DrLLPS - Data resource of LLPS

LLPS-Eqc-1879
LSM4

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U6 snRNA-associated Sm-like protein LSm4
Gene Name:	LSM4
Ensembl Gene:	ENSECAG00000010141.2
Ensembl Protein:	ENSECAP00000008028.2
Organism:	Equus caballus
Taxa ID:	9796
LLPS Type:	Regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Cajal body, Nuclear speckle, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-0863	Q9QXA5	Scaffold	Cajal body, Nuclear speckle	100.00	2e-26	105
Homo sapiens	LLPS-Hos-0328	Q9Y4Z0	Scaffold	P-body	100.00	5e-25	104

▼ FUNCTION

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSECAT00000010409.2	ENSECAP00000008028.2
Ensembl	ENSECAT00000058389.1	ENSECAP00000030882.1
UniProt		F6RM65, F6RM65_HORSE
RefSeq	XM_005604124.2, XM_014734782.1	XP_005604181.1, XP_014590268.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRPCSHGLAP AHVAPPPFAA LAEALYVPLP VYLRREHACS APRAQQAPPY SAWIGCPSLK 60 61 FHADWLVSLP LPFQPSGARR GDRPLARERR RQRRRKWPAS SVPADTMLPL SLLKTAQNHP 120 121 MLVELKNGET YNGHLVSCDN WMNINLREVI CTSRVCLAAG AAVASQAQAG VSPRRSRAAR 180 181 QASSEPSPSP WRPSAATFTA APGLCCHAQA TALLCLQLTS LWRTTQQREE GERRQGLVPP 240 241 LPPPPRPVHF VTLPFT 256
Nucleotide CDS Sequence (FASTA)
1 ATGCGCCCCT GCTCACATGG CCTCGCGCCG GCGCACGTTG CTCCGCCCCC TTTTGCAGCA 60 61 CTCGCTGAGG CACTTTACGT CCCTCTTCCC GTATACCTCC GGAGAGAACA CGCCTGCTCC 120 121 GCCCCTCGTG CCCAGCAGGC CCCGCCCTAC TCCGCGTGGA TTGGTTGTCC TTCTCTCAAG 180 181 TTCCACGCTG ACTGGCTCGT GTCGCTGCCA CTCCCATTTC AGCCTAGTGG CGCGCGGCGG 240 241 GGTGACCGCC CGCTGGCGCG TGAGCGGCGG CGGCAGCGGC GGCGGAAGTG GCCGGCGAGC 300 301 TCTGTGCCTG CCGACACCAT GCTGCCCTTG TCGCTGCTCA AGACGGCTCA GAATCACCCC 360 361 ATGTTGGTGG AGCTTAAAAA CGGGGAGACG TACAATGGTC ACCTGGTGAG CTGTGACAAC 420 421 TGGATGAACA TCAACCTGCG CGAGGTGATC TGCACATCCA GGGACGGGGA CAAGTTCTGG 480 481 CGGATGCCCG AGTGCTACAT TCGGGGCAGC ACCATCAAGT ACCTGCGCAT TCCTGACGAG 540 541 ATCATTGACA TGGTCAAGGA GGAGGTGGTG GCCAAGGGCC GTGGCCGCGG AGGCCTGCAG 600 601 CAGCAGAAGC AGCAGAAGGG CCGAGGCATG GGGGGCGCCG GGCGAGGTGT GTTTGGCGGC 660 661 CGGGGCCGCG GTGGCATCCC AGGCACAGGC CGGGGTCAGC CCGAGAAGAA GCCGGGCCGC 720 721 CAGGCAGGCA AGCAGTGA 738

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0000932	Cellular Component	P-body
GO:0005681	Cellular Component	Spliceosomal complex
GO:0005688	Cellular Component	U6 snRNP
GO:0003723	Molecular Function	RNA binding
GO:0017070	Molecular Function	U6 snRNA binding
GO:0033962	Biological Process	Cytoplasmic mRNA processing body assembly
GO:0000956	Biological Process	Nuclear-transcribed mRNA catabolic process
GO:0000387	Biological Process	Spliceosomal snRNP assembly

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Cas-1677	Carlito syrichta	100.0	1e-25	103
LLPS-Xet-0461	Xenopus tropicalis	100.0	7e-26	104
LLPS-Gaga-0064	Gallus gallus	100.0	9e-26	103
LLPS-Ict-0928	Ictidomys tridecemlineatus	100.0	1e-25	103
LLPS-Ten-1103	Tetraodon nigroviridis	100.0	2e-26	105
LLPS-Poa-2288	Pongo abelii	100.0	1e-25	103
LLPS-Cap-2325	Cavia porcellus	100.0	1e-25	103
LLPS-Mam-1531	Macaca mulatta	100.0	1e-25	103
LLPS-Otg-0384	Otolemur garnettii	100.0	4e-25	102
LLPS-Pes-2671	Pelodiscus sinensis	100.0	5e-25	102
LLPS-Fia-0751	Ficedula albicollis	100.0	5e-25	102
LLPS-Rhb-0228	Rhinopithecus bieti	100.0	1e-20	91.7
LLPS-Orn-1975	Oreochromis niloticus	100.0	7e-26	104
LLPS-Hos-0328	Homo sapiens	100.0	2e-24	102
LLPS-Meg-2282	Meleagris gallopavo	100.0	3e-25	102
LLPS-Dar-1233	Danio rerio	100.0	6e-26	104
LLPS-Pap-1705	Pan paniscus	100.0	2e-24	102
LLPS-Urm-1126	Ursus maritimus	100.0	1e-24	100
LLPS-Pof-0147	Poecilia formosa	100.0	6e-26	105
LLPS-Pat-1007	Pan troglodytes	100.0	2e-24	102
LLPS-Fec-1880	Felis catus	100.0	1e-25	103
LLPS-Mod-1222	Monodelphis domestica	100.0	3e-15	74.7
LLPS-Scm-0405	Scophthalmus maximus	100.0	1e-25	103
LLPS-Lac-1217	Latimeria chalumnae	100.0	1e-25	103
LLPS-Man-0058	Macaca nemestrina	100.0	1e-20	91.7
LLPS-Loa-3419	Loxodonta africana	100.0	5e-25	102
LLPS-Ran-0683	Rattus norvegicus	100.0	1e-25	103
LLPS-Paa-1201	Papio anubis	100.0	1e-23	100
LLPS-Mal-2676	Mandrillus leucophaeus	100.0	1e-23	100
LLPS-Ova-1395	Ovis aries	100.0	1e-24	100
LLPS-Myl-0447	Myotis lucifugus	100.0	8e-25	101
LLPS-Aim-2260	Ailuropoda melanoleuca	100.0	9e-25	101
LLPS-Mup-0283	Mustela putorius furo	100.0	1e-25	103
LLPS-Xim-1668	Xiphophorus maculatus	100.0	6e-26	105
LLPS-Tar-1167	Takifugu rubripes	100.0	4e-26	105
LLPS-Gaa-0886	Gasterosteus aculeatus	100.0	2e-25	103
LLPS-Dio-2628	Dipodomys ordii	100.0	9e-26	103
LLPS-Scf-1016	Scleropages formosus	100.0	5e-26	104
LLPS-Bot-3613	Bos taurus	100.0	1e-25	103
LLPS-Gog-1115	Gorilla gorilla	100.0	1e-24	103
LLPS-Fud-2249	Fukomys damarensis	100.0	8e-25	101
LLPS-Asm-3337	Astyanax mexicanus	100.0	9e-26	104
LLPS-Caj-0664	Callithrix jacchus	100.0	1e-25	103
LLPS-Icp-1549	Ictalurus punctatus	100.0	7e-26	104
LLPS-Mum-0863	Mus musculus	100.0	1e-25	103
LLPS-Maf-0534	Macaca fascicularis	100.0	1e-25	103
LLPS-Chs-3643	Chlorocebus sabaeus	100.0	1e-25	103
LLPS-Orl-0892	Oryzias latipes	100.0	5e-26	104
LLPS-Sus-0811	Sus scrofa	100.0	1e-25	103
LLPS-Leo-0029	Lepisosteus oculatus	100.0	8e-26	104
LLPS-Aon-3874	Aotus nancymaae	100.0	1e-25	103
LLPS-Sah-0369	Sarcophilus harrisii	100.0	1e-25	103
LLPS-Cea-0273	Cercocebus atys	100.0	1e-23	100
LLPS-Cii-1968	Ciona intestinalis	97.92	7e-25	101
LLPS-Cis-0375	Ciona savignyi	97.92	3e-24	99.8
LLPS-Tag-2966	Taeniopygia guttata	97.14	4e-16	77.0
LLPS-Caf-0348	Canis familiaris	94.92	2e-31	119
LLPS-Drm-1305	Drosophila melanogaster	91.67	2e-23	97.8
LLPS-Ora-0137	Ornithorhynchus anatinus	90.2	5e-22	93.2
LLPS-Bro-0543	Brassica oleracea	89.58	5e-22	93.6
LLPS-Zem-1239	Zea mays	89.58	7e-22	94.7
LLPS-Org-1665	Oryza glaberrima	89.58	3e-22	94.7
LLPS-Coc-0170	Corchorus capsularis	89.58	4e-22	94.4
LLPS-Orm-0325	Oryza meridionalis	89.58	3e-22	94.7
LLPS-Prp-1794	Prunus persica	89.58	4e-22	94.4
LLPS-Sob-1247	Sorghum bicolor	89.58	6e-22	94.0
LLPS-Mae-0093	Manihot esculenta	89.58	5e-22	94.4
LLPS-Phv-1578	Phaseolus vulgaris	89.58	7e-22	94.0
LLPS-Amt-0303	Amborella trichopoda	89.58	7e-22	93.6
LLPS-Nia-0080	Nicotiana attenuata	89.58	2e-22	95.1
LLPS-Viv-1482	Vitis vinifera	89.58	6e-22	94.0
LLPS-Ors-1474	Oryza sativa	89.58	3e-22	94.7
LLPS-Brr-0990	Brassica rapa	89.58	5e-22	93.6
LLPS-Art-2101	Arabidopsis thaliana	89.58	5e-22	93.6
LLPS-Gor-1259	Gossypium raimondii	89.58	4e-22	94.4
LLPS-Pot-1685	Populus trichocarpa	89.58	4e-22	94.4
LLPS-Met-1573	Medicago truncatula	89.58	1e-22	95.9
LLPS-Sei-0297	Setaria italica	89.58	6e-22	94.0
LLPS-Cus-0463	Cucumis sativus	89.58	2e-21	94.7
LLPS-Tra-1654	Triticum aestivum	89.58	5e-22	94.0
LLPS-Brd-0233	Brachypodium distachyon	89.58	5e-22	94.0
LLPS-Arl-0189	Arabidopsis lyrata	89.58	8e-22	93.2
LLPS-Vir-0963	Vigna radiata	89.58	4e-21	94.0
LLPS-Via-0455	Vigna angularis	89.58	2e-22	93.6
LLPS-Php-1664	Physcomitrella patens	89.58	5e-22	94.4
LLPS-Thc-0569	Theobroma cacao	89.58	5e-22	94.4
LLPS-Sol-0549	Solanum lycopersicum	89.58	4e-22	94.4
LLPS-Glm-1272	Glycine max	89.58	5e-22	94.0
LLPS-Brn-0005	Brassica napus	89.58	6e-22	93.6
LLPS-Ori-0181	Oryza indica	89.58	3e-22	94.7
LLPS-Sem-0743	Selaginella moellendorffii	89.36	1e-20	91.3
LLPS-Orr-0836	Oryza rufipogon	88.24	2e-13	69.3
LLPS-Orgl-0171	Oryza glumaepatula	88.24	2e-13	69.3
LLPS-Lep-0200	Leersia perrieri	88.24	2e-13	69.3
LLPS-Orni-0680	Oryza nivara	88.24	2e-13	69.3
LLPS-Orb-0753	Oryza barthii	88.24	2e-13	69.3
LLPS-Tru-0782	Triticum urartu	87.8	2e-17	82.0
LLPS-Hea-0164	Helianthus annuus	87.5	4e-21	92.0
LLPS-Mua-1649	Musa acuminata	87.5	1e-21	93.2
LLPS-Orp-0267	Oryza punctata	85.71	1e-08	56.6
LLPS-Abg-0425	Absidia glauca	82.98	3e-18	83.2
LLPS-Cae-0801	Caenorhabditis elegans	81.25	2e-19	86.7
LLPS-Fus-1065	Fusarium solani	78.72	2e-17	80.9
LLPS-Tum-0295	Tuber melanosporum	78.26	1e-16	80.9
LLPS-Osl-1092	Ostreococcus lucimarinus	77.08	5e-18	82.0
LLPS-Chr-0663	Chlamydomonas reinhardtii	77.08	1e-17	81.3
LLPS-Usm-0692	Ustilago maydis	76.6	2e-17	81.3
LLPS-Spr-0416	Sporisorium reilianum	76.6	2e-16	78.6
LLPS-Fuo-0061	Fusarium oxysporum	76.6	5e-17	79.3
LLPS-Asn-0912	Aspergillus nidulans	76.6	2e-16	77.8
LLPS-Fuv-0305	Fusarium verticillioides	76.6	5e-17	79.3
LLPS-Ved-0414	Verticillium dahliae	75.76	3e-09	57.8
LLPS-Mao-1038	Magnaporthe oryzae	75.76	1e-09	58.5
LLPS-Asfu-0680	Aspergillus fumigatus	74.47	3e-16	77.0
LLPS-Cogr-0537	Colletotrichum graminicola	74.47	5e-16	76.6
LLPS-Trv-1045	Trichoderma virens	74.47	4e-16	77.0
LLPS-Trr-0089	Trichoderma reesei	74.47	4e-16	77.8
LLPS-Nef-0203	Neosartorya fischeri	74.47	3e-16	77.0
LLPS-Ast-0107	Aspergillus terreus	74.47	4e-16	76.6
LLPS-Beb-0863	Beauveria bassiana	74.47	2e-16	78.2
LLPS-Asf-0573	Aspergillus flavus	74.47	5e-16	76.6
LLPS-Zyt-0975	Zymoseptoria tritici	74.47	9e-16	75.9
LLPS-Coo-0350	Colletotrichum orbiculare	74.47	4e-15	79.0
LLPS-Asni-0085	Aspergillus niger	74.47	3e-16	77.4
LLPS-Aso-0987	Aspergillus oryzae	73.91	4e-15	74.3
LLPS-Nol-4484	Nomascus leucogenys	73.17	4e-08	54.7
LLPS-Gas-0010	Galdieria sulphuraria	72.92	1e-16	78.6
LLPS-Pyt-0640	Pyrenophora teres	72.73	3e-08	54.7
LLPS-Nec-0569	Neurospora crassa	72.34	2e-16	77.8
LLPS-Blg-0108	Blumeria graminis	72.34	2e-15	75.1
LLPS-Crn-0531	Cryptococcus neoformans	72.34	1e-14	73.6
LLPS-Asc-0756	Aspergillus clavatus	72.34	2e-15	74.7
LLPS-Dos-0060	Dothistroma septosporum	71.74	8e-15	73.2
LLPS-Pytr-0768	Pyrenophora triticirepentis	70.21	3e-14	72.0
LLPS-Miv-0217	Microbotryum violaceum	70.21	2e-14	72.8
LLPS-Pug-0277	Puccinia graminis	70.21	5e-15	75.9
LLPS-Lem-0532	Leptosphaeria maculans	69.7	5e-08	54.3
LLPS-Scj-0753	Schizosaccharomyces japonicus	69.57	2e-14	71.6
LLPS-Scp-0669	Schizosaccharomyces pombe	69.57	2e-14	71.6
LLPS-Phn-0407	Phaeosphaeria nodorum	69.05	3e-11	64.3
LLPS-Map-0016	Magnaporthe poae	68.09	1e-14	72.4
LLPS-Gag-0202	Gaeumannomyces graminis	68.09	1e-14	73.2
LLPS-Mel-0238	Melampsora laricipopulina	67.39	4e-14	70.9
LLPS-Scc-0263	Schizosaccharomyces cryophilus	67.39	5e-13	68.2
LLPS-Chc-0455	Chondrus crispus	66.67	6e-15	73.6
LLPS-Yal-0460	Yarrowia lipolytica	63.64	1e-11	64.7
LLPS-Kop-0049	Komagataella pastoris	59.09	9e-09	56.2
LLPS-Asg-0416	Ashbya gossypii	54.55	3e-09	58.2

LLPS-Eqc-1879LSM4

Protein Sequence

Nucleotide Sequence

LLPS-Eqc-1879
LSM4