• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tra-1465
THI1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Thiamine thiazole synthase, chloroplastic; Thiazole biosynthetic enzyme
Gene Name: THI1
Ensembl Gene: TraesCS7D02G373100
Ensembl Protein: TraesCS7D02G373100.2
Organism: Triticum aestivum
Taxa ID: 4565
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAMATTASS  LLKTSFSGVR  LPAAARTPSC  VATPRAGAIC  NSISSSTPPY  DLNAFKFSPI  60
61    KESIVSREMT  RRYMTDMITY  ADTDVVIVGA  GSAGLSCAYE  LSKDPSISIA  IIEQSVSPGG  120
121   GAWLGGQLFS  AMVVRKPAHL  FLDELNIEYD  EQEDYVVIKH  AALFTSTVMS  RLLARPNVKL  180
181   FNAVAVEDLI  VKENRVAGVV  TNWALVSMNH  DTQSCMDPNV  MEAKVVVSSC  GHDGPFGATG  240
241   VKRLQDIGMI  QAVPGMKALD  MNTAEDAIVR  LTREVVPGMI  VTGMEVAEID  GAPRMGPTFG  300
301   AMMISGQKAA  HLALKALGRP  NGIDGTLKNV  TPALHPEMIL  AATNNGDIVD  A  351
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGCCA  TGGCCACCAC  CGCTTCCAGC  CTCCTCAAGA  CCTCCTTCTC  CGGCGTCCGC  60
61    CTCCCGGCGG  CGGCCCGCAC  CCCGTCCTGC  GTCGCCACCC  CGCGCGCCGG  CGCCATCTGC  120
121   AACTCCATCT  CCTCCTCCAC  CCCTCCCTAC  GACCTCAACG  CCTTCAAGTT  CAGCCCCATC  180
181   AAGGAGTCCA  TCGTGTCCCG  CGAGATGACC  CGCCGCTACA  TGACCGACAT  GATCACCTAC  240
241   GCCGACACCG  ACGTTGTCAT  CGTCGGCGCC  GGCTCCGCGG  GGCTGTCCTG  CGCGTACGAG  300
301   CTCTCCAAGG  ACCCCTCCAT  CAGCATCGCC  ATCATCGAGC  AGTCCGTGTC  CCCCGGCGGC  360
361   GGCGCCTGGC  TCGGCGGCCA  GCTCTTCTCC  GCCATGGTCG  TGCGCAAGCC  GGCGCACCTC  420
421   TTCCTCGACG  AGCTCAACAT  CGAGTACGAC  GAGCAGGAGG  ACTACGTCGT  CATCAAGCAC  480
481   GCCGCGCTCT  TCACCTCCAC  GGTCATGAGC  CGCCTCCTCG  CGCGCCCCAA  CGTGAAGCTC  540
541   TTCAACGCCG  TCGCCGTGGA  GGACCTCATC  GTCAAGGAGA  ACCGCGTTGC  CGGCGTCGTC  600
601   ACCAACTGGG  CGCTCGTCTC  CATGAACCAC  GACACACAGT  CCTGCATGGA  CCCCAACGTC  660
661   ATGGAGGCCA  AGGTCGTGGT  GAGCTCCTGC  GGCCACGACG  GGCCCTTCGG  CGCCACCGGG  720
721   GTCAAGCGGC  TCCAAGACAT  CGGCATGATC  CAGGCGGTGC  CCGGGATGAA  GGCCCTCGGC  780
781   CGGCCGAACG  GCATCGACGG  GACGCTCAAG  AACGTGACCC  CGGCGCTGCA  CCCGGAGATG  840
841   ATCCTGGCGG  CGACCAACAA  CGGCGACATC  GTGGACGCCT  AA  882

▼ KEYWORD

ID
Family
Chloroplast
Complete proteome
Iron
Metal-binding
NAD
Plastid
Reference proteome
Thiamine biosynthesis

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast stroma
Cellular Component
Cytosol
Molecular Function
Metal ion binding
Biological Process
Thiamine biosynthetic process
Biological Process
Thiazole biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tru-1608Triticum urartu99.140.0 709
LLPS-Brd-0348Brachypodium distachyon95.740.0 675
LLPS-Orm-0000Oryza meridionalis89.460.0 649
LLPS-Orbr-1552Oryza brachyantha88.890.0 625
LLPS-Orp-0033Oryza punctata88.480.0 635
LLPS-Orgl-0412Oryza glumaepatula88.420.0 631
LLPS-Org-1540Oryza glaberrima88.170.0 628
LLPS-Ors-1541Oryza sativa88.170.0 628
LLPS-Lep-0129Leersia perrieri88.140.0 639
LLPS-Ori-1748Oryza indica88.10.0 625
LLPS-Orni-1324Oryza nivara88.070.0 621
LLPS-Sob-0736Sorghum bicolor86.690.0 593
LLPS-Sei-1907Setaria italica86.440.0 614
LLPS-Amt-2009Amborella trichopoda84.770.0 541
LLPS-Zem-1935Zea mays83.520.0 564
LLPS-Met-1474Medicago truncatula82.050.0 579
LLPS-Cus-0072Cucumis sativus80.720.0 526
LLPS-Mua-1213Musa acuminata80.194e-48 168
LLPS-Sem-1733Selaginella moellendorffii79.50.0 533
LLPS-Glm-2963Glycine max79.150.0 556
LLPS-Gor-1060Gossypium raimondii79.010.0 555
LLPS-Phv-2134Phaseolus vulgaris78.890.0 561
LLPS-Sot-1873Solanum tuberosum78.790.0 530
LLPS-Sol-1151Solanum lycopersicum78.350.0 536
LLPS-Vir-0404Vigna radiata78.330.0 558
LLPS-Orb-2335Oryza barthii78.310.0 533
LLPS-Viv-0366Vitis vinifera78.240.0 559
LLPS-Thc-1873Theobroma cacao78.130.0 535
LLPS-Hov-0559Hordeum vulgare78.090.0 527
LLPS-Via-1319Vigna angularis78.060.0 558
LLPS-Prp-2498Prunus persica78.030.0 531
LLPS-Dac-0004Daucus carota77.620.0 537
LLPS-Pot-0108Populus trichocarpa77.560.0 556
LLPS-Nia-0832Nicotiana attenuata77.430.0 549
LLPS-Hea-2059Helianthus annuus76.450.0 552
LLPS-Coc-0402Corchorus capsularis76.440.0 524
LLPS-Bro-0324Brassica oleracea76.150.0 541
LLPS-Php-2188Physcomitrella patens76.130.0 526
LLPS-Brn-2307Brassica napus75.930.0 536
LLPS-Arl-0933Arabidopsis lyrata75.770.0 546
LLPS-Brr-0794Brassica rapa75.630.0 546
LLPS-Mae-1206Manihot esculenta74.860.0 544
LLPS-Art-0028Arabidopsis thaliana74.650.0 534
LLPS-Abg-1389Absidia glauca73.984e-151 436
LLPS-Chr-1208Chlamydomonas reinhardtii65.725e-130 383
LLPS-Scp-1218Schizosaccharomyces pombe64.644e-124 367
LLPS-Map-1077Magnaporthe poae64.583e-58 192
LLPS-Fus-0793Fusarium solani64.294e-119 354
LLPS-Dos-0753Dothistroma septosporum64.071e-116 348
LLPS-Fuv-0714Fusarium verticillioides63.918e-119 353
LLPS-Fuo-0798Fusarium oxysporum63.919e-119 353
LLPS-Pyt-1423Pyrenophora teres62.777e-120 357
LLPS-Beb-1360Beauveria bassiana62.648e-119 354
LLPS-Mao-0723Magnaporthe oryzae62.51e-118 353
LLPS-Pytr-0312Pyrenophora triticirepentis62.412e-118 353
LLPS-Scc-1288Schizosaccharomyces cryophilus62.326e-122 362
LLPS-Asf-0728Aspergillus flavus62.273e-115 345
LLPS-Zyt-1438Zymoseptoria tritici62.047e-117 348
LLPS-Ved-1064Verticillium dahliae62.031e-113 340
LLPS-Trv-1189Trichoderma virens61.975e-120 357
LLPS-Put-0937Puccinia triticina61.641e-56 189
LLPS-Asn-1074Aspergillus nidulans61.452e-114 343
LLPS-Lem-1150Leptosphaeria maculans61.054e-121 360
LLPS-Cog-0297Colletotrichum gloeosporioides60.825e-107 322
LLPS-Trr-1598Trichoderma reesei60.741e-119 356
LLPS-Ast-0883Aspergillus terreus60.735e-113 339
LLPS-Kop-0763Komagataella pastoris60.292e-117 351
LLPS-Yal-0832Yarrowia lipolytica60.076e-121 358
LLPS-Nec-1596Neurospora crassa60.05e-120 357
LLPS-Asc-1414Aspergillus clavatus59.857e-114 341
LLPS-Gag-1235Gaeumannomyces graminis59.791e-115 346
LLPS-Phn-1400Phaeosphaeria nodorum59.791e-119 356
LLPS-Asfu-0582Aspergillus fumigatus59.576e-113 339
LLPS-Spr-1444Sporisorium reilianum59.554e-107 324
LLPS-Coo-1567Colletotrichum orbiculare59.337e-120 357
LLPS-Nef-1655Neosartorya fischeri59.213e-112 337
LLPS-Pug-1518Puccinia graminis58.931e-113 341
LLPS-Cogr-0346Colletotrichum graminicola57.514e-119 355
LLPS-Aso-1224Aspergillus oryzae56.64e-116 347
LLPS-Usm-0315Ustilago maydis56.122e-107 325
LLPS-Asni-1024Aspergillus niger56.112e-114 343
LLPS-Scj-0756Schizosaccharomyces japonicus56.026e-124 367
LLPS-Mel-1495Melampsora laricipopulina55.412e-112 338
LLPS-Asg-0622Ashbya gossypii54.939e-106 320
LLPS-Sac-1490Saccharomyces cerevisiae53.81e-101 310