LLPS-Ora-2221 | Ornithorhynchus anatinus | 34.69 | 2e-20 | 87.8 |
| LLPS-Fia-1554 | Ficedula albicollis | 33.33 | 6e-19 | 84.0 |
| LLPS-Anp-0867 | Anas platyrhynchos | 32.72 | 2e-17 | 79.7 |
| LLPS-Gaga-0446 | Gallus gallus | 32.09 | 1e-12 | 66.6 |
| LLPS-Xet-0398 | Xenopus tropicalis | 31.36 | 5e-11 | 62.0 |
| LLPS-Meg-0017 | Meleagris gallopavo | 29.76 | 3e-12 | 65.5 |