DrLLPS - Data resource of LLPS

LLPS-Urm-1126
LSM4

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U6 snRNA-associated Sm-like protein LSm4
Gene Name:	LSM4
Ensembl Gene:	ENSUMAG00000009013.1
Ensembl Protein:	ENSUMAP00000012031.1
Organism:	Ursus maritimus
Taxa ID:	29073
LLPS Type:	Scaffold

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Droplet, Cajal body, Nuclear speckle, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0080	P40070	Scaffold	Droplet, P-body	40.22	3e-14	71.2
Mus musculus	LLPS-Mum-0863	Q9QXA5	Scaffold	Cajal body, Nuclear speckle	75.36	1e-55	177
Homo sapiens	LLPS-Hos-0328	Q9Y4Z0	Scaffold	P-body	100.00	3e-56	182
Mus musculus	LLPS-Mum-0863	Q9QXA5	Client	Cajal body, Nuclear speckle	75.36	1e-55	177

▼ FUNCTION

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSUMAT00000014311.1	ENSUMAP00000012031.1
Ensembl	ENSUMAT00000014308.1	ENSUMAP00000012028.1
UniProt		A0A384D5B8, A0A384D5B8_URSMA
RefSeq	, XM_008703944.1	, XP_008702166.1, XP_008702166.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MWLPLSLLKT AQNHPMLVEL KNGETYNGHL VSCDNWMNIN LREVICTSRD GDKFWRMPEC 60 61 YIRGSTIKYL RIPDEIIDMV KEEVVAKGRG RGGLQQQKQQ KGRGMGGAGR GVFGGRGRGG 120 121 IPGTGRGQPE KKPGRQAGKQ 140
Nucleotide CDS Sequence (FASTA)
1 ATGTGGCTTC CCTTGTCGCT GCTGAAGACG GCTCAGAATC ATCCCATGTT GGTGGAACTC 60 61 AAAAATGGGG AGACATACAA TGGGCACCTG GTGAGCTGTG ATAACTGGAT GAACATTAAC 120 121 CTTCGAGAGG TGATCTGCAC ATCCAGGGAT GGGGACAAGT TCTGGAGGAT GCCCGAGTGC 180 181 TACATCCGCG GCAGCACCAT CAAGTACCTG CGCATCCCCG ACGAGATCAT CGACATGGTC 240 241 AAGGAGGAGG TGGTGGCCAA GGGCCGTGGA CGCGGTGGCC TGCAGCAGCA GAAGCAGCAG 300 301 AAGGGCCGAG GCATGGGGGG TGCTGGGCGA GGTGTGTTTG GTGGCCGGGG CCGAGGTGGG 360 361 ATCCCAGGCA CAGGCAGAGG TCAGCCGGAA AAGAAGCCGG GCAGACAGGC GGGCAAGCAG 420 421 TGA 423

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005681	Cellular Component	Spliceosomal complex
GO:0003723	Molecular Function	RNA binding
GO:0000398	Biological Process	MRNA splicing, via spliceosome
GO:0000956	Biological Process	Nuclear-transcribed mRNA catabolic process

▼ KEGG

umr:103674940

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gog-1115	Gorilla gorilla	100.0	7e-56	181
LLPS-Caj-0664	Callithrix jacchus	100.0	2e-61	192
LLPS-Chs-3643	Chlorocebus sabaeus	100.0	2e-61	192
LLPS-Maf-0534	Macaca fascicularis	100.0	2e-61	192
LLPS-Aon-3874	Aotus nancymaae	100.0	2e-61	192
LLPS-Cea-0273	Cercocebus atys	100.0	2e-55	180
LLPS-Sus-0811	Sus scrofa	100.0	2e-61	192
LLPS-Myl-0447	Myotis lucifugus	100.0	2e-61	192
LLPS-Ova-1395	Ovis aries	100.0	3e-57	182
LLPS-Aim-2260	Ailuropoda melanoleuca	100.0	3e-61	192
LLPS-Mup-0283	Mustela putorius furo	100.0	2e-61	192
LLPS-Mal-2676	Mandrillus leucophaeus	100.0	1e-55	180
LLPS-Paa-1201	Papio anubis	100.0	2e-55	180
LLPS-Tut-1242	Tursiops truncatus	100.0	2e-21	87.8
LLPS-Bot-3613	Bos taurus	100.0	2e-61	192
LLPS-Otg-0384	Otolemur garnettii	100.0	3e-57	181
LLPS-Rhb-0228	Rhinopithecus bieti	100.0	7e-52	170
LLPS-Fec-1880	Felis catus	100.0	2e-61	192
LLPS-Pap-1705	Pan paniscus	100.0	2e-55	180
LLPS-Pat-1007	Pan troglodytes	100.0	2e-55	180
LLPS-Hos-0328	Homo sapiens	100.0	1e-55	180
LLPS-Man-0058	Macaca nemestrina	100.0	7e-52	170
LLPS-Ict-0928	Ictidomys tridecemlineatus	100.0	2e-61	192
LLPS-Eqc-1879	Equus caballus	100.0	2e-25	102
LLPS-Caf-0348	Canis familiaris	100.0	4e-60	189
LLPS-Poa-2288	Pongo abelii	100.0	2e-61	192
LLPS-Mam-1531	Macaca mulatta	100.0	2e-61	192
LLPS-Cas-1677	Carlito syrichta	99.28	6e-61	191
LLPS-Icp-1549	Ictalurus punctatus	98.81	1e-56	180
LLPS-Scf-1016	Scleropages formosus	98.81	8e-57	180
LLPS-Gaa-0886	Gasterosteus aculeatus	98.81	7e-57	181
LLPS-Pes-2671	Pelodiscus sinensis	98.81	4e-57	181
LLPS-Orn-1975	Oreochromis niloticus	98.81	4e-57	181
LLPS-Fia-0751	Ficedula albicollis	98.81	4e-57	181
LLPS-Scm-0405	Scophthalmus maximus	98.81	5e-57	181
LLPS-Pof-0147	Poecilia formosa	98.81	3e-56	180
LLPS-Dar-1233	Danio rerio	98.81	9e-57	180
LLPS-Gaga-0064	Gallus gallus	98.81	5e-57	181
LLPS-Loa-3419	Loxodonta africana	98.55	8e-60	188
LLPS-Dio-2628	Dipodomys ordii	97.83	8e-61	190
LLPS-Cap-2325	Cavia porcellus	97.83	3e-59	186
LLPS-Asm-3337	Astyanax mexicanus	97.62	2e-55	177
LLPS-Leo-0029	Lepisosteus oculatus	97.62	2e-55	176
LLPS-Orl-0892	Oryzias latipes	97.62	9e-56	177
LLPS-Xet-0461	Xenopus tropicalis	97.62	2e-55	177
LLPS-Ten-1103	Tetraodon nigroviridis	97.62	4e-56	179
LLPS-Tag-2966	Taeniopygia guttata	97.22	1e-45	151
LLPS-Fud-2249	Fukomys damarensis	97.1	2e-61	192
LLPS-Tar-1167	Takifugu rubripes	96.43	2e-55	176
LLPS-Mum-0863	Mus musculus	96.38	5e-58	183
LLPS-Sah-0369	Sarcophilus harrisii	96.38	4e-60	189
LLPS-Ran-0683	Rattus norvegicus	96.38	5e-58	183
LLPS-Cis-0375	Ciona savignyi	96.3	1e-51	166
LLPS-Mod-1222	Monodelphis domestica	95.97	3e-49	160
LLPS-Xim-1668	Xiphophorus maculatus	95.35	1e-55	179
LLPS-Mea-3294	Mesocricetus auratus	95.19	4e-28	105
LLPS-Ora-0137	Ornithorhynchus anatinus	93.18	2e-52	168
LLPS-Cii-1968	Ciona intestinalis	91.67	5e-52	167
LLPS-Meg-2282	Meleagris gallopavo	89.86	1e-58	185
LLPS-Drm-1305	Drosophila melanogaster	89.29	7e-52	168
LLPS-Ori-0181	Oryza indica	86.59	7e-48	157
LLPS-Brd-0233	Brachypodium distachyon	86.59	1e-47	157
LLPS-Tra-1654	Triticum aestivum	86.59	1e-47	157
LLPS-Sei-0297	Setaria italica	86.59	1e-47	157
LLPS-Sob-1247	Sorghum bicolor	86.59	1e-47	157
LLPS-Ors-1474	Oryza sativa	86.59	8e-48	157
LLPS-Zem-1239	Zea mays	86.59	1e-47	158
LLPS-Org-1665	Oryza glaberrima	86.59	7e-48	157
LLPS-Orm-0325	Oryza meridionalis	86.59	7e-48	157
LLPS-Brn-0005	Brassica napus	86.42	2e-47	156
LLPS-Met-1573	Medicago truncatula	86.42	4e-48	158
LLPS-Arl-0189	Arabidopsis lyrata	86.42	4e-47	155
LLPS-Art-2101	Arabidopsis thaliana	86.42	2e-47	155
LLPS-Brr-0990	Brassica rapa	86.42	2e-47	155
LLPS-Bro-0543	Brassica oleracea	86.42	2e-47	155
LLPS-Anp-1961	Anas platyrhynchos	85.71	8e-19	81.3
LLPS-Php-1664	Physcomitrella patens	85.54	6e-48	158
LLPS-Tru-0782	Triticum urartu	85.53	3e-43	147
LLPS-Orni-0680	Oryza nivara	85.51	2e-38	133
LLPS-Orb-0753	Oryza barthii	85.51	2e-38	133
LLPS-Orgl-0171	Oryza glumaepatula	85.51	2e-38	133
LLPS-Lep-0200	Leersia perrieri	85.51	1e-38	133
LLPS-Orr-0836	Oryza rufipogon	85.51	2e-38	133
LLPS-Thc-0569	Theobroma cacao	85.37	2e-47	156
LLPS-Mua-1649	Musa acuminata	85.37	1e-47	157
LLPS-Sol-0549	Solanum lycopersicum	85.37	2e-47	156
LLPS-Glm-1754	Glycine max	85.37	3e-47	156
LLPS-Cus-0463	Cucumis sativus	85.37	7e-47	158
LLPS-Via-0455	Vigna angularis	85.37	7e-48	155
LLPS-Amt-0303	Amborella trichopoda	85.37	3e-47	155
LLPS-Mae-0753	Manihot esculenta	85.37	3e-47	156
LLPS-Phv-1578	Phaseolus vulgaris	85.37	4e-47	155
LLPS-Gor-0642	Gossypium raimondii	85.37	1e-47	157
LLPS-Viv-0290	Vitis vinifera	85.37	2e-46	155
LLPS-Pot-1685	Populus trichocarpa	85.37	9e-48	157
LLPS-Coc-0170	Corchorus capsularis	85.37	2e-47	156
LLPS-Prp-1794	Prunus persica	85.37	2e-47	156
LLPS-Hea-0164	Helianthus annuus	84.15	2e-46	154
LLPS-Nia-0080	Nicotiana attenuata	84.15	1e-47	157
LLPS-Vir-0963	Vigna radiata	83.54	1e-43	150
LLPS-Lac-1217	Latimeria chalumnae	82.73	3e-57	181
LLPS-Sem-0743	Selaginella moellendorffii	82.35	5e-45	151
LLPS-Abg-0425	Absidia glauca	80.25	7e-43	144
LLPS-Orp-0267	Oryza punctata	76.81	5e-31	114
LLPS-Cae-0801	Caenorhabditis elegans	76.19	1e-42	143
LLPS-Nol-4484	Nomascus leucogenys	75.94	3e-37	129
LLPS-Tum-0295	Tuber melanosporum	75.0	5e-39	138
LLPS-Pyt-0640	Pyrenophora teres	73.53	4e-31	113
LLPS-Osl-1092	Ostreococcus lucimarinus	73.17	5e-41	139
LLPS-Asn-0912	Aspergillus nidulans	72.5	4e-37	129
LLPS-Fus-1065	Fusarium solani	72.5	5e-37	129
LLPS-Lem-0532	Leptosphaeria maculans	72.06	9e-31	112
LLPS-Mao-1038	Magnaporthe oryzae	71.64	2e-29	109
LLPS-Asf-0573	Aspergillus flavus	71.6	4e-37	129
LLPS-Aso-0987	Aspergillus oryzae	71.6	9e-37	129
LLPS-Asni-0085	Aspergillus niger	70.37	4e-37	129
LLPS-Dos-0060	Dothistroma septosporum	70.37	1e-38	133
LLPS-Pytr-0768	Pyrenophora triticirepentis	70.37	5e-37	129
LLPS-Fuv-0305	Fusarium verticillioides	70.0	4e-36	127
LLPS-Fuo-0061	Fusarium oxysporum	70.0	4e-36	127
LLPS-Trv-1045	Trichoderma virens	70.0	2e-35	125
LLPS-Spr-0416	Sporisorium reilianum	70.0	9e-36	126
LLPS-Phn-0407	Phaeosphaeria nodorum	69.62	3e-34	124
LLPS-Asc-0756	Aspergillus clavatus	69.14	2e-36	127
LLPS-Chr-0663	Chlamydomonas reinhardtii	69.14	5e-37	129
LLPS-Trr-0089	Trichoderma reesei	69.14	7e-36	127
LLPS-Nef-0203	Neosartorya fischeri	69.14	6e-37	129
LLPS-Asfu-0680	Aspergillus fumigatus	69.14	6e-37	129
LLPS-Cogr-0537	Colletotrichum graminicola	68.75	4e-35	124
LLPS-Zyt-0975	Zymoseptoria tritici	68.24	9e-39	134
LLPS-Blg-0108	Blumeria graminis	67.9	2e-36	127
LLPS-Ast-0107	Aspergillus terreus	67.9	5e-36	126
LLPS-Usm-0692	Ustilago maydis	67.5	3e-36	127
LLPS-Gag-0202	Gaeumannomyces graminis	66.25	1e-34	123
LLPS-Beb-0863	Beauveria bassiana	66.25	2e-34	122
LLPS-Chc-0455	Chondrus crispus	65.43	1e-34	123
LLPS-Scp-0669	Schizosaccharomyces pombe	64.63	2e-33	120
LLPS-Mel-0238	Melampsora laricipopulina	64.2	2e-35	124
LLPS-Nec-0569	Neurospora crassa	64.2	4e-35	124
LLPS-Pug-0277	Puccinia graminis	64.2	9e-35	127
LLPS-Gas-0010	Galdieria sulphuraria	63.86	2e-36	127
LLPS-Scj-0753	Schizosaccharomyces japonicus	63.41	3e-33	119
LLPS-Scc-0263	Schizosaccharomyces cryophilus	62.96	8e-32	115
LLPS-Miv-0217	Microbotryum violaceum	62.96	5e-34	122
LLPS-Crn-0531	Cryptococcus neoformans	61.73	9e-31	114
LLPS-Map-0016	Magnaporthe poae	60.61	5e-24	95.1
LLPS-Coo-0350	Colletotrichum orbiculare	54.46	3e-29	116
LLPS-Yal-0460	Yarrowia lipolytica	53.16	2e-22	92.0
LLPS-Ved-0414	Verticillium dahliae	50.56	3e-22	91.3
LLPS-Asg-0416	Ashbya gossypii	47.56	1e-20	87.8
LLPS-Kop-0049	Komagataella pastoris	44.44	1e-17	78.6
LLPS-Sac-1053	Saccharomyces cerevisiae	41.67	1e-12	64.7
LLPS-Orbr-0879	Oryza brachyantha	41.33	2e-11	62.0
LLPS-Dac-0302	Daucus carota	40.0	2e-11	62.0
LLPS-Sot-1527	Solanum tuberosum	38.67	7e-11	60.5

LLPS-Urm-1126LSM4

Protein Sequence

Nucleotide Sequence

LLPS-Urm-1126
LSM4