DrLLPS - Data resource of LLPS

LLPS-Sus-a642
RAB5A

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Ras-related protein Rab-5A
Gene Name:	RAB5A
Ensembl Gene:	ENSSSCG00000037653.1
Ensembl Protein:	ENSSSCP00000034240.1
Organism:	Sus scrofa
Taxa ID:	9823
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-a648	P20339	Client	Postsynaptic density	97.67	2e-156	441
Mus musculus	LLPS-Mum-a642	Q9CQD1	Client	Postsynaptic density	97.67	2e-156	441

▼ FUNCTION

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSSSCT00000045035.1	ENSSSCP00000034240.1
UniProt		Q06AU6, RAB5A_PIG
GeneBank	DQ917629	ABI97174.1
RefSeq	NM_001123180.1	NP_001116652.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MANRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ 60 61 TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR 120 121 QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK 180 181 LPKNEPQNPG INCTRGRGVD LTEPTQPTRS QCCSN 215

▼ KEYWORD

ID	Family
KW-1003	Cell membrane
KW-0966	Cell projection
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0968	Cytoplasmic vesicle
KW-0254	Endocytosis
KW-0967	Endosome
KW-0342	GTP-binding
KW-0449	Lipoprotein
KW-0472	Membrane
KW-0547	Nucleotide-binding
KW-0581	Phagocytosis
KW-0636	Prenylation
KW-0653	Protein transport
KW-1185	Reference proteome
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0015629	Cellular Component	Actin cytoskeleton
GO:0098993	Cellular Component	Anchored component of synaptic vesicle membrane
GO:0030424	Cellular Component	Axon
GO:0005737	Cellular Component	Cytoplasm
GO:0098559	Cellular Component	Cytoplasmic side of early endosome membrane
GO:0005829	Cellular Component	Cytosol
GO:0030425	Cellular Component	Dendrite
GO:0005769	Cellular Component	Early endosome
GO:0032009	Cellular Component	Early phagosome
GO:0030139	Cellular Component	Endocytic vesicle
GO:0005768	Cellular Component	Endosome
GO:0042470	Cellular Component	Melanosome
GO:0045121	Cellular Component	Membrane raft
GO:0045335	Cellular Component	Phagocytic vesicle
GO:0030670	Cellular Component	Phagocytic vesicle membrane
GO:0005886	Cellular Component	Plasma membrane
GO:0098842	Cellular Component	Postsynaptic early endosome
GO:0001726	Cellular Component	Ruffle
GO:0008021	Cellular Component	Synaptic vesicle
GO:0043195	Cellular Component	Terminal bouton
GO:0019003	Molecular Function	GDP binding
GO:0005525	Molecular Function	GTP binding
GO:0003924	Molecular Function	GTPase activity
GO:0150093	Biological Process	Amyloid-beta clearance by transcytosis
GO:0045022	Biological Process	Early endosome to late endosome transport
GO:0006897	Biological Process	Endocytosis
GO:0006886	Biological Process	Intracellular protein transport
GO:0006909	Biological Process	Phagocytosis
GO:0045921	Biological Process	Positive regulation of exocytosis
GO:0032482	Biological Process	Rab protein signal transduction
GO:2000286	Biological Process	Receptor internalization involved in canonical Wnt signaling pathway
GO:0030100	Biological Process	Regulation of endocytosis
GO:0051036	Biological Process	Regulation of endosome size
GO:0051489	Biological Process	Regulation of filopodium assembly
GO:0048169	Biological Process	Regulation of long-term neuronal synaptic plasticity
GO:2000300	Biological Process	Regulation of synaptic vesicle exocytosis
GO:0036465	Biological Process	Synaptic vesicle recycling
GO:0039694	Biological Process	Viral RNA genome replication

▼ KEGG

ssc:100144499

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Hos-a648	Homo sapiens	2e-156	441	undefined
LLPS-Mum-a642	Mus musculus	2e-156	441	undefined

LLPS-Sus-a642RAB5A

Protein Sequence

Nucleotide Sequence

LLPS-Sus-a642
RAB5A