• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scc-1288
SPOG_03172

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Thiamine thiazole synthase; Thiazole biosynthetic enzyme
Gene Name: SPOG_03172
Ensembl Gene: SPOG_03172
Ensembl Protein: EPY53594
Organism: Schizosaccharomyces cryophilus
Taxa ID: 653667
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEPY53594EPY53594
UniProtS9W4Y8, S9W4Y8_SCHCR
GeneBankKE546988EPY53594.1
RefSeqXM_013165830.1XP_013021284.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAPATAVAQV  QNLFKSDLPV  EKDVALVKNE  YNTLAKSFPT  YQLDDAFNFS  PIRESTVSRA  60
61    MTRRYFADLD  KYAESDIVIV  GAGSAGLTAA  YYLGTRRPDL  KIAIIEASVA  PGGGAWLGGQ  120
121   LFSAMVVRKP  ADAFLREIGV  PYEDEGEYVV  IKHAALFTST  VMARALSLPN  IKLFNATAVE  180
181   DLIVKADQDG  NQRIAGVVTN  WTLVSLNHGL  QSCMDPNTIN  AHLVLSATGH  DGPFGAFCVK  240
241   RAHQAGLVPH  LGDMRPLDMN  RSENLIVKGT  REVYPGLVVS  GMELSEIDGA  NRMGPTFGGM  300
301   MFSGIKAAQE  ALNVFEERKA  ANEKCI  326
Nucleotide CDS Sequence (FASTA)
1     ATGGCCCCCG  CTACTGCTGT  TGCTCAAGTT  CAAAATCTCT  TCAAGTCCGA  CTTGCCAGTC  60
61    GAAAAGGACG  TTGCCCTCGT  CAAAAATGAA  TACAACACTT  TGGCGAAATC  TTTCCCTACG  120
121   TACCAACTGG  ATGATGCTTT  CAACTTCTCT  CCTATCCGTG  AAAGTACTGT  TTCTCGTGCC  180
181   ATGACTCGTC  GCTACTTTGC  AGACTTGGAT  AAGTATGCTG  AGTCTGACAT  TGTCATTGTC  240
241   GGTGCCGGAT  CCGCTGGCCT  CACTGCTGCT  TACTATCTTG  GTACTCGCCG  TCCTGACCTG  300
301   AAGATTGCAA  TCATTGAGGC  CTCCGTTGCT  CCTGGTGGTG  GAGCCTGGTT  GGGCGGTCAA  360
361   CTCTTTTCCG  CCATGGTCGT  CCGTAAGCCG  GCTGATGCCT  TCTTGAGAGA  AATCGGTGTT  420
421   CCTTATGAGG  ATGAAGGTGA  ATACGTGGTT  ATCAAGCATG  CTGCTCTCTT  CACAAGCACC  480
481   GTCATGGCCC  GTGCTCTCTC  CCTTCCTAAC  ATCAAGCTCT  TTAACGCTAC  TGCCGTGGAA  540
541   GATTTGATTG  TCAAGGCTGA  TCAAGATGGC  AACCAACGTA  TCGCTGGTGT  TGTCACCAAC  600
601   TGGACTCTTG  TCAGTTTAAA  CCATGGCCTT  CAATCTTGTA  TGGATCCCAA  CACCATCAAT  660
661   GCTCATTTGG  TCCTTTCGGC  CACTGGTCAT  GACGGTCCCT  TTGGTGCTTT  CTGCGTTAAG  720
721   CGTGCTCACC  AAGCTGGCCT  TGTCCCACAT  CTCGGCGACA  TGCGCCCTCT  TGACATGAAT  780
781   CGTTCCGAAA  ACCTCATTGT  GAAGGGTACT  CGTGAGGTGT  ATCCTGGTTT  GGTTGTTTCT  840
841   GGTATGGAAC  TTTCTGAAAT  TGACGGTGCC  AATCGTATGG  GACCTACCTT  TGGAGGTATG  900
901   ATGTTTAGTG  GTATTAAGGC  CGCTCAAGAA  GCTCTCAATG  TCTTCGAAGA  GCGTAAGGCT  960
961   GCCAACGAAA  AGTGCATTTA  A  981

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Iron
Metal-binding
NAD
Nucleus
Reference proteome
Thiamine biosynthesis

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Ferrous iron binding
Biological Process
Mitochondrial genome maintenance
Biological Process
Thiamine biosynthetic process
Biological Process
Thiazole biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scp-1218Schizosaccharomyces pombe82.320.0 564
LLPS-Scj-0756Schizosaccharomyces japonicus75.01e-177 502
LLPS-Dos-0753Dothistroma septosporum74.372e-147 426
LLPS-Beb-1360Beauveria bassiana73.672e-151 436
LLPS-Zyt-1438Zymoseptoria tritici73.212e-149 431
LLPS-Yal-0832Yarrowia lipolytica71.793e-148 427
LLPS-Gag-1235Gaeumannomyces graminis71.335e-146 422
LLPS-Ved-1064Verticillium dahliae70.619e-144 416
LLPS-Aso-1224Aspergillus oryzae70.041e-141 411
LLPS-Asf-0728Aspergillus flavus70.042e-141 410
LLPS-Trv-1189Trichoderma virens69.975e-159 455
LLPS-Asc-1414Aspergillus clavatus68.931e-137 400
LLPS-Trr-1598Trichoderma reesei68.923e-157 451
LLPS-Nef-1655Neosartorya fischeri68.332e-136 398
LLPS-Asfu-0582Aspergillus fumigatus68.333e-136 397
LLPS-Asni-1024Aspergillus niger68.331e-135 395
LLPS-Kop-0763Komagataella pastoris68.331e-143 417
LLPS-Ast-0883Aspergillus terreus67.623e-136 397
LLPS-Fus-0793Fusarium solani67.492e-150 433
LLPS-Asn-1074Aspergillus nidulans67.262e-134 392
LLPS-Cog-0297Colletotrichum gloeosporioides67.032e-131 383
LLPS-Phn-1400Phaeosphaeria nodorum66.671e-146 424
LLPS-Fuo-0798Fusarium oxysporum66.565e-153 439
LLPS-Fuv-0714Fusarium verticillioides66.567e-153 439
LLPS-Lem-1150Leptosphaeria maculans66.457e-143 414
LLPS-Pyt-1423Pyrenophora teres66.065e-150 432
LLPS-Pytr-0312Pyrenophora triticirepentis65.751e-149 431
LLPS-Map-1077Magnaporthe poae65.383e-67 214
LLPS-Coo-1567Colletotrichum orbiculare65.354e-150 432
LLPS-Usm-0315Ustilago maydis65.114e-129 380
LLPS-Spr-1444Sporisorium reilianum64.756e-129 379
LLPS-Nec-1596Neurospora crassa64.624e-146 423
LLPS-Mel-1495Melampsora laricipopulina64.262e-129 380
LLPS-Cogr-0346Colletotrichum graminicola63.145e-145 419
LLPS-Pug-1518Puccinia graminis63.092e-132 388
LLPS-Orbr-1552Oryza brachyantha62.827e-119 353
LLPS-Brd-0348Brachypodium distachyon62.682e-122 363
LLPS-Sei-1907Setaria italica62.376e-117 352
LLPS-Mao-0723Magnaporthe oryzae62.342e-134 392
LLPS-Tra-1465Triticum aestivum62.326e-122 362
LLPS-Orp-0033Oryza punctata62.287e-119 354
LLPS-Brr-0794Brassica rapa62.272e-121 360
LLPS-Chr-1208Chlamydomonas reinhardtii62.191e-119 356
LLPS-Ors-1541Oryza sativa62.098e-118 351
LLPS-Org-1540Oryza glaberrima62.098e-118 351
LLPS-Ori-1748Oryza indica62.099e-118 351
LLPS-Orgl-0412Oryza glumaepatula62.095e-118 352
LLPS-Orm-0000Oryza meridionalis62.012e-118 353
LLPS-Tru-1608Triticum urartu61.977e-121 358
LLPS-Cus-0072Cucumis sativus61.927e-114 341
LLPS-Sot-1873Solanum tuberosum61.83e-116 347
LLPS-Lep-0129Leersia perrieri61.753e-119 355
LLPS-Pot-0108Populus trichocarpa61.736e-118 352
LLPS-Orni-1324Oryza nivara61.732e-116 348
LLPS-Art-0028Arabidopsis thaliana61.629e-119 353
LLPS-Sob-0736Sorghum bicolor61.628e-113 338
LLPS-Nia-0832Nicotiana attenuata61.591e-118 353
LLPS-Amt-2009Amborella trichopoda61.455e-117 349
LLPS-Arl-0933Arabidopsis lyrata61.093e-118 352
LLPS-Abg-1389Absidia glauca61.016e-117 347
LLPS-Zem-1935Zea mays60.921e-110 333
LLPS-Prp-2498Prunus persica60.878e-112 336
LLPS-Put-0937Puccinia triticina60.718e-68 217
LLPS-Sol-1151Solanum lycopersicum60.432e-116 348
LLPS-Coc-0402Corchorus capsularis60.298e-109 328
LLPS-Mae-1206Manihot esculenta60.143e-117 350
LLPS-Met-1474Medicago truncatula60.075e-123 364
LLPS-Php-2188Physcomitrella patens60.02e-114 345
LLPS-Gor-1060Gossypium raimondii59.867e-116 346
LLPS-Sem-1733Selaginella moellendorffii59.789e-117 348
LLPS-Thc-1873Theobroma cacao59.643e-109 329
LLPS-Phv-2134Phaseolus vulgaris59.586e-118 351
LLPS-Dac-0004Daucus carota59.532e-121 360
LLPS-Viv-0366Vitis vinifera59.516e-117 349
LLPS-Asg-0622Ashbya gossypii59.035e-113 338
LLPS-Sac-1490Saccharomyces cerevisiae58.192e-113 339
LLPS-Via-1319Vigna angularis57.682e-117 350
LLPS-Vir-0404Vigna radiata57.681e-116 348
LLPS-Hea-2059Helianthus annuus57.645e-115 344
LLPS-Glm-2963Glycine max57.621e-118 353
LLPS-Bro-0324Brassica oleracea56.745e-121 359
LLPS-Brn-2307Brassica napus56.564e-119 354
LLPS-Mua-1213Musa acuminata55.712e-1784.0
LLPS-Orb-2335Oryza barthii53.075e-91 281
LLPS-Hov-0559Hordeum vulgare49.332e-96 296